EP4405044A4 - Zusammensetzung und verfahren zur prävention und behandlung von hautstrahlungsschäden - Google Patents

Zusammensetzung und verfahren zur prävention und behandlung von hautstrahlungsschäden

Info

Publication number
EP4405044A4
EP4405044A4 EP22873578.3A EP22873578A EP4405044A4 EP 4405044 A4 EP4405044 A4 EP 4405044A4 EP 22873578 A EP22873578 A EP 22873578A EP 4405044 A4 EP4405044 A4 EP 4405044A4
Authority
EP
European Patent Office
Prior art keywords
preventing
composition
treating skin
radiation damage
skin radiation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP22873578.3A
Other languages
English (en)
French (fr)
Other versions
EP4405044A1 (de
Inventor
Reginald L Hardy
Mitchell Brigell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rythera Therapeutics Inc
Original Assignee
Rythera Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2021/051583 external-priority patent/WO2022066791A1/en
Application filed by Rythera Therapeutics Inc filed Critical Rythera Therapeutics Inc
Publication of EP4405044A1 publication Critical patent/EP4405044A1/de
Publication of EP4405044A4 publication Critical patent/EP4405044A4/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP22873578.3A 2021-09-22 2022-09-22 Zusammensetzung und verfahren zur prävention und behandlung von hautstrahlungsschäden Pending EP4405044A4 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202163247234P 2021-09-22 2021-09-22
PCT/US2021/051583 WO2022066791A1 (en) 2020-09-22 2021-09-22 Composition and method for prevention and treatment of cutaneous radiation injury
US202263322181P 2022-03-21 2022-03-21
PCT/US2022/044382 WO2023049262A1 (en) 2021-09-22 2022-09-22 Composition and method for prevention and treatment of cutaneous radiation injury

Publications (2)

Publication Number Publication Date
EP4405044A1 EP4405044A1 (de) 2024-07-31
EP4405044A4 true EP4405044A4 (de) 2025-08-06

Family

ID=85721134

Family Applications (1)

Application Number Title Priority Date Filing Date
EP22873578.3A Pending EP4405044A4 (de) 2021-09-22 2022-09-22 Zusammensetzung und verfahren zur prävention und behandlung von hautstrahlungsschäden

Country Status (8)

Country Link
EP (1) EP4405044A4 (de)
JP (1) JP2024536823A (de)
KR (1) KR20240065134A (de)
AU (1) AU2022351983A1 (de)
CA (1) CA3232527A1 (de)
IL (1) IL311661A (de)
MX (1) MX2024003665A (de)
WO (1) WO2023049262A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2025533533A (ja) * 2022-09-22 2025-10-07 ライセラ セラピューティクス，インコーポレイテッド 皮膚放射線障害の予防及び治療のための組成物及び方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170246267A1 (en) * 2014-08-18 2017-08-31 The Trustees Of Columbia University In The City Of New York Cholinergic antagonism as an adjunct to cancer therapy
WO2022066791A1 (en) * 2020-09-22 2022-03-31 Rythera Therapeutics, Inc. Composition and method for prevention and treatment of cutaneous radiation injury

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3108067A1 (en) * 2018-07-30 2020-02-06 L. Jane Jourdan Engineered hemichannels, engineered vesicles, and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170246267A1 (en) * 2014-08-18 2017-08-31 The Trustees Of Columbia University In The City Of New York Cholinergic antagonism as an adjunct to cancer therapy
WO2022066791A1 (en) * 2020-09-22 2022-03-31 Rythera Therapeutics, Inc. Composition and method for prevention and treatment of cutaneous radiation injury

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
"Doxepin rinse for oral mucositis", DENTAL ABSTRACTS, MOSBY, ST. LOUIS, MO, US, vol. 54, no. 1, 1 January 2009 (2009-01-01), pages 54 - 55, XP025891715, ISSN: 0011-8486, [retrieved on 20090127], DOI: 10.1016/J.DENABS.2008.08.049 *
CHRISTOFOROU JANINA ET AL: "World Workshop on Oral Medicine VII: Non-opioid pain management of head and neck chemo/radiation-induced mucositis: A systematic review", ORAL DISEASES, vol. 25, no. S1, 29 May 2019 (2019-05-29), GB, pages 182 - 192, XP093288905, ISSN: 1354-523X, Retrieved from the Internet <URL:https://onlinelibrary.wiley.com/doi/full-xml/10.1111/odi.13074> DOI: 10.1111/odi.13074 *
JOHANNES KORNHUBER ET AL: "Identification of Novel Functional Inhibitors of Acid Sphingomyelinase", PLOS ONE, vol. 6, no. 8, 31 August 2011 (2011-08-31), pages e23852, XP055396557, DOI: 10.1371/journal.pone.0023852 *
LALEH SHARIATI ET AL: "Protective effects of doxepin cream on radiation dermatitis in breast cancer: A single arm double-blind randomized clinical trial", BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, BLACKWELL SCIENTIFIC PUBL, GB, vol. 86, no. 9, 25 February 2020 (2020-02-25), pages 1875 - 1881, XP071603255, ISSN: 0306-5251, DOI: 10.1111/BCP.14238 *
See also references of WO2023049262A1 *

Also Published As

Publication number Publication date
JP2024536823A (ja) 2024-10-08
WO2023049262A1 (en) 2023-03-30
EP4405044A1 (de) 2024-07-31
MX2024003665A (es) 2024-06-26
CA3232527A1 (en) 2023-03-30
KR20240065134A (ko) 2024-05-14
AU2022351983A1 (en) 2024-04-18
IL311661A (en) 2024-05-01

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