EP4302620A1 - Inhalateur d'arôme de type à chauffage sans combustion, et cartouche - Google Patents

Inhalateur d'arôme de type à chauffage sans combustion, et cartouche Download PDF

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Publication number
EP4302620A1
EP4302620A1 EP21929010.3A EP21929010A EP4302620A1 EP 4302620 A1 EP4302620 A1 EP 4302620A1 EP 21929010 A EP21929010 A EP 21929010A EP 4302620 A1 EP4302620 A1 EP 4302620A1
Authority
EP
European Patent Office
Prior art keywords
aerosol
combustion heating
source
flavor inhaler
flavor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21929010.3A
Other languages
German (de)
English (en)
Inventor
Hirokazu Ichitsubo
Atsuya SHIRAI
Hisashi NISHIDA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Tobacco Inc
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of EP4302620A1 publication Critical patent/EP4302620A1/fr
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
    • A24B15/32—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances by acyclic compounds
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/10—Devices using liquid inhalable precursors
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/40—Constructional details, e.g. connection of cartridges and battery parts

Definitions

  • the present invention relates to a non-combustion heating flavor inhaler and a cartridge.
  • Non-combustion heating flavor inhaler that atomizes an aerosol source, without involving combustion, through heating by electric power supplied from a power source, passes the resulting aerosol through a tobacco source containing a tobacco-derived component to allow the tobacco-derived component to migrate into the aerosol, and supplies the tobacco-derived component to a user
  • PTL Patent Literature
  • Such a non-combustion heating flavor inhaler may be equipped with, for example, a cartridge that includes an aerosol source and an atomizing means for atomizing the aerosol source through heating; a power source unit for supplying electric power to the atomizing means; and a flavor-imparting cartridge that includes a tobacco source and that is disposed downstream of the cartridge.
  • the aerosol source may contain a flavor component, such as menthol.
  • a non-combustion heating flavor inhaler which does not include a flavor-imparting cartridge but includes an aerosol source containing a tobacco-derived component instead.
  • a tobacco-derived component, such as nicotine, or a flavor component, such as menthol, contained in an aerosol is deposited in the mouthpiece and lost in some cases.
  • a non-combustion heating flavor inhaler includes a flavor-imparting cartridge
  • the tobacco-derived component or the flavor component that has migrated into an aerosol is also deposited within the flavor-imparting cartridge and lost in some cases.
  • the object of the present invention is to provide a non-combustion heating flavor inhaler with reduced loss of a flavor component within the aerosol channel and a cartridge used for the non-combustion heating flavor inhaler.
  • the present invention encompasses the following embodiments.
  • a non-combustion heating flavor inhaler includes: an aerosol source containing a compound represented by formula (1) below; and an atomizing means for generating an aerosol through atomization of the aerosol source.
  • R 1 , R 2 , and R 3 are each independently an alkyl group of 3 to 6 carbon atoms.
  • the compound represented by formula (1) migrates into an aerosol when the aerosol is generated through atomization of the aerosol source.
  • the compound represented by formula (1) has a high boiling point.
  • aerosol particles are not readily vaporized and are thus stabilized.
  • the compound represented by formula (1) exhibits high solubility of a tobacco-derived component, such as nicotine, or a flavor component, such as menthol. Accordingly, it is possible to incorporate more tobacco-derived component or flavor component mentioned above into aerosol particles by containing the compound represented by formula (1) in the aerosol particles. Further, the tobacco-derived component or the flavor component becomes not readily released outside the aerosol particles. For these reasons, it is considered that the loss of a flavor component within the aerosol channel is reduced in the non-combustion heating flavor inhaler according to the present embodiment.
  • the non-combustion heating flavor inhaler according to the present embodiment is not particularly limited provided that an aerosol source containing the compound represented by formula (1) and an atomizing means for generating an aerosol through atomization of the aerosol source are included but may include other constituent parts excluding the aerosol source and the atomizing means. Examples of other constituent parts include a tobacco source that contains a tobacco-derived component and that is disposed downstream of the aerosol source.
  • An aerosol source contains the compound represented by formula (1).
  • R 1 , R 2 , and R 3 are each independently an alkyl group of 3 to 6 carbon atoms.
