EP4666289A1 - Personalized testing of muscle performance - Google Patents
Personalized testing of muscle performanceInfo
- Publication number
- EP4666289A1 EP4666289A1 EP23705968.8A EP23705968A EP4666289A1 EP 4666289 A1 EP4666289 A1 EP 4666289A1 EP 23705968 A EP23705968 A EP 23705968A EP 4666289 A1 EP4666289 A1 EP 4666289A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- muscle
- mammal
- personalized
- computer
- implemented method
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/30—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
Definitions
- a computer-implemented method of personalized testing of a mammal s muscle performance with the use of artificial intelligence models and predictive models, by using as input real time biomechanical data obtainable from well-known wearable electronic devices.
- a trained system software artificial intelligence models is used.
- US2019046086A1 describes wearable monitoring devices and a method for generating feedback on the performance of the activity by the user based on the comparison. Nevertheless, the invention describes a professional athlete as a benchmark of comparison. The same training cycle may improve user while harming another one. There is a need for a personalized testing of mammal’s performance.
- FIG. 1 Flowchart of the training of the artificial neural network of the invention.
- FIG. 2 Flowchart of using the artificial neural network of the invention to train a predictive model.
- FIG. 4. Algorithmic flowchart of the invention.
- FIG. 5 Flowchart of the connections of the invention.
- FIG. 6 MRI of a tendon abnormality in the hamstring of the right leg.
- FIG. 7 Processed MRI model for region of injury and plane detail for healthy, initially injured and healed muscle data.
- FIG. 8 Stress strain z section plane right bicep femoris for healthy, initially injured and healed muscle data.
- FIG. 9 Graphical representation of max stress z on plane for healthy, initially injured and healed muscle data.
- FIG. 10 Graphical representation of linear acceleration across the 3 axes vs days of training.
- FIG. 11 A box and whisker plot showing 3 axes acceleration vs injury windows.
- FIG. 12 Graphical representation of aggregated time interval during which the player performs at the highest (personalized) zone 6.
- FIG. 13 A box and whisker plot showing aggregated acceleration vs injury windows.
- the present invention relates to a computer implemented method for testing muscle performance as set forth in claims.
- the present invention relates to a computer implemented method for testing muscle performance in a mammal.
- a mammal is selected from a human, a dog and a horse. More preferably the mammal is an athlete.
- the method is personalized, and the results are customized.
- the present invention relates to use of artificial network models and predictive model to corelate the real-time biomechanical data with specialized personalized data obtained by laboratory use.
- the present invention relates to input a set of parameters relating to biomechanical data and magnetic resonance imaging data. Preferably stored in a cloud.
- the present invention further relates to training of artificial network models and predictive model to corelate the real-time biomechanical data with specialized data obtained by laboratory use.
- the present invention further relates to all data being stored in a cloud storage.
- a personalized testing of a mammal s muscle performance without the use of magnetic resonance imaging data.
- the system software can be fully operable with reposited magnetic resonance imaging data and/or can be based solely on the biomechanical data of the mammal.
- An embodiment of said invention is a computer-implemented method of personalized testing of a mammal’s muscle performance, the method comprising: i) input a set of personalized biomechanical data wherein the biomechanical data comprising at least the linear acceleration, the angular velocity, the speed and the instantaneous acceleration impulse of the mammal into a trained artificial neural network model by using as input biomechanical data, and ground reaction forces and output calculated ground reaction forces ii) optionally, repeat step i) iii) process with proprietary algorithms the personalized features related to at least the calculated ground reaction forces, the personalized biomechanical data and combinations thereof, on the three-dimensional space axis and the pertinent shear planes of each axis and identify and store the distribution of the optimal fit per feature, respectively iv) demarcate a distribution of the optimal fit per feature into more than one equal segments, wherein each segment defines a mammal’s personalized muscle performing zone v) train a predictive model by using as input the processed personalized features of step iv) vi) input real-time biomechanical data
- muscle performance typically refers to the capacity of the muscle to do work.
- the muscle performance is related to strength, power and endurance.
- There are multiple factors which can affect a mammal’s muscles performance such as age, biological age, muscle injuries and many more. Injuries from straining a muscle are common and can minimize the mammal’s quality of life. Calculating the minimum and maximum load per muscle unit, is necessary for testing a mammal’s muscle performance.
- Testing a mammal’s muscle performance comprises a stress-strain curve which is a graphical way to show the reaction of a material, such as a muscle, when a load is applied, to evaluate the current state and predict the future state of each muscle.
- the stress-strain curve corresponds to load per unit vs elongation.
- the muscle stress corresponds to the maximum force per muscle unit, when muscles start failing.
- biomechanical data within the scope of this invention relates to at least the linear acceleration, the angular velocity, the speed and the instantaneous acceleration impulse of the mammal.
- the “biomechanical data” is data which are collected from a wearable electronic device designed to be worn on the mammal’s body, such as vests or cameras.
- the wearable electronic device can be a vest, designed to enclose at most the upper torso of a mammal. Said wearable electronic device is non-restraining to the normal routine of the wearer.
- the wearable electronic device such as vest, comprise communication means for transmission of the biomechanical data to the console/platform which can be stored in a cloud server.
- the data are directed through an application programming interface (API) to the invention’s cloud infrastructure for further processing.
- API application programming interface
- the invention s cloud infrastructure is a cross platform software and/or a web application.
- the user can find stored data, history training data of each mammal, extract graphical representations which can assist in decision making upon the mammal’s muscle performance.
- magnetic resonance imaging data typically refers to a form of pictures of the anatomy, the physiological processes of the body and especially the muscles and their connections to the bones.
- the magnetic resonance imaging can detect abnormalities such as abnormal muscle volume, abnormal muscle signal, mass lesion, and abnormal anatomy and is a diagnostic technique which is non-invasive and does not involve exposing the patient under study to potentially harmful radiation.
- MRI magnetic resonance imaging
- the use of magnetic resonance imaging (MRI) apparatus is needed, but it is only available indoors. The abnormalities cannot be detected by a clinical examination and represent areas with asymptotic pathologies.
- the magnetic resonance imaging data is uploaded by the user to a specified remote repository, embedded to the application of the present invention.
- the healthy muscle is represented by a reverse engineering procedure by taking all micro pathologies as healthy tissue areas.
- the abnormalities are visualized as white spots in the MRI.
- the muscle structural analysis is obtained by processing magnetic resonance imaging data of the mammal into 3-dimensional muscle models using a slicer software, import the 3-dimensional muscle models into pre-processing computer aided engineering software to obtain a muscle’s mesh and import the resulting muscle mesh into a finite element analysis software and using optionally, stored experimental data of the material properties of muscle to final obtain a complete muscle structural analysis.
- the system software of the two artificial intelligence models is used to input personalized biomechanical data, preferably derived from vests or camera and to output calculated load per muscle unit.
- the magnetic resonance imaging data for the mammal’s muscular system software is processed by a software to create a 3D geometry of a muscle. Those geometries are stored in the cloud. Followinged by processing of the stored 3D geometry of a muscle by another software to obtain the geometry’s computational mesh being stored optionally, in a separate file. Furthermore, the geometry’s computational mesh of the muscle is processed by another software to obtain the structural analysis using the mammal’s muscle viscoelastic behavior. Optionally, the mammal’s muscle viscoelastic behavior is determined, by stored experimental data of the material properties of muscle. Preferably, the output of the calculated forces by the first artificial network combined with the structural analysis is used for training a second artificial neural network model.
- the system software of the two artificial neural network models is used to input personalized biomechanical data, preferably derived from vests or camera and to output calculated load per muscle unit.
- the calculated load per muscle unit is necessary for testing muscle performance and the results are personalized for the mammal.
- the outputs are 3D models of the muscle and visualized graphical plots of stress - strain curves. In this way it is viable to assess a part of the human body, which is under the specific strain for a specific time period, in a personalized manner.
