ES2007281A6 - 2, 4, 5-tri-substituted benzamide derivatives - Google Patents

2, 4, 5-tri-substituted benzamide derivatives

Info

Publication number
ES2007281A6
ES2007281A6 ES8802412A ES8802412A ES2007281A6 ES 2007281 A6 ES2007281 A6 ES 2007281A6 ES 8802412 A ES8802412 A ES 8802412A ES 8802412 A ES8802412 A ES 8802412A ES 2007281 A6 ES2007281 A6 ES 2007281A6
Authority
ES
Spain
Prior art keywords
group
tetrahydrofuryl
cyclohexenyl
cycloalkyl
tri
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8802412A
Other languages
Spanish (es)
Inventor
Noverola Armando Vega
Soto Jose Prieto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fordonal SA
Original Assignee
Fordonal SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fordonal SA filed Critical Fordonal SA
Publication of ES2007281A6 publication Critical patent/ES2007281A6/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Compounds of the general formula: < IMAGE > [wherein R<1> represents hydrogen or an acetyl group R<2> represents halogen R<3> represents a group selected from: < IMAGE > (wherein R<5> represents C1-C6 alkyl group R<6> represents hydrogen or a methyl or methoxy group R<7> represents a cyclohexenyl, phenyl, 4-fluorophenoxy, tetrahydrofuryl or 1, 3-dioxolanyl group and n is a number from 1 to 3) R4 represents a C3-C6 cycloalkyl, tetrahydrofuryl, cyclohexenyl or phenoxy group and m 0, 1, 2, 3 or 4 (with the proviso that when m is 0, R<4> is either a C3-C6 cycloalkyl or tetrahydrofuryl group)] and a pharmaceutically acceptable acid addition salts thereof have pharmacological properties rendering them useful as antiemetic agents in the treatment of a wide range of gastrointestinal disorders of somatic, psychosomatic and @in comparison with prior art.
ES8802412A 1987-08-03 1988-08-02 2, 4, 5-tri-substituted benzamide derivatives Expired ES2007281A6 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878718346A GB8718346D0 (en) 1987-08-03 1987-08-03 Substituted benzamides

Publications (1)

Publication Number Publication Date
ES2007281A6 true ES2007281A6 (en) 1989-06-01

Family

ID=10621741

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8802412A Expired ES2007281A6 (en) 1987-08-03 1988-08-02 2, 4, 5-tri-substituted benzamide derivatives

Country Status (2)

Country Link
ES (1) ES2007281A6 (en)
GB (2) GB8718346D0 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9005014D0 (en) * 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
JP2529912B2 (en) * 1990-10-16 1996-09-04 帝国化学産業株式会社 Benzamide derivative
DE69326245T2 (en) * 1992-07-17 2000-05-18 Janssen Pharmaceutica N.V., Beerse 4-AMINO-N- (4-METHYL-4-PIPERIDINYL) -2-METHOXYBENZAMIDES, THEIR PRODUCTION AND USE THEREOF AS 5-HT2 ANTAGONISTS
WO2001064641A1 (en) * 2000-03-02 2001-09-07 Kissei Pharmaceutical Co., Ltd. Hydroxyethoxybenzamide derivatives and drugs containing the same
KR100976063B1 (en) * 2007-03-16 2010-08-17 동아제약주식회사 Novel benzamide derivatives and process for the preparation thereof
CN110950843B (en) * 2019-11-28 2022-12-27 广东东阳光药业有限公司 Substituted benzamide derivatives and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4808624A (en) * 1984-06-28 1989-02-28 Bristol-Myers Company Pharmacologically active substituted benzamides

Also Published As

Publication number Publication date
GB8818350D0 (en) 1988-09-07
GB2207673B (en) 1991-09-11
GB8718346D0 (en) 1987-09-09
GB2207673A (en) 1989-02-08

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001009