  • R 1 , R 2 , and R 3 are alkyl groups of 3 or more carbon atoms, the compound represented by formula (1) has a high boiling point and thus stabilizes aerosol particles.
  • R 1 , R 2 , and R 3 are alkyl groups of 6 or less carbon atoms, it is possible to lower the temperature necessary for vaporizing the compound represented by formula (1) as well as the temperature when atomizing an aerosol source.
  • R 1 , R 2 , and R 3 are preferably each independently an alkyl group of 4 to 6 carbon atoms.
  • the compound represented by formula (1) is preferably tributyl citrate (TBC).
  • TBC tributyl citrate
  • the aerosol source may contain one or two or more of the compound represented by formula (1).
  • the content of the compound represented by formula (1) in the aerosol source is preferably 5 to 70 mass% relative to 100 mass% of the aerosol source.
  • the content is more preferably 5 to 60 mass% and further preferably 10 to 50 mass%.
  • the aerosol source preferably further contains triethyl citrate (TEC) in addition to the compound represented by formula (1).
  • TEC triethyl citrate
  • the compound represented by formula (1) can develop the fullness of body and persistence of a tobacco-derived component, such as nicotine, during use, whereas triethyl citrate can reduce discomfort, such as irritation, due to the tobacco-derived component.
  • the compound represented by formula (1) can develop the fullness of body and persistence of a flavor component, such as menthol, during use, whereas triethyl citrate can develop an advantage of the flavor component, such as brightness. Accordingly, by using these in combination, it is possible to further enhance the sensation based on the tobacco-derived component and the flavor component during use.
  • the aerosol source contains triethyl citrate alone but not the compound represented by formula (1), the effect of the present embodiment cannot be obtained.
  • the content of triethyl citrate in the aerosol source is preferably 3 to 50 mass%, more preferably 5 to 40 mass%, and further preferably 10 to 30 mass% relative to 100 mass% of the aerosol source from the standpoint of being able to obtain the above-mentioned effect satisfactorily.
  • the content ratio of the compound represented by formula (1) to triethyl citrate is preferably 50 to 90:10 to 50, more preferably 50 to 70:30 to 50, and further preferably 50 to 60:40 to 50.
  • the aerosol source may contain an aerosol former.
  • Such an aerosol former is atomized by heating to generate an aerosol.
  • the aerosol former is not particularly limited provided that an aerosol can be generated through atomization by heating and may be selected from substances extracted from various natural products and the constituents thereof.
  • Exemplary aerosol formers include triacetin and polyhydric alcohols, such as glycerol (G), propylene glycol (PG), 1,3-butanediol, sorbitol, xylitol, and erythritol. These aerosol formers may be used alone or in combination of two or more.
  • an aerosol former is preferably at least either propylene glycol or glycerol from the standpoint of exhibiting higher solubility of a tobacco-derived component, such as nicotine, or a flavor component, such as menthol and thus being able to hold the tobacco-derived component or the flavor component more within aerosol particles.
  • the content of aerosol former in the aerosol source is preferably 30 to 95 mass%, more preferably 40 to 90 mass%, and further preferably 45 to 75 mass% relative to 100 mass% of the aerosol source from the standpoint of being able to satisfactorily ensure the amount of aerosol to be generated and thus to deliver the tobacco-derived component or the flavor component sufficiently.
  • the aerosol source preferably further contains at least one selected from the group consisting of nicotine, nicotine salts, and flavor components.
  • the aerosol source contains nicotine, a nicotine salt, and/or a flavor component, these components are incorporated into an aerosol during generation of the aerosol. Since the aerosol contains the compound represented by formula (1), aerosol particles are stabilized and thus do not readily release these components outside. Consequently, the loss of these components within the aerosol channel is reduced further.
  • Nicotine and a nicotine salt may be a liquid containing both nicotine and a nicotine salt.
  • exemplary nicotine salts include nicotine salts formed by mixing nicotine with citric acid, tartaric acid, malic acid, levulinic acid, or benzoic acid, for example.
  • the aerosol source contains nicotine and/or a nicotine salt
  • the content of nicotine and/or nicotine salt in the aerosol source is preferably 1 to 15 mass%, more preferably 2 to 10 mass%, and further preferably 3 to 5 mass% relative to 100 mass% of the aerosol source.
