EP4565128A1 - Verfahren zur quantifizierung der dopplergeschwindigkeitsmessung in blutgefässen - Google Patents

Verfahren zur quantifizierung der dopplergeschwindigkeitsmessung in blutgefässen

Info

Publication number
EP4565128A1
EP4565128A1 EP22772404.4A EP22772404A EP4565128A1 EP 4565128 A1 EP4565128 A1 EP 4565128A1 EP 22772404 A EP22772404 A EP 22772404A EP 4565128 A1 EP4565128 A1 EP 4565128A1
Authority
EP
European Patent Office
Prior art keywords
doppler
blood vessels
area
modalities
measurement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP22772404.4A
Other languages
English (en)
French (fr)
Inventor
Petar Ignatov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
"dreamworks Instrument Solutions" Ltd
Original Assignee
"dreamworks Instrument Solutions" Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by "dreamworks Instrument Solutions" Ltd filed Critical "dreamworks Instrument Solutions" Ltd
Publication of EP4565128A1 publication Critical patent/EP4565128A1/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/026—Measuring blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/026—Measuring blood flow
    • A61B5/0285—Measuring or recording phase velocity of blood waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/06—Measuring blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Clinical applications
    • A61B8/0808—Clinical applications for diagnosis of the brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Clinical applications
    • A61B8/0891—Clinical applications for diagnosis of blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/488—Diagnostic techniques involving Doppler signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/5215—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data
    • A61B8/5223—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for extracting a diagnostic or physiological parameter from medical diagnostic data
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2503/00—Evaluating a particular growth phase or type of persons or animals
    • A61B2503/02—Foetus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/02108—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics
    • A61B5/02116—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics of pulse wave amplitude
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/026—Measuring blood flow
    • A61B5/0295—Measuring blood flow using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography

Definitions

  • the method which is a subject of the present invention, is applicable to all areas of medicine where blood oxidation levels must be monitored and more specifically - in maternal fetal medicine.
  • Doppler velocimetry has been widely used throughout the years as a most valuable tool in the follow-up and prognosis of various pregnancy complications, such as fetal growth restriction, fetal anaemia, as well as twin-to-twin transfusion syndrome in multiple pregnancies (1).
  • middle cerebral artery pulsatility index
  • pulsatility index is a commonly used modality to assess fetal well-being, especially in late FGR.
  • the measurement of middle cerebral artery’s pulsatility index continues to serve as a gold standard for the assessment of fetal brain-sparing.
  • fetal brain Doppler assessment is currently narrowed to monitoring late fetal growth restriction (>32 weeks of gestation), where cerebroplacental ratio and middle cerebral artery Doppler may be of specific clinical value [11,12,13].
  • the so called “dicrotic notch” is a small and brief increase in arterial blood pressure that appears when the aortic valve closes.
  • This landmark has been widely referred to in the descriptive analysis of the arterial waveform (especially of aortic and radial arteries) and is commonly used as an equivalent of end-systolic left ventricular pressure [14,15,16,17],
  • the dicrotic notch is universally associated with aortic valve closure [18], and possibly with changes in the peripheral vascular resistance [19], although to date, no physical mechanism for the existence of the dicrotic notch has been demonstrated convincingly.
  • Doppler velocimetry In middle cerebral artery Doppler velocimetry, it can be used as a marker of the end of systole and beginning of diastole. Visual dicrotic notch representation, as it appears on Pulse wave Doppler, is shown on figure 3.
  • dicrotic notch serving as a readily recognizable marker to indicate the beginning of diastole, it is necessary to appoint a suitable measurement tool to quantify the brain-sparing effect.
  • the systolic area in Pulse wave waveforms is being measured, defined by the presence of dicrotic notch in Doppler velocimetry of blood vessels (arteries or veins).
  • subject of measurement is the diastolic area in Pulse wave waveforms (or other Doppler modalities), defined by the presence of dicrotic notch in Doppler velocimetry of blood vessels (arteries or veins).
  • Figure 1 represents the common use of the Doppler measurement of the blood velocity
  • Figure 1 Shown in the image on the left is a PI of 1.74 at 34 weeks of gestation (normal finding).
  • the DN can be used as a demarcation tool to define systole and diastole
  • the DDA shape is defined by DN - dicrotic notch, D - end diastolic velocity and At - (t2 - tl).
  • Method for evaluation of the blood flow, characterized by measurement of areas under the curve of Pulse wave waveforms (or other Doppler modalities) of blood vessels (arteries or veins).
  • the systolic area in Pulse wave waveforms is being measured, defined by the presence of dicrotic notch in Doppler velocimetry of blood vessels (arteries or veins).
  • subject of measurement is the sdiastolic area in Pulse wave waveforms (or other Doppler modalities), defined by the presence of dicrotic notch in Doppler velocimetry of blood vessels (arteries or veins).
  • the diastolic deceleration area can be quantified with the following trapezoid area formula:
  • A V2 (a + b) h
  • A area
  • a ” and “b ” are the bases of the trapezoid
  • h is height.
  • Doppler curve quantification provides means for earlier diagnosis of fetal hypoxemia/hypoxia and anaemia, growth restriction, as well as broader spectrum of diagnostic possibilities in twin-to-twin transfusion syndrome and other conditions;
  • Pulse wave Doppler calculation of systolic and diastolic areas in Pulse wave Doppler is applicable in all areas of human and veterinary medicine.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Physiology (AREA)
  • Cardiology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
EP22772404.4A 2022-08-05 2022-08-05 Verfahren zur quantifizierung der dopplergeschwindigkeitsmessung in blutgefässen Pending EP4565128A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/BG2022/050004 WO2024026542A1 (en) 2022-08-05 2022-08-05 Method for quantification of doppler velocimetry in blood vessels

Publications (1)

Publication Number Publication Date
EP4565128A1 true EP4565128A1 (de) 2025-06-11

Family

ID=83355119

Family Applications (1)

Application Number Title Priority Date Filing Date
EP22772404.4A Pending EP4565128A1 (de) 2022-08-05 2022-08-05 Verfahren zur quantifizierung der dopplergeschwindigkeitsmessung in blutgefässen

Country Status (2)

Country Link
EP (1) EP4565128A1 (de)
WO (1) WO2024026542A1 (de)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN2014CN03826A (de) * 2011-11-30 2015-10-16 Koninkl Philips Nv
CN110709006B (zh) * 2017-04-13 2022-08-23 安科医疗私人有限公司 非侵入血压测量
EP3622882A1 (de) * 2018-09-14 2020-03-18 Fundació Institut de Ciències Fotòniques System und computerimplementiertes verfahren zur erkennung und kategorisierung von pathologien durch eine analyse des pulsierenden blutflusses
WO2020099218A1 (en) * 2018-11-15 2020-05-22 My-Vitality Sàrl Self-monitoring and care assistant for achieving glycemic goals

Also Published As

Publication number Publication date
WO2024026542A1 (en) 2024-02-08

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