EP4346744A1

EP4346744A1 - Thiol urethane group-containing polymerizable composition

Info

Publication number: EP4346744A1
Application number: EP22732030.6A
Authority: EP
Inventors: Christoph Meier; Andreas Utterodt; Kurt Reischl; Jutta Schneider; Michael Eck; Raif KOCOGLU; Nelli Schönhof
Original assignee: Kulzer GmbH; Kulzer and Co GmbH
Current assignee: Kulzer GmbH
Priority date: 2021-05-27
Filing date: 2022-05-25
Publication date: 2024-04-10
Also published as: WO2022248546A1; JP2024520051A; DE102021113777A1

Abstract

The invention relates to a polymerizable composition comprising 0.01 to 90 wt.% of at least one inorganic filler component, 5 to 99.97 wt.% of at least two urethane acrylates, wherein one urethane acrylate corresponds to formula I, and the second urethane acrylate has at least one bifunctional thiol urethane group and at least one olefinic group as well as mixtures of urethane acrylates comprising same, 0.01 to 25 wt.% of at least one di-, tri-, tetra-, or multifunctional monomer with at least one ether group, thioether group, and at least trifunctional triester and/or a difunctional diester, said diester being selected from tricyclodecane dimethanol dimethacrylate and tricyclodecane dimethanol diacrylate or mixtures of said di-, tri-, tetra-, or multifunctional monomers, and 0.01 to 10 wt,% of at least one initiator, an initiator system, and optionally at least one stabilizer, and optionally at least one pigment. The total composition of the polymerizable composition equals 100 wt.%.

Description

Polymerizable composition containing thiolurethane groups

The invention relates to a polymerizable composition comprising 0.01 to 90% by weight of at least one inorganic filler component, 5 to 99.97% by weight comprising at least two urethane acrylates, with at least one urethane acrylate corresponding to formula I and the second urethane acrylate at least has a bifunctional thiolurethane group and at least one olefinic group and mixtures of urethane acrylates comprising these, 0.01 to 25% by weight of at least one di-, tri-, tetra- or multi-functional monomer having at least one ether group, thioether group, an at least tri-functional triester, in particular with thioether group(s), and/or a difunctional diester, the diester being selected from tricyclodecanedimethanol dimethacrylate and tricyclodecanedimethanol diacrylate or mixtures of these di-, tri-, tetra- or multifunctional monomers, 0.01 to 10% by weight of at least one initiator, an initiator system and optionally at least at least one stabilizer and optionally at least one pigment, the total composition of the polymerizable composition being 100% by weight. The invention also relates to a polymerized composition with high flexural strength, high transparency and high double bond turnover and optionally low shrinkage in the production of three-dimensional articles or objects of greater than 5 mm in at least one of the three dimensions. Likewise, the polymerized compositions exhibit low brittleness.

A combination of bisphenol A glycidyl methacrylate (BisGMA) and triethylene glycol dimethacrylate (TEGDMA) as monomers for dental composites has established itself as one of the standards for dental composites in recent years. Due to the toxicity of the monomers, which has been proven in some cases, they should be substituted by non-toxic monomers with comparable physical properties, which is made possible by the monomer combinations used in this document.

Urethane acrylates with bivalent aromatic groups are known from EP3135271B1. Polymerized compositions based on these urethanes exhibit good flexural strength and low shrinkage. The urethanes with aromatic groups tend to crystallize more than other urethanes. WO2019/107323 A1 discloses the production of thiols containing (meth)acrylate groups, such as thiocarbamates having at least one (met)acrylate group. Compositions based on these thiocarbamates have improved breaking strengths. EP3795597A1 discloses (meth)acrylate-functional thioethers with good breaking strength and toughness. The thioethers have lower viscosities than the thiocarbamates of WO2019/107323 A1.

US2017/0007505A1 discloses diphenyl sulfide functional monomers and US10857073B2 discloses high refractive index difunctional phenyl sulfide monomers.

EP3733150A1 discloses polyurethane resins in dental applications made from polythiols and polyisocyanates. US2007/0185230 A1 Oligomeric thio-ene systems from light-induced conversion of trithio/trivinyl which are said to have increased double bond conversion in dental compositions than dimethyl acrylate systems which have a double bond conversion of 55 to 75% and shrinkage that is too high.

So far there have only been a few publications of these so-called thiol-ene monomers in dental composites. Accordingly, the thiol-ene monomers represent a monomer blend of thiol and acrylate, methacrylate or vinylic monomers. One disadvantage is the odor of these thiol-containing composites. The underlying polymerization mechanism in these monomer blends comprising thiol monomers and acrylate, methacrylate or vinylic monomers due to free radical chain transfer between thiol and (meth)acrylate is also significantly different from the free radical polymerization mechanism present in the compositions according to the invention. The technologies thus describe fundamentally different technologies.

One object of the invention was to further improve the good mechanical properties of urethane acrylates. This should be done on the one hand by improving the storage stability of urethanes that tend to crystallize and, alternatively or additionally, by improving the transparency of the polymerized compositions. In addition, there was the object of increasing the conversion of double bonds in polymerizable compositions, preferably without adversely affecting the shrinkage of the composition. Furthermore, the mechanical properties of the polymerized compositions should advantageously be improved. Furthermore, one Improvement of the modulus of elasticity, especially in combination with an improved depth of hardening, may be possible.

The composition according to the invention is described in independent claims 1 and 12 and in claims 14 and 15 on use. A more detailed disclosure of the invention is given in the subclaims and in the description.

The invention relates to a polymerizable composition, in particular a dental composition, preferably a dental composite, comprising polymerizable urethane (alkyl) acrylates, in particular urethane (meth) acrylates, of the formula I and isomers of these and urethane (meth) acrylates comprising thiol (meth) acrylates, named below as urethane acrylates with a thiol group and an olefinic group, which are used as crosslinkers. The polymerizable composition also includes monomers that are referred to as so-called diluents. These monomers can include di- to multi-functional monomers with ether, thioether groups, triesters or diesters of tricyclodecane monomers. These monomers used as diluents are (meth)acrylate functional monomers.

Surprisingly it was found that compositions comprising as a urethane acrylate a monomer 1, of formula I, and at least one further urethane acrylate referred to as monomer 2, in particular of the formulas V and VI with a thiolurethane group 2a, have very good depths of cure, flexural strength, modulus of elasticity and improved transparency and increased double bond conversion.

Formula V with R ¹⁴ equal to Formula Vld with R ⁷ in which R ⁸ is -CH ₂ -phenyl-CH ₂ -, and R ¹⁰ equal to -CH(CH3)CH2- with R ¹⁵ equal to H. Monomer 2 of Formula Vld with R ⁷ in which R ⁸ is -CH ₂ -phenyl-CH ₂ -, and R ¹⁰ is -CH(CH ₃ )CH ₂ - and with R ¹⁵ is H.

And also in composites, the urethane (meth)acrylate of the formula I and particularly preferably the monomer 1, shows very good properties in relation to the flexural strength, the modulus of elasticity (short E modulus) and the transparency.

The monomers of the formula I can be prepared from corresponding diisocyanates with corresponding hydroxy-functional (meth)acylates or else diols with corresponding isocyanates; the preparation of monomer 1 is disclosed in EP 3135271 B1.

However, monomer 1 shows an increased tendency to crystallize. Surprisingly, this could be avoided by adding, in particular adding less than the stoichiometric amount, a thiol of the formulas V or VI. The preparation of the thiols is disclosed in WO2019/107323 A1. After addition of the thiol and the corresponding isocyanate, a thiol urethane (meth)acrylate, ie thiol ester, is formed with the following general structural formula V, which can be used as monomer 2a or 2 in component (ii) in the composition. Depending on the thiol used, R ¹⁴ can form different structures according to WO2019/107323 A1. The invention relates to a polymerizable composition comprising

(i) 0.01 to 90% by weight of at least one inorganic filler component,

(ii) 5 to 99.97% by weight comprising at least two urethane acrylates, in particular urethane methacrylates and/or urethane acrylates, one urethane acrylate being at least one urethane acrylate of the formula I with a divalent hydrocarbon group with A=O if B=NH or A=NH if B=O, in particular the aforementioned compounds with R ¹ and R ² are each independently selected from H and alkyl having 1 to 8 carbon atoms, R ¹ = is preferred H or CH ₃ , R ² = H or CH ₃ , R ⁵ and R ⁶ are each independently selected from C2 to C6 linear alkylene groups or C2 to C6 linear oxyalkylene groups, with R ⁵ and R ⁶ optionally each independently being one C1-C3-alkyl group or (met)acryloxymethylene group, preferably CH ₃ and R ⁸ a divalent hydrocarbon group with 6 to 12 carbon atoms, and/or the second urethane acrylate has at least one bifunctional thiolurethane group and at least one olefinic group has, and optionally mixtures of urethane acrylates comprising these, in particular of urethane acrylates of the formula I and of thiourethane(s) of the formula V and/or VI and optionally of isomers of these,

(iii) 0.01 to 25% by weight of at least one di-, tri-, tetra- or multi-functional monomer having at least one ether group, thioether group, an at least tri-functional triester and/or a di- functional diester, where the diester is selected from tricyclodecanedimethanol dimethacrylate and tricyclodecanedimethanol diacrylate or mixtures comprising at least two of these di-, tri-, tetra- or multi-functional monomers,

(iv) 0.01 to 10% by weight of at least one initiator, an initiator system and optionally at least one stabilizer and optionally at least one pigment and optionally further additives, the total composition of the polymerizable composition being 100% by weight. Preferred urethane acrylates of formula I include urethane acrylates of formula Ia with A = O, if B = NH or A = NH, if B = O and with R ¹ = H or CH ₃ , R ² = H or CH ₃ , and R ⁸ is a divalent hydrocarbon group with 6 to 12 C- Atoms, R ¹¹ = each independently H, C1-C3 alkyl groups or (met)acryloxymethylene group, preferably CH ₃ . R ⁸ preferably comprises one of the following bivalent groups

The following specific urethane acrylate, in particular comprising urethane methacrylates and urethane acrylates, of the general formula V represents a urethane with an R ¹⁴ corresponding to the formula Vlb.

