EP4743076A2 - Synthetische bifunktionelle degrader von integrinen - Google Patents

Synthetische bifunktionelle degrader von integrinen

Info

Publication number
EP4743076A2
EP4743076A2 EP24840382.6A EP24840382A EP4743076A2 EP 4743076 A2 EP4743076 A2 EP 4743076A2 EP 24840382 A EP24840382 A EP 24840382A EP 4743076 A2 EP4743076 A2 EP 4743076A2
Authority
EP
European Patent Office
Prior art keywords
integrin
fibrosis
binding moiety
bifunctional molecule
bifunctional
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24840382.6A
Other languages
English (en)
French (fr)
Inventor
Bianxiao Cui
Chaitan Khosla
Elise LOPPINET
Harrison BESSER
Lin Liu
He YOU
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Original Assignee
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Publication of EP4743076A2 publication Critical patent/EP4743076A2/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP24840382.6A 2023-07-10 2024-07-08 Synthetische bifunktionelle degrader von integrinen Pending EP4743076A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363525911P 2023-07-10 2023-07-10
PCT/US2024/037070 WO2025014884A2 (en) 2023-07-10 2024-07-08 Synthetic bi-functional degraders of integrins

Publications (1)

Publication Number Publication Date
EP4743076A2 true EP4743076A2 (de) 2026-05-20

Family

ID=94216308

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24840382.6A Pending EP4743076A2 (de) 2023-07-10 2024-07-08 Synthetische bifunktionelle degrader von integrinen

Country Status (4)

Country Link
EP (1) EP4743076A2 (de)
JP (1) JP2026525300A (de)
CN (1) CN121487733A (de)
WO (1) WO2025014884A2 (de)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9441221B2 (en) * 2007-03-30 2016-09-13 Rutgers, The State University Of New Jersey Compositions and methods for gene silencing
MX2020010808A (es) * 2018-04-13 2021-03-02 Sangamo Therapeutics France Receptor de antigeno quimerico especifico para el receptor de interleucina-23.
US20230211001A1 (en) * 2020-07-30 2023-07-06 The Board Of Trustees Of The Leland Stanford Junior University Lysosomal Targeting Molecules Comprising Knottin Peptides And Related Compositions And Methods
WO2022200388A1 (en) * 2021-03-23 2022-09-29 Glycoera Ag Mannose 3 glycan-mediated protein degradation

Also Published As

Publication number Publication date
JP2026525300A (ja) 2026-07-29
WO2025014884A3 (en) 2025-06-12
CN121487733A (zh) 2026-02-06
WO2025014884A2 (en) 2025-01-16

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