EP4288023A1 - Composition anti-transpirante anhydre - Google Patents

Composition anti-transpirante anhydre

Info

Publication number
EP4288023A1
EP4288023A1 EP22700812.5A EP22700812A EP4288023A1 EP 4288023 A1 EP4288023 A1 EP 4288023A1 EP 22700812 A EP22700812 A EP 22700812A EP 4288023 A1 EP4288023 A1 EP 4288023A1
Authority
EP
European Patent Office
Prior art keywords
composition
acid
antiperspirant
organic compound
iso
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP22700812.5A
Other languages
German (de)
English (en)
Inventor
Xiaoke Li
Renjiang LIU
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Unilever Global IP Ltd
Unilever IP Holdings BV
Original Assignee
Unilever Global IP Ltd
Unilever IP Holdings BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever Global IP Ltd, Unilever IP Holdings BV filed Critical Unilever Global IP Ltd
Publication of EP4288023A1 publication Critical patent/EP4288023A1/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/342—Alcohols having more than seven atoms in an unbroken chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4993—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30—Characterized by the absence of a particular group of ingredients
    • A61K2800/31—Anhydrous

Definitions

  • the present invention is in the field of antiperspirant compositions.
  • the present invention relates to compositions that contain antiperspirant actives. These actives are added to compositions to reduce perspiration upon topical application of the compositions to the body, particularly to the underarm regions of the human body viz. the axilla, and sometimes even on the upper part of the body near the chest.
  • conventional antiperspirant actives are salts of certain metals having an astringent effect, such as the salts of aluminium and/or zirconium. Since antiperspirants are used regularly, and have been used for decades, there is an ever-increasing need to develop alternative antiperspirant actives which are equally efficacious.
  • an anhydrous composition comprising certain amount of specific saturated fatty acid, ethanol and specific organic compound can lead to a reduction in perspiration.
  • the specific saturated fatty acid can be stable in an anhydrous composition with the presence of ethanol and another specific organic solvent.
  • the specific saturated fatty acid is capable of forming precipitation/aggregation when they contact with aqueous saline media, which is equivalent to perspiration or sweat, thereby is capable of preventing sweat from rapidly being released. In this manner, such specific saturated fatty acid behave much like conventional antiperspirants.
  • the saturated fatty acid of the present invention should have melting point greater than 37 °C which distinguishes it from other fatty acid.
  • an antiperspirant composition comprising:
  • an organic compound selected from alcohols with 8-24 carbons, alkanes with 7-20 carbons, alkyl or alkyl-aryl esters, glyceryl esters, sorbitan esters, ethoxylated sorbitan esters, and a mixture thereof;
  • a cosmetically acceptable carrier wherein said saturated fatty acid is selected from myristic acid, palmitic acid, stearic acid, arachidic acid, behenic acid, lignoceric acid, cerotic acid and 12- Hydroxystearic acid.
  • a method of reducing perspiration comprising a step of topical application of the composition of the first aspect on to the desired skin surface.
  • composition of the first aspect for reduction of bodily perspiration.
  • An antiperspirant Composition is meant to include a composition for topical application to the skin of mammals, especially humans. Such a composition is preferably of the leave-on type. By a leave-on composition is meant a composition that is applied to the desired skin surface and left on for one minute to 24 hours after which it may be wiped or rinsed off with water, usually during the regular course of personal washing. The composition may also be formulated into a product which is applied to a human body for improving the appearance, cleansing, odor control or general aesthetics.
  • the composition of the present invention can be in the form of a liquid, lotion, cream, gel or stick form and may be delivered through a roll-on device or using an aerosol can which contains a propellant.
  • “Skin” as used herein is meant to include skin on any part of the body (e.g., neck, chest, back, arms, underarms, hands, legs, buttocks and scalp) especially the underarms.