The urethanes of the formula V can be prepared, for example, from the reaction of, for example, di- to polyfunctional thiols, such as thiol ethers or thiol esters of the exemplary structures 2b, 2c and 2d, with corresponding olefinic isocyanate groups

Links. The polymerizable compositions include urethane acrylates, the term urethane acrylates always also including urethane alkyl acrylates, such as urethane methacrylates, or a urethane acrylate without an alkyl group. In the present invention, acrylates are therefore combined to include acrylates and methacrylates, so when a chemical compound is referred to as acrylate in the present text, the term (meth)acrylates, which has been customary up to now, is always meant, which includes both methacrylates and acrylates. The same applies to urethane acrylates (corresponds to urethane (meth)acrylates), which always also include urethane methacrylates and urethane acrylates. Alternatively, in the context of the present invention, urethane acrylates can also be described as urethane (meth)acrylates and acrylates as (meth)acrylates. The same applies to urethane (meth)acrylates (ii) containing thiolurethane groups.

The invention also relates to a composition, in particular a dental composition, preferably a dental composite, in which the urethane acrylate of the general formula I and/or the formula V each independently with R ⁸ comprises bivalent aromatic hydrocarbon having 6 to 12 carbon atoms, bivalent alicyclic hydrocarbon having 6 to 12 carbon atoms or divalent linear or branched alkylene having 6 to 12 carbon atoms or divalent linear or branched alkylene with an aromatic or alicyclic group, in particular bi- or tricyclic group.

In the mixtures according to the invention of the urethanes of the formulas I and V, the crystallization of the pure monomer 1 is suppressed in this way by the presence of the monomer 2. This results in easier handling of the monomer blend/monomer mixture of 1 and 2 with mechanically similar properties to pure 1, as can be shown using the examples. A preferred mass ratio of the urethanes of the formulas I and V, in particular with formula(s) VI, is preferably 1:1 to 20:1, the mass ratio is preferably around 9:1, with the number 9 varying with plus/minus 1 can. In principle, the mass ratio of formulas I to V can be set as desired.

According to a particularly preferred embodiment, a composition according to the invention comprises at least two urethane acrylates, in particular a mixture of at least these urethane acrylates, comprising at least one urethane acrylate of the formula I and the at least one second urethane acrylate having at least one bifunctional thiolurethane group and at least one olefinic group, these Urethane acrylates are present in a mass ratio of from 1:1 to 100:1, in particular from 2:1 to 50:1, preferably from 5:1 to 20:1, more preferably from 7:1 to 10:1 ( ) : 1 +/- 1. Furthermore, it is preferred if the at least two urethane acrylates comprising at least one urethane acrylate of the formula I and at least one second urethane acrylate having at least one bifunctional thiolurethane group and at least one olefinic group in a molar ratio of 1 to 2.5 to 0.0125 to 0.25, in particular from 0.5 to 1.25 to 0.0125 to 0.25.

The two urethane acrylate monomers 1 and 2 preferably have an aromatic and rigid center in combination with flexible aliphatic structures in the periphery of the molecular structures, resulting in high mechanical strength of the thermoset polymer after radical polymerization of the monomer blend of 1 and 2, especially as Component (ii) of the polymerizable composition. Due to the spatial size and the flexible aliphatic side chains in the periphery of the molecular structures in 1 and 2, especially the prepolymer 2, there is a comparatively low polymerization shrinkage of the monomer blend from 1 and 2. The high proportion of sulfur atoms and the high aromatic content in the molecular structure of the monomer blends of 1 and 2 also leads to a high transparency of the composite, which in turn achieves a high depth of cure. In everyday clinical practice, high transparency is also desirable for the production of highly esthetic dental restorations. In addition, it was found that the use of the monomer blend from 1 and 2 leads to a comparatively high conversion of double bonds.

A particularly preferred second urethane acrylate having at least one bifunctional thiolurethane group and having at least one olefinic group has a structure of the general formula V,

R ¹⁴ (-S-(C=O)-NH-R ¹³ ) _w , with w = 1 to 10 (V), with R ¹⁴ equal to a radical comprising at least mono- to deca-functional ester, ether or thioether , and R ¹³ is a radical each independently selected from radicals containing at least one olefinic group. In particular, R ¹³ is -R ⁸ NH(C=O)OR ¹⁰ O(C=O)CH=CH ₂ , -R ⁸ NH(C=O)OR ¹⁰ O(C=O)C(CH ₃ )= _CH2 . R ¹³ is preferably the same as formula VIII

Formula V can also be represented as R ¹⁴ (-R ⁷ ) _w , where w = 1 to 10, preferably w = 2 to 4, where R ⁷ = -R ⁸ NH-R ¹³ . With R ⁷ equal to formula VII with R ¹⁵ is H or C1 to C4 alkyl, preferably -CH3, with R ⁸ and R ¹⁰ as defined above and below. It is further preferred if the radical R ¹⁴ in formula V has one of the following structures Via to Vld

with R ⁷ in formula Via to Vlg each independently selected from

each R ⁸ is independently a divalent hydrocarbon group having 6 to 12 carbon atoms, each R ¹⁰ is independently selected from linear C2 to C6 alkylene groups or linear C2 to C6 oxyalkylene groups, where R ¹⁰ is optionally each independently has a C1-C3 alkyl group or (met)acryloxymethylene group, and with R ¹⁵ each independently being H, C1 to C4-alkyl, in particular CH ₃ or H.

With R ⁸ each independently in R ⁷ or formulas I, Ia, VII and VIII

With each independently R ¹⁰ in R ⁷ or formulas VII and VIII, where the above alkylenes and the oxyalkylene can also be inverted as R ¹⁰ in R ⁷ with p = 1 to 8, preferably p = 1 to 3 Particularly preferred urethane acrylates of general formula I include: with A = O when B = NH or A = NH when B = O and with R ¹ = H or CH ₃ , R ² = H or CH ₃ , and R ⁵ and R ⁶ are each independently selected from linear C2 to C6 -alkylene groups or linear C2 to C6 oxyalkylene groups, where R ⁵ and R ⁶ optionally each independently have a C1-C3 alkyl group or (met)acryloxymethylene group, preferably CH ₃ and R ⁸ one of the following specific bivalent groups includes

More preferably, R ⁵ and R ⁶ are each independently selected from C2 to C6 linear alkylene groups or C2 to C6 linear oxyalkylene groups, with R ⁵ and R ⁶ optionally each independently being a C1-C3 alkyl group or (met)acryloxymethylene group. Therefore, R ⁵ , R ⁶ or even R ¹⁰ can each independently comprise: C2-6 alkylene group in which a hydrogen atom can be substituted with a C1-3 alkyl group or a (meth)acryloyloxymethylene group, or a linear one Oxyalkylene group containing a hydrogen atom with a C1-3 alkyl group or a (meth)acryloyloxymethylene group can be substituted. The aforementioned alkyl groups are preferably linear. Examples _of linear _alkylene _groups include _-CH2CH2- , _-CH2CH2CH2- ^, _{-CH2CH2CH2CH2-} , -CH2CH2CH2CH2CH2-, _{-CH2CH2CH2CH2CH2CH2-} _, with _preferred ^ones _-CH2CH2- _, _-CH2CH2CH2- _, _{-CH2CH2CH2CH2-} _. _{_} _{_} _{_} Preferred linear oxyalkylene groups include -CH2CH2OCH2CH2- and -CH2CH2OCH2CH2OCH2CH2-, with CH2CH2OCH2CH2- being preferred. Likewise, the aforementioned groups can each have a hydrogen atom substituted by a methyl group or (meth)acryloxy group.

