EP4281220A1

EP4281220A1 - Hand-held pipetting device

Info

Publication number: EP4281220A1
Application number: EP22700849.7A
Authority: EP
Inventors: Alisa GRUSCHKA; Kathlen JOST; Negar Rajabi; Jan Eckhoff; Johannes EGGER
Original assignee: Eppendorf SE
Current assignee: Eppendorf SE
Priority date: 2021-01-25
Filing date: 2022-01-24
Publication date: 2023-11-29
Also published as: JP2024505834A; WO2022157363A1; CN116782999A

Abstract

The invention relates to a pipetting device with a touchscreen and to a system comprising said pipetting device. According to the operating concept of the pipetting device, values of pipetting parameters can be set by the user on at least one input screen page, an acutation of the actuation element results in the display of an output screen page and the initiation of a pipetting process defined according to the pipetting parameters, and contacting a separate input field of the output screen page leads back to an input screen page.

Description

Hand-held pipetting device

The invention relates to a hand-held pipetting device, a system for data exchange between this hand-held pipetting device and an external device, and a computer program code which can be executed by the hand-held pipetting device.

Such hand-held pipetting devices are commonly used in medical, biological, biochemical, chemical and other laboratories. They are used in the laboratory to transport and transfer fluid samples with small volumes, in particular for precise dosing of the samples. Two known classes of such hand-held pipetting devices differ in the respective physical principle of liquid intake and delivery. The liquid is either metered using the air cushion principle or the principle of direct displacement is used. The first class of devices are referred to as air cushion pipettes, the second class as positive displacement.

Air cushion pipettes use a piston and cylinder system to do the actual measurement. An air cushion separates the sample aspirated into a plastic tip from the piston inside the pipette. As the plunger slides up, a vacuum is created in the tip, which causes the liquid to rise into the tip. The air cushion moved by the piston acts like an elastic spring on which the volume of liquid in the tip hangs. Hand-held pipetting devices that work according to the positive displacement principle use tips with an integrated piston as the transfer container, which is coupled to the piston rod of the dosing device during the pipetting process and takes over the actual dosing process. In this case, since the plunger can displace the entire interior volume of the tip, essentially no air cushion forms between the aspirated sample and the end of the plunger. Both classes of hand-held pipetting devices, the air-cushion pipettes and the positive displacement pipettes, are also included under the term piston-operated pipette.

There are hand-held pipetting devices whose piston system is manually driven will, and those with electric drive. An electrically driven, hand-held piston pipette can often be controlled by at least one pipetting program in order to carry out at least one type of pipetting process in an automated or partially automated manner.

Hand-held pipettes are designed for one-handed use by human users. However, there are also laboratory machines with robotized gripping arms whose gripping tools simulate the activities of a human hand for operating a hand-held pipette and which are set up for handling and operating a hand-held pipette.

In the case of a pipetting device, the amount of sample dispensed by a single actuation can correspond to the amount of sample sucked into the device. However, it can also be provided that a quantity of sample taken corresponding to a plurality of delivery quantities is released again step by step. In addition, a distinction is made between single-channel pipetting devices and multi-channel pipetting devices, with single-channel pipetting devices containing only a single dispensing/receiving channel and multi-channel pipetting devices containing multiple dispensing/receiving channels, which in particular allow multiple samples to be dispensed or received in parallel.

The hand-held pipetting devices described within the scope of the present invention are hand-held, computer-controlled piston-operated pipettes with an electric piston drive, also referred to as hand-held, electric pipetting devices or hand-held, electric piston-operated pipettes.

An example of a prior art hand-held electronic air-cushion pipette is the Eppendorf Xplorer® and Xplorer® plus from Eppendorf AG, Germany, Hamburg; Examples of hand-held, electronic dispensers are the Multipette® E3 and Multipette® E3x from Eppendorf AG, Germany, Hamburg.

Electric pipetting devices offer numerous advantages over non-electrical pipetting devices, since a large number of functions are implemented in a simple manner can be. In particular, the implementation of specific, program-controlled pipetting processes can be simplified in electric pipetting devices by automating or partially automating them. Typical pipetting parameters for controlling such pipetting processes by means of corresponding pipetting programs relate to the volume when liquid is sucked in or dispensed, its sequence and repetitions, and possibly its time parameters in the time distribution of these processes. An electrical pipetting device can be designed to be operated in one operating mode or in a plurality of operating modes. An operating mode can provide that a set with one or more pipetting parameters of the pipetting device, which influence or control a pipetting process of the pipetting device, is automatically queried, set and/or used.