  • Melting point refers to the temperature at which the solid and liquid forms of a pure substance can exist in equilibrium. “Melting point” for the purpose of the present invention is specified at a standard pressure such as 1 atmosphere.
  • a saturated fatty acid is a type of fatty acid that lacks unsaturated linkages between carbon atoms. Without wishing to be bound by theory it is believed that the fatty acid has to be in solid form upon application of the composition to the skin, e.g., the underarms. Therefore, it is required that the fatty acid of the present invention has relatively high melting point, have melting point greater than 37 °C.
  • Antiperspirant compositions of the present invention comprise a saturated fatty acid.
  • the saturated fatty acid of the present invention contains carbon-chains with 14-26 carbons.
  • the saturated fatty acid may have one or more hydroxyl groups.
  • the saturated fatty acid has a linear hydrocarbon chain.
  • the saturated fatty acid of the present invention is selected from myristic acid, palmitic acid, stearic acid, arachidic acid, behenic acid, lignoceric acid, cerotic acid, and 12- Hydroxystearic acid. It is more preferred that the saturated fatty acid is selected from stearic acid, palmitic acid, and 12-Hydroxystearic acid.
  • Antiperspirant compositions in accordance with this invention comprises , from 4 to 30 wt%, and preferably from 4 to 20 wt%, and more preferably from 5 to 15 wt% the saturated fatty acid, based on total weight of the composition.
  • Antiperspirant composition in accordance with this invention comprises an organic compound selected from alcohols with 8-24 carbons, alkanes with 7-20 carbons, alkyl or alkyl-aryl esters, glyceryl esters, sorbitan esters, ethoxylated sorbitan esters, and a mixture thereof. It is preferred that the organic compound is an alkyl or alkyl-aryl ester, alkanes with 7-20 carbons and alcohols with 8-24 carbons.
  • the organic compound is isopropyl palmitate, isostearyl alcohol or n-dodecane, n-tridecane, n-tetradecane, n-pentadecane, n-hexadecane, isododecane, isohexadecane or a mixture thereof.
  • the organic compound has a melting point lower than 37°C, more preferably lower than 20 °C. Without wishing to be bound by theory it is believed that the organic compound has to be in liquid form to dissolve the saturated fatty acid together with ethanol. Therefore, it is required that the organic compound has relatively low melting point.
  • the organic compound is an alcohol with 8-24 carbons
  • organic compound is an alkyl or alkyl-aryl ester
  • it is preferred to be selected from isopropyl myristate, isopropyl palmitate, myristyl palmitate and C12-15 alkyl benzoate, more preferably, it is isopropyl myristate.
  • the organic compound is a glyceryl ester
  • it is preferred to be selected from glyceryl oleate, glyceryl linoleate, glyceryl linolenate and glyceryl ricinoleate, more preferably it is capric/caprylic triglyceride.
  • the organic compound is an alkane with 7-20 carbons
  • it is an alkane with 10-16 carbons, selected from n- decane, n-undecane, n-dodecane, n-tridecane, n-tetradecane, n-pentadecane, n- hexadecane, iso-decane, iso-undecane, iso-dodecane, iso-tridecane, iso-tetradecane, iso-hexadecane, and a mixture thereof, more preferably, it is dodecane.
  • the organic compound is a sorbitan ester or ethoxylated sorbitan ester
  • the antiperspirant compositions in accordance with this invention comprises from 5 to 91 wt%, more preferably from 10 to 60wt%, furthermore preferably from 15 to 30 wt% of the organic compound, based on total weight of the composition.
  • Antiperspirant composition in accordance with this invention additionally comprises ethanol. It comprises from 5 wt% to 80wt%, preferably from 5 to 70wt%, preferably from 5 to 60wt%, more preferably from 10% to 50wt%, furthermore preferably from 30wt% to 60wt%, most preferably from 40% to 50wt%, based on total weight of the composition.
  • Antiperspirant compositions in accordance with this invention may advantageously comprise an additional antiperspirant active.
  • the composition of the present invention is preferably free from antiperspirant active which comprises aluminium or zirconium.
  • the composition of the present invention is preferably free from antiperspirant active which is zinc based.