  • Flavor components are not particularly limited, and examples include terpenes, such as menthol and linalool; aromatic aldehydes, such as furfural; and other aldehydes, such as nonanal. These flavor components may be used alone or in combination of two or more.
  • the content of flavor component in the aerosol source is preferably 1 to 15 mass%, more preferably 2 to 10 mass%, and further preferably 3 to 5 mass% relative to 100 mass% of the aerosol source.
  • An aerosol source according to the present embodiment may contain other components, such as water, in addition to the above-described respective components.
  • the aerosol source may be disposed, for example, within a cartridge described hereinafter.
  • the compound represented by formula (1) need to be contained in an aerosol source.
  • the compound represented by formula (1) when the compound represented by formula (1) is contained in a tobacco source that is disposed downstream of an aerosol source, the compound represented by formula (1) does not satisfactorily migrate into an aerosol. Consequently, the effect of the present embodiment cannot be obtained.
  • the non-combustion heating flavor inhaler includes an atomizing means for generating an aerosol through atomization of the aerosol source.
  • the atomizing means is not particularly limited provided that an aerosol can be generated through atomization of the aerosol source and may be an atomizing means by heating, for example. Concrete examples include heating resistors, such as heating wires, which generate heat by electric power supplied from a power source described hereinafter.
  • the atomizing means may be disposed, for example, within a cartridge described hereinafter.
  • the non-combustion heating flavor inhaler according to the present embodiment may further include a tobacco source that contains a tobacco-derived component and that is disposed downstream of the aerosol source.
  • a tobacco-derived component contained in the tobacco source migrates into the aerosol and is supplied to a user.
  • Exemplary tobacco-derived components include nicotine.
  • the non-combustion heating flavor inhaler according to the present embodiment need not necessarily include a tobacco source, and an aerosol source may contain a tobacco-derived component in this case.
  • a tobacco-derived component may be incorporated into an aerosol source, for example, by immersing a tobacco source in an aerosol source, by mixing an aerosol source with a liquid tobacco-derived component extracted from a tobacco source, or by mixing an aerosol source with a tobacco-derived component obtained through chemical synthesis.
  • the tobacco source may contain raw material pieces that impart a tobacco-derived component to an aerosol generated through atomization of an aerosol source.
  • a raw material piece has a size of preferably 0.2 to 1.2 mm and more preferably 0.2 to 0.7 mm.
  • a raw material piece of smaller size has a larger specific surface area, and hence, readily releases a tobacco-derived component therefrom. Consequently, it is possible to reduce the amount of raw material pieces for imparting a desirable amount of tobacco-derived component to an aerosol.
  • Exemplary raw material pieces include shredded tobacco, tobacco raw material formed into granules, and tobacco raw material formed into a sheet.
  • Such raw material pieces are obtained, for example, by sieving in accordance with JIS Z 8815 using a stainless steel sieve based on JIS Z 8801.
  • raw material pieces are subjected to sieving using a stainless steel sieve having openings of 0.71 mm by a dry mechanical shaking process for 20 minutes to obtain raw material pieces that have passed through the stainless steel sieve having openings of 0.71 mm.
  • the resulting raw material pieces are subjected to sieving using a stainless steel sieve having openings of 0.212 mm by a dry mechanical shaking process for 20 minutes to remove raw material pieces that have passed through the stainless steel sieve having openings of 0.212 mm.
  • the upper limit of the size of raw material pieces is defined by the openings of a stainless steel sieve specifying the upper limit
  • the lower limit of the size of raw material pieces is defined by the openings of a stainless steel sieve specifying the lower limit.
  • the tobacco source may contain a flavor component in addition to a tobacco-derived component.
  • the raw material pieces may contain a flavor component in addition to a tobacco-derived component.
  • Exemplary flavor components include the above-described flavor components, and menthol is preferably contained.
  • the raw material pieces may also contain plants excluding tobacco, such as mint or other herbs.
  • the tobacco source may be disposed, for example, within a flavor-imparting cartridge provided downstream of a cartridge as described hereinafter.
  • a cartridge according to the present embodiment includes an aerosol source containing the compound represented by formula (1).
  • the cartridge is detachably mounted on a non-combustion heating flavor inhaler.
