EP4360475A1 - Vorrichtung zum inhalieren von trockenen partikeln einer substanz auf nikotinbasis - Google Patents

Vorrichtung zum inhalieren von trockenen partikeln einer substanz auf nikotinbasis Download PDF

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Publication number
EP4360475A1
EP4360475A1 EP22203663.4A EP22203663A EP4360475A1 EP 4360475 A1 EP4360475 A1 EP 4360475A1 EP 22203663 A EP22203663 A EP 22203663A EP 4360475 A1 EP4360475 A1 EP 4360475A1
Authority
EP
European Patent Office
Prior art keywords
air
inhalation device
nicotine
reservoir
based substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP22203663.4A
Other languages
English (en)
French (fr)
Inventor
Pier Paolo MONTICONE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JT International SA
Original Assignee
JT International SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JT International SA filed Critical JT International SA
Priority to EP22203663.4A priority Critical patent/EP4360475A1/de
Publication of EP4360475A1 publication Critical patent/EP4360475A1/de
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/05—Devices without heating means
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
    • A24F40/48—Fluid transfer means, e.g. pumps
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/20—Devices using solid inhalable precursors
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
    • A24F40/42—Cartridges or containers for inhalable precursors
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F42/00—Simulated smoking devices other than electrically operated; Component parts thereof; Manufacture or testing thereof
    • A24F42/20—Devices without heating means

Definitions

  • the invention refers to a device for inhaling dry particles of nicotine-based substance.
  • a current practice for consuming a tobacco product consists in inhaling or sniffing a dry snuff tobacco product after having prepared a dose of the product on a surface, e.g. the back surface of a hand.
  • the tobacco product is not burned nor heated, so that this practice is smokeless.
  • the inhaled dry snuff tobacco product - or snuff - is a tobacco made from finely ground or pulverized tobacco leaves. It is generally inhaled into the nasal cavity, delivering a swift hit of nicotine and a lasting flavored scent (especially if flavoring has been blended with the tobacco).
  • snuff is inhaled lightly after a pinch of snuff is either placed onto the back surface of the hand, held pinched between thumb and index finger, or held by a specially made "snuffing" device.
  • Snuff comes in a range of texture and moistness, from very fine to coarse, and from toast (very dry) to very moist. Often drier snuffs are ground more finely.
  • First nicotine may not be delivered efficiently as the powder is not completely delivered to the lungs.
  • dosing of the tobacco product is critical, and under/overdosing of the tobacco product often occurs.
  • Sniffing tobacco product may also be uncomfortable or even unpleasant.
  • sniffing tobacco may trigger sneezing.
  • the tobacco product may drop while preparing the dose leading to wasting some product.
  • CN-A-113491824 discloses an inhalation device that delivers aerosol formed of a powdered substance to the nasal passages of a user.
  • the inhalation device comprises a power supply unit, a strength adjuster, an air fan, an inner container, and a discharge port.
  • the container contains powdered substance.
  • the air fan delivers air to the container which entrain the substance and deliver it to the user via the discharge port.
  • the power supply supplies power to the air fan and the strength adjuster.
  • the strength adjuster controls the rotation of the air fan.
  • the inhalation device that delivers powdered therapeutic formulation into the nostril of a user.
  • the inhalation device is constructed to receive nozzle that includes a capsule which contains powdered substance.
  • the inhalation device comprises an electrical air pump, a valve assembly, and a nozzle hole.
  • the air pump delivers air to the capsule which carry the substance and deliver it to the user via the nozzle hole.
  • the valve assembly controls the airflow from the pump to the nozzle.
  • the pump comprises a slidable piston which can be actuated by electric means.
  • WO-A-2013128447 seems to disclose an inhalation device that delivers nicotine-based substance to the nasal passages of a user.
  • the inhalation device comprises a capsule, an air flow pump, a valve, and a nosepiece.
  • the nosepiece and the capsule form a single unit which is attached to the inhalation device.
  • the capsule contains nicotine-based substance.
  • the airflow pump delivers air to the capsule which carry the substance and deliver it to the user via the nosepiece.
  • the valve is used to control the airflow to the capsule for the pump.
  • an inhalation device for inhaling dry particles of nicotine-based substance comprising:
  • Fig. 1 shows an example of an inhalation device 10 for inhaling dry particles of nicotine-based substance by a user.
  • the inhalation device 10 is a handheld device. Indeed, the dimensions and weight of the inhalation device 10 are such that the inhalation device 10 can easily be carried by a user, e.g. with only one hand.
  • the handheld inhalation device 10 comprises a casing 12 and an endpiece 14 mounted on the casing 12 .
  • the casing 12 can be made of a single part.
  • the casing 12 is preferably made of several parts, for example at least two parts which can be separated from each other, to facilitate access to one or several pieces of the inhalation device 10 received in the casing 12 .
  • the endpiece 14 may be a nosepiece. However, in the present case, the endpiece 14 is a mouthpiece. In both cases indeed, particles inhaled through the nose or through the mouth can be carried to the lungs of a consumer. Moreover, inhaling particles through the mouth is deemed less likely to cause sneezing to the consumer.
  • the casing 12 here receives a battery 16 .
  • the battery 16 can for example be received at a first end of the casing 12 opposite to a second end of the casing 12 on which the endpiece 14 is mounted.
  • the casing 12 further receives an electronic command unit 18 (or ECU).
  • ECU 18 can comprise or even consist in a printed circuit board (or PCB). As illustrated, the ECU 18 can be close to the battery 16 to avoid long and bulky wirings inside the casing 12 .
  • the casing 12 also receives an air pump 20 of the inhalation device 10 as illustrated on Fig. 1 .
  • the air pump 20 is in fluid communication with outside the casing 12 through an air input 22 provided on the casing 12 .
  • an air filter 24 is provided in the air input 22 or between the air input 22 on the casing 12 and the air input of the air pump 20 , so that only filtered air goes through the air pump 20 .
  • the air pump 20 is here adapted to suck air from outside the casing 12 , to pressurized said air, and to feed said air into an air flow inlet of an air flow feeding element 26.
  • the air flow feeding elements 26 here comprises a manifold 26 .
  • the manifold 26 can comprise at least one air flow inlet 28 in fluid communication with an outlet of the air pump 20 .
  • the manifold 26 preferably comprises only one air flow inlet 28 in fluid communication with the single outlet of the air pump 20 .
  • the manifold 26 can further comprise a plurality of air flow outlets 30 , each air flow outlet 30 being in airtight fluid communication with the at least one air flow inlet 28 or with the single air flow inlet 28 .
  • the manifold 26 thus allows to divide the air flow provided by the air pump 20 into several air flows at the air flow outlets 30 of the manifold 26 .
  • each of the air flow outlets 30 can be formed at a free end of a needle 32 .
  • the needles 32 can form an array 34 or matrix of needles 32 .
  • the array 34 of needles 32 has a base portion 36 , e.g. formed as a circular disc.
  • the manifold 26 comprises:
  • the outlets 30 at the free end of the needles 32 are received within a reservoir 38 of dry particles of nicotine-based substance.
  • the reservoir 38 can consist in a cartridge 40 received in a corresponding housing 42 formed in the casing 12 of the inhalation device 10 .
  • the housing 42 is open when the two parts of the casing 12 are separated from each other.
  • the casing 12 or at least one part of the casing comprises a flap which can selectively be opened and closed to allow a user to reach the housing 42 inside the casing 12 .
  • FIG. 3 and 4 An example of a cartridge 40 is illustrated on Figs. 3 and 4 .
  • the cartridge 40 as illustrated is comprised of a bowl 44 , which is substantially hemispheric in the illustrated example, and a lid 46 closing the space 48 inside the bowl 44 .
  • the bowl 44 and the lid 46 are sealed together along a rim 50 .
  • the bowl 44 can be made in any suitable material, e.g. in aluminum. Preferably the bowl 44 is made in an airtight material.
  • the lid 46 can also be made in any suitable material, e.g. of aluminum. Preferably the lid 46 is made of an airtight material.
  • the bowl 44 and the lid 46 can be made of a one same material or of different materials.
  • the space 48 inside the bowl 44 closed by the lid 46 comprises dry particles 52 of nicotine-based substance, e.g. as a powder.
  • Said dry particles may comprise, inter allia :
  • the dry particles 52 can have a particle size (D90) below 100 ⁇ m.
  • the dry particles 52 of nicotine-based substance do not totally fill the space 48 inside the bowl 44 .
  • a part 54 of the space 48 is preferably kept empty, id est void or filled with air or another gas, for example nitrogen, at a pressure substantially equal to or above 1 bar, at a temperature of 25 °C.
  • air or another gas for example nitrogen