Preferred urethanes of the general formula I include the urethanes of the formulas Ia

R ¹¹ is each independently H, C1-C3 alkyl groups or (met)acryloxymethylene group, preferably H or CH ₃ . Both R ¹¹ can be the same or different. With R ⁸ as defined above as specific groups.

As a monomer blend, the two urethane acrylate monomers and optionally further urethane acrylates require the addition of a reactive diluent due to the comparatively high viscosity of monomers 1 and 2 in order to adjust the processability of the composition, in particular as a dental composite.

Component (iii) preferably has the at least one di-, tri-, tetra- or multifunctional monomer having at least one ether group, thioether group, an at least trifunctional triester and/or a difunctional diester, the diester is selected from tricyclodecanedimethanol dimethacrylate and tricyclodecanedimethanol diacrylate or mixtures comprising at least two of these di-, tri-, tetra- or multifunctional monomers a viscosity of less than or equal to 2000 mPas, preferably less than or equal to 1000 mPas, particularly preferably less than or equal to 500 mPas . The aforementioned monomers of component (iii) are preferably aliphatic and/or cycloaliphatic bis(meth)acrylates with a viscosity of less than or equal to 2000 mPas, preferably less than or equal to 1000 mPas, particularly preferably less than or equal to 500 mPas. Examples of component (iii) monomers which can be used in combination with the urethanes of component (ii) include, preferably, triethylene glycol dimethacrylate, triethylene glycol diacrylate, tetraethylene glycol dimethacrylate, tetraethylene glycol diacrylate, tricyclodecanedimethanol dimethacrylate, tricyclodecanedimethanol diacrylate.

Likewise, acrylate-functional thioethers or tri- or tetra-functional esters can be used as component (iii).

A combination with thioethers as component (iii) has particularly high transparency combined with low shrinkage and high double bond conversion. These properties are particularly advantageous in dental applications for the production of dental composites. Each of the monomers of components (iii) advantageously has a viscosity of less than or equal to 2000 mPas, preferably less than or equal to 1000 mPas, particularly preferably less than or equal to 500 mPas.

Preferred di-, tri-, tetra- or multi-functional monomers having at least one thioether group, preferably as reactive diluents, are di- to multi-functional thio(meth)acrylate compounds. These are thioacrylates and thio(meth)acrylates, which are distinguished by the absence of aromatic groups such as phenyl, phenylene or bisphenol-A in the molecular structure. The preparation of acrylates containing thioether groups is disclosed in EP3795597A1, to which reference is made in its entirety.

The monomers in component (iii) comprising thioether groups can in particular comprise at least one of the following monomers or also mixtures of at least two of the monomers of component (ii). Particular preference is given to using one or more of the following monomers 4 to 9 in component (iii).

Due to the increased sulfur content in the molecular structure of the thioether group-containing monomers, in particular the thio(meth)acrylates, in addition to a low viscosity of the dental composite, there is also increased transparency of the resulting composite, comprising at least two urethanes - monomers 1 and 2 and the Monomers of component (iii), in particular the respective reactive diluents 4 to 9 achieved. The reactive diluents 4 to 9 as component (iii) have a high molecular weight compared to commercially available reactive diluents, which leads to comparatively low polymerization shrinkage.

Furthermore, the comparatively high molecular weight of the reactive diluents 4 to 9 leads to a lower brittleness of the polymerized composite, which can be determined from the relationship between the modulus of elasticity and the flexural strength, as can be seen, for example, from the exemplary embodiments.

The monomers of component (ii), in particular the reactive diluents containing thioether groups or tri- or tetra-ester groups, can be used in combination with the monomer blend of 1 and 2, of the formulas I and V, either individually or in mixtures with one another.

The polymerizable composition particularly preferably comprises as component (iii) at least one di-, tri-, tetra- or multifunctional monomer having at least one ether group of the formula III, thioether group of the formula IV and/or an at least tri- or tetrafunctional triester of the formula II or mixtures of at least two of the monomers, in particular comprising at least one monomer of the formulas IIa, Mb, IIc, III, IVa, IVb, IVc and/or IVd

CH ₂ =C(CH ₃ )COO(CH ₂ CH ₂ 0) _V COC(CH ₃ )=CH ₂ (III), with V = 3 to 20, in particular v = 3 bis

15, preferably v = 3 to 8

each independently of formulas IIa, IIb, IIc, Iva, IVb, IVc, IVc and/or IVd with R ⁴ = with each independently R ⁹ = H or CH ₃ , and with R ³ , where R ³ can be present as shown below or in inverted form, R ³ = selected from n = 1 to 8, preferably n = 3.

Particularly preferred compositions comprise: (i) 5 to 40%, especially 5 to 30% by weight of an inorganic

Filler component, in particular comprising at least one glass, in particular dental glass, silicate, metal oxide, mixed oxide, silicon dioxide, zirconium dioxide, zinc oxide and/or mixtures of at least two of the components mentioned, the components have an average particle size of 0.2 mhi to 10 mhi, and optionally at least one amorphous metal oxide with an average primary particle size of 10 nm to 115 nm, and

(ii) 60 to 85% by weight of at least two urethane acrylates, the urethane acrylates comprising at least one urethane acrylate of the formula I and at least one second urethane acrylate having at least one bifunctional thiolurethane group and at least one olefinic group

(iii) 0.5 to 25% by weight of at least one di-, tri-, tetra- or multifunctional monomer having at least one ether group, thioether group and/or an at least trifunctional triester and/or one difunctional diester, where the diester is selected from tricyclodecanedimethanol dimethacrylate and tricyclodecanedimethanol diacrylate or mixtures of at least two of these di-, tri-, tetra- or multi-functional monomers,

(iv) 0.01 to 10% by weight of at least one initiator, an initiator system and optionally at least one stabilizer and optionally at least one pigment, the total composition of the composition being 100% by weight.

Also particularly preferred compositions include:

(i) 5 to 90% by weight, in particular 14.98 to 90% by weight, of an inorganic filler component, in particular comprising at least one glass, in particular dental glass, silicate, metal oxide, mixed oxide, silicon dioxide, zirconium dioxide, zinc oxide and/or mixtures of at least two of the components mentioned, the components having an average particle size of 0.2 mhi to 10 mhi, and optionally at least one amorphous metal oxide having an average primary particle size of 10 nm to 115 nm, and

(ii) 10 to 85% by weight of at least two urethane acrylates, the urethane acrylates comprising at least one urethane acrylate of formula I and at least one second urethane acrylate having at least one bifunctional thiolurethane group and at least one olefinic group.

(iii) 0.01 to 25% by weight of at least one di-, tri-, tetra- or multifunctional monomer having at least one ether group, thioether group and/or an at least trifunctional triester and/or one difunctional diester, where the diester is selected from tricyclodecanedimethanol dimethacrylate and tricyclodecanedimethanol diacrylate or mixtures of at least two of these di-, tri-, tetra- or multi-functional monomers,

(iv) 0.01 to 10% by weight of at least one initiator, an initiator system and optionally at least one stabilizer and optionally at least one pigment, the total composition of the composition being 100% by weight. An equally particularly preferred composition comprises

(i) 40 to 90% by weight of an inorganic filler component, in particular comprising at least one glass, in particular dental glass, silicate, quartz, feldspar, metal oxide, mixed oxide, silicon dioxide, zirconium dioxide and/or zinc oxide with an average particle size of 0.4 μM to 10 mhi, and optionally at least one amorphous metal oxide with an average primary particle size of 10 nm to 115 nm, and

(ii) 10 to 59.98% by weight of at least two urethane acrylates, the urethane acrylates comprising at least one urethane acrylate of the formula I and at least one second urethane acrylate having at least one bifunctional thiolurethane group and at least one olefinic group, or a mixture of urethane acrylates of the formulas I and V and optionally of isomers of the formula I,

(iii) 0.01 to 15% by weight of at least one di-, tri-, tetra- or multifunctional monomer having at least one ether group, thioether group and/or an at least trifunctional triester and/or one difunctional diester, where the diester is selected from tricyclodecanedimethanol dimethacrylate and tricyclodecanedimethanol diacrylate or mixtures of at least two of these di-, tri-, tetra- or multi-functional monomers,

Other preferred compositions include:

(i) 50 to 90% by weight of an inorganic filler component, in particular comprising at least one glass, in particular dental glass, silicate, quartz, feldspar, metal oxide, mixed oxide, silicon dioxide, zirconium dioxide and/or zinc oxide with an average particle size of from 0.4 mgH 10 mhi, and optionally at least one amorphous metal oxide with an average primary particle size of 10 nm to 115 nm, and

(ii) 20 to 49.98% by weight comprising at least two urethane acrylates, the urethane acrylates comprising at least one urethane acrylate of the formula I and at least one second urethane acrylate having at least one bifunctional thiolurethane group and at least one olefinic group,

(iii) 0.01 to 15% by weight of at least one di-, tri-, tetra- or multifunctional monomer having at least one ether group, thioether group and/or an at least trifunctional triester and/or one difunctional diester, where the diester is selected from tricyclodecanedimethanol dimethacrylate and tricyclodecanedimethanol diacrylate or mixtures of at least two of these di-, tri-, tetra- or multi-functional monomers, (iv) 0.01 to 10% by weight of at least one initiator, an initiator system and optionally at least one stabilizer and optionally at least one pigment, the total composition of the composition being 100% by weight.