  • Antiperspirant active which comprises aluminium or zirconium is preferably selected from aluminium/zirconium halides and halohydrate salts, aluminum-zirconium tetrachlorohydrex glycine complex, aluminum-zirconium octachlorohydrex glycine complex, aluminum-zirconium pentachlorohydrate, aluminum sesquichlorohydrate or mixtures thereof, more preferably aluminum sesquichlorohydrate or aluminium chlorohydrates.
  • Antiperspirant active which comprises aluminium or zirconium can also be complexes based on the above-mentioned astringent aluminium and/or zirconium salts and the complex often employs a compound with a carboxylate group, and advantageously this is an amino acid.
  • Zinc based antiperspirant active is preferably selected from zinc oxide, zinc hydroxide, zinc hydroxide ions with counter ions, and zinc ions with counter ions.
  • Counter ions may include halides and amino acid salt.
  • Non-aluminum and non-zirconium, non-zinc antiperspirant actives may be present to augment or supplement the antiperspirant activity of the non-thermoplastic polymeric material as disclosed.
  • Non- aluminum or zirconium, or non-zinc antiperspirant active is preferably selected from glycerol monolaurate plus isostearyl alcohol, chitosan or a salt thereof with a weight average molecular weight of from 250 to 650 kDa, titanium compound chelated by alkanolamine with an acid and a polyhydric alcohol, or cholic acid derivative selected from a hydroxycholic acid or a salt thereof with a multivalent metal salt.
  • the composition of the present invention is free from metal based antiperspirant active.
  • the metal includes aluminum, zirconium, zinc, titanium, copper, gallium, stannum, Indium, hafnium, vanadium, cobalt. pH of compositions
  • pH of the antiperspirant composition of the present invention is preferably from 2 to 9, more preferably 3 to 7.
  • compositions of the present invention may also be incorporated in the compositions of the present invention.
  • Such components include skin care agents such as emollients, humectants and skin barrier promoters; skin appearance modifiers such as skin lightening agents and skin smoothing agents; antimicrobial agents, in particular organic anti-microbial agents, and preservatives.
  • the antiperspirant compositions of the invention are applied cosmetically and topically to the skin, broadly speaking, by one of two methods. Different consumers prefer one method or the other. In one method, sometimes called a contact method, the composition is wiped across the surface of the skin, depositing a fraction of the composition as it passes. In the second method, sometimes called the non-contact method, the composition is sprayed from a dispenser held proximate to the skin, often in an area of about 10 to 20 cm 2 .
  • the spray can be developed by mechanical means of generating pressure on the contents of a dispenser, such as a pump or a squeezable sidewall or by internally generated pressure arising from a fraction of a liquefied propellant volatilizing, the dispenser commonly being called an aerosol.
  • the carrier fluid comprises a solvent for the antiperspirant and in a second variation, the antiperspirant remains a particulate solid that is suspended in an oil, usually a blend of oils.
  • composition of the invention is anhydrous and comprises cosmetically acceptable carrier.
  • the cosmetically acceptable carrier can be any compound or solvent which is compatible with the other ingredients of the composition. It can be saturated fatty acid or ethanol.
  • composition of the invention is in the form of a spray, a firm solid, a soft solid or is a lotion packaged in a roll-on applicator.
  • composition when said composition is a spray it comprises a propellant and the composition is in the form of an aerosol.
  • the antiperspirant composition of the invention is a stick composition.
  • Antiperspirant sticks can be formulated as clear (i.e., translucent or transparent) or opaque compositions. Translucent or transparent sticks go on clear and, depending upon their formulation, may remain clear for extended periods of time, reducing the consumer perceived negative of "white marks" associated with deposition of antiperspirant active.