Hand-held pipetting devices are known in which a touch-sensitive screen is used to allow the user to enter pipetting parameters, based on which a pipetting process can be carried out at least partially automatically by the hand-held pipetting device.

The document EP2814612B1 describes a pipetting device with one or more touch screens, by means of which the pipetting processes are essentially completely defined by touch and controlled by the user. The use of several touchscreens indicates the potential of using such touchscreens, but ultimately it remains speculative as to whether a pipette defined in this way can be used ergonomically.

The object of the present invention is to provide a hand-held pipetting device with an efficient and ergonomic operating concept.

The invention solves this problem in particular by means of the pipetting device according to claim 1. Preferred configurations are the subject matter of the dependent claims and can also be found in the description.

The invention relates to a hand-held pipetting device for pipetting at least one liquid sample, with a connecting section for connecting at least one pipetting container, with an electrically controlled movement element for sucking in the at least one sample into the at least one pipetting container, holding the sample in the at least one pipetting container and sample delivery from the at least one pipetting container when carrying out a pipetting process, with a touch-sensitive screen for entering the values of user-definable pipetting parameters, with a parameter set of at least one pipetting parameter defining a pipetting process, with an electrical control device which has a data processing device which programs to control the movement element depending on the at least one pipetting parameter of the parameter set is, with at least one operating element, the actuation of which by the user starts the pipetting process defined according to the parameter set. Further features of the pipetting device according to the invention result from the following description and the claims.

The advantage of hand-held, electric pipetting devices (referred to below as pipetting devices for short) lies in the electronic configurability of the automated or partially automated pipetting processes in these devices. The challenge is to find an operating concept for such devices, which can implement an unmanageable number of functions, configuration options and programming, that gives the user an intuitive, efficient and ergonomic working experience. The inventors developed an operating concept that solves the problem using a number of inventions, including the invention according to the present claims.

Whenever automated pipetting processes are referred to below, semi-automated pipetting processes are also always meant, unless the respective context contradicts this. Performing an automated pipetting process always includes also at least one user activity that triggers at least the automated pipetting process, usually by actuating an operating element of the pipetting device. Partially automated pipetting processes of certain application scenarios can require, for example, that a user, in addition to starting a pipetting process divided into sub-processes, at least also starts triggering a sub-process by actuating an operating element. In certain embodiments of the pipetting device, the automated pipetting processes of a specific application scenario can be defined by a set of pipetting parameters which the user sets before starting an automated pipetting process using the operating device of a user interface device of the pipetting device and/or adopts from default settings and/or from a memory loads. Typically, the user interface of such embodiments of the pipetting device has a selection option, for example a control wheel or a list of selectable fields on a touchscreen, by means of which a so-called "operating mode" can be selected, which represents the specific application scenario or in which the whole Set of pipetting parameters is selected that belong to this specific application scenario and that the user can set before starting the associated automated pipetting process. The automated pipetting process then runs according to a pipetting program specified as an operating program in this operating mode.

In a preferred embodiment, the pipetting device or data processing device is programmed so that the user manually defines an automated pipetting process by selecting pipetting parameters, and thus in particular defines a set of pipetting parameters (pipetting parameter set) of a user-defined pipetting process. This set of pipetting parameters can partially or completely correspond to a predetermined set of pipetting parameters of an operating mode. Pipetting parameters of a pipetting process relate to or preferably quantify the volume to be pipetted, in the step of aspirating the sample into a pipetting container connected to the piston-operated pipette or in the step of dispensing the sample from this pipetting container, if necessary the sequence and repetitions of these steps, and if necessary time parameters the temporal distribution of these processes, in particular the temporal change in such processes, in particular the Velocity and/or acceleration of sample aspiration or dispensing. In this embodiment, the automated pipetting process runs according to a pipetting program that is fully defined according to these user-defined pipetting parameters.

The hand-held pipetting device according to the invention is preferably designed to be used to carry out at least one pipetting process according to at least one parameter set of at least one, or at least two, or at least three pipetting parameters, in particular in at least one predetermined operating mode according to a predetermined parameter set of the pipetting device or in a user-defined one parameter set to be used. In one operating mode, a parameter set of pipetting parameters (pipetting parameter set) is preferably provided, the pipetting parameters of which can optionally not be selected by the user or can optionally be at least partially deselected by the user and additional pipetting parameters can be added.

