EP4357482A1 - Electrocatalytic generation of imines from alcohols and amines - Google Patents
Electrocatalytic generation of imines from alcohols and amines Download PDFInfo
- Publication number
- EP4357482A1 EP4357482A1 EP22202245.1A EP22202245A EP4357482A1 EP 4357482 A1 EP4357482 A1 EP 4357482A1 EP 22202245 A EP22202245 A EP 22202245A EP 4357482 A1 EP4357482 A1 EP 4357482A1
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- EP
- European Patent Office
- Prior art keywords
- alcohol
- amine
- use according
- anyone
- electrocatalytic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001412 amines Chemical class 0.000 title claims abstract description 62
- 150000002466 imines Chemical class 0.000 title claims abstract description 58
- 150000001298 alcohols Chemical class 0.000 title description 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 60
- 239000003054 catalyst Substances 0.000 claims abstract description 47
- 238000007254 oxidation reaction Methods 0.000 claims abstract description 34
- 230000003647 oxidation Effects 0.000 claims abstract description 33
- 238000006356 dehydrogenation reaction Methods 0.000 claims abstract description 17
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 15
- 238000003786 synthesis reaction Methods 0.000 claims abstract description 15
- 238000006243 chemical reaction Methods 0.000 claims description 37
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 claims description 26
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 claims description 18
- 229910021607 Silver chloride Inorganic materials 0.000 claims description 18
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 claims description 18
- 239000003446 ligand Substances 0.000 claims description 17
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 12
- 210000000080 chela (arthropods) Anatomy 0.000 claims description 12
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 12
- 239000002904 solvent Substances 0.000 claims description 12
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 10
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 9
- 229910052799 carbon Inorganic materials 0.000 claims description 9
- 229910000073 phosphorus hydride Inorganic materials 0.000 claims description 9
- 230000009467 reduction Effects 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- -1 CsOEt Chemical compound 0.000 claims description 7
- 150000002148 esters Chemical class 0.000 claims description 7
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 125000000129 anionic group Chemical group 0.000 claims description 6
- FJDQFPXHSGXQBY-UHFFFAOYSA-L caesium carbonate Chemical compound [Cs+].[Cs+].[O-]C([O-])=O FJDQFPXHSGXQBY-UHFFFAOYSA-L 0.000 claims description 6
- HUCVOHYBFXVBRW-UHFFFAOYSA-M caesium hydroxide Chemical compound [OH-].[Cs+] HUCVOHYBFXVBRW-UHFFFAOYSA-M 0.000 claims description 6
- 230000036647 reaction Effects 0.000 claims description 6
- 125000001424 substituent group Chemical group 0.000 claims description 6
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 6
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 4
- ADLVDYMTBOSDFE-UHFFFAOYSA-N 5-chloro-6-nitroisoindole-1,3-dione Chemical compound C1=C(Cl)C([N+](=O)[O-])=CC2=C1C(=O)NC2=O ADLVDYMTBOSDFE-UHFFFAOYSA-N 0.000 claims description 4
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims description 4
- 125000001931 aliphatic group Chemical group 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 4
- UORVGPXVDQYIDP-UHFFFAOYSA-N borane Chemical compound B UORVGPXVDQYIDP-UHFFFAOYSA-N 0.000 claims description 4
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 4
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical compound C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 claims description 4
- 150000002576 ketones Chemical class 0.000 claims description 4
- 125000002524 organometallic group Chemical group 0.000 claims description 4
- 150000003335 secondary amines Chemical class 0.000 claims description 4
- 150000003512 tertiary amines Chemical class 0.000 claims description 4
- VDZOOKBUILJEDG-UHFFFAOYSA-M tetrabutylammonium hydroxide Chemical compound [OH-].CCCC[N+](CCCC)(CCCC)CCCC VDZOOKBUILJEDG-UHFFFAOYSA-M 0.000 claims description 4
- WGTYBPLFGIVFAS-UHFFFAOYSA-M tetramethylammonium hydroxide Chemical compound [OH-].C[N+](C)(C)C WGTYBPLFGIVFAS-UHFFFAOYSA-M 0.000 claims description 4
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 4
- 229920002554 vinyl polymer Polymers 0.000 claims description 4
- 125000003545 alkoxy group Chemical group 0.000 claims description 3
- 125000000217 alkyl group Chemical group 0.000 claims description 3
- 229910000024 caesium carbonate Inorganic materials 0.000 claims description 3
- 125000002541 furyl group Chemical group 0.000 claims description 3
- XGZVUEUWXADBQD-UHFFFAOYSA-L lithium carbonate Chemical compound [Li+].[Li+].[O-]C([O-])=O XGZVUEUWXADBQD-UHFFFAOYSA-L 0.000 claims description 3
- 229910052808 lithium carbonate Inorganic materials 0.000 claims description 3
- 125000001544 thienyl group Chemical group 0.000 claims description 3
- 239000012224 working solution Substances 0.000 claims description 3
- ACQYZSFXPXXIHL-UHFFFAOYSA-N 2-phenylmethoxycarbonyl-3,4-dihydro-1h-isoquinoline-1-carboxylic acid Chemical compound C1CC2=CC=CC=C2C(C(=O)O)N1C(=O)OCC1=CC=CC=C1 ACQYZSFXPXXIHL-UHFFFAOYSA-N 0.000 claims description 2
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims description 2
- 229910052777 Praseodymium Inorganic materials 0.000 claims description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
- NDKBVBUGCNGSJJ-UHFFFAOYSA-M benzyltrimethylammonium hydroxide Chemical compound [OH-].C[N+](C)(C)CC1=CC=CC=C1 NDKBVBUGCNGSJJ-UHFFFAOYSA-M 0.000 claims description 2
- 229910000085 borane Inorganic materials 0.000 claims description 2
- LGVUAXNPXVXCCW-UHFFFAOYSA-M cesium;2,2-dimethylpropanoate Chemical compound [Cs+].CC(C)(C)C([O-])=O LGVUAXNPXVXCCW-UHFFFAOYSA-M 0.000 claims description 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 2
- 125000001153 fluoro group Chemical group F* 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 150000002527 isonitriles Chemical class 0.000 claims description 2
- AZVCGYPLLBEUNV-UHFFFAOYSA-N lithium;ethanolate Chemical compound [Li+].CC[O-] AZVCGYPLLBEUNV-UHFFFAOYSA-N 0.000 claims description 2
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 2
- 150000002825 nitriles Chemical class 0.000 claims description 2
- RPDAUEIUDPHABB-UHFFFAOYSA-N potassium ethoxide Chemical compound [K+].CC[O-] RPDAUEIUDPHABB-UHFFFAOYSA-N 0.000 claims description 2
- 125000000075 primary alcohol group Chemical group 0.000 claims description 2
- 150000003141 primary amines Chemical class 0.000 claims description 2
- 150000003333 secondary alcohols Chemical class 0.000 claims description 2
- 125000004469 siloxy group Chemical group [SiH3]O* 0.000 claims description 2
- 125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 claims description 2
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 claims description 2
- LFQULJPVXNYWAG-UHFFFAOYSA-N sodium;phenylmethanolate Chemical compound [Na]OCC1=CC=CC=C1 LFQULJPVXNYWAG-UHFFFAOYSA-N 0.000 claims description 2
- 239000011877 solvent mixture Substances 0.000 claims description 2
- 150000003462 sulfoxides Chemical class 0.000 claims description 2
- 150000007944 thiolates Chemical class 0.000 claims description 2
- 150000003573 thiols Chemical class 0.000 claims description 2
- 125000001425 triazolyl group Chemical group 0.000 claims 2
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 66
- 235000019445 benzyl alcohol Nutrition 0.000 description 23
