EP4724601A2 - Biomarqueurs de structure de chromatine - Google Patents

Biomarqueurs de structure de chromatine

Info

Publication number
EP4724601A2
EP4724601A2 EP24824018.6A EP24824018A EP4724601A2 EP 4724601 A2 EP4724601 A2 EP 4724601A2 EP 24824018 A EP24824018 A EP 24824018A EP 4724601 A2 EP4724601 A2 EP 4724601A2
Authority
EP
European Patent Office
Prior art keywords
transcripts
sample
data
abundance
samples
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24824018.6A
Other languages
German (de)
English (en)
Inventor
Vishrawas Gopalakrishnan
James H. Kaufman
Achal MAHAJAN
Francesca RATTI
Ban Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Altos Labs Inc
Original Assignee
Altos Labs Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altos Labs Inc filed Critical Altos Labs Inc
Publication of EP4724601A2 publication Critical patent/EP4724601A2/fr
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Evolutionary Biology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention décrit des procédés de détermination de l'état de chromatine d'un échantillon à partir de données d'abondance de transcription à partir de l'échantillon. Les procédés consistent à recevoir des données d'abondance de transcription pour une pluralité de transcrits à partir de l'échantillon ; à déterminer, pour chaque compartiment d'une pluralité de compartiments de distance génomique, une mesure de corrélation entre l'abondance de transcription pour des paires de transcrits qui sont séparées par une distance génomique à l'intérieur du compartiment respectif ; et à générer une valeur d'une mesure de biomarqueur dérivée de la mesure de corrélation pour la pluralité de compartiments, la mesure de biomarqueur caractérisant la plage de distance génomique au niveau de laquelle des paires de transcrits présentent une expression corrélée, des échantillons présentant différents états de chromatine avec différentes valeurs de la mesure de biomarqueur. L'invention décrit également des procédés, des systèmes et des produits associés.
EP24824018.6A 2023-06-12 2024-06-11 Biomarqueurs de structure de chromatine Pending EP4724601A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363507720P 2023-06-12 2023-06-12
PCT/US2024/033444 WO2024258871A2 (fr) 2023-06-12 2024-06-11 Biomarqueurs de structure de chromatine

Publications (1)

Publication Number Publication Date
EP4724601A2 true EP4724601A2 (fr) 2026-04-15

Family

ID=93852857

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24824018.6A Pending EP4724601A2 (fr) 2023-06-12 2024-06-11 Biomarqueurs de structure de chromatine

Country Status (3)

Country Link
EP (1) EP4724601A2 (fr)
CN (1) CN121773217A (fr)
WO (1) WO2024258871A2 (fr)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014039729A1 (fr) * 2012-09-05 2014-03-13 Stamatoyannopoulos John A Procédés et compositions associés à la régulation des acides nucléiques
US20170286597A1 (en) * 2014-09-05 2017-10-05 Koninklijke Philips N.V. Methods and systems for visualizing gene expression data
CA3090102A1 (fr) * 2018-01-31 2019-08-08 Dovetail Genomics, Llc Preparation d'echantillon pour recuperation de liaison d'adn

Also Published As

Publication number Publication date
CN121773217A (zh) 2026-03-31
WO2024258871A3 (fr) 2025-04-17
WO2024258871A2 (fr) 2024-12-19

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