A pipetting process typically provides that, according to a pipetting program, a certain amount of sample is taken from a start container into a pipetting container connected to the piston-operated pipette, in particular a pipette tip, and/or is dispensed into a target container, in particular dispensed in doses. A pipetting process can preferably be controlled by at least one, two, three or preferably more pipetting parameters, with which the said pipetting process, or a function or component thereof, can be influenced or defined in the desired manner.

Pipetting parameters for controlling a pipetting process relate or quantify, preferably, the volume to be pipetted, in the step of sucking the sample into a pipetting container connected to the piston-operated pipette or in the step of dispensing the sample from this pipetting container, if necessary the sequence and repetitions of these steps, and if necessary time Parameters in the temporal distribution of these processes, in particular the change in such processes over time, in particular the speed and/or acceleration of the suction or dispensing of the sample, or the number of pre-wetting steps and optionally the volume sucked in and dispensed in each case.

These pipetting parameters are preferably at least partially and preferably completely selected and/or entered by the user, in particular via the at least one operating element of the user interface device of a piston-operated pipette or an external data processing device.

The pipetting process can preferably be clearly defined or defined by the pipetting parameter set. This set of pipetting parameters is preferably at least partially and preferably completely selected and/or entered by the user, in particular via the operating device of the pipetting device or the external data processing device.

However, it is possible that a pipetting process is not clearly defined by the pipetting parameter set; In this case, the pipetting device is in particular set up or the data processing device is programmed to automatically supplement the set of pipetting parameters with at least one further pipetting parameter, in particular as a function of the (selected) pipetting parameters. It is possible and preferred that at least one pipetting parameter is not defined by the user, but is specified, for example, by the pipetting device, in that it is stored there, for example in a known manner, in a data memory or is determined automatically.

Preferably, at least one pipetting parameter is provided, with which the number of immediately consecutive or indirectly consecutive pipetting volumes is defined, preferably at least one pipetting parameter, with which the number of aspiration steps and/or dispensing steps and preferably also the respective associated pipetting volumes, the respective associated pipetting speeds and/or accelerations, and/or the respectively associated time intervals between the steps. Typical pipetting parameters that can be used to manually define user-defined pipetting processes can be found in the following description of typical application scenarios for automated pipetting processes:

A typical application scenario, which is provided as a partially automated process in pipetting devices, is the dispensing (abbreviated to “DIS”) of a volume taken up in the pipetting container (pipette tip or dispenser tip). Each partial delivery, e.g. the dispensing of a total sample of 1 ml from a pipetting container into a total of ten separate target containers of a microtiter plate, requires the user to position the pipetting device above a storage container with sample liquid to be distributed, dip the tip of the pipetting container into the storage liquid, by actuating a control element takes up a starting volume, triggers a reverse stroke by actuating a control element, whereby the system is brought into a defined starting position, positioned above the first target container, the electrically driven delivery of a metered partial volume of 0.1 ml starts by actuating a control element, the pipetting device above moves and positions the next target container of the microtiter plate, restarts the electrically driven delivery of a metered partial volume of 0.1 ml by actuating an operating element, and this is carried out manually n sub-operations (positioning, triggering) followed by the automated sub-operation of electrically driven partial delivery of 0.1 ml sample (out of a total of 10 steps of partial delivery) repeated eight more times. The dosed delivery of the partial amounts is carried out according to the specification of pipetting parameters including one, several or all of the following pipetting parameters: the total volume of the sample to be distributed, the partial volumes of the sample to be distributed and/or the number of dispensing steps for dispensing the same partial volumes, the sample intake rate and/or a possibly deviating sample dispensing speed, the volume of a reverse stroke, the volume of an overstroke. The dispensing function is particularly suitable for quickly filling a microtiter plate with a reagent liquid and can be used, for example, to carry out an ELISA.

