EP4792135A1 - Procédés de détection de cancer, de prédiction de réponse à une thérapie et de traitement - Google Patents

Procédés de détection de cancer, de prédiction de réponse à une thérapie et de traitement

Info

Publication number
EP4792135A1
EP4792135A1 EP24878008.2A EP24878008A EP4792135A1 EP 4792135 A1 EP4792135 A1 EP 4792135A1 EP 24878008 A EP24878008 A EP 24878008A EP 4792135 A1 EP4792135 A1 EP 4792135A1
Authority
EP
European Patent Office
Prior art keywords
monocytes
cluster
cancer
therapy
blockade
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24878008.2A
Other languages
German (de)
English (en)
Inventor
Margaret A. Shipp
Julia I. PACZKOWSKA
Ming Tang
Kyle T. WRIGHT
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dana Farber Cancer Institute Inc
Original Assignee
Dana Farber Cancer Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Institute Inc filed Critical Dana Farber Cancer Institute Inc
Publication of EP4792135A1 publication Critical patent/EP4792135A1/fr
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des procédés de détection de cancer chez un sujet et des procédés de prédiction d'une réponse à une thérapie anticancéreuse de blocage PD-1/PD-L1 chez un patient cancéreux avant et/ou pendant l'utilisation de la thérapie, ainsi que des procédés de traitement, dans lesquels des monocytes sanguins périphériques sont analysés pour un sous-ensemble unique de monocytes classiques qui expriment une signature à base d'ARN transcriptionnel associée à une sensibilité à la thérapie anticancéreuse de blocage PD-1/PD-L1.
EP24878008.2A 2023-10-11 2024-10-10 Procédés de détection de cancer, de prédiction de réponse à une thérapie et de traitement Pending EP4792135A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PL44635423 2023-10-11
US202363543820P 2023-10-12 2023-10-12
PCT/US2024/050787 WO2025080842A1 (fr) 2023-10-11 2024-10-10 Procédés de détection de cancer, de prédiction de réponse à une thérapie et de traitement

Publications (1)

Publication Number Publication Date
EP4792135A1 true EP4792135A1 (fr) 2026-08-19

Family

ID=95396301

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24878008.2A Pending EP4792135A1 (fr) 2023-10-11 2024-10-10 Procédés de détection de cancer, de prédiction de réponse à une thérapie et de traitement

Country Status (2)

Country Link
EP (1) EP4792135A1 (fr)
WO (1) WO2025080842A1 (fr)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201903015D0 (en) * 2019-03-08 2019-04-17 Univ Edinburgh Macrophage expression in breast cancer
TW202340480A (zh) * 2021-11-23 2023-10-16 義大利商義大利藥品股份有限公司 檢測rna生物標記之方法
WO2024108114A2 (fr) * 2022-11-18 2024-05-23 The Regents Of The University Of California Procédés de sélection de patients atteints d'un cancer réceptifs à un traitement avec un inhibiteur de point de contrôle immunitaire

Also Published As

Publication number Publication date
WO2025080842A1 (fr) 2025-04-17

Legal Events

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