EP4570824A3 - Pd1- und vegfr2-doppelbindende mittel - Google Patents

Pd1- und vegfr2-doppelbindende mittel Download PDF

Info

Publication number
EP4570824A3
EP4570824A3 EP25159487.5A EP25159487A EP4570824A3 EP 4570824 A3 EP4570824 A3 EP 4570824A3 EP 25159487 A EP25159487 A EP 25159487A EP 4570824 A3 EP4570824 A3 EP 4570824A3
Authority
EP
European Patent Office
Prior art keywords
binding agents
vegfr2
dual
antibody molecules
vegfr2 dual
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP25159487.5A
Other languages
English (en)
French (fr)
Other versions
EP4570824A2 (de
Inventor
William James Jonathan Finlay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ottimo Pharma Ltd
Original Assignee
Ottimo Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ottimo Pharma Ltd filed Critical Ottimo Pharma Ltd
Priority to EP25212556.2A priority Critical patent/EP4671279A2/de
Publication of EP4570824A2 publication Critical patent/EP4570824A2/de
Publication of EP4570824A3 publication Critical patent/EP4570824A3/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/528—CH4 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
EP25159487.5A 2019-10-11 2020-10-09 Pd1- und vegfr2-doppelbindende mittel Pending EP4570824A3 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP25212556.2A EP4671279A2 (de) 2019-10-11 2020-10-09 Pd1- und vegfr2-doppelbindende mittel

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB201914747A GB201914747D0 (en) 2019-10-11 2019-10-11 PD1 and vegfr2 dual-binding agents
GBGB2013180.1A GB202013180D0 (en) 2019-10-11 2020-08-24 Pd1 and vegfr2 dual-binding agents
EP20789105.2A EP4041763B1 (de) 2019-10-11 2020-10-09 Pd1 und vegfr2 dual bindende agentien
PCT/EP2020/078427 WO2021069670A1 (en) 2019-10-11 2020-10-09 Pd1 and vegfr2 dual-binding agents

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP20789105.2A Division EP4041763B1 (de) 2019-10-11 2020-10-09 Pd1 und vegfr2 dual bindende agentien

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP25212556.2A Division EP4671279A2 (de) 2019-10-11 2020-10-09 Pd1- und vegfr2-doppelbindende mittel

Publications (2)

Publication Number Publication Date
EP4570824A2 EP4570824A2 (de) 2025-06-18
EP4570824A3 true EP4570824A3 (de) 2025-06-25

Family

ID=68619556

Family Applications (3)

Application Number Title Priority Date Filing Date
EP25159487.5A Pending EP4570824A3 (de) 2019-10-11 2020-10-09 Pd1- und vegfr2-doppelbindende mittel
EP20789105.2A Active EP4041763B1 (de) 2019-10-11 2020-10-09 Pd1 und vegfr2 dual bindende agentien
EP25212556.2A Pending EP4671279A2 (de) 2019-10-11 2020-10-09 Pd1- und vegfr2-doppelbindende mittel

Family Applications After (2)

Application Number Title Priority Date Filing Date
EP20789105.2A Active EP4041763B1 (de) 2019-10-11 2020-10-09 Pd1 und vegfr2 dual bindende agentien
EP25212556.2A Pending EP4671279A2 (de) 2019-10-11 2020-10-09 Pd1- und vegfr2-doppelbindende mittel

Country Status (20)

Country Link
US (2) US20240101674A1 (de)
EP (3) EP4570824A3 (de)
JP (2) JP7689116B2 (de)
KR (1) KR20220091490A (de)
CN (2) CN114981301B (de)
AU (1) AU2020365021A1 (de)
CA (2) CA3156096C (de)
DK (1) DK4041763T3 (de)
ES (1) ES3027238T3 (de)
FI (1) FI4041763T3 (de)
GB (2) GB201914747D0 (de)
HR (1) HRP20250523T1 (de)
HU (1) HUE071341T2 (de)
IL (1) IL292158A (de)
LT (1) LT4041763T (de)
PL (1) PL4041763T3 (de)
PT (1) PT4041763T (de)
RS (1) RS66837B1 (de)
SI (1) SI4041763T1 (de)
WO (1) WO2021069670A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109053895B (zh) 2018-08-30 2020-06-09 中山康方生物医药有限公司 抗pd-1-抗vegfa的双功能抗体、其药物组合物及其用途
GB201914747D0 (en) 2019-10-11 2019-11-27 Ultrahuman Eight Ltd PD1 and vegfr2 dual-binding agents
CN116143935A (zh) * 2021-11-22 2023-05-23 杭州翰思生物医药有限公司 重组抗体及其应用
CN119654343A (zh) * 2022-08-09 2025-03-18 上海济煜医药科技有限公司 一种靶向pd-1和vegf的抗体及其应用
CN118620082A (zh) * 2023-03-10 2024-09-10 南京维立志博生物科技有限公司 靶向vegf途径和pd-1的双特异性抗原结合蛋白、其组合物和用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015085847A1 (zh) * 2013-12-12 2015-06-18 上海恒瑞医药有限公司 Pd-1抗体、其抗原结合片段及其医药用途
WO2019170885A1 (en) * 2018-03-08 2019-09-12 Ultrahuman Eight Limited Pd1 binding agents

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2161336T5 (pl) 2005-05-09 2017-10-31 Ono Pharmaceutical Co Ludzkie przeciwciała monoklonalne przeciwko białku Programmed Death 1 (PD-1) oraz sposoby leczenia raka z zastosowaniem samych przeciwciał anty-PD-1 lub w połączeniu z innymi środkami immunoterapeutycznymi
KR101586617B1 (ko) 2007-06-18 2016-01-20 머크 샤프 앤 도메 비.브이. 사람 프로그램된 사멸 수용체 ｐｄ-1에 대한 항체
JP6312659B2 (ja) * 2012-05-31 2018-04-18 ジェネンテック， インコーポレイテッド Ｐｄ−１系結合アンタゴニスト及びｖｅｇｆアンタゴニストを用いた癌の治療方法
LT3702373T (lt) 2013-09-13 2022-11-10 Beigene Switzerland Gmbh Anti-pd1 antikūnai ir jų naudojimas terapijai ir diagnostikai
DK3356411T3 (da) 2015-10-02 2021-09-06 Hoffmann La Roche Bispecifikke antistoffer, der er specifikke for PD1 og TIM3
CN109893654B (zh) * 2017-12-11 2021-07-27 江苏恒瑞医药股份有限公司 Vegfr抑制剂治疗肿瘤的方法
GB201803746D0 (en) 2018-03-08 2018-04-25 Ultrahuman Eight Ltd PD1 binding agents
CN109053895B (zh) * 2018-08-30 2020-06-09 中山康方生物医药有限公司 抗pd-1-抗vegfa的双功能抗体、其药物组合物及其用途
JP2022512822A (ja) 2018-11-06 2022-02-07 ジエンス ヘンルイ メデイシンカンパニー リミテッド 腫瘍を治療するための薬物の調製におけるファミチニブと組み合わせた抗ｐｄ－１抗体の使用
GB201914747D0 (en) 2019-10-11 2019-11-27 Ultrahuman Eight Ltd PD1 and vegfr2 dual-binding agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015085847A1 (zh) * 2013-12-12 2015-06-18 上海恒瑞医药有限公司 Pd-1抗体、其抗原结合片段及其医药用途
WO2019170885A1 (en) * 2018-03-08 2019-09-12 Ultrahuman Eight Limited Pd1 binding agents

Also Published As

Publication number Publication date
US20240101674A1 (en) 2024-03-28
JP2025134713A (ja) 2025-09-17
FI4041763T3 (fi) 2025-05-15
GB201914747D0 (en) 2019-11-27
IL292158A (en) 2022-06-01
CA3156096A1 (en) 2021-04-15
EP4570824A2 (de) 2025-06-18
CA3289307A1 (en) 2026-03-02
PT4041763T (pt) 2025-05-16
ES3027238T3 (en) 2025-06-13
CN114981301B (zh) 2026-04-14
SI4041763T1 (sl) 2025-08-29
EP4041763A1 (de) 2022-08-17
GB202013180D0 (en) 2020-10-07
CN114981301A (zh) 2022-08-30
PL4041763T3 (pl) 2025-07-07
EP4041763B1 (de) 2025-02-26
US12479920B2 (en) 2025-11-25
RS66837B1 (sr) 2025-06-30
WO2021069670A1 (en) 2021-04-15
LT4041763T (lt) 2025-06-10
AU2020365021A1 (en) 2022-05-26
DK4041763T3 (da) 2025-05-19
JP7689116B2 (ja) 2025-06-05
US20250243276A1 (en) 2025-07-31
CN121758618A (zh) 2026-03-31
HRP20250523T1 (hr) 2025-07-04
KR20220091490A (ko) 2022-06-30
EP4671279A2 (de) 2025-12-31
JP2022553908A (ja) 2022-12-27
CA3156096C (en) 2026-03-17
HUE071341T2 (hu) 2025-08-28

Similar Documents

Publication Publication Date Title
Tanenbaum et al. A protein-tagging system for signal amplification in gene expression and fluorescence imaging
WO2021163064A3 (en) Antibodies and fusion proteins that bind to ccr8 and uses thereof
PH12022551636A1 (en) Anti-cd73 antibodies and uses thereof
ZA202210065B (en) Interleukin-21 muteins and methods of treatment
MX2022000652A (es) Anticuerpos contra claudina 18 y metodos de tratamiento del cancer.
MX2025012685A (es) Anticuerpos para claudin6 y metodos para tratar el cancer
PH12020551039A1 (en) Non-viral dna vectors and uses thereof for antibody and fusion protein production
BR112017010110A2 (pt) anticorpos contra cd73 e usos do mesmo
EP4527854A3 (de) Antikorper gegen pd-l1
SG170080A1 (en) Human monoclonal antibodies to o8e
EP4434997A3 (de) Freisetzung von negativ geladenen proteinen unter verwendung von kationischen lipiden
GEAP202416574A (en) Anti-cd122 antibodies and uses thereof
Oliver Monobodies as possible next-generation protein therapeutics–a perspective
EP4339615A3 (de) Anti-pd-1-antikörper
Chaudhary et al. Phenotypic alterations, clinical impact and therapeutic potential of regulatory T cells in cancer
EP4620976A3 (de) Pharmazeutische zusammensetzung mit niedrigem ph-wert mit t-zell-aktivierenden antikörperkonstrukten
BR112022022353A2 (pt) Composições e métodos para reprogramação de tcr usando proteínas de fusão específicas de cd70
WO2019180201A3 (en) Antagonistic pd-1, pd-l1 and lag-3 binding proteins
EP4306544A3 (de) Herstellung heteromultimerer proteine unter verwendung von säugetierzellen
BR112022012327A2 (pt) Anticorpos ou fragmentos dos mesmos, ácido nucleico, vetor e célula hospedeira
CA3156096A1 (en) Pd1 and vegfr2 dual-binding agents
AU2019356414A8 (en) Binding proteins specific for HA-1H and uses thereof
Pijuan-Galitó et al. Serum inter-α-inhibitor activates the Yes tyrosine kinase and YAP/TEAD transcriptional complex in mouse embryonic stem cells
EA202192893A1 (ru) Среда для культивирования эукариотических клеток
WO2022236276A3 (en) Anti-tigit antibodies, anti-cd96 antibodies, and methods of use thereof

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN PUBLISHED

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AC Divisional application: reference to earlier application

Ref document number: 4041763

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

RIC1 Information provided on ipc code assigned before grant

Ipc: C07K 16/28 20060101ALI20250520BHEP

Ipc: A61P 35/00 20060101ALI20250520BHEP

Ipc: C07K 16/30 20060101AFI20250520BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN