EP4367518A4 - Funktionelle porosommanipulation - Google Patents

Funktionelle porosommanipulation

Info

Publication number
EP4367518A4
EP4367518A4 EP23847857.2A EP23847857A EP4367518A4 EP 4367518 A4 EP4367518 A4 EP 4367518A4 EP 23847857 A EP23847857 A EP 23847857A EP 4367518 A4 EP4367518 A4 EP 4367518A4
Authority
EP
European Patent Office
Prior art keywords
porosome
manipulation
functional
porosome manipulation
functional porosome
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP23847857.2A
Other languages
English (en)
French (fr)
Other versions
EP4367518A1 (de
Inventor
Bhanu Pratap Jena
Won Jin Cho
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Viron Inc
Original Assignee
Viron Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US18/222,784 external-priority patent/US20230357329A1/en
Application filed by Viron Inc filed Critical Viron Inc
Publication of EP4367518A1 publication Critical patent/EP4367518A1/de
Publication of EP4367518A4 publication Critical patent/EP4367518A4/de
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
EP23847857.2A 2022-08-08 2023-08-08 Funktionelle porosommanipulation Pending EP4367518A4 (de)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US202263396040P 2022-08-08 2022-08-08
US202263431946P 2022-12-12 2022-12-12
US202363444451P 2023-02-09 2023-02-09
US202363447371P 2023-02-22 2023-02-22
US202363458471P 2023-04-11 2023-04-11
US202363459762P 2023-04-17 2023-04-17
US202363472674P 2023-06-13 2023-06-13
US202363523970P 2023-06-29 2023-06-29
US202363526786P 2023-07-14 2023-07-14
US18/222,784 US20230357329A1 (en) 2020-05-02 2023-07-17 Combined use of nanobody, cyclodextrin and quercetin for protection from enveloped viruses
PCT/US2023/029733 WO2024035703A1 (en) 2022-08-08 2023-08-08 Functional porosome manipulation

Publications (2)

Publication Number Publication Date
EP4367518A1 EP4367518A1 (de) 2024-05-15
EP4367518A4 true EP4367518A4 (de) 2025-10-15

Family

ID=89852415

Family Applications (1)

Application Number Title Priority Date Filing Date
EP23847857.2A Pending EP4367518A4 (de) 2022-08-08 2023-08-08 Funktionelle porosommanipulation

Country Status (4)

Country Link
EP (1) EP4367518A4 (de)
JP (1) JP2025530654A (de)
CN (1) CN120188045A (de)
WO (1) WO2024035703A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2026015731A1 (en) * 2024-07-10 2026-01-15 Porosome Therapeutics, Inc. Functional porosome manipulation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240053354A1 (en) * 2022-08-08 2024-02-15 Porosome Therapeutics, Inc. Functional porosome manipulation
US20240316152A1 (en) * 2022-08-08 2024-09-26 Porosome Therapeutics, Inc. Functional porosome manipulation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180372751A1 (en) * 2017-06-23 2018-12-27 The Scripps Research Institute Lysine reactive probes and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240053354A1 (en) * 2022-08-08 2024-02-15 Porosome Therapeutics, Inc. Functional porosome manipulation
US20240316152A1 (en) * 2022-08-08 2024-09-26 Porosome Therapeutics, Inc. Functional porosome manipulation

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
CHO W J ET AL: "Structure, isolation, composition and reconstitution of the neuronal fusion pore", CELL BIOLOGY INTERNATIONAL, ACADEMIC PRESS, GB, vol. 28, no. 10, 1 October 2004 (2004-10-01), pages 699 - 708, XP004630274, ISSN: 1065-6995, DOI: 10.1016/J.CELLBI.2004.07.004 *
CHO WON JIN ET AL: "Reprogramming the cells secretory machinery: A cystic fibrosis rescue", BIORXIV, 9 December 2023 (2023-12-09), XP093271071, Retrieved from the Internet <URL:https://www.biorxiv.org/content/10.1101/2023.12.09.570886v1> DOI: 10.1101/2023.12.09.570886 *
JENA BHANU P: "Neuronalporosome- The secretory portal at the nerve terminal: Its structure-function, composition, and recons", JOURNAL OF MOLECULAR STRUCTURE, ELSEVIER AMSTERDAM, NL, vol. 1073, 24 April 2014 (2014-04-24), pages 187 - 195, XP029008461, ISSN: 0022-2860, DOI: 10.1016/J.MOLSTRUC.2014.04.055 *
MAIDORN MANUEL ET AL: "Nanobodies reveal an extra-synaptic population of SNAP-25 and Syntaxin 1A in hippocampal neurons", MABS, vol. 11, no. 2, 28 December 2018 (2018-12-28), US, pages 305 - 321, XP093271024, ISSN: 1942-0862, DOI: 10.1080/19420862.2018.1551675 *
NAIK AKSHATA R. ET AL: "Functional Reconstitution of the Insulin-Secreting Porosome Complex in Live Cells", ENDOCRINOLOGY, vol. 157, no. 1, 1 January 2016 (2016-01-01), US, pages 54 - 60, XP093271044, ISSN: 0013-7227, Retrieved from the Internet <URL:http://academic.oup.com/endo/article-pdf/157/1/54/11029079/endo0054.pdf> DOI: 10.1210/en.2015-1653 *
PLEINER TINO ET AL: "Nanobodies: site-specific labeling for super-resolution imaging, rapid epitope- mapping and native protein complex isolation", ELIFE, vol. 4, 3 December 2015 (2015-12-03), pages e11349, XP093271028, Retrieved from the Internet <URL:https://elifesciences.org/articles/11349> *
See also references of WO2024035703A1 *
SHANG YUTONG ET AL: "Mechanism of clinically relevant neurosecretory and metabolic impairment in Alzheimers and identification of engineered nanotherapy", BIORXIV, 10 April 2025 (2025-04-10), XP093271038, Retrieved from the Internet <URL:https://www.biorxiv.org/content/10.1101/2025.04.09.647859v1> DOI: 10.1101/2025.04.09.647859 *
SIMONE A. COSTA: "Active Targeting of Cancer Cells by Nanobody Decorated Polypeptide Micelle with Bio-orthogonally Conjugated Drug", NANO LETTERS, vol. 19, no. 1, 12 December 2018 (2018-12-12), United States, pages 247 - 254, XP093154429, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.8b03837 *
WON JIN CHO ET AL: "Porosome reconstitution therapy: A biologic rescue from cystic fibrosis", BIORXIV, 12 September 2024 (2024-09-12), pages 1 - 18, XP093271020, Retrieved from the Internet <URL:https://www.biorxiv.org/content/10.1101/2024.09.11.612494v1> DOI: 10.1101/2024.09.11.612494 *

Also Published As

Publication number Publication date
EP4367518A1 (de) 2024-05-15
CN120188045A (zh) 2025-06-20
WO2024035703A1 (en) 2024-02-15
JP2025530654A (ja) 2025-09-17

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RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 39/44 20060101ALI20250508BHEP

Ipc: A61K 35/12 20150101ALI20250508BHEP

Ipc: G01N 33/544 20060101ALI20250508BHEP

Ipc: G01N 33/68 20060101AFI20250508BHEP

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RIC1 Information provided on ipc code assigned before grant

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