- 239000000047 product Substances 0.000 description 12
- BMVXCPBXGZKUPN-UHFFFAOYSA-N 1-hexanamine Chemical compound CCCCCCN BMVXCPBXGZKUPN-UHFFFAOYSA-N 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 238000005859 coupling reaction Methods 0.000 description 7
- 239000003792 electrolyte Substances 0.000 description 7
- 230000008569 process Effects 0.000 description 7
- 238000012552 review Methods 0.000 description 6
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 description 5
- 150000001299 aldehydes Chemical class 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 229910052707 ruthenium Inorganic materials 0.000 description 5
- 229910052723 transition metal Inorganic materials 0.000 description 5
- 150000003624 transition metals Chemical class 0.000 description 5
- 239000006227 byproduct Substances 0.000 description 4
- 230000008878 coupling Effects 0.000 description 4
- 238000010168 coupling process Methods 0.000 description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 230000003197 catalytic effect Effects 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 230000005518 electrochemistry Effects 0.000 description 3
- 239000004744 fabric Substances 0.000 description 3
- 230000037361 pathway Effects 0.000 description 3
- 150000003852 triazoles Chemical class 0.000 description 3
- GQWWGRUJOCIUKI-UHFFFAOYSA-N 2-[3-(2-methyl-1-oxopyrrolo[1,2-a]pyrazin-3-yl)propyl]guanidine Chemical compound O=C1N(C)C(CCCN=C(N)N)=CN2C=CC=C21 GQWWGRUJOCIUKI-UHFFFAOYSA-N 0.000 description 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 2
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 229960004217 benzyl alcohol Drugs 0.000 description 2
- WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 description 2
- 229910017052 cobalt Inorganic materials 0.000 description 2
- 239000010941 cobalt Substances 0.000 description 2
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 2
- 150000004985 diamines Chemical class 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 229910052748 manganese Inorganic materials 0.000 description 2
- 239000011572 manganese Substances 0.000 description 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000001590 oxidative effect Effects 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 150000003138 primary alcohols Chemical class 0.000 description 2
- 239000010948 rhodium Substances 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 2
- 230000007306 turnover Effects 0.000 description 2
- LAXRNWSASWOFOT-UHFFFAOYSA-J (cymene)ruthenium dichloride dimer Chemical compound [Cl-].[Cl-].[Cl-].[Cl-].[Ru+2].[Ru+2].CC(C)C1=CC=C(C)C=C1.CC(C)C1=CC=C(C)C=C1 LAXRNWSASWOFOT-UHFFFAOYSA-J 0.000 description 1
- GETTZEONDQJALK-UHFFFAOYSA-N (trifluoromethyl)benzene Chemical compound FC(F)(F)C1=CC=CC=C1 GETTZEONDQJALK-UHFFFAOYSA-N 0.000 description 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 239000002028 Biomass Substances 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 101100030361 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) pph-3 gene Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000012327 Ruthenium complex Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000003905 agrochemical Substances 0.000 description 1
- 150000004705 aldimines Chemical class 0.000 description 1
- 150000001414 amino alcohols Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- YLFIGGHWWPSIEG-UHFFFAOYSA-N aminoxyl Chemical compound [O]N YLFIGGHWWPSIEG-UHFFFAOYSA-N 0.000 description 1
- 239000012300 argon atmosphere Substances 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 150000003938 benzyl alcohols Chemical class 0.000 description 1
- 125000001743 benzylic group Chemical group 0.000 description 1
- PNPBGYBHLCEVMK-UHFFFAOYSA-N benzylidene(dichloro)ruthenium;tricyclohexylphosphanium Chemical compound Cl[Ru](Cl)=CC1=CC=CC=C1.C1CCCCC1[PH+](C1CCCCC1)C1CCCCC1.C1CCCCC1[PH+](C1CCCCC1)C1CCCCC1 PNPBGYBHLCEVMK-UHFFFAOYSA-N 0.000 description 1
- 125000001246 bromo group Chemical group Br* 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- LBFUKZWYPLNNJC-UHFFFAOYSA-N cobalt(ii,iii) oxide Chemical compound [Co]=O.O=[Co]O[Co]=O LBFUKZWYPLNNJC-UHFFFAOYSA-N 0.000 description 1
- 150000004696 coordination complex Chemical class 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- DHCWLIOIJZJFJE-UHFFFAOYSA-L dichlororuthenium Chemical compound Cl[Ru]Cl DHCWLIOIJZJFJE-UHFFFAOYSA-L 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000010411 electrocatalyst Substances 0.000 description 1
- 238000005868 electrolysis reaction Methods 0.000 description 1
- 238000004146 energy storage Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000446 fuel Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000010439 graphite Substances 0.000 description 1
- 229910002804 graphite Inorganic materials 0.000 description 1
- 125000001183 hydrocarbyl group Chemical group 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 229910052741 iridium Inorganic materials 0.000 description 1
- GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 description 1
- 150000004658 ketimines Chemical class 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 239000012035 limiting reagent Substances 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 229910052987 metal hydride Inorganic materials 0.000 description 1
- 150000004681 metal hydrides Chemical class 0.000 description 1
- DWDWQJHDVOKTDZ-UHFFFAOYSA-N nickel dihydride Chemical class [NiH2] DWDWQJHDVOKTDZ-UHFFFAOYSA-N 0.000 description 1
- 229910000652 nickel hydride Inorganic materials 0.000 description 1
- 150000002828 nitro derivatives Chemical class 0.000 description 1
- 239000012038 nucleophile Substances 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 229910052762 osmium Inorganic materials 0.000 description 1
- SYQBFIAQOQZEGI-UHFFFAOYSA-N osmium atom Chemical compound [Os] SYQBFIAQOQZEGI-UHFFFAOYSA-N 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 1
- 150000003217 pyrazoles Chemical class 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 239000002265 redox agent Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 229910052703 rhodium Inorganic materials 0.000 description 1
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000003115 supporting electrolyte Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000009901 transfer hydrogenation reaction Methods 0.000 description 1
- 150000000202 triazepanes Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
- C25B3/00—Electrolytic production of organic compounds
- C25B3/01—Products
- C25B3/09—Nitrogen containing compounds
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
- C25B1/00—Electrolytic production of inorganic compounds or non-metals
- C25B1/01—Products
- C25B1/02—Hydrogen or oxygen
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
- C25B1/00—Electrolytic production of inorganic compounds or non-metals
- C25B1/01—Products
- C25B1/23—Carbon monoxide or syngas
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
- C25B1/00—Electrolytic production of inorganic compounds or non-metals
- C25B1/50—Processes
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
- C25B3/00—Electrolytic production of organic compounds
- C25B3/20—Processes
- C25B3/23—Oxidation
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
- C25B3/00—Electrolytic production of organic compounds
- C25B3/20—Processes
- C25B3/29—Coupling reactions
Definitions
- the invention generally relates to a process of electrocatalytic generation of imines from alcohols and amines using Acceptor-less Alcohol Dehydrogenation (AAD) catalysts.
- AAD Acceptor-less Alcohol Dehydrogenation
- AAD Acceptor-less Alcohol Dehydrogenation
- alcohols are dehydrogenated in the presence of a transition metal complex to yield carbonyls compounds, such as aldehydes or ketones, together with molecular hydrogen.
- carbonyls compounds such as aldehydes or ketones
- hydrogen gas is formed, making those systems extremely interesting in terms of atom efficiency and green synthesis.
- AAD catalysts have been used extensively for the oxidation of alcohols to e.g. esters, amides, acids, thiosesters, under thermal conditions (high temperatures).
- AAD catalysts Various pincer complexes have been reported as AAD catalysts, the transition metal used being e.g. manganese, ruthenium, rhodium, osmium, platinum, cobalt, iridium.
- Various complexes are commercially available for the acceptorless alcohol oxidation, such as RuCI 3 ⁇ nH 2 O/phosphine/NaOH system and [RuCl 2 (p-Cymene)] 2 /diamine ligand, Grubb's catalyst in presence of KOH, base free Shvo di nuclear ruthenium complex, and Milstein complex and various Milstein pincer-ligands.
- a recent review of manganese-based pincer complexes as AAD is presented by Chandra et al. (Recent advancement in oxidation or acceptorless dehydrogenation of alcohols to valorized products using manganese based catalysts, Coordination chemistry reviews, 411, 2020, 10.1016/j.ccr.2020.213241 ) .
- a recent review of pincer transition metal catalysts used for AAD is presented by Piccirilli et al. (Catalysts, 10, 773, 2020, 10.3390/catal10070773 ) .
- a recent review of homogeneously catalyzed acceptorless dehydrogenation of alcohols is presented by Trincado et al. (Coordination Chemistry Reviews 443, 2021, 10.1016/j.ccr.2021.213967 ) .
- Imines are versatile functional groups used in pharmaceuticals or agrochemicals, imines being important intermediates in the formation of other organic compounds, e.g. products of reaction of azomethine includes derivatives of pyrazoles, triazoles, triazepanes.
- Pincer complexes have been tested as catalysts for the dehydrogenation of alcohol and the production of imines. Examples can be found e.g. in Zhang et al. (Cobalt-catalyzed acceptorless alcohol dehydrogenation: synthesis of imines from alcohols and amines, Org. Lett. 15, 2013, 10.1021/0l303479f ), Midya et al. (Direct access to N-alkylated amines and imines via acceptorless dehydrogenative coupling catalyzed by a cobalt (ii)-NNN pincer complex, Catal. Sci. Technol. 8, 2018, 10.1039/C8CY00859K ) , Bottaro et al. (In situ generated cobalt catalyst for the dehydrogenative coupling of alcohols and amines into imines, ChemCatChem, 11, 2019, 10.1002/cctc.201900392 ) .
- Higuchi et al. disclose the selective synthesis of imines using RuCl 2 (dpea) 2 , in the presence of catalytic amounts of Zn(OCOCF 3 ) 2 and KO t Bu, alcohol being preferably methoxy or methyl substituted benzyl alcohols.
- Sindhuja et al. (Direct synthesis of imines from primary alcohols and amines using an active ruthenium pincer complex, Tetrahedron Letters 55, 2014 ) disclose the use of a ruthenium pincer metal complex, containing bis(benzimidazole)pyridine ligand, for the coupling reaction between benzylalcohol and benzylamine, the temperature being between 30°C and 189°C.
- electrochemistry allows to control the energy input directly via the applied potentials and makes the coupling of chemical reactions to renewable energy resources feasible.
- electrochemistry can thus help to overcome the limitations of thermal chemistry outlined above.
- WO2022136475 disclose the use of acceptor-less dehydrogenation catalyst for an electrocatalytic oxidation of an alcohol to an ester or/and an acid.
- the invention provides AAD catalysts that can be used under electrochemical conditions to conduct the selective oxidation of alcohols in the presence of amines to the corresponding imines.
- the invention provides use of an acceptor-less alcohol dehydrogenation (AAD) catalyst for an electrocatalytic oxidation of an alcohol with an amine, to an imine, by electrocatalytic synthesis, the acceptor-less dehydrogenation catalyst used under electrochemical conditions being represented by the structure of any one of the formulae F1 or F2:
- AAD acceptor-less alcohol dehydrogenation
- Phosphine PR2 are for example monodentate phosphine of the type PR 2 , R being Ph, Me, Et, i -Pr, t -Bu, Cy.
- Phosphine PR3 are for example tertiary phosphine PR 3 , where R is alkyl, aryl, alkoxyl.
- the electrocatalytic oxidation is carried out in a homogeneous phase.
- the alcohol oxidation is carried out under neat conditions without added solvent.
- the alcohol oxidation is carried out in the presence of a solvent or binary solvent mixtures.
- the alcohol oxidation is carried out in heterogeneous phase, the acceptor-less dehydrogenation catalyst being immobilized on a conductive support.
- Advantageously water is used as solvent and the pH is between 7 and 14.
- the alcohol oxidation is carried out under potential control, with an applied potential in the range of -0.5-0.5 V vs Ag/AgCl.
- the alcohol oxidation is carried out under current control, with an applied current between 0.2 and 50 mA.
- the alcohol oxidation is carried out in a divided electrochemical cell with ratio working electrode surface/cell volume between 0.5 and 10 cm -1 .
- the alcohol oxidation is carried at a temperature below 60°C. In some embodiments the alcohol oxidation is carried at room temperature without heating.
- the organometallic catalyst is in contact with a working solution comprising the alcohol, the amine and a base chosen in the group comprising: LiOH, NaOH, KOH, CsOH, tetramethylammonium hydroxide, tetrabutylammonium hydroxide, trimethylbenzylammonium hydroxide, Cs 2 CO 3 , Li 2 CO 3 , NaOPiv, KOPiv, LiOPiv, CsOPiv, tetrabutylammonium dihydrogen phosphate, Na t Bu, K t Bu, Li t Bu, Cs t Bu, NaOEt, KOEt, LiOEt, CsOEt, NaOBn, KOBn, LiOBn, CsOBn, or a tertiary amine NR 3 , with R being a substituent selected from the group of: i -Pr, t-Bu, Cyclohexyl, Bn, Ph, Me, Et, Pr, Bu,
- the alcohol is a primary or secondary alcohol of the form HOR' and the amine is a primary amine of the form H 2 NR', with R' being an alkyl or benzyl group bearing substituents from the group of H, Me, Et, Pr, i -Pr, Bu, n-Bu, cyclopropyl, vinyl, allyl, fluoro, chloro, bromo, iodo, nitro, phenyl, alkoxo , borane , a borate , silyl , siloxyl , vinyl, allyl, furanyl, thiophenyl, a thiolate , an ester , a ketone, a sulfoxide.
