EP4746870A2 - Auf proteolyse gerichtete chimäre zur behandlung von neurodegeneration - Google Patents
Auf proteolyse gerichtete chimäre zur behandlung von neurodegenerationInfo
- Publication number
- EP4746870A2 EP4746870A2 EP24843920.0A EP24843920A EP4746870A2 EP 4746870 A2 EP4746870 A2 EP 4746870A2 EP 24843920 A EP24843920 A EP 24843920A EP 4746870 A2 EP4746870 A2 EP 4746870A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- alkyl
- conjugate
- formula
- disease
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202363527519P | 2023-07-18 | 2023-07-18 | |
| PCT/US2024/038408 WO2025019604A2 (en) | 2023-07-18 | 2024-07-17 | Proteolysis targeting chimeras for treating neurodegeneration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP4746870A2 true EP4746870A2 (de) | 2026-05-27 |
Family
ID=94282595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP24843920.0A Pending EP4746870A2 (de) | 2023-07-18 | 2024-07-17 | Auf proteolyse gerichtete chimäre zur behandlung von neurodegeneration |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP4746870A2 (de) |
| JP (1) | JP2026524953A (de) |
| CN (1) | CN122206430A (de) |
| WO (1) | WO2025019604A2 (de) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3710430B9 (de) * | 2017-11-15 | 2024-10-30 | Metabomed Ltd | Acss2-hemmer und verfahren zur verwendung |
| AU2021214148A1 (en) * | 2020-01-30 | 2022-07-14 | Anima Biotech Inc. | Collagen 1 translation inhibitors and methods of use thereof |
| CN118613257A (zh) * | 2021-12-23 | 2024-09-06 | 鲁汶大学 | 用于抑制yap/taz-tead的四氢吡唑并嘧啶及相关类似物 |
| WO2023122782A2 (en) * | 2021-12-23 | 2023-06-29 | The Katholieke Universiteit Leuven | Indoles, indazoles, and related analogs for inhibiting yap/taz-tead |
-
2024
- 2024-07-17 CN CN202480059327.8A patent/CN122206430A/zh active Pending
- 2024-07-17 EP EP24843920.0A patent/EP4746870A2/de active Pending
- 2024-07-17 WO PCT/US2024/038408 patent/WO2025019604A2/en not_active Ceased
- 2024-07-17 JP JP2026502817A patent/JP2026524953A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2025019604A2 (en) | 2025-01-23 |
| CN122206430A (zh) | 2026-06-12 |
| WO2025019604A3 (en) | 2025-04-24 |
| JP2026524953A (ja) | 2026-07-24 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
| 17P | Request for examination filed |
Effective date: 20260306 |
|
| AK | Designated contracting states |
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