EP4777522A2 - Verfahren, zusammensetzungen und kits mit zellpenetrierenden mitteln - Google Patents

Verfahren, zusammensetzungen und kits mit zellpenetrierenden mitteln

Info

Publication number
EP4777522A2
EP4777522A2 EP24783406.2A EP24783406A EP4777522A2 EP 4777522 A2 EP4777522 A2 EP 4777522A2 EP 24783406 A EP24783406 A EP 24783406A EP 4777522 A2 EP4777522 A2 EP 4777522A2
Authority
EP
European Patent Office
Prior art keywords
cmip
cell
amino acid
salt
acid residue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24783406.2A
Other languages
English (en)
French (fr)
Inventor
Tarlochan S. Nijjar
Stephen Jed TAM
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Prothena Platform Technologies Ltd
Original Assignee
Prothena Platform Technologies Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prothena Platform Technologies Ltd filed Critical Prothena Platform Technologies Ltd
Publication of EP4777522A2 publication Critical patent/EP4777522A2/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Insects & Arthropods (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Cell Separators (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Battery Mounting, Suspending (AREA)
EP24783406.2A 2023-09-15 2024-09-13 Verfahren, zusammensetzungen und kits mit zellpenetrierenden mitteln Pending EP4777522A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363538596P 2023-09-15 2023-09-15
PCT/US2024/046659 WO2025059491A2 (en) 2023-09-15 2024-09-13 Methods, compositions, and kits including cell-penetrating agents

Publications (1)

Publication Number Publication Date
EP4777522A2 true EP4777522A2 (de) 2026-07-22

Family

ID=92966495

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24783406.2A Pending EP4777522A2 (de) 2023-09-15 2024-09-13 Verfahren, zusammensetzungen und kits mit zellpenetrierenden mitteln

Country Status (10)

Country Link
EP (1) EP4777522A2 (de)
KR (1) KR20260074695A (de)
CN (1) CN122029182A (de)
AR (1) AR133830A1 (de)
AU (1) AU2024342899A1 (de)
IL (1) IL327041A (de)
PY (1) PY2480771A (de)
TW (1) TW202528337A (de)
UY (1) UY40891A (de)
WO (1) WO2025059491A2 (de)

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0279582A3 (de) 1987-02-17 1989-10-18 Pharming B.V. DNA-Sequenzen die Proteine zwecks effizienter Abscheidung zur Milchdrüse leiten
US5633076A (en) 1989-12-01 1997-05-27 Pharming Bv Method of producing a transgenic bovine or transgenic bovine embryo
AU6014094A (en) 1992-12-02 1994-06-22 Baylor College Of Medicine Episomal vectors for gene therapy
US5827690A (en) 1993-12-20 1998-10-27 Genzyme Transgenics Corporatiion Transgenic production of antibodies in milk
US5505947A (en) 1994-05-27 1996-04-09 The University Of North Carolina At Chapel Hill Attenuating mutations in Venezuelan Equine Encephalitis virus
US5786464C1 (en) 1994-09-19 2012-04-24 Gen Hospital Corp Overexpression of mammalian and viral proteins
US7153510B1 (en) 1995-05-04 2006-12-26 Yale University Recombinant vesiculoviruses and their uses
DE19539493A1 (de) 1995-10-24 1997-04-30 Thomae Gmbh Dr K Starker homologer Promotor aus Hamster
US6114148C1 (en) 1996-09-20 2012-05-01 Gen Hospital Corp High level expression of proteins
US5888809A (en) 1997-05-01 1999-03-30 Icos Corporation Hamster EF-1α transcriptional regulatory DNA
PE20020574A1 (es) 2000-12-06 2002-07-02 Wyeth Corp Anticuerpos humanizados que reconocen el peptido amiloideo beta
DE50308030D1 (de) 2002-11-29 2007-10-04 Boehringer Ingelheim Pharma Neue neomycin-phosphotransferase-gene und verfahren zur selektion von hochproduzierenden rekombinanten zellen
DE10338531A1 (de) 2003-08-19 2005-04-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Reklonierung von Produktionszellen
EP1820022B1 (de) 2004-11-10 2009-06-03 Boehringer Ingelheim Pharma GmbH & Co. KG Verwendung von durchflusszytometrischer analyse zur optimierung von zellbankingstrategien für cho-zellen
US20080124760A1 (en) 2006-07-26 2008-05-29 Barbara Enenkel Regulatory Nucleic Acid Elements
EP2522730A1 (de) 2007-03-02 2012-11-14 Boehringer Ingelheim Pharma GmbH & Co. KG Verbesserung der Herstellung von Proteinen
EP2031064A1 (de) 2007-08-29 2009-03-04 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Steigerung von Proteintitern
GB201916884D0 (en) * 2019-11-20 2020-01-01 Evox Therapeutics Ltd Nanoparticle-like delivery system
AU2021339003A1 (en) 2020-09-10 2023-02-09 Ludwig-Maximilians-Universität München Engineered AAV vectors

Also Published As

Publication number Publication date
AR133830A1 (es) 2025-11-05
PY2480771A (es) 2025-05-12
UY40891A (es) 2025-02-28
CN122029182A (zh) 2026-05-12
WO2025059491A3 (en) 2025-05-15
KR20260074695A (ko) 2026-05-26
WO2025059491A2 (en) 2025-03-20
IL327041A (en) 2026-05-01
AU2024342899A1 (en) 2026-04-23
TW202528337A (zh) 2025-07-16

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