Particularly preferred compositions include

(i) 60 to 85 wt optionally at least one amorphous metal oxide with an average primary particle size of 10 nm to 115 nm, and

(ii) 10 to 39.98% by weight of at least two urethane acrylates, the urethane acrylates comprising at least one urethane acrylate of the formula I and at least one second urethane acrylate having at least one bifunctional thiolurethane group and at least one olefinic group, or a mixture of urethane acrylates of the formulas I and V and optionally of isomers of the formula I,

Fundamentally preferred (ii) urethanes include urethanes of the formula I and optionally of the formula V with VII and/or mixtures of these urethanes of the formula I and optionally mixtures of the isomers of the aforementioned compounds with R ¹ , R ² and R ¹⁵ each independently selected from H and alkyl with 1 to 8 carbon atoms, R ¹ , R ² and R ¹⁵ are particularly preferably H or CH ₃ .

Particularly preferred urethane acrylates of the formula I or mixtures of urethane acrylates include urethanes of the formula I and optionally mixtures of isomers with R ¹ , R ² , R ⁸ and R ¹¹ as defined above,

lc

Urethane acrylates of the formula I very particularly preferably include at least one compound of the formulas Ic to Io and/or mixtures of these and optionally mixtures of isomers of these, and/or mixtures of these urethanes of the formula I and optionally mixtures of the isomers of the aforementioned compounds with R ¹ and R ² each independently selected from H and alkyl having 1 to 8 carbon atoms, le

Compositions with (iii) 0.01 to 15% by weight of at least one di-, tri-, tetra- or multi-functional monomer are also preferred, the total composition of the composition being 100% by weight.

According to one embodiment, the compositions can comprise at least one inorganic filler component comprising at least one glass, silicate, feldspar, Metal oxide Mixed oxide, silicon dioxide, zirconium dioxide with an average particle size dso of 0.5 to 10 mGP. Alternatively preferred are compositions comprising a) at least one inorganic filler component comprising at least one glass, silicate, quartz, feldspar, metal oxide, mixed oxide, silicon dioxide, zirconium dioxide or a mixture comprising at least two of the components with an average particle size of dso of 1.8 mhi, and preferably dg9 less than or equal to 20 mhi, or b) at least one inorganic filler component comprising at least one glass, feldspar, metal oxide, mixed oxide, silicon dioxide, zirconium dioxide or a mixture comprising at least two of the components as a mixture of different fractions with mean particle sizes, with i) dso from 2 to 8 mhi, ii) dso from 1.0 to 2.0 mhi, and iii) dso from 0.5 mhi to 2 mhi, the fractions of i) to ii) to iii) in the ratio of 1 to 4:1:4 to 8, especially from 2 to 3:1:6 to 7.

Furthermore, the compositions can comprise as amorphous metal oxide at least one non-agglomerated amorphous metal oxide with a primary particle size of 2 to 150 nm, and wherein the amorphous metal oxide optionally comprises precipitated silica, fumed silica, zirconia or mixed oxides.

The compositions particularly preferably comprise as (i) inorganic filler component (i.1) 0.005 to 85% by weight, in particular 50 to 85% by weight, of at least one glass, silicate, quartz, feldspar, metal oxide mixed oxide, silicon dioxide, zirconium dioxide or a mixture comprising at least two of these filler components, and optionally (i.2) 0.005 to 5% by weight, in particular 0.05 to 2% by weight, amorphous metal oxide, in particular fumed silica and/or precipitated silicon dioxide, in particular 0 1 to 90% by weight, in particular 50.005 to 90% by weight, of filler component, based on the total composition of the composition of 100% by weight.

Equally preferred compositions may comprise as (iii) monomers selected from di-methacrylic esters of polyethers, tri-, tetra- or multi-functional methacrylic esters of polyethers and 2,2-bis-[4-(2-hydroxy-3-methacryloyloxy- propoxy)phenyl]propane, bis(2'-oxa-3'-oxopentyl-4'-ene)tetrahydrodicyclopentadiene, triesters of thioethers, diesters including tricyclodecane, and isomers thereof and optionally pentaerythritol tetrapropoxyacrylate. Component (iii) may preferably include dimethacrylate polyethylene glycol, dimethacrylate polypropylene glycol. Especially preferred are dimethacrylate triethylene glycol (TEGDMA), diethylene glycol dimethacrylate (DEGMA) and dimethacrylate tetraethylene glycol (TEDMA).

Additionally, a composition may comprise as (v) from 0.01% to 15% by weight of a polymeric particulate filler, the total composition of the composition being 100% by weight.

Preferred stabilizers include water, at least one benzophenone and/or at least one phenol derivative.

The invention also relates to polymerized compositions, in particular obtained or obtainable by polymerization of one of the polymerizable compositions, the polymerized compositions comprising

- 0.01 to 90% by weight of at least one inorganic filler component,

- 5 to 99.98% by weight of at least one polymer, in particular copolymer, based on the polymerization of at least monomers and/or prepolymers comprising at least two urethane acrylates, where at least one urethane acrylate of the formula I, as defined above and below, with a bivalent hydrocarbon group and the second urethane acrylate has at least one bifunctional thiol urethane group and at least one olefinic group, and/or mixtures of urethane acrylates comprising these, and

- at least one di-, tri-, tetra- or multi-functional monomer having at least one ether group, thioether group, an at least tri-functional triester and/or a di-functional diester, where the diester is selected from tricyclodecanedimethanol dimethacrylate and tricyclodecanedimethanol diacrylate or mixtures of at least two of the di-, tri-, tetra- or multifunctional monomers, and - 0 to 10% by weight, in particular 0.01 to 10% by weight, preferably 0.01 to 10 % by weight of at least one pigment, the total composition of the polymerized composition being 100% by weight.

The invention also relates to a polymerized composition obtained or obtainable by polymerizing the composition i) with a UV and/or Vis radiation source, preferably with a Vis radiation source with emission maxima in the spectral range from 380 nm to 530 nm, preferably with at least one Maximum or maxima in the spectral range from 400 to 500 nm and / or thermal polymerization ii). a pressure of 50 to 300 MPa and/or elevated temperature, preferably at 90 to 150°C.

The polymerized composition is preferably in the form of a block of material, in particular the block of material is in the form of a three-dimensional geometric shaped body, in particular as a milling blank without an adapter or as a milling blank with an adapter for fixing in an automated material-removing device.

The composition is very particularly preferred for use as a dental material, in particular as a fissure sealant, dental composite material, direct adhesive dental restoration, as a hoof repair material, as a bone cement, or as a bone cement for cementing artificial joint prostheses.

The invention also relates to the use of a polymerizable composition, in particular as a dental composite material, preferably in additive manufacturing processes, in radiation-based generative manufacturing processes, in a stereolithography process, SLA process (laser-based stereolithography process), a DLP process (digital light Processing) or an SLA and DLP process, in generative LED beamer-based manufacturing processes, in radiation and thermal-based generative manufacturing processes, in thermal generative manufacturing processes, in 3D printing processes, multitjet processes (MJM) or polyjet processes, and /or b) for the production of dental prosthetic supplies, orthodontic appliances and/or instruments in a material-removing process, in particular in a process in which the polymerized composition is removed by means of milling, cutting, polishing, breaking, chipping and/or drilling, in particular e in a process in which the polymerized composition is ablated using laser energy.

The invention also relates to the use of a polymerizable composition in radiation-based polymerization processes, in particular UV and/or VIS polymerization processes, free-radically induced polymerization processes, thermally based polymerization processes and/or redox-based polymerization processes.

The invention relates to the use of a polymerizable or a polymerized composition for the production of dental prosthetics Provisions including crowns, inlays, onlays, superstructures, artificial teeth, dental bridges, dental bars, spacers, abutments, veneers or for the production of a bite splint, milling blank, dental prosthesis, part of a surgical prosthesis, drilling template, implant, mouthguard, joint prosthesis, telescope, implant part, orthodontic appliance, instrument or hoof part.

In combination with the monomer blend of 1 and 2 and in combination with the reactive diluents of component (iii) comprising at least one of the monomers 4 to 9, triethylene glycol dimethacrylate, triethylene glycol diacrylate, tetraethylene glycol dimethacrylate, tetraethylene glycol diacrylate, tricyclodecanedimethanol dimethacrylate, tricyclodecanedimethanol diacrylate or mixtures of at least two All commercially available photoinitiators can be used for the monomers. A combination of camphorquinone with 2-ethylhexyl-4-dimethylaminobenzoate (EHA) is preferably used in the composition. Equally, peroxides or hydroperoxides, for example, and redox initiators for auto- or cold-polymerization can be used for thermal polymerization. When using redox initiators, the composition is formulated as a 2K composition that polymerizes only after the two components have been mixed.