  • Many different materials have been proposed as gellants for a continuous oil phase, including waxes, small molecule gelling agents and polymers. They each have their advantages and of them, one of the most popular class of gellants is waxes, partly at least due to their ready availability and ease of processing, including in particular linear fatty alcohol wax gellants.
  • a gelled antiperspirant composition is applied topically to skin by wiping it across and in contact with the skin, thereby depositing on the skin a thin film.
  • the nature of the film depends to a significant extent on the gellant that is employed.
  • wax fatty alcohols have been employed as gellants for many years, and are effective for the purpose of gelling, the resultant product is rather ineffective at improving the visual appearance of skin, and in particular underarm skin, to which the composition has been applied.
  • This problem has been solved by including ameliorating materials for example, di or polyhydric humectants and/or a triglyceride oil.
  • Stick compositions are usually available in the form of a firm solid or a soft solid.
  • Firm solids as the name indicates, are harder and can be directly applied by way of an applicator, for example, to the underarms.
  • Soft solids also need an applicator which is similar to the firm solids, the difference being that the soft solids are softer and the applicator needs to be designed in order to permit extrusion of the solids through a cap member comprising plurality of orifices and the extruded composition can then be applied to the underarms.
  • the composition of the invention is a liquid composition, that can be dispensed from a roll-on package.
  • a hydrophobic carrier such as a volatile silicone
  • a carrier liquid such as glycerin and propylene glycol
  • the antiperspirant composition of the invention is delivered through an aerosol composition which comprises a propellant in addition to the applicable other ingredients described hereinabove.
  • the propellant is employed in a weight ratio to the base formulation of from 95:5 to 5:95.
  • the ratio of propellant to base formulation is normally at least 20:80, generally at least 30:70, particularly at least 40:60, and in many formulations, the weight ratio is from 90:10 to 50:50.
  • a ratio range of from 70:30 to 90:10 is sometimes preferred.
  • Propellants herein generally are one of three classes; (i) low boiling-point gasses liquified by compression, (ii) volatile ethers and (iii) compressed non-oxidising gases.
  • Class (i) is conveniently a low boiling-point material, typically boiling below -5°C, and often below -15°C, and in particular, alkanes and/or halogenated hydrocarbons.
  • This class of propellant is usually liquefied at the pressure in the aerosol canister and evaporates to generate the pressure to expel the composition out of the canister. Examples of suitable alkanes include particularly propane, butane or isobutane.
  • the class (ii) of propellant comprises a very volatile ether of which the most widely employed ether hitherto is dimethyl ether.
  • This propellant can advantageously be employed at relatively low weight ratio of propellant to base formulation, for example to as low as 5:95. It can also be employed in admixture with, for example, compressible/liquefiable alkane gasses.
  • the class (iii) of propellant comprises compressed non-oxidising gasses, and in particular carbon dioxide or nitrogen. Inert gases like neon are a theoretical alternative.
  • composition of the present invention can comprise a wide range of other optional components.
  • CTFA Personal Care Ingredient Handbook Second Edition, 1992, which is incorporated by reference herein in its entirety, describes a wide variety of nonlimiting personal care and pharmaceutical ingredients commonly used in the skin care industry, which are suitable for use in the compositions of the present invention. Examples include: antioxidants, binders, biological additives, buffering agents, colorants, thickeners, polymers, astringents, fragrance, conditioners, exfoliating agents, pH adjusters, other than the ones already discussed earlier, preservatives, natural extracts, essential oils, skin sensates, skin soothing agents, and skin healing agents.
  • a preservative is a preferred additional component in compositions of the invention.
  • a preservative serves to reduce or eliminate microbial contamination of compositions of the invention.
  • Preservatives are typically employed at a total level of from 0.05 to 3%, preferably at from 0.1 to 2% and most preferably at from 0.4 to 1%.