- the term “application database” typically refers to a database that is controlled and accessed by a single application, wherein the single application is the invention’s application.
- Artificial Intelligence (Al) model preferably an artificial neural network (ANN) comprises of an input layer, a number of hidden layers and an output layer; each layer further comprises of a different number of artificial neurons and each artificial neuron has at least one input, within the scope of this invention.
- training of an artificial neural network model comprises each artificial neuron has at least one input with an associated weight and bias which is adjusted while this artificial neural network is trained by using the observed data as input and through backpropagation changing the weights and bias using real time measured data input.
- the first step in training, involves input data into a artificial intelligence system software and evaluate their accuracy.
- the second step validating, evaluates how well the trained a artificial intelligence model performs on previously unseen data. Finally, testing is done to find out if the final artificial intelligence model makes accurate predictions with new data that it has never seen before.
- a system software comprising trained a artificial intelligence model is used within the scope of this invention, wherein training involves input biomechanical data, selected from at least the linear acceleration, the angular velocity, the speed and the instantaneous acceleration impulse of the mammal and measured in force platforms ground reaction forces.
- the artificial intelligence model is evaluated and tested for the accuracy of the calculated ground reaction forces.
- the system software can further input muscle structural analysis and calculated ground forces to output the load per muscle unit.
- the artificial intelligence model can be independently evaluated and tested for accuracy.
- the trained artificial intelligence model is stored in a computing repository.
- a system software for use in a computer- implemented method of personalized testing of a mammal’s muscle performance of the invention according to the claims obtainable by training of artificial intelligence model using as input measured biomechanical data, ground reaction forces and optionally, a muscle structural analysis and output calculated ground reaction forces and calculate optionally, the load per muscle unit.
- a system software for use in a computer- implemented method of personalized testing of a mammal’s muscle performance of the invention according to the claims obtainable by training of artificial intelligence model using as input measured biomechanical data, ground reaction forces and a muscle structural analysis and output calculated ground reaction forces and calculate the load per muscle unit.
- a artificial neural network model for use in a computer-implemented method of personalized testing of a mammal’s muscle performance of the invention according to the claims obtainable by training using as input measured biomechanical data, ground reaction forces and output calculated ground reaction forces.
- an artificial intelligence model for use in a computer-implemented method of personalized testing of a mammal’s muscle performance of the invention according to any of the claims obtainable by training using as input a muscle structural analysis and calculated ground reaction forces to output the load per muscle unit.
- processing with proprietary algorithms a series of the personalized features related to at least the ground reaction forces, biomechanical data, load per muscle unit and combinations thereof, on the three-dimensional space axis and the pertinent shear planes of each axis and identify and store the distribution of the optimal fit per feature, respectively.
- the optimal fit can be based on the minimum Kolmogorov-Smirnov test statistic, which is a non-parametric test statistic that quantifies the distance between 2 continuous distributions (within the scope of this invention, the empirical distribution function of the sample and the cumulative distribution function of each reference distribution).
- the calculated measurement of at least the ground reaction forces, biomechanical data, load per muscle unit and combinations thereof is fitted with numerous different distributions, to find the one with the optimum fit.
- the processing of the personalized features with proprietary algorithms and their demarcation into the optimal fit are executed and stored on the invention’s cloud-based servers.
- the term “personalized performance zones” per feature typically refers to the result of demarcating a distribution of the optimal fit per feature into more than one segments.
- the optimum distribution s inverse Cumulative Distribution Function (CDF) are calculated for every feature. Preferably, the segments are six. Each feature is demarcated in 6 equal segments, to reduce the bias of the results.
- the invention s personalized performing zones calculation does not demarcate each feature in fixed (constant) zones. When demarcating each feature in fixed (constant) zones, especially, for lower muscle performance, the workload is disproportionately distributed in the lower zones which leads to the erroneous conclusion that mammal’s muscle under-performs.
- FIG. 1 is a system diagram illustrating an exemplary operating environment for the various embodiments disclosed herein. Embodiments may be implemented on a commercial MRI system and biomechanical data obtained by commercial vest and/or cameras.