  • the cartridge may include an atomizing means for generating an aerosol through atomization of the aerosol source.
  • FIG. 1 illustrates an exemplary non-combustion heating flavor inhaler according to the present embodiment.
  • a non-combustion heating flavor inhaler 100 illustrated in Fig. 1 is an apparatus for inhaling a flavor component without involving combustion and has a shape extending in a predetermined direction A, which is a direction from a non-mouth end toward a mouth end.
  • Fig. 2 illustrates a cartridge 111 into which a flavor-imparting cartridge 130 has been inserted in Fig. 1 .
  • the non-combustion heating flavor inhaler 100 is simply referred to as flavor inhaler 100 in some cases.
  • the flavor inhaler 100 includes an inhaler body 110 and a flavor-imparting cartridge 130 provided with a tobacco source.
  • the inhaler body 110 constitutes the body of the flavor inhaler 100 and has a shape connectable with the flavor-imparting cartridge 130.
  • the inhaler body 110 includes an inhaler housing 110X, and the flavor-imparting cartridge 130 is connected with the mouth end of the inhaler housing 1 10X.
  • the inhaler body 110 includes: a cartridge 111 provided with an atomizing means and an aerosol source according to the present embodiment; and a power source unit 112, which are configured to atomize the aerosol source without involving combustion.
  • the cartridge 111 includes a first tube 111X, which constitutes a part of the inhaler housing 110X. As illustrated in Fig. 2 , the cartridge 111 includes a reservoir 111P, a wick 111Q, and an atomizing means 111R. The reservoir 111P, the wick 111Q, and the atomizing means 111R are held within the first tube 111X.
  • the first tube 111X has a tubular shape (cylindrical shape, for example) extending in the predetermined direction A.
  • the reservoir 111P holds an aerosol source according to the present embodiment.
  • the reservoir 111P is a porous body of a resin web or other materials.
  • the wick 111Q is an exemplary liquid holding member for holding an aerosol source supplied from the reservoir 111P.
  • the wick 111Q includes glass fibers.
  • the atomizing means 111R atomizes an aerosol source held by the wick 111Q.
  • the atomizing means 111R may include a heating resistor (heating wire, for example) wound around the wick 111Q at a predetermined pitch.
  • an absorber member 111S for absorbing a condensed aerosol is provided on the walls exposed to the channel of an aerosol generated by the atomizing means 111R.
  • the walls exposed to the aerosol channel are, for example, the inner surface of the first tube 111X exposed to the aerosol channel and the outer surface of the reservoir 111P exposed to the aerosol channel.
  • an aerosol (condensed aerosol) absorbed by the absorber member 111S is preferably guided therefrom to the atomizing means 111R by capillary action.
  • the absorber member 111S may be any member that acts to absorb a condensed aerosol and may include the same material as the reservoir 111P (resin web) or the same material as the wick 111Q (glass fibers), for example.
  • the power source unit 112 includes a second tube 112X, which constitutes a part of the inhaler housing 110X.
  • the power source unit 112 has an inlet 112A. As illustrated in Fig. 2 , the air that enters from the inlet 112A is guided to the cartridge 111 (atomizing means 111R). More specifically, the power source unit 112 includes a power source 10, an inhalation sensor 20, a push button 30, a light emitting element 40, and a control circuit 50.
  • the power source 10, the inhalation sensor 20, the push button 30, and the control circuit 50 are held within the second tube 112X.
  • the second tube 112X has a tubular shape (cylindrical shape, for example) extending in the predetermined direction A.
  • the power source 10 is a lithium-ion battery, for example.
  • the power source accumulates electric power necessary for the operation of the flavor inhaler 100.
  • the power source accumulates electric power to be supplied to the inhalation sensor 20 and the control circuit 50.
  • the power source 10 accumulates electric power to be supplied to the cartridge 111 (atomizing means 111R).
  • the inhalation sensor 20 detects a fluid flow within the inhalation channel continuous from the inlet 112A to the outlet 130A.
  • the inhalation sensor 20 detects inhalation (inhaling state) when a fluid flow from the inlet 112A toward the outlet 130A is equal to or more than a predetermined threshold. Meanwhile, the inhalation sensor 20 detects non-inhalation (non-inhaling state) when a fluid flow from the inlet 112A toward the outlet 130A is less than the predetermined threshold.