- R' being an alkyl or benzyl group bearing substituents from the group of H, Me, Et, Pr, i -Pr, Bu, n-Bu, cyclopropyl, vinyl, allyl, fluoro, chloro,
- the amine presents a center of chirality which is maintained in the imine product.
- the organometallic catalyst is chosen among the following structures
- an anodic half-cell reaction is coupled with a cathodic half-cell reaction, the cathodic half-cell reaction being an electrochemical reduction of CO 2 to CO, H 2 production or O 2 reduction and the reaction being carried out in a flow-cell.
- the alcohol is oxidized with at least 50-100 FE% (Faradaic efficiency), 50-100% amine conversion and 50-100% selectivity (from amine) to an imine, in the presence of 0.1-2 M base, 0.1-3 M alcohol, 0.05-1.5 M amine 0.01-10 mM catalysts, at a potential between -0.5-0.5 V vs Ag/AgCl, using a carbon-based working electrode, in a divided cell with cell dimensions (working electrode surface-to-cell volume) comprised between 0.1 - 10 cm -1 , the temperature being below 60°C, for instance under argon atmosphere.
- the alcohol is oxidized with at least 50-100 FE% (Faradaic efficiency), 50-100% amine conversion and 50-100% selectivity (from amine) to an imine in the presence of 0.1-2 M Base, at an alcohol to amine ratio between 20:1-200:1, an amine to catalyst ratio of 20:1-200:1 and an alcohol to catalyst ratio of 50:1-5000:1, at a potential between -0.5-0.5 V vs Ag/AgCl, using a carbon-based working electrode, in a divided cell with working electrode surface-to-cell volume comprised between 0.1-10 cm -1 , at a temperature below 60°C.
- the amine can be an aliphatic amine, or a benzylic amine.
- the reaction scheme and conditions for the selective electrocatalytic synthesis of imines from alcohol and amines, together with possible other side-products is presented below:
- Possible side-products are an aldehyde, ester, secondary amine.
- the synthesis is conducted at room temperature (25°C), and ambient pressure.
- the synthesis is conducted without the use of solvent.
- the working electrode (WE) is a carbon cloth and the counter electrode (CE) is Pt-mesh, the cell being a divided cell.
- the use of carbon cloth ensures the effective penetration of electrolyte into the electrode surface.
- the reference electrode is an Ag/AgCl electrode, and the working electrode is maintained at a constant trajectory of 0.3V (controlled potential electrolysis CPE).
- amine nucleophiles can be used for the generation of the corresponding imines, including aliphatic, benzylic and aromatics.
- a variety of functional groups can be tolerated such as, bromo, trifluromethyl, nitro, methyl, thiophenyl, furanyl and methoxy substituents.
- These parameters include the concentration of the alcohol, the nature of co-solvents, the alcohol to amine ratio, the nature and concentration of the supporting electrolyte/base, water content, working potential, as well as cell/electrode dimensions.
- reaction conditions such as concentration ranges, electrolyte composition, electrochemical cell dimensions, applied potential, it is possible to selectively carry out the two-electron oxidation of alcohols in the presence of amines to the imine product with negligible amount of 4-electron overoxidation products and complete conversion of the limiting amine reagent.
- the invention combines the advantages of homogeneous electrocatalysis with the selectivities and products so-far only observed under thermal conditions, opening the way towards more sustainable synthetic procedures.
- thermal AAD catalysts in an electrochemical set-up that produces imines is an important step beyond the current state-of-the-art in homogeneous electrocatalysis.
- the technology can be used to generate amount of imine on a reasonable time scale (roughly 6 h) at room temperature.
- An alcohol (preferentially under neat conditions) can be oxidized in the presence of an amine as the limiting agent to the corresponding imine with the help of an Acceptor-less Alcohol Dehydrogenation catalysts and an applied potential.
- Some of the AAD are commercially available.
- the invention allows to form the corresponding imine with excellent conversions (generally above >95%), selectivities (around 80%) and faradaic efficiency (up to 100%) at catalyst loading of 1 mM, low working potential of 0.3 V vs Ag/AgCl and at room temperature (25°C).
- ruthenium pincer complexes A large range of ruthenium pincer complexes can be employed successfully. Under the employed conditions, catalytic turnover is generally in the order of 30-50 TONs.
- the process allows to retain chiral centers, making it possibly attractive for pathways towards chiral (pharmaceutical) molecular targets.
- electrochemical approach benefits from the advantages of electrochemistry, such as safety, scalability, cheapest redox agent (electron), possibility to couple to other redox processes, direct usage of renewable energy for chemical synthesis and importantly direct control of the energy input.
- electrochemistry such as safety, scalability, cheapest redox agent (electron), possibility to couple to other redox processes, direct usage of renewable energy for chemical synthesis and importantly direct control of the energy input.
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Abstract
A use of an acceptor-less alcohol dehydrogenation catalyst for an electrocatalytic oxidation of an alcohol with an amine, to an imine by electrocatalytic synthesis under electrochemical conditions.
Description
- The invention generally relates to a process of electrocatalytic generation of imines from alcohols and amines using Acceptor-less Alcohol Dehydrogenation (AAD) catalysts.
- Acceptor-less Alcohol Dehydrogenation (AAD) catalysts have become a powerful tool for green synthetic approaches and energy storage over recent years.
- Acceptorless alcohol dehydrogenation catalyzed by transition metal complexes was first reported in 1987 by Murahashi et al. (Ruthenium-catalyzed oxidative transformation of alcohols and aldehydes to esters and lactones, J.Org. Chem. 52, 10.1021/jo00228a032).
- In the acceptorless alcohols dehydrogenation reaction, alcohols are dehydrogenated in the presence of a transition metal complex to yield carbonyls compounds, such as aldehydes or ketones, together with molecular hydrogen. As the only byproduct, hydrogen gas is formed, making those systems extremely interesting in terms of atom efficiency and green synthesis.
- In particular, AAD catalysts have been used extensively for the oxidation of alcohols to e.g. esters, amides, acids, thiosesters, under thermal conditions (high temperatures).
- Various pincer complexes have been reported as AAD catalysts, the transition metal used being e.g. manganese, ruthenium, rhodium, osmium, platinum, cobalt, iridium. Various complexes are commercially available for the acceptorless alcohol oxidation, such as RuCI3·nH2O/phosphine/NaOH system and [RuCl2(p-Cymene)]2/diamine ligand, Grubb's catalyst in presence of KOH, base free Shvo di nuclear ruthenium complex, and Milstein complex and various Milstein pincer-ligands.
- A recent review of manganese-based pincer complexes as AAD is presented by Chandra et al. (Recent advancement in oxidation or acceptorless dehydrogenation of alcohols to valorized products using manganese based catalysts, Coordination chemistry reviews, 411, 2020, 10.1016/j.ccr.2020.213241). A recent review of pincer transition metal catalysts used for AAD is presented by Piccirilli et al. (Catalysts, 10, 773, 2020, 10.3390/catal10070773). A recent review of homogeneously catalyzed acceptorless dehydrogenation of alcohols is presented by Trincado et al. (Coordination Chemistry Reviews 443, 2021, 10.1016/j.ccr.2021.213967).
