EP4295904A3 - Use of glutamine synthetase for treating hyperammonemia - Google Patents

Use of glutamine synthetase for treating hyperammonemia Download PDF

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Publication number
EP4295904A3
EP4295904A3 EP23206416.2A EP23206416A EP4295904A3 EP 4295904 A3 EP4295904 A3 EP 4295904A3 EP 23206416 A EP23206416 A EP 23206416A EP 4295904 A3 EP4295904 A3 EP 4295904A3
Authority
EP
European Patent Office
Prior art keywords
glutamine synthetase
relates
hyperammonemia
protein
treating hyperammonemia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP23206416.2A
Other languages
German (de)
French (fr)
Other versions
EP4295904A2 (en
Inventor
Tamara NICOLSON
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thoeris GmbH
Original Assignee
Thoeris GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1708288.4A external-priority patent/GB201708288D0/en
Priority claimed from GBGB1800867.2A external-priority patent/GB201800867D0/en
Application filed by Thoeris GmbH filed Critical Thoeris GmbH
Publication of EP4295904A2 publication Critical patent/EP4295904A2/en
Publication of EP4295904A3 publication Critical patent/EP4295904A3/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/53—Ligases (6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/01—Acid-ammonia (or amine)ligases (amide synthases)(6.3.1)
    • C12Y603/01002—Glutamate-ammonia ligase (6.3.1.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to the use of glutamine synthetase as a protein therapy (such as enzyme replacement protein therapy) for the treatment of hyperammonemia. In particular the invention relates to the systemic administration of glutamine synthetase. The glutamine synthetase may be provided in conjugated or fusion form, to increase its half-life in the circulation. Also provided is a pharmaceutical composition comprising glutamine synthetase. The invention also relates to the uses, methods and compositions involving a combination of the glutamine synthetase protein and an ammonia lowering agent, such as a nitrogen scavenger.
EP23206416.2A 2017-05-24 2018-05-24 Use of glutamine synthetase for treating hyperammonemia Pending EP4295904A3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB1708288.4A GB201708288D0 (en) 2017-05-24 2017-05-24 Use of glutamine synthetase for treating hyperammonemia
GBGB1800867.2A GB201800867D0 (en) 2018-01-19 2018-01-19 Use of glutamine synthetase for treating hyperammonemia
EP18728717.2A EP3630077A1 (en) 2017-05-24 2018-05-24 Use of glutamine synthetase for treating hyperammonemia
PCT/GB2018/051415 WO2018215780A1 (en) 2017-05-24 2018-05-24 Use of glutamine synthetase for treating hyperammonemia

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP18728717.2A Division EP3630077A1 (en) 2017-05-24 2018-05-24 Use of glutamine synthetase for treating hyperammonemia

Publications (2)

Publication Number Publication Date
EP4295904A2 EP4295904A2 (en) 2023-12-27
EP4295904A3 true EP4295904A3 (en) 2024-02-28

Family

ID=62492675

Family Applications (3)

Application Number Title Priority Date Filing Date
EP23206416.2A Pending EP4295904A3 (en) 2017-05-24 2018-05-24 Use of glutamine synthetase for treating hyperammonemia
EP22176864.1A Pending EP4119133A1 (en) 2017-05-24 2018-05-24 Glutamine synthetase protein conjugate
EP18728717.2A Pending EP3630077A1 (en) 2017-05-24 2018-05-24 Use of glutamine synthetase for treating hyperammonemia

Family Applications After (2)

Application Number Title Priority Date Filing Date
EP22176864.1A Pending EP4119133A1 (en) 2017-05-24 2018-05-24 Glutamine synthetase protein conjugate
EP18728717.2A Pending EP3630077A1 (en) 2017-05-24 2018-05-24 Use of glutamine synthetase for treating hyperammonemia

Country Status (11)

Country Link
US (4) US20210145946A1 (en)
EP (3) EP4295904A3 (en)
JP (3) JP2020520677A (en)
KR (1) KR20200018488A (en)
CN (1) CN111093641A (en)
AU (2) AU2018272294B2 (en)
BR (1) BR112019024750A2 (en)
CA (1) CA3064352A1 (en)
IL (1) IL270817A (en)
MX (1) MX2019014027A (en)
WO (1) WO2018215780A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020065082A1 (en) * 2018-09-28 2020-04-02 Thoeris Gmbh Use of glutamine synthetase for treating fatty liver disease
CN110133287B (en) * 2019-05-22 2021-07-30 上海碧云天生物技术有限公司 Protein extraction solution and application thereof
WO2022005201A1 (en) 2020-06-30 2022-01-06 경상국립대학교산학협력단 Composition for preventing, ameliorating, or treating diseases caused by nitration of tyrosine in protein, containing tyrosine as active ingredient

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7590493B2 (en) 2000-07-31 2009-09-15 Ocimum Biosolutions, Inc. Methods for determining hepatotoxins
US6812339B1 (en) 2000-09-08 2004-11-02 Applera Corporation Polymorphisms in known genes associated with human disease, methods of detection and uses thereof
US6451547B1 (en) 2001-04-25 2002-09-17 Syn X Pharma Process for differential diagnosis of Alzheimer's dementia and device therefor
US20040142325A1 (en) 2001-09-14 2004-07-22 Liat Mintz Methods and systems for annotating biomolecular sequences
AUPR805101A0 (en) 2001-10-03 2001-10-25 University Of New South Wales, The A method of genetic screening using an amplifiable gene
JP2003225093A (en) 2001-11-30 2003-08-12 Sumitomo Pharmaceut Co Ltd Marker for cartilage disorder and use thereof
US6875792B2 (en) 2002-01-31 2005-04-05 Mso Pharma Llc Dosage form of L-Methionine S-Sulfoximine
JP2003274963A (en) 2002-03-22 2003-09-30 Japan Science & Technology Corp Gene recombinant cell strain and liver function supporting equipment using the same
US20050074865A1 (en) * 2002-08-27 2005-04-07 Compound Therapeutics, Inc. Adzymes and uses thereof
EP1578996A4 (en) 2002-10-18 2007-12-19 Genentech Inc Compositions and methods for the diagnosis and treatment of tumor
US20050255114A1 (en) 2003-04-07 2005-11-17 Nuvelo, Inc. Methods and diagnosis for the treatment of preeclampsia
AU2003269876A1 (en) 2003-05-21 2005-01-21 Divergence, Inc Nematode GS-like sequences
WO2005019258A2 (en) 2003-08-11 2005-03-03 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
US20070098702A1 (en) * 2005-02-17 2007-05-03 University Of Maryland, Baltimore Recombinant protein polymer vectors for systemic gene delivery
EP1752143A1 (en) 2005-08-08 2007-02-14 NewThera Novel uses for drugs targeting glutamine synthetase
ES2672205T3 (en) 2005-12-21 2018-06-13 Université Catholique de Louvain Liver Stem Cells Isolated
RU2362572C2 (en) 2007-07-17 2009-07-27 Юрий Георгиевич Каминский Way of depression of concentration of ammonia in blood by means of ammocytes and incapsulated glutamin synthetase
EP2330892B1 (en) * 2008-04-29 2016-06-29 Horizon Therapeutics, Inc. Methods of treatment using ammonia-scavenging drugs
CN102177235A (en) 2008-09-08 2011-09-07 赛莱克蒂斯公司 Meganuclease variants cleaving a DNA target sequence from a glutamine synthetase gene and uses thereof
RU2012157572A (en) * 2010-05-28 2014-07-10 МЕН-ЭнЭрЖ СА NEYREGULIN ISOFORM, NEUREGULIN POLYPEPTIDES AND THEIR APPLICATION
WO2013020914A1 (en) * 2011-08-10 2013-02-14 Celares Gmbh Peg-conjugated peptides
US9567577B2 (en) 2012-03-12 2017-02-14 Ares Trading S.A. Expression vector comprising a polynucleotide encoding a modified glutamine synthetase and a method for preparing a target protein employing the same
EP2674495A1 (en) 2012-06-14 2013-12-18 Sanofi CHO expression system
MX2014013566A (en) 2014-11-07 2016-05-09 Inst Nac De Ciencias Medicas Y Nutricion Salvador Zubiran Gene therapy to treat hyperammonemia in hepatic encephalopathy and other liver diseases.
AU2015353703B2 (en) 2014-11-24 2021-04-01 Ucl Business Plc Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies
JP6817966B2 (en) * 2015-06-10 2021-01-20 シンロジック オペレーティング カンパニー インコーポレイテッド Bacteria engineered to treat diseases associated with hyperammonemia
US20190078099A1 (en) 2016-03-30 2019-03-14 Spark Therapeutics, Inc. Cell line for recombinant protein and/or viral vector production
CN109219660B (en) 2016-05-11 2023-01-06 美国安进公司 Direct selection of cells expressing high levels of heteromultimers using complementary vectors in the glutamine synthetase gene
US20190352631A1 (en) 2016-11-16 2019-11-21 Agency For Science Technology And Research Attenuated Glutamine Synthetase as a Selection Marker
EP3638777A4 (en) 2017-07-13 2021-05-12 Memphis Meats, Inc. Compositions and methods for increasing the efficiency of cell cultures used for food production
US11713468B2 (en) 2017-08-02 2023-08-01 Dna Twopointo Inc. DNA vectors and elements for sustained gene expression in eukaryotic cells
CN109988777A (en) 2017-12-29 2019-07-09 南京金斯瑞生物科技有限公司 Glutamine synthetase gene and application
CN110714057A (en) 2018-07-11 2020-01-21 成都金洛克生物技术有限公司 Universal FISH probe for detecting exogenous gene integration and positioning and application thereof
CN109504709B (en) 2018-11-28 2020-07-24 上海安民生物技术有限公司 Albumin expression vector driven by albumin promoter
WO2020227206A1 (en) 2019-05-07 2020-11-12 Amgen Inc. Vectors and expression systems for producing recombinant proteins

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
H 7 NAO ET AL: "VANCOUVER GENERAL HOSPITAL CSU PHARMACEUTICAL SCIENCES SPECIAL ACCESS PROGRAM (SAP) DRUG DATA SHEET DRUG NAME ALTERNATE NAME Sodium Phenylacetate / Sodium Benzoate (SA/SB) C 8 * REPORT ANY ADVERSE DRUG REACTIONS TO CSU PHARMACEUTICAL SCIENCES", 1 July 2007 (2007-07-01), XP055499951, Retrieved from the Internet <URL:http://www.vhpharmsci.com/pdtm/Drug%20Data%20Sheets%20-%20SAP%20&%20NF/Sodium%20Phenylacetate-Sodium%20Benzoate%20SAP.pdf> [retrieved on 20180815] *
M A TORRES-VEGA ET AL: "Delivery of glutamine synthetase gene by baculovirus vectors: a proof of concept for the treatment of acute hyperammonemia", GENE THERAPY, vol. 22, no. 1, 23 October 2014 (2014-10-23), GB, pages 58 - 64, XP055499916, ISSN: 0969-7128, DOI: 10.1038/gt.2014.89 *
MIGUEL A TORRES-VEGA: "Reduction of Hyperammonemia In Vitro and In Vivo by a Baculovirus-Delivered Glutamine Synthetase as a New Approach for the Treatment of Hepatic Encephalopathy", BLOOD REVIEWS, vol. 30, no. 5, 1 May 2013 (2013-05-01), AMSTERDAM, NL, XP055499936, ISSN: 0268-960X *

Also Published As

Publication number Publication date
IL270817A (en) 2020-01-30
EP4295904A2 (en) 2023-12-27
AU2018272294A1 (en) 2020-01-16
KR20200018488A (en) 2020-02-19
JP2024059833A (en) 2024-05-01
US20210145946A1 (en) 2021-05-20
CA3064352A1 (en) 2018-11-29
JP2020520677A (en) 2020-07-16
MX2019014027A (en) 2020-08-03
EP3630077A1 (en) 2020-04-08
AU2018272294B2 (en) 2024-05-23
WO2018215780A1 (en) 2018-11-29
US20220401531A1 (en) 2022-12-22
JP2023085301A (en) 2023-06-20
BR112019024750A2 (en) 2020-06-09
EP4119133A1 (en) 2023-01-18
US20240150746A1 (en) 2024-05-09
AU2024201089A1 (en) 2024-03-14
US20220401532A1 (en) 2022-12-22
CN111093641A (en) 2020-05-01
US11932885B2 (en) 2024-03-19

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