A thermally polymerizable composition is understood here to mean a composition which can be polymerized at greater than or equal to 60 to 150.degree. C., preferably at greater than or equal to 70 to 150.degree. C., particularly preferably from 90 to 150.degree. It is further preferred according to the invention if the volume shrinkage is small.

The invention also relates to a dental composite material obtainable by polymerization i) with a UV/Vis radiation source, preferably with a Vis radiation source with emission maxima in the spectral range from 380 nm to 530 nm, preferably with at least one maximum or maxima in the spectral range from 400 to 500 nm and optionally ii) at a pressure of 50 to 300 MPa and/or elevated temperature, preferably at 90 to 150° C., or i) with a UV and/or Vis radiation source, preferably with a Vis radiation source with emission maxima in the spectral range from 380 nm to 530 nm, preferably with at least one maximum or maxima in the spectral range from 400 to 500 nm and/or ii) at a pressure of 50 to 300 MPa and/or elevated temperature, preferably at 90 to 150°C. The polymerizable compositions can also contain other additives, such as stabilizers, colorants and pigments, microbiocidal active ingredients, fluoride ion-releasing additives, optical brighteners, plasticizers and/or UV absorbers, inhibitors and UV stabilizers.

Glasses, in particular dental glasses, are preferably: aluminum silicate glasses or fluoroaluminum silicate glasses, fluoroaluminum silicate glasses containing boron, barium aluminum silicate, strontium silicate, strontium borosilicate, potassium silicate, calcium borosilicate, sodium silicate glass, potassium silicate glass, lithium silicate and/or lithium aluminum silicate and mixtures of at least two of the aforementioned glasses. Amorphous spherical fillers based on oxide or mixed oxides, such as amorphous S1O2, ZrO2 or mixed oxides of S1O2 and ZrO2, can be used as amorphous metal oxide or as a mixture of amorphous metal oxides. Alternatively, mixed oxides of zirconium dioxide and silicon dioxide, zirconium dioxide or zinc oxide as well as crystalline silicates can be used as filler components in the composition. All fillers, such as glasses, amorphous metal oxides or radiopaque and/or pigments are preferably functionally silanized. Suitable silanes are, in particular, thiol-, vinyl-, allyl-, norborn-2-enyl-, methacrylic- or alkyne-functionalized silanes. The invention thus also relates to compositions comprising fillers functionally silanized with thiol-, vinyl-, allyl-, norborn-2-enyl-, methacryl- or alkyne-functionalized silanes.

More preferably each in combination with an amorphous silicon dioxide at 4 to 7.5% by weight in the total composition. The amorphous metal oxide is preferably a non-agglomerated amorphous metal oxide with a primary particle size of 2 to 150 nm, in particular 2 to 100 nm, preferably 2 to 45 nm, the amorphous metal oxide being silicon dioxide, precipitated silicon dioxide, fumed silica, zirconium oxide, mixed oxides or mixtures this includes, in particular, the metal oxides are silanized. (Meth)acryloxyalkyl-functional silanes or other alkyl- or olefinically-functionalized silanes can be considered as silanizing agents.

According to one embodiment, fillers can be added to the compositions for the production of dental composites. Fillers based on oxides with a particle size of 0.4 μm to 20 μm, such as S1O2, ZrO2 and T1O2 or mixed oxides of S1O2, ZrO2, ZnO and/or T1O2 are particularly suitable. In addition, nanoscale or microfine fillers with a particle size of 0.01 to 500 nm are used, such as pyrogenic ones silicic acid or precipitated silicic acid. Likewise, as fillers dental glasses and / or tectosilicates with a particle size of 0.4 pm to 20 pm and / or 0.01 mm to 15 mm, such as quartz powder, glass ceramic powder and / or feldspar powder or X-ray opaque dental glass powder of barium or strontium aluminum silicate glasses, and radiopaque fillers with a particle size of 0.4 μm to 20 μm and/or 0.01 mm to 15 mm are used. This can also be ytterbium trifluoride, tantalum(V) oxide, barium sulfate or mixed oxides of S1O2 with ytterbium(III) oxide or tantalum(V) oxide, in particular of the aforementioned particle sizes of 0.4 μm to 20 μm and/or 0.01 mm up to 15 mm can be used. All particle sizes mentioned are weight-average particle sizes, such as D50 in particular.

To improve the bond between the filler particles and the crosslinked polymer matrix, Si0 ₂ -based fillers can be surface-modified with thiol-, vinyl-, allyl-, norborn-2-enyl-, methacryl- or alkyne-functionalized silanes.

Examples of such silanes are 3-thiopropyltrimethoxysilane, 3-allyltriethoxysilane, methacryloxypropyltrimethoxysilane or N-[3-(triethoxysilyl)propyl]carbamic acid propargyl ester. Functionalized acid phosphates such as 10-methacryloyloxydecyl dihydrogen phosphate can also be used to modify the surface of non-siliceous fillers such as ZrÜ2 or PO2.

In a preferred alternative, the composition may contain a polymeric particulate filler content in addition to the inorganic filler component. The total content of such a polymeric particulate filler can be from 0.01 to 15% by weight, preferably from 0.5 to 10% by weight in the total composition of the composition of 100% by weight. The particle sizes of the polymeric filler are preferably in the range from 10 to 200 microns, in particular from 30 to 90 microns, particularly preferably 20 to 50 microns.

The term acrylate in the present invention includes (alkyl) acrylate or (meth) acrylate or urethane (alkyl) acrylate with (alkyl) in brackets or urethane (meth) acrylate with (meth) in brackets means that the term acrylates or urethane acrylates with and without alkyl groups or methyl group. The alkyl groups preferably contain 1 to 10 carbon atoms, preferably 1 to 2 carbon atoms, in the urethane alkyl acrylates mentioned. The alkyl groups preferably contain 1 to 10 carbon atoms, preferably 1 to 2 carbon atoms, in the (alkyl)acrylates mentioned. Component (ii) comprising at least two urethane acrylates can additionally comprise at least one difunctional urethane acrylate, urethane (alkyl) acrylate, urethane (alkyl) acrylate with divalent alkylene group or urethane (meth) acrylate with divalent alkylene group, this is preferably selected from linear or branched urethane dimethacrylates functionalized with a bivalent alkylene group, urethane dimethacrylate-functionalized polyethers with alkylene group(s), such as bis(methacryloxy-2-ethoxycarbonylamino)-alkylene, bis(methacryloxy-2-ethoxycarbonylamino)-substituted polyalkylene ethers, preferably 1 ,6-Bis(methacryloxy-2-ethoxycarbonylamino)-2,4,4-trimethylhexane, UDMA alternatively named HEMA-TDMI. A bis(methacryloxy-2-ethoxycarbonylamino)-alkylene is preferred, where alkylene comprises linear or branched C3 to C20, preferably C3 to C6, such as particularly preferably an alkylene substituted with methyl groups, such as HEMA-TMDI. The divalent alkylene preferably includes 2,2,4-trimethylhexamethylene and/or 2,4,4-trimethylhexamethylene. Furthermore, the component (ii) may include di-HEMA trimethylhexyl dicarbamate, diurethane dimethacrylate, a methacrylate adduct, urethane dimethacrylate. R'CH2[C(CH3)(R)CH2]2CH2 _R ', R=H or _CH3 , R'= _NHC02CH2CH2 O2CC(CH3)=CH2

Water can be added to the composition as a stabilizer to improve consistency and flow behavior for process engineering workability. Stabilizers are preferably added to the composition to prevent premature polymerisation and to give the material a certain shelf life. As preferred stabilizers, the composition comprises in component (iv) at least one stabilizer selected from water, at least one benzophenone derivative, preferably alkoxy-substituted benzophenone and/or phenol derivative, such as 2-hydroxy-4-methoxybenzophenone, 2,6-bis (1,1-dimethyl)-4-methylphenol, or a mixture of the three stabilizers. The stabilizers are preferably present at 0.01 to 10% by weight in the total composition, particularly preferably from 0.7 to 10% by weight, in particular from 0.5 to 2% by weight. Furthermore, it is preferred if the composition contains 0.01 to 2% by weight of water as a stabilizer, preferably 0.1 to 1.0% by weight of water.

At least one pigment comprising at least one fluorescent pigment and optionally at least one organic color pigment and/or at least one inorganic color pigment such as titanium dioxide, in particular non-fluorescent color pigments, can be added to optimally adjust the color and the aesthetics of the polymerized composition. The at least one fluorescent pigment is preferably an organic one Fluorescent pigment, in particular a non-polymerizable organic fluorescent pigment optionally comprising aryl carboxylic acid esters, aryl carboxylic acids, coumarin, rhodamine, naphthanic imide or a derivative of the respective substance. Inorganic fluorescent pigments may include CaAI ₄ O ₇ :Mn ²⁺ , (Ba0.98Eu0.02)MgAlioOi ₇ , BaMgF ₄ :Eu ²⁺ , Y(1 995)Ce(0.005)SiO ₅ .