  • the push button 30 is configured to be pushed from the outside toward the inside of the flavor inhaler 100.
  • the push button 30 is provided at the non-mouth end of the flavor inhaler 100 and is configured to be pushed in the direction from the non-mouth end toward the mouth end (in other words, the predetermined direction A).
  • the power source of the flavor inhaler 100 may be turned off by continuously pushing the push button 30 a predetermined number of times.
  • the power source of the flavor inhaler 100 may be turned off by continuously pushing the push button 30 a predetermined number of times.
  • the power source of the flavor inhaler 100 may be turned off.
  • the power source of the flavor inhaler 100 may be turned off.
  • the light emitting element 40 is, for example, a light source, such as a LED or an electric light.
  • the light emitting element 40 is provided on the sidewall extending in the predetermined direction.
  • the light emitting element 40 is preferably provided on the sidewall near the non-mouth end. Consequently, a user can easily see the lighting pattern of the light emitting element 40 during puffing actions as compared with the case in which a light emitting element is provided solely on the end face at the non-mouth end on the axis of the predetermined direction A.
  • the lighting pattern of the light emitting element 40 is a pattern that informs a user of the state of the flavor inhaler 100.
  • the light emitting element 40 may constitute a reporting section for reporting that a desirable amount of aerosol can be supplied.
  • the light emitting element 40 may intermittently report, throughout the period in which a desirable amount of aerosol can be supplied, that a desirable amount of aerosol can be supplied.
  • the light emitting element 40 may constitute a reporting section for reporting that a desirable amount of aerosol cannot be supplied.
  • the light emitting element 40 may intermittently report, throughout the period in which a desirable amount of aerosol cannot be supplied, that a desirable amount of aerosol cannot be supplied.
  • the control circuit 50 controls the operation of the flavor inhaler 100. Specifically, the control circuit 50 regulates power output for the cartridge 111 (atomizing means 111R). Moreover, the control circuit 50 controls the light emitting element 40.
  • the flavor-imparting cartridge 130 is configured to be connectable with the inhaler body 110, which constitutes the flavor inhaler 100.
  • the flavor-imparting cartridge 130 is provided downstream of the cartridge 1 1 1 on the channel of a gas (hereinafter, air) inhaled at the mouthpiece.
  • the flavor-imparting cartridge 130 need not necessarily be provided on the mouth side of the cartridge 111 physically or spatially and may be provided downstream of the cartridge 111 on the aerosol channel that guides an aerosol generated from the cartridge 111 to the mouth side.
  • the flavor-imparting cartridge 130 includes a flavor-imparting cartridge housing 131, a tobacco source 132, a mesh 133A, and a filter 133B. Moreover, the flavor-imparting cartridge 130 has an outlet 130A provided at the mouthpiece.
  • the flavor-imparting cartridge housing 131 has a tubular shape (cylindrical shape, for example) extending in the predetermined direction A.
  • the flavor-imparting cartridge housing 131 holds the tobacco source 132 inside.
  • the flavor-imparting cartridge housing 131 is configured to be inserted into the inhaler housing 110X in the predetermined direction A.
  • the tobacco source 132 is provided on the outlet 130A (mouth) side of the cartridge 111 on the inhalation channel continuous from the inlet 112A to the outlet 130A.
  • the tobacco source 132 imparts a tobacco-derived component to an aerosol generated from an aerosol source.
  • a tobacco-derived component imparted to an aerosol by the tobacco source 132 is conveyed to the outlet 130A (mouthpiece).
  • the above-described tobacco source according to the present embodiment may be used as the tobacco source 132.
  • the mesh 133A is provided to cover the opening of the flavor-imparting cartridge housing 131 upstream of the tobacco source 132.
  • the filter 133B is provided to cover the opening of the flavor-imparting cartridge housing 131 downstream of the tobacco source 132.
  • the mesh 133A has the coarseness that does not allow raw material pieces of the tobacco source 132 to pass therethrough.
  • the mesh 133A has the coarseness or openings of 0.077 to 0.198 mm, for example.
  • the filter 133B is formed from an air-permeable substance.
  • the filter 133B is preferably an acetate filter, for example.
  • the filter 133B has the coarseness that does not allow raw material pieces of the tobacco source 132 to pass therethrough.
  • the mouth end of a non-combustion heating flavor inhaler was inserted into a filter holder in which a filter for trapping components had been set, and the downstream portion of the filter holder was connected with a smoking machine.
  • a smoking machine Through inhalation by the smoking machine, an aerosol released from the non-combustion heating flavor inhaler was collected inside the filter holder.
  • the inhalation under conditions of 55 cc/puff for 3 seconds was repeated five times at an interval of 30 seconds to collect aerosols for five puffs inside the filter holder.
  • the filter was removed from the filter holder, and components were subjected to shaking extraction with methanol to quantify the amounts of nicotine and/or menthol by GC.
  • a non-combustion heating flavor inhaler having the structure illustrated in Fig. 1 was prepared.
  • As an aerosol source a solution containing 45.0 mass% of propylene glycol (PG), 45.0 mass% of glycerol (G), and 10.0 mass% of tributyl citrate (TBC) was used.
  • As a tobacco source a tobacco source containing a tobacco-derived component, such as nicotine, but not menthol (M) was used.
  • the amount of nicotine delivered during use was measured by the above-described method. The result is shown in Fig. 3 .
  • Each non-combustion heating flavor inhaler was prepared in the same manner as Example 1 except for using, as an aerosol source, an aerosol source having the composition shown in Table 1, and the amount of nicotine delivered during use was measured similarly. The results are shown in Fig. 3 .
  • PG represents propylene glycol
  • G represents glycerol
  • TEC represents triethyl citrate
  • TBC represents tributyl citrate
  • M represents menthol.
  • Aerosol source Tobacco source PG mass%) G (mass%) TEC (mass%) TBC (mass%) M (mass%) M addition Comp.
  • Examples 1 and 2 in which the aerosol source was added with tributyl citrate, exhibited increases in the amount of nicotine delivered as compared with Comparative Example 1, in which the aerosol source did not contain tributyl citrate, and the amount delivered increased as the amount of tributyl citrate added increases. Moreover, from the results of Examples 3 and 4, in which glycerol was replaced by triethyl citrate and tributyl citrate, it was confirmed that the amount of nicotine delivered is comparable to or more than that of Example 2 by using triethyl citrate in combination even when the content of tributyl citrate is reduced.
  • Example 5 From the result in Example 5, it was confirmed that the amount of nicotine delivered increases slightly as compared with Comparative Example 1 even when tributyl citrate alone was used as an aerosol source. However, the amount of nicotine delivered is smaller than the amounts in Examples 2 to 4. This revealed that the amount of nicotine delivered increases further by adding the compound represented by formula (1), such as tributyl citrate, or by adding both the compound represented by formula (1) and triethyl citrate in the presence of an aerosol former, such as propylene glycol or glycerol.
  • an aerosol former such as propylene glycol or glycerol.
  • Example 2 reduced irritation due to nicotine, developed more satisfactory nicotine sensation over repeated passing through the throat, and further developed the fullness of body and persistence of nicotine, as compared with Comparative Example 1. Meanwhile, an odor peculiar to tributyl citrate and bitterness were slightly sensed.
  • the non-combustion heating flavor inhaler of Example 3 reduced irritation due to nicotine as compared with Comparative Example 1 but caused stronger irritation than Examples 2 and 4. Meanwhile, an odor peculiar to tributyl citrate and bitterness were reduced as compared with Example 2. It was confirmed that the non-combustion heating flavor inhaler of Example 4 reduced irritation due to nicotine and developed the fullness of body and persistence of nicotine, which are comparable to Example 2. Moreover, an odor peculiar to tributyl citrate and bitterness were reduced as compared with Example 2.
  • Each non-combustion heating flavor inhaler was prepared in the same manner as Example 1 except for using, as an aerosol source, an aerosol source having the composition shown in Table 1 and using, as a tobacco source, a tobacco source added with menthol (M), and the amounts of nicotine and menthol delivered during use were measured similarly. The results are shown in Figs. 4 and 5 .