  • Suitable preservatives for use with the present invention include 2-phenoxyethanol, polylysine, iodopropynyl butylcarbamate, C1-C3 alkyl parabens, sodium benzoate, caprylyl glycol and EDTA.
  • Particularly preferred preservatives are 2-phenoxyethanol, iodopropynyl butylcarbamate, sodium benzoate, caprylyl glycol and EDTA and especially preferred are 2-phenoxyethanol and iodopropynyl butylcarbamate.
  • a preferred additional component of compositions of the invention is a fragrance.
  • suitable materials include conventional perfumes, such as perfume oils and also include so-called deo-perfumes, as described in EP 545,556 and other publications.
  • Levels of incorporation are preferably up to 4% by weight, particularly from 0.1 % to 2% by weight, and especially from 0.7% to 1.7% by weight.
  • An antimicrobial deodorant active is a preferred an additional component in compositions of the invention.
  • Such components serve to reduce or eliminate body odour by reducing or otherwise impeding the function of microbes on the skin of the body responsible for malodour generation.
  • the antimicrobial deodorant active may also be a preservative for the composition.
  • the anti-microbial deodorant agent is typically incorporated into the composition at from 0.01% to 3% and particularly at from 0.03% to 0.5%.
  • Preferred anti-microbial deodorant agents have a minimum inhibitory concentration (MIC) of 1 mg. ml -1 or less, particularly 200 pg. ml' 1 or less, and especially 100 pg. ml' 1 or less.
  • the MIC of an anti-microbial agent is the minimum concentration of the agent required to significantly inhibit microbial growth. Inhibition is considered “significant” if an 80% or greater reduction in the growth of an inoculum of Staphylococcus epidermidis is observed, relative to a control medium without an anti-microbial agent, over a period of 16 to 24 hours at 37°C.
  • MICs of anti-microbials suitable for inclusion in the compositions of the invention are triclosan: 0.01-10 pg. ml' 1 (J. Regos etal., Dermatologica (1979), 158: 72-79) and farnesol: ca.
  • Suitable organic anti-microbials are bactericides, for example quaternary ammonium compounds, like cetyltrimethylammonium salts; chlorhexidine and salts thereof; and diglycerol monocaprate, diglycerol monolaurate, glycerol monolaurate, and similar materials, as described in “Deodorant Ingredients”, S.A. Makin and M.R. Lowry, in “Antiperspirants and Deodorants”, Ed. K. Laden (1999, Marcel Dekker, New York).
  • More preferred anti-microbials for use in the compositions of the invention are polyhexamethylene biguanide salts (also known as polyaminopropyl biguanide salts), an example being Cosmocil CQTM available from Zeneca PLC, preferably used at up to 1% and more preferably at 0.03% to 0.3% by weight; 2',4,4'-trichloro,2-hydroxy-diphenyl ether (triclosan), preferably used at up to 1 % by weight of the composition and more preferably at 0.05-0.3%; and 3,7,11-trimethyldodeca-2,6,10-trienol (farnesol), preferably used at up to 1% by weight of the composition and more preferably at up to 0.5%.
  • polyhexamethylene biguanide salts also known as polyaminopropyl biguanide salts
  • Cosmocil CQTM available from Zeneca PLC
  • transition metal chelators as described in W001/52805, for example.
  • Transitional metal chelators having a binding coefficient for iron(lll) of greater than 10 26 for example diethylenetriaminepentaacetic acid and salts thereof are preferred.
  • the present invention also provides for a method of reducing perspiration comprising a step of topical application of the composition of the first aspect.
  • the present invention provides for a method wherein the composition of the first aspect is applied on the underarms.
  • the present invention also provides for a method wherein topical application of the composition of the first aspect reduces perspiration from the surface of the human body.
  • the method in accordance with the invention is preferably non- therapeutic. By non-therapeutic is meant that the method is cosmetic in nature.
  • the invention also provides for use of the composition of the first aspect for reduction of bodily perspiration.
  • the use in accordance with the invention is preferably non- therapeutic in nature, more preferably cosmetic in nature.
  • the invention provides for use of the combination of saturated fatty acid with 14-26 carbons, ethanol and organic compound selected from alcohols with 8-24 carbons, alkyl or alkyl-aryl esters, glyceryl esters, sorbitan esters and ethoxylated sorbitan esters as an antiperspirant agent.
  • model ionic sweat (pH 6.9) is as given below in Table -3:
  • Table -3 The aggregation/precipitation formation behaviour of the compositions in Table -2 was tested by following the procedure: 1.0 mL of the concerned composition was taken in a vial and mixed with 1.0 mL model ionic sweat. The appearance of each sample was checked visually and recorded.
  • Results are summarised in Table -4.
  • compositions as per the invention demonstrate that compositions as per the invention (Reference No. 1 to 11) are capable of forming an aggregation/precipitation under the test conditions disclosed earlier, which further indicates their ability to reduce perspiration when used in an antiperspirant composition, while compositions outside the invention (Examples A) do not exhibit such efficacy. Stability test
  • compositions indicated in Table -5 were prepared.
  • compositions above were prepared and clear solutions were obtained at room temperature (around 25 °C). Then the samples were stored in fridge at 4 °C overnight (18 hours). Subsequently, the samples were placed under room temperature (around 25 °C) for 24 hours. The appearance of each sample was checked visually and recorded. Clear solution indicates the sample is stable, while the precipitation indicates the sample is unstable.
  • Results are summarised in Table -6.
  • compositions as per the invention demonstrate that compositions as per the invention (Reference No. 1 and 14) are stable under the test conditions disclosed earlier, which, while compositions outside the invention (Examples B to D) do not exhibit such stability.
  • the compositions indicated in Table -7 were prepared.
  • Results are summarised in Table -8.
  • compositions as per the invention demonstrate that compositions as per the invention (Reference No. 15 to 16) are capable of forming an aggregation/precipitation under the test conditions disclosed earlier, which further indicates their ability to reduce perspiration when used in an antiperspirant composition.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne le domaine des compositions anti-transpirantes, en particulier des compositions comprenant des substances actives anti-transpirantes. L'invention concerne une composition anti-transpirante anhydre comprenant (i) 4 à 30 % d'un ou de plusieurs acides gras saturés avec 14 à 26 atomes de carbone en poids de la composition ; (ii) un composé organique choisi parmi les alcools ayant 8 à 24 atomes de carbone, les alcanes ayant 7 à 20 atomes de carbone, les esters d'alkyle ou d'alkyl-aryle, les esters de glycéryle, les esters de sorbitane, les esters de sorbitane éthoxylés, et un mélange de ceux-ci ; (iii) 5 à 80 % d'éthanol en poids de la composition ; et (iv) un excipient cosmétiquement acceptable ; ledit acide gras saturé étant choisi parmi l'acide myristique, l'acide palmitique, l'acide stéarique, l'acide arachidique, l'acide béhénique, l'acide lignocérique, l'acide cérotique et l'acide 12-hydroxystéarique. L'invention concerne également un procédé de réduction de la transpiration comprenant une étape d'application topique de la composition anti-transpirante anhydre.
EP22700812.5A 2021-02-02 2022-01-18 Composition anti-transpirante anhydre Pending EP4288023A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2021074753 2021-02-02
EP21161647 2021-03-10
PCT/EP2022/050962 WO2022167211A1 (fr) 2021-02-02 2022-01-18 Composition anti-transpirante anhydre

Publications (1)

Publication Number Publication Date
EP4288023A1 true EP4288023A1 (fr) 2023-12-13

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EP22700812.5A Pending EP4288023A1 (fr) 2021-02-02 2022-01-18 Composition anti-transpirante anhydre

Country Status (3)

Country Link
EP (1) EP4288023A1 (fr)
MX (1) MX2023008915A (fr)
WO (1) WO2022167211A1 (fr)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3560989B2 (ja) 1991-11-08 2004-09-02 クウエスト・インターナシヨナル・ベー・ベー 香料組成物
EP1248591B1 (fr) 2000-01-18 2007-08-08 Unilever Plc Compositions antimicrobiennes comprenant un sel d'un chelateur de metal de transition
GB0102562D0 (en) * 2001-02-01 2001-03-21 Unilever Plc Cosmetic products for the reduction of sweat acidity

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