EP4762048A2 - Resmetiropolymorphe und verfahren zu ihrer herstellung - Google Patents

Resmetiropolymorphe und verfahren zu ihrer herstellung

Info

Publication number
EP4762048A2
EP4762048A2 EP24799689.5A EP24799689A EP4762048A2 EP 4762048 A2 EP4762048 A2 EP 4762048A2 EP 24799689 A EP24799689 A EP 24799689A EP 4762048 A2 EP4762048 A2 EP 4762048A2
Authority
EP
European Patent Office
Prior art keywords
resmetirom
polymorph
drying
solid
temperature
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24799689.5A
Other languages
English (en)
French (fr)
Inventor
Arijit Das
Ramanaiah CHENNURU
Anjaneyaraju Indukuri
Manjunath BOLLINENI
Yerramnaidu BOTCHA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cipla Ltd
Original Assignee
Cipla Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cipla Ltd filed Critical Cipla Ltd
Publication of EP4762048A2 publication Critical patent/EP4762048A2/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
EP24799689.5A 2023-10-16 2024-10-08 Resmetiropolymorphe und verfahren zu ihrer herstellung Pending EP4762048A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN202321070120 2023-10-16
PCT/IN2024/052019 WO2025083699A2 (en) 2023-10-16 2024-10-08 Resmetirom polymorphs and process thereof

Publications (1)

Publication Number Publication Date
EP4762048A2 true EP4762048A2 (de) 2026-06-24

Family

ID=93335128

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24799689.5A Pending EP4762048A2 (de) 2023-10-16 2024-10-08 Resmetiropolymorphe und verfahren zu ihrer herstellung

Country Status (2)

Country Link
EP (1) EP4762048A2 (de)
WO (1) WO2025083699A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2026074443A1 (en) 2024-10-01 2026-04-09 Assia Chemical Industries Ltd. Solid state forms of resmetirom
WO2026107045A1 (en) 2024-11-12 2026-05-21 Madrigal Pharmaceuticals, Inc. Resmetirom for use in treating cardiomyopathy and/or related heart failure and portal hypertension

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE480524T1 (de) 2005-07-21 2010-09-15 Hoffmann La Roche Pyridazinonderivate als schilddrüsenhormon- rezeptoragonisten
ES2795450T3 (es) 2012-09-17 2020-11-23 Madrigal Pharmaceuticals Inc Procedimiento para sintetizar análogos de hormonas tiroideas y polimorfos de los mismos
MX394463B (es) 2016-10-18 2025-03-19 Madrigal Pharmaceuticals Inc Métodos para tratar trastornos del hígado o trastornos lipídicos con un agonista de thr-beta.
TW202615431A (zh) 2018-07-02 2026-04-16 美商瑪德瑞高製藥公司 ２－（３，５－二氯－４－（（５－異丙基－６－側氧基－１，６－二氫噠嗪－３－基）氧）苯基）－３，５－二側氧基－２，３，４，５－四氫－１，２，４－三嗪－６－腈之固體型式
WO2021063367A1 (zh) 2019-09-30 2021-04-08 苏州科睿思制药有限公司 一种Resmetirom晶型及其制备方法和用途
WO2021129465A1 (zh) * 2019-12-26 2021-07-01 苏州科睿思制药有限公司 一种Resmetirom晶型及其制备方法和用途
KR20230066408A (ko) * 2020-09-10 2023-05-15 크리스탈 파마슈티컬 (쑤저우) 씨오., 엘티디. 레스메티롬의 결정형, 이의 제조 방법 및 이의 용도
CN114907327A (zh) * 2021-02-10 2022-08-16 杭州领业医药科技有限公司 Resmetirom的晶型及其制备方法和用途
CN115124515A (zh) * 2021-04-16 2022-09-30 杭州领业医药科技有限公司 Resmetirom的晶型及其制备方法
CN119143733A (zh) 2023-06-14 2024-12-17 四川弘远药业有限公司 一种甲状腺激素受体激动剂的晶型及其制备方法和用途
WO2025011259A1 (zh) 2023-07-07 2025-01-16 苏州科睿思制药有限公司 瑞司美替罗的晶型及其制备方法和用途

Also Published As

Publication number Publication date
WO2025083699A3 (en) 2025-07-31
WO2025083699A2 (en) 2025-04-24

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