As pigments, in particular colored pigments, the composition can comprise organic pigments and also inorganic pigments, in particular comprising diethyl 2,5-dihydroxyterephthalate, N,N'-bis(3,5-xylyl)perylene-3,4:9,10-bis (dicarbimide), copper phthalocyanine, titanate pigment, in particular chromium antimony titanate (rutile structure), spinel black, in particular pigments based on iron oxide black (Fe ₃ 0 ₄ ), iron (Fe) being partially substituted by chromium and copper or nickel and chromium or manganese , zinc iron chromium spinel, brown spinel, ((Zn,Fe)(Fe,Cr) ₂ 0 ₄ ) cobalt zinc aluminate blue spinel and/or titanium oxide. The pigments, including fluorescent and color pigments, are preferably present in the total composition at 0.01 to 10% by weight, particularly preferably from 0.01 to 5% by weight, preferably from 0.01 to 1% by weight.

According to a further preferred embodiment, the composition may comprise: (iv) 0.01 to 2% by weight of a UV and/or Vis photoinitiator or a UV and/or Vis photoinitiator system, and 0.01 to 2 wt% stabilizer.

Furthermore, the polymerized composition can be used to produce technical components that are particularly exposed to high mechanical loads, such as plastic templates, nails, screws and other components familiar to the person skilled in the art, etc.

The following are also preferably suitable as additional urethane (meth)acrylates of component (ii): at least one urethane (meth)acrylate, in particular a urethane dimethacrylate, preferably a bis(methacryloxy-2-ethoxycarbonylamino)alkylene, diurethane acrylate oligomers, alkyl functional urethane dimethacrylate oligomers, aromatically functionalized urethane dimethacrylate oligomers, aliphatic unsaturated urethane acrylates, bis(methacryloxy-2-ethoxycarbonylamino) substituted polyethers, aromatic urethane diacrylate oligomers, aliphatic urethane diacrylate oligomers, aliphatic urethane diacrylates, hexafunctional aliphatic urethane resins, aliphatic urethane triacrylate, aliphatic Urethane acrylate oligomer, unsaturated aliphatic urethane acrylates. Preference is given to difunctional and polyfunctional urethane (meth)acrylates, such as in particular urethane di(eth)acrylates, particular preference being given to at least one (iii) urethane dimethacrylate selected from linear or branched alkyl-functionalized urethane dimethacrylates, urethane dimethacrylate-functionalized polyethers, in particular bis(methacryloxy-2- ethoxycarbonylamino)-alkylene, bis(methacryloxy-2-ethoxycarbonylamino)-substituted polyethers, preferably 1,6-bis(methacryloxy-2-ethoxycarbonylamino)-2,4,4-trimethylhexane. Suitable urethane (meth)acrylates are available under the following trade names: Ebecryl 230 (aliphatic urethane diacrylate), Actilane 9290, Craynor 9200 (di-urethane acrylate oligomer), Ebecryl 210 (aromatic urethane diacrylate oligomer), Ebecryl 270 (aliphatic urethane diacrylate oligomer), Actilane 165, Actilane 250, Genomer 1122 (monofunctional urethane acrylate), Photomer 6210 (Cas No. 52404-33-8, aliphatic urethane diacrylate), Photomer 6623 (hexafunctional aliphatic urethane resin), Photomer 6891 (aliphatic urethane triacrylate), UDMA, Roskydal LS 2258 (aliphatic urethane acrylate oligomer), Roskydal XP 2513 (unsaturated aliphatic urethane acrylate). The urethane (meth)acrylates can preferably be selected from the aforementioned urethane (meth)acrylates or from a mixture of at least two different, preferably at least three different, aforementioned urethane (meth)acrylates.

The at least one di-, tri-, tetra- or multi-functional monomer of component (iii) can also comprise at least one of the following monomers, in particular a mixture of monomers comprising bis-(2'-oxa-3'-oxo- pentyl-4'-en)tetrahydrodicyclopentadiene and isomers thereof, 1,4-butanediol dimethacrylate (1,4-BDMA) or pentaerythritol tetraacrylate, decanediol di(meth)acrylate, dodecanediol di(meth)acrylate, hexyldecanediol di(meth )acrylate, trimethylolpropane tri(meth)acrylate, pentaerythritol tetra(meth)acrylate and butanediol di(meth)acrylate, ethylene glycol di(meth)acrylate, a mixture containing at least one of these (meth)acrylates and/or Copolymers comprising one or at least two of the aforementioned monomers.

In addition to the di-, tri- or multi-functional monomer or monomers, at least one of the following monomers can be present in the composition comprising at least one monomer, in particular a mixture of monomers of methyl methacrylate, ethyl methacrylate, propyl methacrylate, butyl methacrylate, n-hexyl methacrylate, 2 -phenoxyethyl methacrylate, isobornyl methacrylate, isodecyl methacrylate, Polypropylene glycol mono-methacrylate, tetrahydrofuryl methacrylate, methyl acrylate,

Ethyl acrylate, propyl acrylate, butyl acrylate, n-hexyl acrylate, 2-phenoxyethyl acrylate, isobornyl acrylate, isodecyl acrylate, tetrahydrofuryl acrylate, hydroxyethyl acrylate, hydroxypropyl acrylate, hydroxyethyl methacrylate, hydroxypropyl methacrylate, benzyl, furfuryl or phenyl (meth)acrylate, a mixture containing at least one of these (meth)acrylates and/or copolymers comprising one or at least two of the aforementioned monomers.

The invention also relates to a composition which preferably additionally contains at least one or more substance(s) from the groups of fillers, pigments, stabilizers, regulators, antimicrobial additives, UV absorbers, thixotropic agents, catalysts and crosslinkers. Such additives - like pigments, stabilizers and regulators - are used in rather small amounts, e.g. B. a total of 0.01 to 3.0, especially 0.01 to 1.0 wt .-% based on the total composition of the composition. Suitable stabilizers are e.g. B. hydroquinone monomethyl ether or 2,6-di-tert-butyl-4-methylphenol (BHT).

As component (iv), the composition preferably contains from 0.01 to 10% by weight, in particular from 0.5 to 5% by weight, preferably 0.5 to 2% by weight, of at least one initiator or initiator system, preferably i) at least one photoinitiator for the UV and/or Vis range or a photoinitiator system for the UV and/or Vis range and optionally at least one stabilizer, and optionally further customary additives, optionally pigment(s) or dye(s).

Particularly preferred photoinitiators include alpha-hydroxyphenyl ketone, benzildimethylketal or 2,4,6-trimethylbenzoyldiphenylphosphine oxide, phenylbis(2,4,6-trimethylbenzoyl)phosphine oxide, 2,4,6-trimethylbenzoylphenylphosphinic acid ethyl ester, and mixtures of at least two of the photoinitiators bisacylphosphine oxides (BAPO). Or also camphorquinone with amines selected from N,N-dimethyl-p-toluidine, N,N-dihydroxyethyl-p-toluidine and diethyl p-dimethylaminobenzoate.

Typical stabilizers include 2,6-di-tert-butyl-4-methylphenol (BHT) or hydroquinone monomethyl ether (MEHQ), 2-hydroxy-4-methoxybenzophenone, HALS (Hindered Amine Light Stabilizers), benzotriazole ultraviolet absorbers (UVAs), and hydroxy Phenyl triazines (HPT). Particularly suitable stabilizers are, for. B. hydroquinone monomethyl ether or 2,6-di-tert-butyl-4-methylphenol (BHT). Peroxides, hydroxyperoxides, optionally azo compounds, or mixtures comprising these are suitable as initiators, in particular thermal initiators or initiator systems. Suitable thermal initiators can be used as free-radical initiators in the temperature range from 70 to 150.degree. C., preferably from 90 to 150.degree. Preferred thermal initiators include at least one initiator selected from: dilauroyl peroxide, di-tert-butyl peroxide, tert-butyl peroxy-2-ethylhexanoate, dibenzoyl peroxide, dicumyl peroxide, dicumyl hydroperoxide, 2,2'-azobis-isobutyronitrile, benzylbarbituric acid derivative, particularly preferably tert-butyl peroxy-2-ethylhexanoate, dibenzoyl peroxide, dicumyl peroxide, dicumyl hydroperoxide, azobisisobutyronitrile, benzylbarbituric acid derivatives such as phenylbenzylbarbituric acid, cyclohexylbenzylbarbituric acid.

