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Centro Marga Para la Investigacion SA
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Centro Marga Para la Investigacion SA
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Publication date
Application filed by Centro Marga Para la Investigacion SAfiledCriticalCentro Marga Para la Investigacion SA
Priority to ES8904063ApriorityCriticalpatent/ES2017864A6/en
Publication of ES2017864A6publicationCriticalpatent/ES2017864A6/en
Process for the preparation of N-cyclopropyl quinolones of formula I which are prepared by reacting quinolones of formula II with triflates of formula III in the presence of a tertiary base. < IMAGE > < IMAGE > R1 can be hydrogen, methyl, ethyl, substituted cyclopropyl, R2 chlorine, fluorine or a 1-piperacinyl, R3 is hydrogen, ethyl or trimethylsilyl and R is selected from hydrogen, cyano, carboxy or carboxy derivative. Alternatively I is obtained from the reaction of III with II, where R2 is chlorine, and then with a piperazine.
ES8904063A1989-11-291989-11-29Process for the preparation of N-cyclopropyl quinolones
Expired - Fee RelatedES2017864A6
(en)
Process for the preparation of 3-phenyl-1-methylenedioxyphenyl-indane-2-carboxylic acide and cyclopentapyridine derivatives and their intermediates and the novel intermediates thereof