- Imines are compounds containing the N=C double bond. In other words, imines are related to ketones and aldehydes by replacement of the oxygen with an NR group. When R is H, the compound is a primary imine. When R is hydrocarbyl, the compound is a secondary imine. Various subclass of imines are known, e.g. aldimines having the structure RCH-NH or RCH-NR', ketimines have the structure R'2C=NR (where R' is not H). Imines are versatile functional groups used in pharmaceuticals or agrochemicals, imines being important intermediates in the formation of other organic compounds, e.g. products of reaction of azomethine includes derivatives of pyrazoles, triazoles, triazepanes.
- Classical synthetic pathways to imines generally employ stoichiometric amounts of oxidants and/or high temperature. Recently, there has been growing interest in catalytic processes utilizing biomass-derived alcohols for sustainable production of imines.
- Pincer complexes have been tested as catalysts for the dehydrogenation of alcohol and the production of imines. Examples can be found e.g. in Zhang et al. (Cobalt-catalyzed acceptorless alcohol dehydrogenation: synthesis of imines from alcohols and amines, Org. Lett. 15, 2013, 10.1021/0l303479f), Midya et al. (Direct access to N-alkylated amines and imines via acceptorless dehydrogenative coupling catalyzed by a cobalt (ii)-NNN pincer complex, Catal. Sci. Technol. 8, 2018, 10.1039/C8CY00859K), Bottaro et al. (In situ generated cobalt catalyst for the dehydrogenative coupling of alcohols and amines into imines, ChemCatChem, 11, 2019, 10.1002/cctc.201900392).
- Higuchi et al. (Tunable ligand effects on ruthenium catalyst activity for selectively preparing imines or amides by dehydrogenative coupling reactions of alcohols and amines, Chem. Eur. J. 2017, 10.1002/chem.201701342) disclose the selective synthesis of imines using RuCl2(dpea)2, in the presence of catalytic amounts of Zn(OCOCF3)2 and KOtBu, alcohol being preferably methoxy or methyl substituted benzyl alcohols.
- Sindhuja et al. (Direct synthesis of imines from primary alcohols and amines using an active ruthenium pincer complex, Tetrahedron Letters 55, 2014 ) disclose the use of a ruthenium pincer metal complex, containing bis(benzimidazole)pyridine ligand, for the coupling reaction between benzylalcohol and benzylamine, the temperature being between 30°C and 189°C.
- AAD systems of the prior art have some limitations.
- These systems often work under refluxing conditions to eliminate evolving H2 gas, thus relying on elevated temperatures.
- When it comes to specific molecular motifs, in particular imines, additional problems arise from difficulties in selectively oxidizing primary alcohols to the two-electron imine product, without over-oxidation to possible four electron products.
- In principal, electrochemistry allows to control the energy input directly via the applied potentials and makes the coupling of chemical reactions to renewable energy resources feasible. In combination with catalysts that allow to follow reaction pathways with minimal thermal dissipation, electrochemistry can thus help to overcome the limitations of thermal chemistry outlined above.
- Over recent years, electrochemical processes for the homogeneous electrocatalytic oxidation of alcohols have emerged, using a variety of well-defined catalysts or electro-transfer mediators.
- In 2010, Grützmacher et al. have described a fuel cell operating in a strongly basic media (2M KOH) for the oxidation of ethanol to acetate (CH3COO-), using as the anode catalyst a molecular [Rh(OTf)(trop2NH)(PPh3)] complex, deposited on a conductive carbon support (Angewandte Chemie International Edition 2010, 49 (40), 7229-7233, 10.1002/anie.201002234 ).
- In a 2020 review paper, Cook et al. have presented the current state-of-the-art for molecular electrocatalysis capable of alcohol oxidation, illustrated by three case studies; namely a copper/nitroxyl radical cooperative catalyst system, noble metal-hydrides with proximal amine group for transfer hydrogenation, nickel hydrides with P2N2 ligands ( Molecular Electrocatalysts for Alcohol Oxidation: Insights and Challenges for Catalyst Design, ACS Appl. Energy Mater. 2020, 3 (1), 38-46, 10.1021/acsaem.9b01820).
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WO2022136475 disclose the use of acceptor-less dehydrogenation catalyst for an electrocatalytic oxidation of an alcohol to an ester or/and an acid. - Although prior art systems demonstrate that electrocatalytic oxidation is possible, they often operate at high potentials (many Tempo-based mediators, Ru=O species), with low turnover number TON for most transition metal-based systems, and limited access to functionalized products involving C-N bonds.
- No reports on such systems for the synthesis of imines (or other C-N functionalized alcohol oxidation products) exist to the best of the knowledge of the inventors.
- In contrast, classical methodologies to access imines from alcohols and amines due to their thermal nature, do not offer the advantages of electrochemical approaches.
- The invention provides AAD catalysts that can be used under electrochemical conditions to conduct the selective oxidation of alcohols in the presence of amines to the corresponding imines.
- Various embodiments are directed to address the effects of one or more of the problems set forth above. The following presents a simplified summary of embodiments in order to provide a basic understanding of some aspects of the various embodiments. This summary is not an exhaustive overview of these various embodiments. It is not intended to identify key/critical elements or to delineate the scope of these various embodiments. Its sole purpose is to present some concepts in a simplified form as a prelude to the more detailed description that is discussed later. The invention provides use of an acceptor-less alcohol dehydrogenation (AAD) catalyst for an electrocatalytic oxidation of an alcohol with an amine, to an imine, by electrocatalytic synthesis,
the acceptor-less dehydrogenation catalyst used under electrochemical conditions being represented by the structure of any one of the formulae F1 or F2: - L and L* being tridentate aliphatic or aromatic pincer ligands, with L* being the deprotonated or dearomatized anionic form of the pincer ligand L,
- D being a donor group chosen from: a phosphine PR2, tertiary amine NR2, secondary amine NHR, thiol SR, or an N-heterocyclic carbene derived from imidazole, imidazoline, thiazole or triazole units,
- R being a substituent selected from the group of: i-Pr, t-Bu, Cyclohexyl, Bn, Ph, Me, Et, Pr, Bu, H,
- X being an anionic ligand, selected from the group of: H-, BH4 -, OH-, Cl-, Br-, F-, PF6 -, NH2 -, NHR-, NR2 -, OR-, with R as defined above,
- L' being a mono-dentate strong field ligand selected from the group of: CO, a phosphine PR3, NO, a nitrile RCN, an isonitrile RNC or an N-heterocyclic carbene, derived from imidazole, imidazoline, thiazole or triazole units, with R as defined above,
- L" and L"* being bidentate ligands with 1 to 4 CH2 units and with R and D as defined above and L"* being the deprotonated anionic form of the ligand L".
- Phosphine PR2 are for example monodentate phosphine of the type PR2, R being Ph, Me, Et, i-Pr, t-Bu, Cy.
- Phosphine PR3 are for example tertiary phosphine PR3, where R is alkyl, aryl, alkoxyl.
- Advantageously, the electrocatalytic oxidation is carried out in a homogeneous phase.
- Advantageously, the alcohol oxidation is carried out under neat conditions without added solvent.
- In some embodiments, the alcohol oxidation is carried out in the presence of a solvent or binary solvent mixtures.