- FIG. 1 illustrates training an artificial intelligence model, preferable an artificial neutral network, using as input biomechanical data comprising at least the linear acceleration, the angular velocity, the speed and the instantaneous acceleration impulse of the mammal obtained by commercial vests and/or camera and ground reaction forces obtainable by a force plats. Ground reactions forces can be measured once of.
- the output of the artificial intelligence model are the calculated ground reaction forces.
- the artificial intelligence model is an artificial neutral network model.
- the ground reaction forces obtained in lab environment are used to train the artificial neutral network model and are obtained for this purpose.
- the calculated ground reaction forces are further used to the training of another artificial intelligence model.
- Said artificial intelligence model uses as input processed magnetic resonance imaging data and the calculated ground forces obtained by the first artificial intelligence model.
- the magnetic resonance imaging data are processed by a computer-aided design and drafting/simulation software.
- the derived data represent the mammal’s structural analysis and the muscles 3D model, which are used for training the artificial intelligence model.
- Biomechanical data are again fed into the system software comprising the trained Al models, to calculate the load per muscle unit as illustrated in FIG. 2.
- the obtained load per muscle, the calculated ground reaction forces and the personalized biomechanical data are being processed with proprietary algorithms into the optimal fit.
- the demarcation of the optimal fit into segments, is followed.
- the personized muscle performance zone is obtained as shown in FIG.2.
- the personalized performing zone and personalized features can be graphically displayed.
- the personalized performing zones include and are graphically illustrated, with reference to the biomechanical data and the ground reaction forces.
- the load per muscle unit is graphically displayed.
- the predictive model is trained using at least once, as input the personized muscle performing zone, enclosing all stored data regarding to ground reaction forces and biomechanical data, preferably more than once, more preferably at least 5 consequent set of data or days of training.
- real-time biomechanical data are used as input in the predictive model to calculate real time personalized muscle performance.
- the application software makes the information accessible to the end user.
- FIG. 4 shows the algorithmic flowchart of an embodiment of the invention, wherein data from force plates (3) and wearable tracking devices (2) are used to train the Al models. Further data from wearable tracking devices (2) are processed and used as input in the trained Al models. The outcome corresponds to the workload metrics which are the calculated ground forces and to a personalized database of the mammal.
- the magnetic resonance imaging data (4) can be processed by a serious of software comprising slicer software, a pre-processing computer aided engineering software finite analysis software and software system for biomechanical modeling, simulation and analysis, using the obtained workload metrics to obtain the myoskeletal metrics from the muscle structural analysis of each mammal. Both metrics/data are stored and processed into the invention’s cloud infrastructure being available to the end user by various devices (5).
- biomechanical data are received from conventional wearable tracking devices (2) through third party console/platform (6) and are stored to a cloud server.
- An application programming interface translates the data from the conventional applications of the wearable devices (2) into data suitable for the embodiment’s application.
- the biomechanical raw data, the ground reaction forces raw data and the magnetic resonance imaging raw data are processed according to the invention in the invention’s cloud infrastructure using proprietary algorithm’s processing.
- the output calculated data are stored in the invention’s cloud infrastructure and are available to the end user through cross platform or web software for various devices (5).
- the force plates were embedded in the laboratory floor.
- the mammals participating wore a vest consisting of GPS sensors and a gyroscope, while performing a series of exercises. These sensors recorded a multi-dimensional input which corresponds to the linear acceleration on the three axes of motion (x,y,z), gyroscope measures one for each axis (x,y,z), the speed and the instantaneous acceleration impulse.
- the output consists of the three-dimensional force components on the three spatial axes. Meanwhile the mammals were performing the exercises on the force plates that were measuring the ground reaction forces.
- Exercise 1 The human, while standing on one foot, pushed-off at maximal capacity in order to achieve a maximal-height vertical jump. He landed on the same foot, took a step forward onto the second force plate with the other foot and then immediately maneuvered to the other side. The exercise was executed two times, once for each leg.