  • a density of air bath being lower than the compressed particles, such that preferably 10% to 100% empty volumes should be added to the volume of the compressed particles 52.
  • the inhalation device 10 further comprises an outlet pipe 56 in airtight fluid communication with the space 48 inside the bowl 44 of the cartridge 40 .
  • the outlet pipe 56 can be adapted to pierce the bowl 44 when the cartridge 40 is installed in the housing 42 formed in the casing 12 and/or when the casing 12 is closed after the cartridge has been installed in the housing 42 formed in the casing 12 .
  • a consumer may have to remove a lid or foil on the cartridge 40 (for instance, the top of the bowl could have an opening sealed by a foil (like a sticker). The foil could be peeled or perforated), especially on the bowl 44 to allow the outlet pipe 56 to be in fluid communication with the space 48 inside the bowl 44 of the cartridge 40 once the cartridge 40 has been installed in the housing 42 formed in the casing 12 .
  • the inhalation device 10 further comprises a diluting air channel 58 .
  • the diluting air channel 58 extends between a diluting air inlet on the casing 12 of the inhalation device 10 and a diluting air outlet in fluid communication of with the outlet pipe 56 .
  • the diluting air channel 58 allows air to be sucked from outside the casing 12 into the outlet pipe 56 . Air sucked through the diluting channel 58 is then mixed up with the mixture of particles of nicotine-based substance and pressurized air from the cartridge 40 , before this mixture exits the casing 12 .
  • the cross section of the diluting air channel 58 may be modified.
  • the cross section of the diluting air channel can be adjustable manually.
  • a user may modify the quantity of dry particles of nicotine-based substance in the inhaled mixture.
  • a flapper or diaphragm may be provided so as to modify the cross section of the diluting air channel 58 , e.g. of an orifice of the diluting air channel 58 .
  • the cross section of the diluting air channel 58 is automatically adjustable.
  • the ECU 18 can for example control any means adapted to modify the cross section of the diluting air channel 58 , e.g. a flapper or diaphragm.
  • the cross section of the diluting air channel 58 can be modified to mimic the ratio of nicotine by puff delivered by a cigarette.
  • the cross section of the diluting air channel 58 can be comprised between 0.5 and 1.5 mm 2 .
  • the diluting air channel 58 can have a length between 4 and 20 mm.
  • the outlet pipe 56 extends into the endpiece 14 .
  • a filter 60 can be provided in the outlet pipe 56 or between the outlet pipe 56 and the endpiece 14 , preferably downstream from the diluting air channel 58 .
  • the filter 60 can be static or moving, e.g. spinning, to remain clean and/or to increase the velocity of the particles going through the filter 60 and/or to mix the particles and the air going through the filter 60 .
  • the filter 60 is provided in the cartridge such as by a piece of gauze or fibrous sheet attached to the inner surface of the bowl in the air inlet region.
  • the inhalation device 10 is adapted to deliver dry snuff tobacco powder when used like a vaping device.
  • the inhalation device 10 is used to be sucked by mouth ( id est the endpiece is a mouthpiece).
  • the inhalation device 10 comprise an endpiece which is a nosepiece, adapted to be received in a nose of a user.
  • cartridges 40 can be used as reservoir 38 of dry particles of nicotine-based substance in the inhalation device 10 .
  • Using cartridges 40 is particularly advantageous. First, this limits the risks that the tobacco product to be inhaled, drops and is wasted.
  • using cartridge 40 can allow a particularly precise dosing of the particles of nicotine-based substance to be inhaled.
  • the cartridge 40 can comprise a quantity of dry particles of nicotine-based substance for eight puffs rather than only one single sniff.
  • the cartridge 40 is pierced by both the needles 32 of the manifold 36 as well as by the outlet pipe 56 .
  • the pump 20 is started, the pump 20 being controlled by the ECU 18 .
  • the ECU 18 can control the pump 20 so that the pressure and the rate of flow of the air flow provided by the pump 20 inside the cartridge 40 forms a fluidized bed with the dry particles 52 of nicotine-based substance.
  • a fluidized bed is a well-known physical phenomenon that occurs when a solid particulate substance is under the right conditions so that it behaves like a fluid.
  • the usual way to achieve a fluidize bed is to pump pressurized fluid into the particles.
  • the resulting medium then has many properties and characteristics of normal fluids, such as the ability to free flow under gravity.
  • a fluidized bed consists of fluid-solid mixture that exhibits fluid-like properties.
  • a fluidized bed can be considered as a heterogeneous mixture of fluid and solid that can be represented by a single bulk density.
  • a fluidized bed of particles of nicotine-based substance in air lead to a particularly comfortable inhalation of the mixture by a user, through his/her mouth. This also maximize the quantity of particles of nicotine-based substance by puff.
  • the pressure and the rate of flow of the air flow provided by the pump 20 inside the cartridge 40 can be such that the dry particles 52 of nicotine-based substance are boiling inside the cartridge 40 without flying away nor depositing on a surface of the cartridge 40 , especially on the lowest surface of the cartridge 40 .
  • the dry particles 52 of nicotine-based substance also boil in the cartridge 40 because of the number of air flow outlets 30 of the manifold 26 opening inside the cartridge 40 . More specifically since several air flow outlets 30 of the manifold 26 are inside the cartridge 40 then the air flow inside the cartridge 40 is more homogeneously divided. This helps to form a fluidized bed compared to the case where only one air flow outlet 30 would be inside the cartridge 40 .
  • the distribution of the air flow inside the cartridge 40 would be heterogenous to form a fluidized bed inside the whole space 48 in the cartridge 40 .
  • a fluidized bed could be formed including some of the dry particles 52 of nicotine-based substance present in the cartridge 40 . But not all the dry particles 52 would be in such a fluidized bed, so that some product would be wasted.
  • the powder of the dry particles 52 of nicotine-based substance is "boiling" without flying away or depositing. This can be achieved by injecting diffused air into the powder at a rate that is just not enough to make the powder fly away but just “boils". In this way, the powder of dry particles 52 is like weightless because the injected air is balancing out the gravity. If the injected air is too much, the force created by the airflow would be greater than the gravity, and the powder of dry particles 52 would fly away if not constrained by a cover. Contrary, if the injected air is not enough, the powder would sediment and behave like a solid. When lift force and weight are equal, the powder bath appears “boiling" and acts like a liquid, e.g., not being compressed when inserting/moving an object in the bath.
  • a fluidized bed of particles of nicotine-based substance can easily and comfortably be inhaled by a user, through the outlet pipe 56 .
  • the reservoir 38 consists in an exchangeablecartridge 40 .
  • the reservoir 38 can be open tank, where the dry particles 52 of nicotine-based substance is charged by the user.
  • a fluidized bed of particles of nicotine-based substance is formed in the cartridge.
  • a user it is also possible for a user to inhale a mixture of air and particles of nicotine-based substance even if no fluidized bed is created in the cartridge.
  • the creation of fluidized bed inside the cartridge proves an increased comfort to a user and ensures more cleanliness to the system.
  • an air pump 20 is used to create a flow of air inside the reservoir 38 .
  • other air pressure device to create this flow of air inside the cartridge 40 , such as a compressed air cartridge for example.

