ES2006891A6 - Oligo saccharide fractions prepn. - by ultrafiltering aq. heparin soln. prior to de:polymerisation and partition perforated between liq. phases - Google Patents
Oligo saccharide fractions prepn. - by ultrafiltering aq. heparin soln. prior to de:polymerisation and partition perforated between liq. phasesInfo
- Publication number
- ES2006891A6 ES2006891A6 ES8801088A ES8801088A ES2006891A6 ES 2006891 A6 ES2006891 A6 ES 2006891A6 ES 8801088 A ES8801088 A ES 8801088A ES 8801088 A ES8801088 A ES 8801088A ES 2006891 A6 ES2006891 A6 ES 2006891A6
- Authority
- ES
- Spain
- Prior art keywords
- heparin
- soln
- fractions
- low
- ultrafiltering
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Peptides Or Proteins (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Prodn. of oligosaccharide fractions derived from heparin is claimed, the fractions having pharmacological properties, such as high antithrombotic activity, low effects on platelet function, high bioavailability, low haemorrhagic risk and virtually no toxic effects. Aq. heparin soln. is subjected to ultrafiltration using membranes with nominal mol. wt. cut-off of 3,000, in order to exclude low mol. wt. fractions form the depolymerisation step the rejected ultrafiltered heparin soln. is phase partitioned as a quat. ammonium complex formed with aq. saline soln. and CH2Cl2, in order to segregate fractions of low anionicity, i.e. low specificity for antithrombin, from the depolymerisation step and the obtd. heparin soln. is chemically depolymerised in more than one step, sepn. after each cycle a defined depolymerised fraction from the reaction mixt. by phase partition.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES8801088A ES2006891A6 (en) | 1988-04-09 | 1988-04-09 | Oligo saccharide fractions prepn. - by ultrafiltering aq. heparin soln. prior to de:polymerisation and partition perforated between liq. phases |
EP89106213A EP0337327A1 (en) | 1988-04-09 | 1989-04-07 | Process for the preparation of new oligosaccharide fractions by controlled chemical depolimerization of heparin |
US07/335,942 US5084564A (en) | 1988-04-09 | 1989-04-10 | Production of oligosaccharide fractions having antithrombotic properties by controlled chemical depolymerization of heparin |
JP1091692A JPH02206601A (en) | 1988-04-09 | 1989-04-10 | Preparation of oligosaccharlde fraction having antithrombin action |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES8801088A ES2006891A6 (en) | 1988-04-09 | 1988-04-09 | Oligo saccharide fractions prepn. - by ultrafiltering aq. heparin soln. prior to de:polymerisation and partition perforated between liq. phases |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2006891A6 true ES2006891A6 (en) | 1989-05-16 |
Family
ID=8255754
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8801088A Expired ES2006891A6 (en) | 1988-04-09 | 1988-04-09 | Oligo saccharide fractions prepn. - by ultrafiltering aq. heparin soln. prior to de:polymerisation and partition perforated between liq. phases |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2006891A6 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2036922A1 (en) * | 1990-06-26 | 1993-06-01 | Rhone Poulenc Rorer Sa | Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events |
-
1988
- 1988-04-09 ES ES8801088A patent/ES2006891A6/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2036922A1 (en) * | 1990-06-26 | 1993-06-01 | Rhone Poulenc Rorer Sa | Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Walenga et al. | Biochemical and pharmacologic rationale for the development of a synthetic heparin pentasaccharide | |
ATE88197T1 (en) | PROCESS FOR PRODUCTION OF CLEAR BLOCK COPOLYMERS. | |
US5013724A (en) | Process for the sulfation of glycosaminoglycans, the sulfated glycosaminoglycans and their biological applications | |
ATE131176T1 (en) | SULFATED POLYSACCHARIDES, ANTICOAGULATION AND ANTICOMPLMENTARY AGENTS PRODUCED FROM BROWN ALGAE FUCANES AND METHOD FOR THE PRODUCTION THEREOF. | |
CA2045433A1 (en) | Low molecular weight polysaccharide mixes; process for their preparation and use | |
EP1616883A3 (en) | Antibodies against VLA-4 | |
WO1990004607A3 (en) | Novel dermatan sulfate and heparin oligosaccharides having antiatherosclerotic activity | |
KR970042568A (en) | Process for preparing cycloolefin copolymer | |
EP0733653A3 (en) | Method for the preparation of ethylene polymer compositions | |
EP0227838A4 (en) | Polyethylene composition. | |
Dušek et al. | Graphlike state of matter. 10. Cyclization and concentration of elastically active network chains in polymer networks | |
ES2006891A6 (en) | Oligo saccharide fractions prepn. - by ultrafiltering aq. heparin soln. prior to de:polymerisation and partition perforated between liq. phases | |
ES8402319A1 (en) | Process for manufacturing low molecular weight heparins by depolymerization of normal heparin. | |
CA2032771A1 (en) | Process for the preparation of a syndiotactic propylene copolymer | |
DE59005222D1 (en) | Expandable styrene polymers with high oil resistance and process for their production. | |
Hoppensteadt et al. | Comparative antithrombotic and hemorrhagic effects of dermatan sulfate, heparin sulfate and heparin | |
Gettins et al. | One-and two-dimensional 13C-nmr characterization of two series of oligosaccharides derived from porcine intestinal mucosal heparin by degradation with heparinase | |
EP0287762A3 (en) | Methathesis polymerized copolymer | |
Lindenberger et al. | Copolymerization of 1, 6‐anhydroglucose and 1, 6‐anhydromaltose derivatives | |
DK0410326T3 (en) | Genetic control of acetylation and pyruvylation of xanthan gum | |
Bamford et al. | Network properties: 2. A broadline nmr study of molecular motions in some multicomponent crosslinked polymers | |
CA2033286A1 (en) | Polymer and polypropylene resin composition | |
SE8204108L (en) | FTALOCYANINPRODUKTER | |
Podešva et al. | Effect of structure of copolymers on the extent of selective sorption in dilute solutions in mixed solvents | |
Sumitomo et al. | Cationic Ring-Opening Polymerization of Bicyclic Acetals in Relation to the Synthesis of Polysaccharides |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20010410 |