- In other embodiments, the alcohol oxidation is carried out in heterogeneous phase, the acceptor-less dehydrogenation catalyst being immobilized on a conductive support.
- Advantageously water is used as solvent and the pH is between 7 and 14.
- Advantageously, the alcohol oxidation is carried out under potential control, with an applied potential in the range of -0.5-0.5 V vs Ag/AgCl. Advantageously, the alcohol oxidation is carried out under current control, with an applied current between 0.2 and 50 mA.
- In some embodiments, the alcohol oxidation is carried out in a divided electrochemical cell with ratio working electrode surface/cell volume between 0.5 and 10 cm-1.
- Advantageously, the alcohol oxidation is carried at a temperature below 60°C. In some embodiments the alcohol oxidation is carried at room temperature without heating.
- In some embodiments, the organometallic catalyst is in contact with a working solution comprising the alcohol, the amine and a base chosen in the group comprising: LiOH, NaOH, KOH, CsOH, tetramethylammonium hydroxide, tetrabutylammonium hydroxide, trimethylbenzylammonium hydroxide, Cs2CO3, Li2CO3, NaOPiv, KOPiv, LiOPiv, CsOPiv, tetrabutylammonium dihydrogen phosphate, NatBu, KtBu, LitBu, CstBu, NaOEt, KOEt, LiOEt, CsOEt, NaOBn, KOBn, LiOBn, CsOBn, or a tertiary amine NR3 , with R being a substituent selected from the group of: i-Pr, t-Bu, Cyclohexyl, Bn, Ph, Me, Et, Pr, Bu, H.
- In some embodiments, the alcohol is a primary or secondary alcohol of the form HOR' and the amine is a primary amine of the form H2NR', with R' being an alkyl or benzyl group bearing substituents from the group of H, Me, Et, Pr, i-Pr, Bu, n-Bu, cyclopropyl, vinyl, allyl, fluoro, chloro, bromo, iodo, nitro, phenyl, alkoxo , borane , a borate , silyl , siloxyl , vinyl, allyl, furanyl, thiophenyl, a thiolate , an ester , a ketone, a sulfoxide.
- Advantageously, the amine presents a center of chirality which is maintained in the imine product.
-
- In some embodiments, an anodic half-cell reaction is coupled with a cathodic half-cell reaction, the cathodic half-cell reaction being an electrochemical reduction of CO2 to CO, H2 production or O2 reduction and the reaction being carried out in a flow-cell.
- In some embodiments, the alcohol is oxidized with at least 50-100 FE% (Faradaic efficiency), 50-100% amine conversion and 50-100% selectivity (from amine) to an imine, in the presence of 0.1-2 M base, 0.1-3 M alcohol, 0.05-1.5 M amine 0.01-10 mM catalysts, at a potential between -0.5-0.5 V vs Ag/AgCl, using a carbon-based working electrode, in a divided cell with cell dimensions (working electrode surface-to-cell volume) comprised between 0.1 - 10 cm-1, the temperature being below 60°C, for instance under argon atmosphere.
- In some embodiments, the alcohol is oxidized with at least 50-100 FE% (Faradaic efficiency), 50-100% amine conversion and 50-100% selectivity (from amine) to an imine in the presence of 0.1-2 M Base, at an alcohol to amine ratio between 20:1-200:1, an amine to catalyst ratio of 20:1-200:1 and an alcohol to catalyst ratio of 50:1-5000:1, at a potential between -0.5-0.5 V vs Ag/AgCl, using a carbon-based working electrode, in a divided cell with working electrode surface-to-cell volume comprised between 0.1-10 cm-1, at a temperature below 60°C.
- Detailed description
- Examples presented below concerns the synthesis of imines from amines and alcohols. The amine can be an aliphatic amine, or a benzylic amine. The reaction scheme and conditions for the selective electrocatalytic synthesis of imines from alcohol and amines, together with possible other side-products is presented below:
- Possible side-products are an aldehyde, ester, secondary amine. Advantageously, the synthesis is conducted at room temperature (25°C), and ambient pressure.
- Advantageously, the synthesis is conducted without the use of solvent. In the presented scheme, the working electrode (WE) is a carbon cloth and the counter electrode (CE) is Pt-mesh, the cell being a divided cell. The use of carbon cloth ensures the effective penetration of electrolyte into the electrode surface.
- The reference electrode is an Ag/AgCl electrode, and the working electrode is maintained at a constant potentiel of 0.3V (controlled potential electrolysis CPE).
- The process is demonstrated in a home-made 8 mL working compartment H-Cell, using a simple carbon cloth as the working electrode (3x 1*1*0.5 cm carbon felt connected to 2.0*0.6 cm graphite rod) under controlled potential (CPE, vs. Ag/AgCl) with shut-off after 2F electrons corresponding to reaction times generally between 4-6 hours.
-
- Elevated conversion of amine and high imine selectivity is obtained using the above-mentioned catalysts Ru1-Ru10 or Mn-1 for the reaction presented in the above scheme. Results are given below, in standard condition: neat 0.2M LiOH/BnOH (6mL), 50 µL hexylamine, 1.3 mM catalyst, CPE 0.3 V vs Ag/AgCl, 25°C, 2F mol amine.
- For Ru-1, Ru-2, Ru5, Ru-10 and Mn-1, imine selectivity is higher than 99%. For Ru-3, Ru6, Ru7 and Ru8, imine selectivity is 99%. The reaction scheme and conditions for the electrocatalytic synthesis of imines from alcohol and amines enable the production of imines nearly without any other side-products such as aldehyde, ester or secondary amine.
Entry Catalyst Conversion Selectivity (%) F.E. (%) Amine (%) BnOH (mmol) Imine 1 Ru-1 >99 0.40 >99 102 2 Ru-2 >99 0.34 >99 85 3 Ru-3 >99 0.33 99 85 4 Ru-4 62 0.22 65 55 5 Ru-5 90 0.26 >99 66 6 Ru-6 93 0.25 99 65 7 Ru-7 97 0.27 99 69 8 Ru-8 91 0.27 99 70 9 Ru-9 72 0.25 65 63 10 Ru-10 93 0.36 >99 66 11 Mn-1 >99 0.38 >99 98 - In standard condition (neat 0.2M LiOH/BnOH (6mL), 0.38 mmol amine, 1.3 mM catalyst, CPE 0.3 V vs Ag/AgCl, 25°C, 2F mol per amine), elevated conversion of various amines and high imine selectivity is obtained using the above-mentioned catalysts Ru1-Ru10 or Mn-1 for the reaction presented in the above scheme. Results are presented below for various amines (aliphatic or aromatic).