- Exercise 2 The human, while standing on both feet, pushed-off at maximal capacity in order to achieve a maximal-height vertical jump. He landed on both feet and then took a step forward on the second force plate with one foot and immediately maneuvered to the other side direction. The exercise was executed two times for each direction.
- Exercise 3 The human performed a rapid acceleration up to the center of the second force plate, where they abruptly made a sidestep cutting maneuver with one leg stopping followed by sidestepping. The exercise was executed twice for each side.
- Exercise 4 The human performed maximal acceleration efforts over the corridor of X m length where the force plates were embedded.
- Exercise 5 The human performed maximal acceleration efforts until they reached the second force plate, where they abruptly tried to decelerate as fast as possible.
- the artificial neural network used consist of computational units that are interconnected to each other and distributed in layers.
- a feedforward network with backpropagation was used.
- the connections between units of continuous layers are weights.
- Input data is presented to the units of the first layer. From this layer the data is forwarded to the units in the hidden layer while the data is multiplied by the weight factor.
- the weighted data of all incoming connections is summed, and a bias term is added. Then the summed input plus the bias term is processed by an activation function. This is the output value and is then forwarded to the units of the next layer.
- the network can be trained. It can find relationships between input and output patterns, which in this study is the relationship between GPS sensor data and ground reaction forces. To train a neural network we provide data from both ground reaction forces measurements and GPS sensors, for several conditions.
- the artificial neural network can use one specific pattern.
- the artificial neural network can generalize 'knowledge' obtained during training for a selected set of situations, to new situations for which it has not been trained.
- FIG.6 is the modeling of the injury to the right bicep femoris muscle origin, as detected by the MRI.
- the right is the MRI with the initial injury and the left is after six weeks with the muscle under healing procedure.
- the healed model is close to the healthy one so the athlete possible return to action soon.
- a box and whisker plot is defined as a graphical method of displaying variation in a set of data, which provides additional detail than a histogram. In addition, it allows multiple sets of data to be displayed in the same graph.
- FIG. 11 shows that the latest 5 days prior to injury (1 st bar), the distribution shows high values, close to the upper limit of 1 .3. Particularly, 50% and 75% of the values are above 1 .3 and 1 .4, respectively - a clear indication that an injury may happen. Then, it is the aggregated time interval during which the mammal performs at the highest (personalized) zone 6. In particular, the mammal shows a remarkable maximum duration right at the day before the injury happened as in FIG.12.
- FIG. 13 shows that during the latest 5 days prior to injury (1 st bar), the aggregated (net) acceleration’s distribution shows high values, where 75% of the values (Q3) significantly exceed the respective one of the last-1 Odays-prior-window (3 rd bar); a clear indication that an injury may happen.
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Abstract
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2023/053543 WO2024170061A1 (en) | 2023-02-13 | 2023-02-13 | Personalized testing of muscle performance |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP4666289A1 true EP4666289A1 (en) | 2025-12-24 |
Family
ID=85283947
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP23705968.8A Pending EP4666289A1 (en) | 2023-02-13 | 2023-02-13 | Personalized testing of muscle performance |
Country Status (2)
| Country | Link |
|---|---|
| EP (1) | EP4666289A1 (en) |
| WO (1) | WO2024170061A1 (en) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10314511B2 (en) | 2011-08-11 | 2019-06-11 | University Of Virginia Patent Foundation | Image-based identification of muscle abnormalities |
| US9498128B2 (en) | 2012-11-14 | 2016-11-22 | MAD Apparel, Inc. | Wearable architecture and methods for performance monitoring, analysis, and feedback |
| US11364418B2 (en) * | 2018-10-08 | 2022-06-21 | John Piazza | Device, system and method for automated global athletic assessment and / or human performance testing |
-
2023
- 2023-02-13 WO PCT/EP2023/053543 patent/WO2024170061A1/en not_active Ceased
- 2023-02-13 EP EP23705968.8A patent/EP4666289A1/en active Pending
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| Publication number | Publication date |
|---|---|
| WO2024170061A1 (en) | 2024-08-22 |
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