EP4788674A1 - Carbamate zur verwendung als sarm1-inhibitoren - Google Patents
Carbamate zur verwendung als sarm1-inhibitorenInfo
- Publication number
- EP4788674A1 EP4788674A1 EP24798624.3A EP24798624A EP4788674A1 EP 4788674 A1 EP4788674 A1 EP 4788674A1 EP 24798624 A EP24798624 A EP 24798624A EP 4788674 A1 EP4788674 A1 EP 4788674A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- formula
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202363588208P | 2023-10-05 | 2023-10-05 | |
| US202463683372P | 2024-08-15 | 2024-08-15 | |
| PCT/US2024/049501 WO2025076017A1 (en) | 2023-10-05 | 2024-10-02 | Carbamates for use as sarm1 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP4788674A1 true EP4788674A1 (de) | 2026-08-12 |
Family
ID=93289080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP24798624.3A Pending EP4788674A1 (de) | 2023-10-05 | 2024-10-02 | Carbamate zur verwendung als sarm1-inhibitoren |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP4788674A1 (de) |
| CN (1) | CN121969615A (de) |
| WO (1) | WO2025076017A1 (de) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4192828A1 (de) * | 2020-08-04 | 2023-06-14 | Nura Bio, Inc. | Substituierte pyridinderivate als sarm1-inhibitoren |
| TW202334117A (zh) * | 2020-08-24 | 2023-09-01 | 美商達薩瑪治療公司 | Ｓａｒｍ１之抑制劑 |
| CN121218985A (zh) * | 2022-12-08 | 2025-12-26 | 森雅制药有限公司 | Sarm1抑制剂、药物组合物和治疗应用 |
-
2024
- 2024-10-02 WO PCT/US2024/049501 patent/WO2025076017A1/en not_active Ceased
- 2024-10-02 EP EP24798624.3A patent/EP4788674A1/de active Pending
- 2024-10-02 CN CN202480063570.7A patent/CN121969615A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2025076017A1 (en) | 2025-04-10 |
| CN121969615A (zh) | 2026-05-01 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: UNKNOWN |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
| 17P | Request for examination filed |
Effective date: 20260506 |
|
| AK | Designated contracting states |
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