The following initiators and/or initiator systems for auto- or cold-polymerization include a) at least one initiator, in particular at least one peroxide and/or azo compound, in particular LPO: dilauroyl peroxide, BPO: dibenzoyl peroxide, t-BPEH: tert-butyl per-2-ethylhexanoate, AIBN: 2,2'-azobis-(isobutyronitrile), DTBP: di-tert-butyl peroxide, and optionally b) at least one activator, in particular at least one aromatic amine, such as N,N-dimethyl-p-toluidine, N,N -Dihydroxyethyl-p-toluidine and/or diethyl p-dibenzylaminobenzoate or c) at least one initiator system selected from redox systems, in particular a combination selected from dibenzoyl peroxide, dilauroyl peroxide and camphorquinone with amines selected from N,N-dimethyl-p-toluidine, N-N- Dihydroxyethyl-p-toluidine and diethyl p-dimethylaminobenzoate. Alternatively, the initiator system can be a redox system comprising a peroxide and a reducing agent selected from ascorbic acid, ascorbic acid derivative, barbituric acid or a barbituric acid derivative, sulfinic acid, sulfinic acid derivative, a redox system comprising (i) barbituric acid or thiobarbituric acid or a barbituric acid is particularly preferred or thiobarbituric acid derivative and (ii) at least one copper salt or copper complex and (iii) at least one compound having an ionic halogen atom, a redox system comprising 1-benzyl-5-phenylbarbituric acid, copper acetylacetonate and benzyldibutylammonium chloride is particularly preferred. The polymerization in the 2-component prosthesis base material is particularly preferably started via a barbituric acid derivative.

In principle, suitable initiators for the polymerization reaction of cold- or autopolymerizing starting mixtures are those with which free-radical polymerization reactions can be started. Preferred initiators are peroxides and azo compounds such as the following: LPO: dilauroyl peroxide, BPO: Dibenzoyl peroxide, t-BPEH: tert-butyl per-2-ethylhexanoate, AIBN: 2,2'-azobis-(isobutyronitrile), DTBP: di-tert-butyl peroxide.

Suitable activators, e.g. As aromatic amines are added. Examples of suitable amines which may be mentioned are N,N-dimethyl-p-toluidine, N,N-dihydroxyethyl-p-toluidine and diethyl p-dibenzylaminobenzoate. Here, the amines regularly function as co-initiators and are usually present in an amount of up to 0.5% by weight.

The following exemplary embodiments are intended to illustrate the invention without restricting the invention to these examples.

Examples:

methods

Production of the composite pastes: The monomers, reactive diluents, initiators, additives and fillers are weighed out and homogenized with the aid of a speed mixer (Hauschild—DAC 600.1 FVZ) at 1500 ^rpm at normal pressure for 5 minutes. The fillers are weighed into the monomer mixture one after the other and the mixture is again homogenized in a speed mixer at 1500 ^rpm for 5 minutes under normal pressure. The composite is then homogenized again using a three-roll mill. The composite is again degassed in a speed mixer at 700 min ^-1 for 5 min in a vacuum.

Determination of the flexural strength and the modulus of elasticity: The production of the bending rods and the determination of the flexural strength and the modulus of elasticity (E modulus) are carried out according to DIN EN ISO 4049:2019, 7.11 on a test specimen with the dimensions 25 +/- 2 mm x 2.0 +/- 0.1 mm x 2.0 +/- 0.1 mm, the specimens are stored in water at 37 °C until the start of the measurement (light source: Kulzer, Translux Wave, with blue light (emission maximum approx. 440 to 460 nm), 700 mW/cm ² , 20 s). 24 hours after irradiation, the test specimen is loaded at a crosshead speed of 0.75 +/- 0.25 mm/min or with an increase in load of 50 +/- 16 N/min up to the yield point or until fracture.

Determination of the depth of cure: The depth of cure/depth of polymerisation is determined in accordance with DIN EN ISO 4049:2019, 7.10 (light source: Translux 2Wave, 1200 mW/cm ² , 20 s), cylindrical specimen greater than 6 mm in length, diameter 4 mm. If the If the depth of polymerisation is more than 3 mm, the specimen was at least 2 mm longer than the double specified polymerisation depth. The value of the depth of polymerisation given in this document therefore corresponds to the absolute value of the depth of polymerisation divided by two.

Determination of Transparency: Circular test specimens with a diameter of 20 mm and a thickness of 1 mm are produced from the composite paste by means of photopolymerization (light source: Kulzer, Translux Wave, 700 mW/cm ² ). The colorimetric measurement of the test specimens is carried out using the Datacolor SF 800 device, with the test specimens being transparent against a black background.

Determination of the polymerization shrinkage using the Watts or Bonded Disk method:

The composite is applied to a slide glass between a 1 mm high spacer ring and covered with a cover glass. The material sample wets the underside of the coverslip. The material sample is now irradiated from the underside using a light source (Kulzer Translux 2Wave, 1200 mW/cm ² , 20s) and the deflection of the cover slip is determined using a laser from the top (Lit. Determination of polymerization shrinkage kinetics in visible-light -cured materials: methods development; DC Watts et al, Dental Materials, Oct. 1991, 281 ff).

Determination of the double bond conversion U: The double bond conversion U is determined using ATR-IR. A material sample is applied in a 2mm deep cylindrical form. The composite-filled cylindrical mold is placed on an ATR crystal, which is now on the underside of the material sample. An IR spectrum (wavelength range: 4000 cm ^-1 - 700 cm ^-1 ) is recorded. The composite is then covered on the upper side with a transparent film, irradiated using a light source (light source: Translux 2Wave, 1200 mW/cm ² , 20 s) and another IR spectrum is recorded 10 minutes after the end of the photopolymerization. The quotient of the integral of the -C=C- double bond signal (-1645 cm ^-1 ) before and after photopolymerization gives the residual double bond content, from which the double bond conversion L/ is determined in %. Method Determination of particle sizes: The particle sizes can be determined using established testing methods, preferably using laser diffraction (DLS), SOP, MALVERN Mastersizer 2000. Other methods familiar to the person skilled in the art are defined in the standards ISO 22412:2017 Particle Size Analysis - Dynamic Light Scattering (DLS) or ISO 13320:2020 Particle Size Analysis - Laser Diffraction Methods. In addition, the particle sizes can be determined batchwise using DLS with the Zeta Sizer Advanced Range devices (0.3 nm to 15 microns) or continuously in an in-process control using the Zetasizer AT (0.3 nm to 10 microns) from Malvernpananalytical. D10, D50, D90 can also be determined using these methods. Viscosity: The viscosity is preferably measured according to DIN 1342-2;2003-11 Newtonian liquids or DIN 1342-3;2003-11 non-Newtonian liquids with a rheometer (Anton Par, physicist NCR 301, viscosity ranges 200-3000 m-Pas at 100 /s 23 °C). examples

Notational in the following examples: VG: comparative example

For the present disclosure, the following dental composites were prepared and cured by means of photoinitiation (light source: Translux Wave (Kulzer), 1000 mW/cm ²

20s):

Table 1a: Composite formulations with a filler content of 68% by weight in the overall composition. Table 1b: Composite formulations with a filler content of 68% by weight in the overall composition.

Table 1c: Composite formulations with a filler content of 68% by weight in the overall composition.

Table 1d: Composite formulations with a filler content of 68% by weight in the overall composition. Table 2: Composite formulations with varying proportions of fillers from 30 to 75% by weight in the overall composition.

Table 3a: Compositions - crosslinkers with different filler contents. Table 3b: Properties of crosslinkers with different filler contents.

Table 4a: Comparative examples VG1 to VG5 with crosslinker: Bis-GMA

Table 4b: Comparative Examples VG1 to VG5

Table 5a: Examples according to the invention with monomers no. 1 and no. 2 as crosslinkers Table 5b: Examples according to the invention Table 6: VG 1 to 5, examples 6 to 10 with thinner 6

Table 7: VG 1 to 5, examples of crosslinkers 1+2 and thinner TEGDMA

Claims

patent claims

A polymerizable composition comprising

(i) 0.01 to 90% by weight of at least one inorganic filler component,

(ii) 5 to 99.97% by weight comprising at least two urethane acrylates, one urethane acrylate being at least one urethane acrylate of the formula I with a divalent hydrocarbon group with A = O if B = NH or A = NH if B = O,

R ¹ = H or CH ₃ , R ² = H or CH ₃ ,

R ⁵ and R ⁶ are each independently selected from C2 to C6 linear alkylene groups or C2 to C6 linear oxyalkylene groups, with R ⁵ and R ⁶ optionally each independently having a C1-C3 alkyl group or (met)acryloxymethylene group , and

R ⁸ is a bivalent hydrocarbon group with 6 to 12 carbon atoms, and the second urethane acrylate has at least one bifunctional thiol urethane group and at least one olefinic group, and/or mixtures of urethane acrylates comprising these,

(iii) 0.01 to 25% by weight comprising at least one di-, tri-, tetra- or multi-functional monomer having at least one ether group, thioether group, an at least tri-functional triester and/or a di- functional diester, where the diester is selected from tricyclodecanedimethanol dimethacrylate and tricyclodecanedimethanol diacrylate or mixtures comprising at least two of these di-, tri-, tetra- or multi-functional monomers,

(iv) 0.01 to 10% by weight of at least one initiator, an initiator system, optionally at least one stabilizer and optionally at least one pigment and optionally further additives, the total composition of the polymerizable composition being 100% by weight.