Entry Amine Conversion Selectivity (%) F.E. (%) Amine (%) BnOH (mmol) Imine 1 >99 0.40 >99 102 2 >99 0.41 >99 105 3 85 0.43 76 99 4 22 0.14 77 35 5 >99 0.42 >99 107 6 >99 0.38 >99 98 7 >99 0.44 99 110 8 75 0.31 >99 80 9 >99 0.46 >99 110 10 98 0.41 >99 103 12 99 0.34 >99 88 12 88 0.39 99 101 13 >99 0.43 >99 110 14 >99 0.41 >99 106 15 >99 0.43 >99 108 16 84 0.34 >99 88 17 69 0.29 >99 (diamine) 75 - Results of different alcohol derivatives screened in the study in standard condition (3 M alcohol, 0.2 M LiOH/(THF/H2O - 7:1 v/v) (6 mL), 0.38 mmol n-hexylamine, 1.3 mM catalyst, CPE 0.3 V vs Ag/AgCl, 25oC, 2F mol amine) are presented below:
Entry Alcohol Conversion Selectivity (%) F.E. (%) Amine (%) BnOH (mmol) Imine 1∗ >99 0.40 >99 102 2 52 0.18 93 47 3 86 0.31 95 79 4 60 0.22 72 68 5 90 0.36 98 94 6 90 0.34 73 104 7 42 0.16 91 42 8 53 0.22 90 56 9 82 0.28 91 75 10 52 0.21 >99 53 11 26 0.06 80 17 12 72 0.39 >99 100 - A variety of amine nucleophiles can be used for the generation of the corresponding imines, including aliphatic, benzylic and aromatics.
- A variety of functional groups can be tolerated such as, bromo, trifluromethyl, nitro, methyl, thiophenyl, furanyl and methoxy substituents.
- A number of different parameters were optimized in order to obtain the desirable results.
- These parameters include the concentration of the alcohol, the nature of co-solvents, the alcohol to amine ratio, the nature and concentration of the supporting electrolyte/base, water content, working potential, as well as cell/electrode dimensions.
- Some results are presented below.
- By finely tuning the reaction conditions, such as concentration ranges, electrolyte composition, electrochemical cell dimensions, applied potential, it is possible to selectively carry out the two-electron oxidation of alcohols in the presence of amines to the imine product with negligible amount of 4-electron overoxidation products and complete conversion of the limiting amine reagent.
- Results of different electrolyte (base) screened in the study in standard condition (neat 0.1M BnOH (6 mL), 100 µL hexylamine (130 mM), 1.3 mM Ru-1, CPE 0.3 V vs Ag/AgCl, 25°C, 6 hours) are presented below:
Entry Electrolyte (0.1 M) Conversion Selectivity (%) F.E. (%) Amine (%) BnOH (mmol) Imine 1 LiOH 43 0.31 96 90 2 NaOH 41 0.31 95 98 3 KOH 28 0.20 96 102 4 CsOH 34 0.26 95 108 5 Cs2CO3 13 0.11 90 135 6 Li2CO3 4 0.04 78 373 7 (CH3)3CCOOK 0 0 0 0 8 (C4H9)4NH2PO4 15 0.14 86 158 9 (CH3)4NOH ∗10% of water presence 49 0.34 95 62 - Results of different electrolyte (base) concentration screened in the study in standard condition (neat 0.1M BnOH (6 mL), 100 µL hexylamine (130 mM), 1.3 mM Ru-1, CPE 0.3 V vs Ag/AgCl, 25°C, 6 hours) are presented below:
Entry [LiOH] (M) Conversion Selectivity (%) F.E. (%) Amine (%) BnOH (mmol) Imine 1 0.1 43 0.31 96 90 2 0.2 62 0.49 92 77 3 0.5 32 0.24 97 99 4 1.0 29 0.21 98 101 - Results of different benzyl alcohol (BnOH) concentration screened in the study in standard condition (0.1M LiOH 1:7 v/v H2O/THF*, 100 µL hexylamine (130 mM), 1.3 mM Ru-1, CPE 0.3 V vs Ag/AgCl, 25°C, 6 hours) are presented below.
*(the amount of BnOH was replaced by for retaining the total amount of working solution at 6 mL)Entry [BnOH] (M) Conversion Selectivity (%) F.E. (%) Amine (%) BnOH (mmol) Imine 1 Neat 43 0.31 96 90 2 3.0 32 0.20 88 70 3 1.6 30 0.20 84 55 4 0.6 46 0.29 73 29 - Results of different amine concentration screened in the study in standard condition (0.1M LiOH/BnOH, x mM hexylamine, 1.3 mM Ru-1, CPE 0.3 V vs Ag/AgCl, 25oC, 6 hours) are presented below:
Entry [Hexylamine] (mM) Conversion Selectivity (%) F.E. (%) Amine (%) BnOH (mmol) Imine 1 1,500 0.01 0.06 96 28 2 130 62 0.49 92 77 3 63 100 0.39 85 84 - Results of different solvent screened in the study in standard condition (0.1M LiOH/solvent, 0.6 M BnOH, 130 mM hexylamine, 1.3 mM Ru-1, CPE 0.3 V vs Ag/AgCl, 25oC, 6 hours) are presented below:
Entry Solvent (0.1 M LiOH) Conversion Selectivity (%) F.E. (%) Amine (%) BnOH (mmol) Imine 1 Neat 43 0.31 96 90 2 CH2Cl2/water (7:1) 20 0.15 84 78 3 PhCF3/water (7:1) 4 0.087 94 980 4 THF/water (7:1) 46 0.29 73 29 5 1,4-Dioxane/water (7:1) 22 0.23 96 32 - Table below allows comparison of blank experiments to standard conditions in terms of amine conversion, as well as product selectivity. (neat 0.2 M LiOH/BnOH (6 mL), 50 µL hexylamine, 25 °C, 6 hours, 1.3 mM catalyst, CPE 0.3 V vs Ag/AgCl; the presence of two latter conditions is indicated in the table):
Entry Catalyst Applied potential Conversion Selectivity (%) F.E. (%) Amine (%) BnOH (mmol) Imine 1 • • 43 0.31 96 90 2 • - 11 0.03 100 - 3 - • 4 0.02 50 4 4 - - 0 0 0 - 5 As entry 4, the 1.2 mL of 1 M (CH3)4NOH/H2O solution was replaced LiOH and BnOH 6 0.03 79 - - In the absence of applied potential, or catalysts, or both, conversions under otherwise identical conditions are negligible (<15%), demonstrating the electrification of the AAD systems.
- Possible applications of the invention are anyone or a combination of the following:
- safe, room temperature and energy efficient (as controlled) synthesis of imines from renewable feedstock (alcohol),
- use as a anode reaction for electrolyzers (H2 or CO2) for the co-generation of imines from renewable feedstock (alcohols) with small molecule transformation (CO2 reduction, H2 production, O2 reduction),
- value-added co-generation of oxidized products in low-voltage (compared to oxygen evolution) electrolyzers (e.g. in water reduction, CO2 reduction etc.),
- association with other electrochemical set-ups, such as convergent synthetic routes, e.g. with concomitant reduction of nitro-compounds to amines on the cathode and utilization of the so-formed amines in the anodic coupling reactions;
- hydrogen release from small amino-alcohols (equally via intermolecular coupling) to form possible cyclic imine-hydrogen storage molecules.
- The invention combines the advantages of homogeneous electrocatalysis with the selectivities and products so-far only observed under thermal conditions, opening the way towards more sustainable synthetic procedures. Using thermal AAD catalysts in an electrochemical set-up that produces imines is an important step beyond the current state-of-the-art in homogeneous electrocatalysis.
- The technology can be used to generate amount of imine on a reasonable time scale (roughly 6 h) at room temperature.
