EP4716744A2 - Genetisch modifizierte zellen mit einem heterologen nukleinsäuremolekül, das an einem cd5-genlokusfeld eingesetzt wird - Google Patents

Genetisch modifizierte zellen mit einem heterologen nukleinsäuremolekül, das an einem cd5-genlokusfeld eingesetzt wird

Info

Publication number
EP4716744A2
EP4716744A2 EP24811929.9A EP24811929A EP4716744A2 EP 4716744 A2 EP4716744 A2 EP 4716744A2 EP 24811929 A EP24811929 A EP 24811929A EP 4716744 A2 EP4716744 A2 EP 4716744A2
Authority
EP
European Patent Office
Prior art keywords
cell
cancer
antigen binding
gene
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP24811929.9A
Other languages
English (en)
French (fr)
Inventor
Nicholas A. Siciliano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vittoria Biotherapeutics Inc
Original Assignee
Vittoria Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vittoria Biotherapeutics Inc filed Critical Vittoria Biotherapeutics Inc
Publication of EP4716744A2 publication Critical patent/EP4716744A2/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
EP24811929.9A 2023-05-23 2024-05-23 Genetisch modifizierte zellen mit einem heterologen nukleinsäuremolekül, das an einem cd5-genlokusfeld eingesetzt wird Pending EP4716744A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363503809P 2023-05-23 2023-05-23
PCT/US2024/030831 WO2024243436A2 (en) 2023-05-23 2024-05-23 Genetically modified cells comprising a heterologous nucleic acid molecule inserted at a cd5 gene locus field

Publications (1)

Publication Number Publication Date
EP4716744A2 true EP4716744A2 (de) 2026-04-01

Family

ID=93590466

Family Applications (1)

Application Number Title Priority Date Filing Date
EP24811929.9A Pending EP4716744A2 (de) 2023-05-23 2024-05-23 Genetisch modifizierte zellen mit einem heterologen nukleinsäuremolekül, das an einem cd5-genlokusfeld eingesetzt wird

Country Status (4)

Country Link
EP (1) EP4716744A2 (de)
KR (1) KR20260051108A (de)
CN (1) CN121844048A (de)
WO (1) WO2024243436A2 (de)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020132327A1 (en) * 2018-12-19 2020-06-25 The Trustees Of The University Of Pennsylvania Use of cd2/5/7 knock-out anti-cd2/5/7 chimeric antigen receptor t cells against t cell lymphomas and leukemias
US20240041932A1 (en) * 2020-09-14 2024-02-08 Vor Biopharma Inc. Compositions and methods for cd5 modification

Also Published As

Publication number Publication date
CN121844048A (zh) 2026-04-10
WO2024243436A2 (en) 2024-11-28
WO2024243436A3 (en) 2025-04-24
KR20260051108A (ko) 2026-04-15

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