2. Polymerizable composition according to claim 1, characterized in that the second urethane acrylate having at least one bifunctional thiolurethane group and having at least one olefinic group has a structure of the general formula V,

R ¹⁴ (-S-(C=0)-NH-R ¹³ ) _w , with w = 1 to 10

V where R ¹⁴ is a group comprising at least mono- to deca-functional ester, ether or thioether and R ¹³ is a group each independently selected from groups containing at least one olefinic group.

3. Polymerizable composition according to claim 2, characterized in that the formula V as R ¹⁴ has one of the following structures of the formulas Via to VIg

15 with R ⁷ in formula Via to Vlg each independently selected from each R ⁸ is independently a divalent hydrocarbon group having 6 to 12 carbon atoms, each R ¹⁰ is independently selected from linear C2 to C6 alkylene groups or linear C2 to C6 oxyalkylene groups, where R ¹⁰ is optionally each independently has a C1-C3 alkyl group or (met)acryloxymethylene group and with R ¹⁵ each independently H or C1 to C4 alkyl.

4. Polymerizable composition according to any one of claims 1 to 3, characterized in that the urethane acrylate of the general formula I and / or the formula V each independently with R ⁸ and / or comprises divalent aromatic hydrocarbon having 6 to 12 carbon atoms, divalent alicyclic Hydrocarbon with 6 to 12 carbon atoms or bivalent linear or branched alkylene with 6 to 12 carbon atoms or bivalent linear or branched alkylene with an aromatic or alicyclic group.

5. Polymerizable composition according to any one of claims 1 to 4, characterized in that it comprises at least one urethane acrylate of the general formula I with A = O when B = NH or A = NH when B = O and with R ¹ = H or CH ₃ , R ² = H or CH ₃ , and R ⁵ and R ⁶ are each independently selected from C2 to C6 linear alkylene groups or C2 to C6 linear oxyalkylene groups, with R ⁵ and R ⁶ optionally each independently being a C1-C3 alkyl group or (met)acryloxymethylene group have, and R ⁸ comprises one of the following divalent groups

6. Polymerizable composition according to any one of claims 1 to 5, characterized in that it comprises (iii) at least one di-, tri-, tetra- or multi-functional monomer having at least one ether group of the formula III, thioether group of Formula IV and/or an at least tri- or tetra-functional triester of the formula II or mixtures of at least two of the monomers, in particular comprising at least one monomer of the formulas IIa, Mb, IIc, III, IVa, IVb, IVc, IVd or mixtures comprising at least two of the monomers,

_CH2 =C(CH3)C00(CH2CH20) _V COC( _CH3 )=CH2 III with v = 3 to 20, v = 3 to 15, v = 3 to 8 5 with each independently R ⁴ =

with each independently R ⁹ = H or CH ₃ , and with R ³ = till 8.

7. Composition according to any one of claims 1 to 6, characterized in that it comprises

(i) 5 to 90% by weight of an inorganic filler component comprising at least one glass, silicate, metal oxide, mixed oxide, silicon dioxide, zirconium dioxide, zinc oxide and/or mixtures of at least two of the components mentioned, the components having an average particle size of 0.2 μm to 10 mhi, and optionally at least one amorphous metal oxide with an average primary particle size of 10 nm to 115 nm, and

(ii) 10 to 85% by weight of at least two urethane acrylates, the urethane acrylates comprising at least one urethane acrylate of the formula I and at least one second urethane acrylate having at least one bifunctional thiolurethane group and at least one olefinic group,

(iii) 0.01 to 25% by weight of at least one di-, tri-, tetra- or multi-functional monomer having at least one ether group, thioether group and/or an at least tri-functional triester and/or one difunctional diester, where the diester is selected from tricyclodecanedimethanol dimethacrylate and tricyclodecanedimethanol diacrylate or mixtures of at least two of these di-, tri-, tetra- or multi-functional monomers,

8. Composition according to any one of claims 1 to 7, characterized in that it comprises

(i) 40 to 90% by weight of an inorganic filler component comprising at least one glass, silicate, quartz, feldspar, metal oxide, mixed oxide,

Silicon dioxide, zirconium dioxide and/or zinc oxide with an average particle size of 0.4 μm to 10 mhi, and optionally at least one amorphous metal oxide with an average primary particle size of 10 nm to 115 nm, and

(ii) 10 to 59.98% by weight of at least two urethane acrylates, the urethane acrylates comprising at least one urethane acrylate of the formula I and at least one second urethane acrylate having at least one bifunctional thiolurethane group and at least one olefinic group,

(iii) 0.01 to 15% by weight of at least one di-, tri-, tetra- or multi-functional monomer having at least one ether group, thioether group and/or an at least tri-functional triester and/or one difunctional diester, where the diester is selected from tricyclodecanedimethanol dimethacrylate and tricyclodecanedimethanol diacrylate or mixtures of these di-, tri-, tetra- or multifunctional monomers,

9. The composition as claimed in any of claims 1 to 8, characterized in that it comprises, as the urethane acrylate of the formula I, at least one compound of the formulas Ic to Io and/or mixtures of these and optionally mixtures of isomers of these

10. The composition as claimed in any of claims 1 to 9, characterized in that it comprises inorganic filler components as (i).

(1.1) 0.005 to 85% by weight of at least one glass, silicate, quartz, feldspar, metal oxide mixed oxide, silicon dioxide, zirconium dioxide or a mixture comprising at least two of these filler components, and optionally

(1.2) 0.005 to 5% by weight of amorphous metal oxide, in particular fumed silica and/or precipitated silica, with respect to the total composition of the composition of 100% by weight.

11. The composition according to any one of claims 1 to 10, characterized in that it comprises at least two urethane acrylates comprising at least one urethane acrylate of the formula I and at least one second urethane acrylate having at least one bifunctional thiolurethane group and at least one olefinic group in a mass ratio of 1 : 1 to 100 : 1.

12. A polymerized composition comprising

- 0.01 to 90% by weight of at least one inorganic filler component,

- 5 to 99.98% by weight of at least one polymer based on the polymerization of at least monomers and/or prepolymers and mixtures thereof

- At least two urethane acrylates, at least one urethane acrylate of the formula I having a bivalent hydrocarbon group with A = O if B = NH or A = NH if B = O and with R ¹ = H or CH ₃ , R ² = H or CH ₃ ,

R ⁵ and R ⁶ are each independently selected from linear C2 to C6 alkylene groups or linear C2 to C6 oxyalkylene groups, where R ⁵ and R ⁶ optionally each independently have a C1-C3-alkyl group or (met)acryloxymethylene group, preferably CH ₃ and

R ⁸ is a bivalent hydrocarbon group having 6 to 12 carbon atoms, and the second urethane acrylate has at least one bifunctional thiolurethane group and at least one olefinic group, and/or mixtures of urethane acrylates comprising these, and

- At least one di-, tri-, tetra- or multifunctional monomer having at least one ether group, thioether group, an at least trifunctional triester and/or a difunctional diester, the diester being selected from tricyclodecanedimethanol dimethacrylate and tricyclodecanedimethanol diacrylate or

Mixtures of at least two of the di-, tri-, tetra- or multi-functional monomers, and

- 0 to 10% by weight of at least one pigment, the total composition of the polymerized composition being 100% by weight.

13. Polymerized composition according to claim 12, characterized in that the polymerized composition is in the form of a block of material, in particular the block of material is in the form of a three-dimensional geometric shaped body, in particular as a milling blank without an adapter or as a milling blank with an adapter for fixing in an automated material-removing device .

14. The composition according to any one of claims 1 to 11 for use as a dental material, in particular as a fissure sealant, dental composite material, direct adhesive dental restoration, as a hoof repair material, as bone cement, or as bone cement for cementing artificial joint prostheses.

15. Use of a polymerizable composition according to any one of claims 1 to 11 in additive manufacturing processes, in radiation-based generative manufacturing processes, in a stereolithography process, SLA process (laser-based stereolithography process), a DLP process (digital light processing) or a SLA and DLP processes, in additive manufacturing processes based on LED projectors, in radiation and thermal-based additive manufacturing processes, in thermal additive manufacturing processes, in 3D Printing processes, Multitjet processes (MJM) or Polyjet processes, in radiation-based polymerization processes, in particular UV and/or VIS polymerization processes, radically induced polymerization processes, thermally based polymerization processes and/or redox-based polymerization processes.

16. Use according to claim 15 or use of a polymerized composition according to claim 12 or 13 for the production of dental prosthetic supplies comprising crowns, inlays, onlays, superstructures, artificial teeth, dental bridges, dental bars, spacers, abutments, veneers or for the production of a bite splint, Milling blanks, dental prosthesis, part of a surgical prosthesis, drilling template, implant, mouthguard, joint prosthesis, telescope, implant part, orthodontic appliance, instrument or hoof part.