EP4728279A2 - Verwendung von personalisierten peptiden zur massenkalibrierung - Google Patents

Verwendung von personalisierten peptiden zur massenkalibrierung

Info

Publication number
EP4728279A2
EP4728279A2 EP24746796.2A EP24746796A EP4728279A2 EP 4728279 A2 EP4728279 A2 EP 4728279A2 EP 24746796 A EP24746796 A EP 24746796A EP 4728279 A2 EP4728279 A2 EP 4728279A2
Authority
EP
European Patent Office
Prior art keywords
composition
calibrant
mass
synthetic peptides
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24746796.2A
Other languages
English (en)
French (fr)
Inventor
Sasikumar PILLAI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DH Technologies Development Pte Ltd
Original Assignee
DH Technologies Development Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DH Technologies Development Pte Ltd filed Critical DH Technologies Development Pte Ltd
Publication of EP4728279A2 publication Critical patent/EP4728279A2/de
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
EP24746796.2A 2023-06-15 2024-06-14 Verwendung von personalisierten peptiden zur massenkalibrierung Pending EP4728279A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363508339P 2023-06-15 2023-06-15
PCT/IB2024/055867 WO2024257055A2 (en) 2023-06-15 2024-06-14 Use of custom-designed peptides for mass calibration

Publications (1)

Publication Number Publication Date
EP4728279A2 true EP4728279A2 (de) 2026-04-22

Family

ID=91969067

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24746796.2A Pending EP4728279A2 (de) 2023-06-15 2024-06-14 Verwendung von personalisierten peptiden zur massenkalibrierung

Country Status (2)

Country Link
EP (1) EP4728279A2 (de)
WO (1) WO2024257055A2 (de)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5881262B2 (ja) * 2011-03-31 2016-03-09 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 質量分析計を較正するための、組成物、方法およびキット
US20250136810A1 (en) * 2021-08-17 2025-05-01 Dh Technologies Development Pte. Ltd. Discrete peg molecules as analytes for ms calibration and tuning in positive and negative modes

Also Published As

Publication number Publication date
WO2024257055A2 (en) 2024-12-19
WO2024257055A3 (en) 2025-01-23

Similar Documents

Publication Publication Date Title
Cox et al. Role of the site of protonation in the low-energy decompositions of gas-phase peptide ions
Reid et al. A mass spectrometric and ab initio study of the pathways for dehydration of simple glycine and cysteine-containing peptide [M+ H]+ ions
US8933396B2 (en) Analyte mass spectrometry quantitation using a universal reporter
Wu et al. Proton affinities of polyglycines assessed by using the kinetic method
Loo et al. Protein structural effects in gas phase ion/molecule reactions with diethylamine
González et al. Differentiating α‐and β‐aspartic acids by electrospray ionization and low‐energy tandem mass spectrometry
Summerfield et al. Fragmentation efficiencies of peptide ions following low energy collisional activation
KR101081053B1 (ko) 가변질량 라벨링제와 이를 이용한 아미노산 서열 및 단백질정량 동시 분석방법
Yoo et al. Toward top-down determination of PEGylation site using MALDI in-source decay MS analysis
Saminathan et al. The extent and effects of peptide sequence scrambling via formation of macrocyclic b ions in model proteins
Guan Identification and localization of the fatty acid modification in ghrelin by electron capture dissociation
US20050224710A1 (en) Method for measuring hydrophobic peptides using maldi mass spectrometer
EP4728279A2 (de) Verwendung von personalisierten peptiden zur massenkalibrierung
Nishikaze et al. Study of factors governing negative molecular ion yields of amino acid and peptide in FAB, MALDI and ESI mass spectrometry
Petre et al. Structural characterisation of tyrosine-nitrated peptides by ultraviolet and infrared matrix-assisted laser desorption/ionisation Fourier transform ion cyclotron resonance mass spectrometry
US20130062570A1 (en) Matrix additive for mass spectrometry
KR102691545B1 (ko) 안정동위원소가 표지된 내부 표준 펩타이드를 이용한 질량분석 기반의 표적 펩타이드의 정량 방법
CN113419007A (zh) 一种用于检测样本中目标氨基酸和肌酐的方法及其检测试剂盒
US20060022129A1 (en) Peptide mass spectrometry rich in daughter ions
Jones et al. Probing the mechanisms of electron capture dissociation mass spectrometry with nitrated peptides
Schug et al. Isomeric discrimination of arginine-containing dipeptides using electrospray ionization-ion trap mass spectrometry and the kinetic method
US7951602B2 (en) Mass defect labeling and methods of use thereof
Kitanaka et al. A facile method for preferential modification of the N-terminal amino group of peptides using triazine-based coupling reagents
Happersberger et al. A mass spectrometric approach to the characterization of protein folding reactions
US20150276756A1 (en) Mass spectrometry method using matrix additive

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: UNKNOWN

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20260112

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR