EP4426490A4 - Mikromischer und verfahren zur konzentrationsmessung einer unbekannten probe - Google Patents

Mikromischer und verfahren zur konzentrationsmessung einer unbekannten probe

Info

Publication number
EP4426490A4
EP4426490A4 EP22889540.5A EP22889540A EP4426490A4 EP 4426490 A4 EP4426490 A4 EP 4426490A4 EP 22889540 A EP22889540 A EP 22889540A EP 4426490 A4 EP4426490 A4 EP 4426490A4
Authority
EP
European Patent Office
Prior art keywords
micromic
concentration measurement
unknown sample
unknown
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP22889540.5A
Other languages
English (en)
French (fr)
Other versions
EP4426490A1 (de
Inventor
Natalya Mizrahi
Victor Yashunsky
Oran Zohar
Yoel Ezra
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EFA Engineering For All Ltd
E F A Eng For All Ltd
Original Assignee
EFA Engineering For All Ltd
E F A Eng For All Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EFA Engineering For All Ltd, E F A Eng For All Ltd filed Critical EFA Engineering For All Ltd
Publication of EP4426490A1 publication Critical patent/EP4426490A1/de
Publication of EP4426490A4 publication Critical patent/EP4426490A4/de
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1484—Optical investigation techniques, e.g. flow cytometry microstructural devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/305—Micromixers using mixing means not otherwise provided for
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/713—Feed mechanisms comprising breaking packages or parts thereof, e.g. piercing or opening sealing elements between compartments or cartridges
    • B01F35/7131—Breaking or perforating packages, containers or vials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5094—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B01L2400/0683—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers mechanically breaking a wall or membrane within a channel or chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/012—Red blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/016—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/018—Platelets
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1486—Counting the particles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Ecology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
EP22889540.5A 2021-11-02 2022-11-01 Mikromischer und verfahren zur konzentrationsmessung einer unbekannten probe Pending EP4426490A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163274551P 2021-11-02 2021-11-02
PCT/IB2022/060511 WO2023079436A1 (en) 2021-11-02 2022-11-01 Micromixer and method for concentration measurement of unknown sample

Publications (2)

Publication Number Publication Date
EP4426490A1 EP4426490A1 (de) 2024-09-11
EP4426490A4 true EP4426490A4 (de) 2025-12-24

Family

ID=86240882

Family Applications (1)

Application Number Title Priority Date Filing Date
EP22889540.5A Pending EP4426490A4 (de) 2021-11-02 2022-11-01 Mikromischer und verfahren zur konzentrationsmessung einer unbekannten probe

Country Status (3)

Country Link
EP (1) EP4426490A4 (de)
IL (1) IL312501A (de)
WO (1) WO2023079436A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025248526A1 (en) * 2024-05-29 2025-12-04 E.F.A. Engineering For All Ltd. Test chip for analyzing fluids of organ

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8383043B2 (en) * 2004-05-14 2013-02-26 Honeywell International Inc. Analyzer system
WO2018009920A1 (en) * 2016-07-08 2018-01-11 Medica Corporation Automated microscopic cell analysis
WO2020141463A2 (en) * 2019-01-03 2020-07-09 Pixcell Medical Technologies Ltd. Systems and methods for analyzing a fluid sample
EP3772371A1 (de) * 2019-08-06 2021-02-10 EFA - Engineering For All Ltd. Mikromischer

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8383043B2 (en) * 2004-05-14 2013-02-26 Honeywell International Inc. Analyzer system
WO2018009920A1 (en) * 2016-07-08 2018-01-11 Medica Corporation Automated microscopic cell analysis
WO2020141463A2 (en) * 2019-01-03 2020-07-09 Pixcell Medical Technologies Ltd. Systems and methods for analyzing a fluid sample
EP3772371A1 (de) * 2019-08-06 2021-02-10 EFA - Engineering For All Ltd. Mikromischer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2023079436A1 *

Also Published As

Publication number Publication date
IL312501A (en) 2024-07-01
WO2023079436A1 (en) 2023-05-11
EP4426490A1 (de) 2024-09-11

Similar Documents

Publication Publication Date Title
EP4165207C0 (de) Verfahren zur bestimmung der position eines analyten in einer biologischen probe
EP4476565A4 (de) Verfahren und vorrichtung zur bistatischen messung mehrerer vorrichtungen
EP4128936A4 (de) Verfahren und gerät zur erfassungsmessung und meldung von nr-sidelink
EP3759465C0 (de) Verfahren und systeme zur kalibrierung und verwendung einer kamera zur detektion eines analyten in einer probe
EP4185914C0 (de) Systeme und verfahren zur durchführung einer mikroskopischen analyse einer probe
EP4162236A4 (de) System und verfahren zur kalibrierung von messinstrumenten
EP4010688C0 (de) Systeme und verfahren zur bestimmung von proteinkonzentrationen unbekannter proteinproben basierend auf einer automatischen multiwellenlängenkalibrierung
EP4217873A4 (de) Computerimplementiertes verfahren und system zur testautomatisierung einer zu testenden anwendung
EP4042135C0 (de) Vorrichtung und verfahren zur herstellen einer analytischen probe
EP3922992A4 (de) Kit zur messung eines analyten und verfahren zur bestimmung eines analyten
EP4212845A4 (de) Konzentrationsvorrichtung, verfahren zur konzentration von flüssigen proben, verfahren zur inspektion von flüssigen proben und inspektionskit
EP4426490A4 (de) Mikromischer und verfahren zur konzentrationsmessung einer unbekannten probe
EP4139671A4 (de) Photoionisationsdetektor und verfahren zur gasprobenanalyse
EP4145122C0 (de) Vorrichtung zur zerstörungsfreien prüfung und verfahren zur zerstörungsfreien prüfung
EP4337947A4 (de) System und verfahren zur identifizierung von komponenten einer unbekannten arzneimittelprobe
EP4323756A4 (de) Einrichtung von pflegebereichen zur inspektion einer probe
EP4294265C0 (de) Verfahren und vorrichtung zur transdermalen messung der impedanz
EP4168770A4 (de) Messvorrichtung und verfahren zur verwendung davon
EP4109096A4 (de) Verfahren zur analyse biologischer proben
EP4163395A4 (de) System und verfahren zur identifizierung von spezies oder subspezies nichttuberkulose mykobakterien in einer probe
EP4453552C0 (de) Verfahren zur bestimmung der konzentration eines analyten in einer probe
EP4624592A4 (de) Verfahren und vorrichtung zur bestimmung der konzentration fötaler dna
EP4314805C0 (de) Verfahren zur ableitung einer alkalinitätsmessung einer probe
EP4483170C0 (de) Vorrichtung zur messung der intrinsischen autofluoreszenz einer biologischen probe und verfahren zu deren verwendung
EP4495221A4 (de) System und verfahren zur behandlung einer biologischen probe

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20240528

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
RIC1 Information provided on ipc code assigned before grant

Ipc: B01L 3/00 20060101AFI20250828BHEP

Ipc: G01N 15/00 20240101ALI20250828BHEP

Ipc: B01F 33/30 20220101ALI20250828BHEP

Ipc: B01F 35/71 20220101ALI20250828BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20251124

RIC1 Information provided on ipc code assigned before grant

Ipc: B01L 3/00 20060101AFI20251118BHEP

Ipc: G01N 15/00 20240101ALI20251118BHEP

Ipc: B01F 33/30 20220101ALI20251118BHEP

Ipc: B01F 35/71 20220101ALI20251118BHEP