ES2017032A6 - 4,5-dihydro-3(2h)-pyridazinones, process for producing them and their use - Google Patents
4,5-dihydro-3(2h)-pyridazinones, process for producing them and their useInfo
- Publication number
- ES2017032A6 ES2017032A6 ES8902791A ES8902791A ES2017032A6 ES 2017032 A6 ES2017032 A6 ES 2017032A6 ES 8902791 A ES8902791 A ES 8902791A ES 8902791 A ES8902791 A ES 8902791A ES 2017032 A6 ES2017032 A6 ES 2017032A6
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- alkyl
- alkyl moiety
- residue
- imidazolyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
4,5-Dihydro-3(2H)-pyridazinones of general formula (I), wherein R denotes hydrogen, alkyl with 1 to 3 carbon atoms or hydroxymethyl and R<1> denotes a phenyl residue of formula (II) or an indolyl residue of formula (III), R<2> being pyridyl, thiazolyl, imidazolyl, linked via an oxygen, nitrogen or sulphur atom or via a sulfinyl or sulfonyl group with the phenyl or indolyl residue, or imidazolyl, in which the thiazolyl and imidazolyl residues can possibly be substituted by alkyl with 1 to 3 carbon atoms, halogen, nitro, amino, alkylcarbonylamino with 1 to 3 carbon atoms in the alkyl moiety, mono- or dialkylamino with 1 to 3 carbon atoms per alkyl moiety or alkoxycarbonylamino with 1 to 3 carbon atoms in the alkyl moiety, R<3> being hydrogen, alkyl with 1 to 4 carbon atoms, alkoxy with 1 to 4 carbon atoms, hydroxy or halogen, and R<4> being hydrogen, alkyl with 1 to 5 carbon atoms, alkylcarbonyl with 1 to 4 carbon atoms in the alkyl moiety, phenylcarbonyl, alkoxycarbonyl with 1 to 4 carbon atoms in the alkyl moiety or phenalkoxycarbonyl with 1 to 4 carbon atoms in the alkyl moiety, as well as their producible, pharmaceutically acceptable acid addition salts, in which when R<1> is a phenyl residue, R<2> cannot be a pyridyl or imidazolyl residue linked via a nitrogen atom, are useful pharmacological active ingredients.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3826855A DE3826855A1 (en) | 1988-08-06 | 1988-08-06 | 4,5-DIHYDRO-3 (2H) -PYRIDAZINONE, PROCESS FOR THEIR PREPARATION AND THEIR USE |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2017032A6 true ES2017032A6 (en) | 1990-12-16 |
Family
ID=6360424
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8902791A Expired - Fee Related ES2017032A6 (en) | 1988-08-06 | 1989-08-04 | 4,5-dihydro-3(2h)-pyridazinones, process for producing them and their use |
Country Status (4)
Country | Link |
---|---|
KR (1) | KR900701777A (en) |
DE (1) | DE3826855A1 (en) |
ES (1) | ES2017032A6 (en) |
WO (1) | WO1990001479A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2007277163B2 (en) | 2006-07-25 | 2012-06-21 | Cephalon, Inc. | Pyridizinone derivatives |
CU24334B1 (en) * | 2013-06-27 | 2018-04-03 | Pfizer | PIRIDIN-2 CONTAINING IL-4-SUBSTITUTED DERIVATIVES OF 1-DIAZINO PHENYL USEFUL AS LEGANDOS OF DOPAMINE |
CN110117257B (en) * | 2018-02-05 | 2022-12-06 | 安徽省新星药物开发有限责任公司 | P2Y12 receptor antagonist containing guanidyl as well as preparation method and application thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU190412B (en) * | 1981-09-17 | 1986-09-29 | Warner-Lambert Co,Us | Process for producing substituted 4,5-dihiydro-6-bracket-substituted-bracket closed-phenyl-3-bracket-2h-bracket closed-pyridazinones and 6-bracket-substituted-bracket closed-phenyl-3-bracket-2h-bracket closed-pyridazinones |
DE3212304A1 (en) * | 1982-04-02 | 1983-10-06 | Nattermann A & Cie | IMIDAZOLYLPHENYL-TETRAHYDROPYRIDAZINE, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM |
US4717730A (en) * | 1982-12-03 | 1988-01-05 | Warner-Lambert Company | 4,5-dihydro-6-(substituted)phenyl-5-methyl-3-(2H)-pyridazinones and pharmaceutical compositions containing the compounds as active components |
HU193067B (en) * | 1983-12-14 | 1987-08-28 | Mitsubishi Chem Ind | Process for the production of new pyridazinon-derivatives and of their salts |
AU5428686A (en) * | 1985-03-12 | 1986-09-18 | Smith Kline & French Laboratories Limited | Imidazolinone and thiazolinone derivatives |
DE3531658A1 (en) * | 1985-09-05 | 1987-03-12 | Boehringer Mannheim Gmbh | HETEROCYCLICALLY SUBSTITUTED INDOLE, INTERMEDIATE PRODUCTS, METHOD FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS |
-
1988
- 1988-08-06 DE DE3826855A patent/DE3826855A1/en not_active Withdrawn
-
1989
- 1989-07-21 WO PCT/EP1989/000859 patent/WO1990001479A1/en unknown
- 1989-07-21 KR KR1019900700710A patent/KR900701777A/en not_active Application Discontinuation
- 1989-08-04 ES ES8902791A patent/ES2017032A6/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE3826855A1 (en) | 1990-02-15 |
KR900701777A (en) | 1990-12-04 |
WO1990001479A1 (en) | 1990-02-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20001204 |