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  • Medicinal Preparation (AREA)
EP22203663.4A 2022-10-25 2022-10-25 Vorrichtung zum inhalieren von trockenen partikeln einer substanz auf nikotinbasis Pending EP4360475A1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP22203663.4A EP4360475A1 (de) 2022-10-25 2022-10-25 Vorrichtung zum inhalieren von trockenen partikeln einer substanz auf nikotinbasis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP22203663.4A EP4360475A1 (de) 2022-10-25 2022-10-25 Vorrichtung zum inhalieren von trockenen partikeln einer substanz auf nikotinbasis

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EP4360475A1 true EP4360475A1 (de) 2024-05-01

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Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030183229A1 (en) * 1994-09-21 2003-10-02 Inhale Therapeutic Systems, A Corporation Of The State Of California Apparatus and method for dispersing dry powder medicaments
WO2011013003A2 (en) 2009-07-31 2011-02-03 Shin Nippon Biomedical Laboratories, Ltd. Intranasal granisetron and nasal applicator
WO2013128447A1 (en) 2012-02-28 2013-09-06 Sipnose Ltd. Nasal delivery device
US10071211B2 (en) * 2011-01-31 2018-09-11 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices
CN113491824A (zh) 2020-04-02 2021-10-12 郑龙采 便携式气雾剂喷射健康吸入器
WO2022010182A1 (en) * 2020-07-09 2022-01-13 Kt&G Corporation Aerosol generating device
US20220126036A1 (en) * 2010-08-23 2022-04-28 Darren Rubin Systems and methods of aerosol delivery with airflow regulation
US11452825B2 (en) * 2017-05-31 2022-09-27 Philip Morris Products S.A. Inhaler article with occluded airflow element

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030183229A1 (en) * 1994-09-21 2003-10-02 Inhale Therapeutic Systems, A Corporation Of The State Of California Apparatus and method for dispersing dry powder medicaments
WO2011013003A2 (en) 2009-07-31 2011-02-03 Shin Nippon Biomedical Laboratories, Ltd. Intranasal granisetron and nasal applicator
US20220126036A1 (en) * 2010-08-23 2022-04-28 Darren Rubin Systems and methods of aerosol delivery with airflow regulation
US10071211B2 (en) * 2011-01-31 2018-09-11 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices
WO2013128447A1 (en) 2012-02-28 2013-09-06 Sipnose Ltd. Nasal delivery device
US11452825B2 (en) * 2017-05-31 2022-09-27 Philip Morris Products S.A. Inhaler article with occluded airflow element
CN113491824A (zh) 2020-04-02 2021-10-12 郑龙采 便携式气雾剂喷射健康吸入器
WO2022010182A1 (en) * 2020-07-09 2022-01-13 Kt&G Corporation Aerosol generating device

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