- An alcohol (preferentially under neat conditions) can be oxidized in the presence of an amine as the limiting agent to the corresponding imine with the help of an Acceptor-less Alcohol Dehydrogenation catalysts and an applied potential. Some of the AAD are commercially available.
- The invention allows to form the corresponding imine with excellent conversions (generally above >95%), selectivities (around 80%) and faradaic efficiency (up to 100%) at catalyst loading of 1 mM, low working potential of 0.3 V vs Ag/AgCl and at room temperature (25°C).
- A large range of ruthenium pincer complexes can be employed successfully. Under the employed conditions, catalytic turnover is generally in the order of 30-50 TONs.
- The process allows to retain chiral centers, making it possibly attractive for pathways towards chiral (pharmaceutical) molecular targets.
- An electrochemical approach benefits from the advantages of electrochemistry, such as safety, scalability, cheapest redox agent (electron), possibility to couple to other redox processes, direct usage of renewable energy for chemical synthesis and importantly direct control of the energy input.
- The use of potentially renewable feedstocks, such as alcohols, for the production of imines under energy efficient conditions (energy input controlled) is a key development towards more sustainable processes for fine chemistry.
Claims (18)
- A use of an acceptor-less alcohol dehydrogenation catalyst for an electrocatalytic oxidation of an alcohol with an amine, to an imine by electrocatalytic synthesis under electrochemical conditions,
the acceptor-less dehydrogenation catalyst used under electrochemical conditions being represented by the structure of any one of the formulae F1 or F2:L and L* being tridentate aliphatic or aromatic pincer ligands of the type shown-above, with L* being the deprotonated or dearomatized anionic form of the pincer ligand L,D being a donor group chosen from: a phosphine PR2, tertiary amine NR2, secondary amine NHR, thiol SR, or an N-heterocyclic carbene derived from imidazole, imidazoline, thiazole or triazole units,with R being a substituent selected from the group of: i-Pr, t-Bu, Cyclohexyl, Bn, Ph, Me, Et, Pr, Bu, H,X being an anionic ligand, selected from the group of: H-, BH4 -, OH-, Cl-, Br-, F-, PF6 -, NH2 -, NHR-, NR2 -, OR-, with R as defined above,L' being a mono-dentate strong field ligand selected from the group of: CO, a phosphine PR3, NO, a nitrile RCN, an isonitrile RNC or an N-heterocyclic carbene, derived from imidazole, imidazoline, thiazole or triazole units, with R as defined above,L" and L"* being bidentate ligands as shown above with 1 to 4 CH2 units and with R and D as defined above and L"* being the deprotonated anionic form of the ligand L". - The use according to claim 1, wherein in that the electrocatalytic alcohol oxidation is carried out in a homogeneous phase.
- The use according to claim 2, wherein the electrocatalytic alcohol oxidation is carried out under neat conditions without added solvent.
- The use according to claim 2, wherein that the electrocatalytic alcohol oxidation is carried out in the presence of a solvent or binary solvent mixtures.
- The use according to claim 1, wherein in that the electrocatalytic alcohol oxidation is carried out in heterogeneous phase, and in that the acceptor-less dehydrogenation catalyst is immobilized on a conductive support.
- The use according to anyone of claims 1, 2, 4 or 5, wherein solvent is water and the pH is between 7 and 14.
- The use according to anyone of claims 1 to 6, wherein the electrocatalytic alcohol oxidation is carried out under potential control, with an applied potential in the range of -0.5-0.5 V vs Ag/AgCl.
- The use according to anyone of claims 1 to 6, wherein the electrocatalytic alcohol oxidation is carried out under current control, with an applied current between 0.2 and 50 mA.
- The use according to anyone of claims 1 to 8, wherein the electrocatalytic alcohol oxidation is carried out in a divided electrochemical cell with a ratio of working electrode surface to cell volume between 0.5 and 10 cm-1.
- The use according to anyone of claims 1 to 9, wherein the electrocatalytic alcohol oxidation is carried at a temperature below 60°C.
- The use according to anyone of claims 1 to 10, wherein the electrocatalytic alcohol oxidation is carried at room temperature without heating.
- The use according to anyone of claims 1 to 11, wherein in that the organometallic catalyst is in contact with a working solution comprising the alcohol, the amine and a base chosen in the group comprising: LiOH, NaOH, KOH, CsOH, tetramethylammonium hydroxide, tetrabutylammonium hydroxide, trimethylbenzylammonium hydroxide, Cs2CO3, Li2CO3, NaOPiv, KOPiv, LiOPiv, CsOPiv, tetrabutylammonium dihydrogen phosphate, NatBu, KtBu, LitBu, CstBu, NaOEt, KOEt, LiOEt, CsOEt, NaOBn, KOBn, LiOBn, CsOBn, or a tertiary amine NR3 , with R being a substituent selected from the group of: i-Pr, t-Bu, Cyclohexyl, Bn, Ph, Me, Et, Pr, Bu, H.
- The use according to anyone of claims 1 to 12, wherein in that the alcohol oxidized is a primary or secondary alcohol of the form HOR' and the amine is a primary amine of the form H2NR', with R' being an alkyl or benzyl group bearing substituents from the group of: H, Me, Et, Pr, i-Pr, Bu, n-Bu, cyclopropyl, vinyl, allyl, fluoro, chloro, bromo, iodo, nitro, phenyl, alkoxo , borane , a borate , silyl , siloxyl , vinyl, allyl, furanyl, thiophenyl, a thiolate , an ester , a ketone, a sulfoxide.
- The use according to anyone of claims 1 to 13, wherein the amine presents a center of chirality which is maintained in the imine product.
- The use according to anyone of claim 1 to 15, wherein in that an anodic half-cell reaction is coupled with a cathodic half-cell reaction, the cathodic half-cell reaction being an electrochemical reduction of CO2 to CO, H2 production or O2 reduction and the reaction being carried out in a flow-cell.
- The use according to anyone of claims 1 to 16, wherein in that the alcohol is oxidized with at least 50-100 FE% (Faradaic efficiency), 50-100% amine conversion and 50-100% selectivity (from amine) to an imine in the presence of 0.1-2 M Base, 0.1-3 M alcohol, 0.05-1.5 M amine 0.01-10 mM catalysts, at a potential between -0.5-0.5 V vs Ag/AgCl, using a carbon-based working electrode, in a divided cell with working electrode surface-to-cell volume comprised between 0.1 - 10 cm-1, at a temperature below 60°C.
- The use according to anyone of claims 1 to 17, wherein in that the alcohol is oxidized with at least 50-100 FE% (Faradaic efficiency), 50-100% amine conversion and 50-100% selectivity (from amine) to an imine in the presence of 0.1-2 M Base, at an alcohol to amine ratio between 20:1-200:1, an amine to catalyst ratio of 20:1-200:1 and an alcohol to catalyst ratio of 50:1-5000:1, at a potential between -0.5-0.5 V vs Ag/AgCl, using a carbon-based working electrode, in a divided cell with working electrode surface-to-cell volume comprised between 0.1-10 cm-1, at a temperature below 60°C.
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WO2022136475A1 (en) | 2020-12-24 | 2022-06-30 | Ocado Innovation Limited | Motion control of a motion device |
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