  • Examples 6 and 7 in which the aerosol source was added with tributyl citrate, exhibited increases in the amount of nicotine delivered as compared with Comparative Example 2, in which the aerosol source did not contain tributyl citrate. Moreover, from the results of Examples 8 and 9, in which glycerol was replaced by triethyl citrate and tributyl citrate, it was confirmed that the amount of nicotine delivered is comparable to that of Example 7 by using triethyl citrate in combination even when the content of tributyl citrate is reduced. Further, as shown in Fig.
  • Examples 6 and 7 in which the aerosol source was added with tributyl citrate, exhibited significant increases in the amount of menthol delivered as compared with Comparative Example 2, in which the aerosol source did not contain tributyl citrate, and the amount delivered increased as the amount of tributyl citrate added increases.
  • Example 7 An odor peculiar to tributyl citrate and bitterness were reduced as compared with Example 7.
  • the non-combustion heating flavor inhaler of Example 9 further developed menthol sensation as compared with Examples 7 and 8 and developed the fullness of body and persistence of menthol and nicotine comparable to Example 7.
  • an odor peculiar to tributyl citrate and bitterness were reduced as compared with Example 7.
  • a non-combustion heating flavor inhaler the same as in Fig. 1 except for lacking the flavor-imparting cartridge 130 was prepared.
  • As an aerosol source a solution containing 43.0 mass% of propylene glycol (PG), 43.0 mass% of glycerol (G), 9.6 mass% of tributyl citrate (TBC), and 4.5 mass% of nicotine (NIC) was used.
  • PG propylene glycol
  • G glycerol
  • TBC 9.6 mass% of tributyl citrate
  • NIC 4.5 mass% of nicotine
  • Each non-combustion heating flavor inhaler was prepared in the same manner as Example 10 except for using, as an aerosol source, an aerosol source having the composition shown in Table 2, and the amount of nicotine delivered during use was measured similarly. The results are shown in Fig. 6 .
  • Aerosol source PG mass%) G (mass%) TEC (mass%) TBC (mass%) NIC (mass%) M (mass%) Comp.
  • Examples 10 and 11 in which the aerosol source was added with tributyl citrate, exhibited increases in the amount of nicotine delivered as compared with Comparative Example 3, in which the aerosol source did not contain tributyl citrate, and the amount delivered increased as the amount of tributyl citrate added increases.
  • Examples 12 and 13 in which glycerol was replaced by triethyl citrate and tributyl citrate, it was confirmed that the amount of nicotine delivered is equal to or more than Example 11 by using triethyl citrate in combination even when the content of tributyl citrate is reduced.
  • the addition of both the compound represented by formula (1) and triethyl citrate is preferable also in a non-combustion heating flavor inhaler which does not include a tobacco source but includes an aerosol source containing a tobacco-derived component instead.
  • Each non-combustion heating flavor inhaler was prepared in the same manner as Example 10 except for using, as an aerosol source, an aerosol source having the composition shown in Table 2, and the amount of menthol delivered during use was measured similarly. The results are shown in Fig. 7 .

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Manufacture Of Tobacco Products (AREA)
EP21929010.3A 2021-03-03 2021-03-03 Inhalateur d'arôme de type à chauffage sans combustion, et cartouche Pending EP4302620A1 (fr)

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PCT/JP2021/008098 WO2022185434A1 (fr) 2021-03-03 2021-03-03 Inhalateur d'arôme de type à chauffage sans combustion, et cartouche

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Publication number Priority date Publication date Assignee Title
WO2012133289A1 (fr) * 2011-03-29 2012-10-04 日本たばこ産業株式会社 Produit de tabac de type à aspiration mais sans combustion
CN105636466B (zh) * 2013-09-30 2018-09-11 日本烟草产业株式会社 非燃烧型香味吸取器
GB201407426D0 (en) * 2014-04-28 2014-06-11 Batmark Ltd Aerosol forming component
CA2984454C (fr) * 2015-05-01 2021-05-25 Japan Tobacco Inc. Inhalateur d'arome de type sans combustion, unite source de composant d'inhalation d'arome, et unite d'atomisation
WO2017185051A1 (fr) * 2016-04-22 2017-10-26 Pax Labs, Inc. Dispositifs aérosol ayant des matériaux compartimentés
GB201707769D0 (en) 2017-05-15 2017-06-28 British American Tobacco Investments Ltd Liquid tobacco extract

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