ES2017278A6 - Procedimiento de obtencion de un derivado del 2-amino-1-fenilpropan-1-ol. - Google Patents

Procedimiento de obtencion de un derivado del 2-amino-1-fenilpropan-1-ol.

Info

Publication number
ES2017278A6
ES2017278A6 ES8903187A ES8903187A ES2017278A6 ES 2017278 A6 ES2017278 A6 ES 2017278A6 ES 8903187 A ES8903187 A ES 8903187A ES 8903187 A ES8903187 A ES 8903187A ES 2017278 A6 ES2017278 A6 ES 2017278A6
Authority
ES
Spain
Prior art keywords
phenylpropan
amino
derivative
treatment
obtaining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES8903187A
Other languages
English (en)
Inventor
Ernesto Forne
Romeo Andreoli
Ricardo Cepero
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sociedad Espanola de Especialidades Farmaco Terapeuticas SA
Original Assignee
Sociedad Espanola de Especialidades Farmaco Terapeuticas SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sociedad Espanola de Especialidades Farmaco Terapeuticas SA filed Critical Sociedad Espanola de Especialidades Farmaco Terapeuticas SA
Priority to ES8903187A priority Critical patent/ES2017278A6/es
Publication of ES2017278A6 publication Critical patent/ES2017278A6/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE UN DERIVADO DEL 2-AMINO-1-FENILPROPAN-1-OL. (LA PRESENTE INVENCION TRATA DE UN) PROCEDIMIENTO PARA LA PREPARACION INDUSTRIAL DE UN DERIVADO DEL 2-AMINO-1-FENILPROPAN-1-OL, CONCRETAMENTE DEL (-)-ERITRO-N,N-[2-(10,11-DIHIDRO-5H-DIBENZO[A,D]CICLOHEPTEN-5-ILIDEN)ETIL]METIL-2-AMINO-1-FENILPROPAN-1-OL (I), CONOCIDO TAMBIEN COMO WAS-4304 O TRECADRINE, CARACTERIZADO PORQUE EL (10,11-DIHIDRO-5H-DIBENZO-[A,D]CICLOPHEPTEN-5-ILIDEN)ACETALDEHIDO SE HACE REACCIONAR CON (-)-EFEDRINA PARA OBTENER COMO INTERMEDIO UN DERIVADO 1,3-OXAZOLIDINA, EL CUAL PUEDE O NO AISLARSE, Y SE TRANSFORMA EN TRECADRINE (I) POR REDUCCION. LOS DISOLVENTES USADOS EN LA PREPARACION DEL INTERMEDIO SON POCOS POLARES, COMO HIDROCARBUROS, ETERES O DISOLVENTES CLORADOS. LA REDUCCION PUEDE REALIZARSE MEDIANTE HIDROGENACION CATALITICA, TRATAMIENTO CON HIDRUROS O TRATAMIENTO CON AMALGAMA DE ALUMINIO O SODIO. (EL PROCEDIMIENTO OBJETO DE LA PRESENTE INVENCION PROPORCIONA EL PRODUCTO (I) VENTAJOSAMENTE, A PARTIRDE PRODUCTOS DE PARTIDA MAS ACCESIBLES Y PRODUCIENDO UN PRODUCTO MAS FACILMENTE PURIFICABLE.) EL PRODUCTO OBTENIDO (I) ES UTIL COMO PRINCIPIO ACTIVO FARMACEUTICO PARA EL TRATAMIENTO DE LAS ULCERAS.
ES8903187A 1989-09-21 1989-09-21 Procedimiento de obtencion de un derivado del 2-amino-1-fenilpropan-1-ol. Expired - Lifetime ES2017278A6 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES8903187A ES2017278A6 (es) 1989-09-21 1989-09-21 Procedimiento de obtencion de un derivado del 2-amino-1-fenilpropan-1-ol.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES8903187A ES2017278A6 (es) 1989-09-21 1989-09-21 Procedimiento de obtencion de un derivado del 2-amino-1-fenilpropan-1-ol.

Publications (1)

Publication Number Publication Date
ES2017278A6 true ES2017278A6 (es) 1991-01-16

Family

ID=8263977

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8903187A Expired - Lifetime ES2017278A6 (es) 1989-09-21 1989-09-21 Procedimiento de obtencion de un derivado del 2-amino-1-fenilpropan-1-ol.

Country Status (1)

Country Link
ES (1) ES2017278A6 (es)

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