ES2006891A6 - Oligo saccharide fractions prepn. - by ultrafiltering aq. heparin soln. prior to de:polymerisation and partition perforated between liq. phases - Google Patents

Oligo saccharide fractions prepn. - by ultrafiltering aq. heparin soln. prior to de:polymerisation and partition perforated between liq. phases

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Publication number
ES2006891A6
ES2006891A6 ES8801088A ES8801088A ES2006891A6 ES 2006891 A6 ES2006891 A6 ES 2006891A6 ES 8801088 A ES8801088 A ES 8801088A ES 8801088 A ES8801088 A ES 8801088A ES 2006891 A6 ES2006891 A6 ES 2006891A6
Authority
ES
Spain
Prior art keywords
heparin
soln
fractions
low
ultrafiltering
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8801088A
Other languages
Spanish (es)
Inventor
Pahi Francisco J Vila
Alberto David Nusimovich
Torne Pedro Gomis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioiberica SA
Original Assignee
Bioiberica SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioiberica SA filed Critical Bioiberica SA
Priority to ES8801088A priority Critical patent/ES2006891A6/en
Priority to EP89106213A priority patent/EP0337327A1/en
Priority to US07/335,942 priority patent/US5084564A/en
Priority to JP1091692A priority patent/JPH02206601A/en
Publication of ES2006891A6 publication Critical patent/ES2006891A6/en
Expired legal-status Critical Current

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  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Prodn. of oligosaccharide fractions derived from heparin is claimed, the fractions having pharmacological properties, such as high antithrombotic activity, low effects on platelet function, high bioavailability, low haemorrhagic risk and virtually no toxic effects. Aq. heparin soln. is subjected to ultrafiltration using membranes with nominal mol. wt. cut-off of 3,000, in order to exclude low mol. wt. fractions form the depolymerisation step the rejected ultrafiltered heparin soln. is phase partitioned as a quat. ammonium complex formed with aq. saline soln. and CH2Cl2, in order to segregate fractions of low anionicity, i.e. low specificity for antithrombin, from the depolymerisation step and the obtd. heparin soln. is chemically depolymerised in more than one step, sepn. after each cycle a defined depolymerised fraction from the reaction mixt. by phase partition.
ES8801088A 1988-04-09 1988-04-09 Oligo saccharide fractions prepn. - by ultrafiltering aq. heparin soln. prior to de:polymerisation and partition perforated between liq. phases Expired ES2006891A6 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ES8801088A ES2006891A6 (en) 1988-04-09 1988-04-09 Oligo saccharide fractions prepn. - by ultrafiltering aq. heparin soln. prior to de:polymerisation and partition perforated between liq. phases
EP89106213A EP0337327A1 (en) 1988-04-09 1989-04-07 Process for the preparation of new oligosaccharide fractions by controlled chemical depolimerization of heparin
US07/335,942 US5084564A (en) 1988-04-09 1989-04-10 Production of oligosaccharide fractions having antithrombotic properties by controlled chemical depolymerization of heparin
JP1091692A JPH02206601A (en) 1988-04-09 1989-04-10 Preparation of oligosaccharlde fraction having antithrombin action

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES8801088A ES2006891A6 (en) 1988-04-09 1988-04-09 Oligo saccharide fractions prepn. - by ultrafiltering aq. heparin soln. prior to de:polymerisation and partition perforated between liq. phases

Publications (1)

Publication Number Publication Date
ES2006891A6 true ES2006891A6 (en) 1989-05-16

Family

ID=8255754

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8801088A Expired ES2006891A6 (en) 1988-04-09 1988-04-09 Oligo saccharide fractions prepn. - by ultrafiltering aq. heparin soln. prior to de:polymerisation and partition perforated between liq. phases

Country Status (1)

Country Link
ES (1) ES2006891A6 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2036922A1 (en) * 1990-06-26 1993-06-01 Rhone Poulenc Rorer Sa Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2036922A1 (en) * 1990-06-26 1993-06-01 Rhone Poulenc Rorer Sa Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events

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FD1A Patent lapsed

Effective date: 20010410