An application scenario preferably relates to “Automatic Dispensing” (ADS) a sample. Associated operating parameters are each preferably: the volume of the individual sample, relating to the pipetting volume during one of several dispensing steps; the number of dispensing steps; the duration of the time interval according to which the dispensing steps are automatically carried out one after the other at constant time intervals--the time interval can define these time intervals or, for example, the delay between the end and the beginning of successive dispensing steps; the speed at which the sample(s) is taken up; the rate at which the sample(s) is dispensed. This dispensing function is even more convenient for filling a microtiter plate, since the user does not have to repeatedly trigger a dispensing step by pressing a button, for example, but dispensing is time-controlled after the automatic dispensing has started. The execution of the operating program belonging to such a set of pipetting parameters, the automatic dispensing can take place under the condition that the corresponding program takes place at least when an actuating element is actuated continuously, for example when a button is continuously pressed. This is advantageous, for example, in the case of long dispensing series or reactions in which precise observation of a time window is required. The automatic dispensing function is even more convenient for filling a microtiter plate, as the user does not have to trigger a single dispensing step himself, but this is done automatically, which can be used to carry out an ELISA, for example.

An application scenario preferably relates to the “pipetting” (pip) of a sample. Associated pipetting parameters are in particular: the volume of the sample to be pipetted; the speed of picking up the sample; the speed at which the sample is dispensed.

An application scenario preferably relates to the "pipetting with subsequent mixing" (P/Mix) of a sample. Assigned pipetting parameters are preferably: the volume of the sample to be sucked in and/or the sample to be dispensed; the mixing volume; the number of mixing cycles; the speed of picking up the sample; the speed at which the sample is dispensed. The "pipette with subsequent mixing" function is recommended, for example, for pipetting very small volumes. Becomes a dosing volume < 10 . L is selected, it is advisable to flush this into the respective reaction liquid. This is possible by automatically starting a mixing movement after the liquid has been dispensed. The mixing volume and the mixing cycles are defined beforehand. An application for this operating mode is, for example, the delivery of a liquid that is heavier to dose than water due to its physical properties, the residues of which in the pipette container, in particular the pipette tip, are then rinsed out of the pipette container or pipette tip using the liquid already provided. Another application would be the immediate mixing of the liquid dispensed with the liquid provided. This operating mode is advantageous, for example, when adding DNA to a PCR mixed solution.

An application scenario preferably relates to the "multiple recording" of a sample, also referred to as "reverse dispensing" or as "ASP" for aspiration. Associated pipetting parameters are preferably: the volume of the sample(s) to be aspirated; the number of samples; the recording speed; the delivery speed. The function is used for multiple intake of a quantity of liquid and delivery of the total quantity. In this case, multiple filling of the pipetting container in one operation is not provided. The speed is the same for all samples. The following preferably occurs in the embodiment: starting from the basic position, the pipetting device takes up a partial volume in each case by actuating the first type of operating device. After the last partial volume has been taken up, the pipetting device preferably issues a warning message, which preferably has to be confirmed by the user actuating the second type of operating device. The total volume is released again the next time the second type of operating device is actuated. For actuation of the first or second type, the operating device preferably has at least two operating elements, one for inputting an operating signal “first type” to the control device and one for inputting an operating signal “second type” to the control device. The operating device can in particular have a Wppe, which can be pivoted in particular about an axis perpendicular to the longitudinal axis of the pipetting device, between a first signal-triggering position ("Wppe up") for actuation of the first type and a second signal-triggering position ("Wppe down") for actuation of the second type. An application scenario preferably relates to the “diluting” (Dil) of a sample, also referred to as “dilution”. Associated pipetting parameters are each preferably: the sample volume; the air bubble volume; the diluent volume; the speed of recording; the speed of delivery. The maximum diluent volume = nominal volume - (sample + air bubble)). This function is used to collect a sample and a diluent, separate them with an air bubble and dispense the whole. The speed is the same for all partial volumes. The following preferably occurs in the embodiment: starting from the basic position, the pipetting device first takes up the diluent volume, then the air bubble and finally the sample. Each recording is preferably triggered separately by actuating the operating device of the first type. Then the total amount is delivered in one go.

An application scenario preferably relates to the "sequential dispensing" (SeqD) of samples. Assigned pipetting parameters are preferably: number of samples (preferably up to a fixed maximum number Nmax of preferably 5<=Nmax<=15, preferably Nmax=10); individual volume of the individual samples; recording speed; speed of delivery. This function is used for the sequential dispensing of Nmax freely selectable volumes; multiple filling of the pipetting container is preferably not provided for here. The speed is the same for all samples. The number of samples is preferably the leading parameter for entering the individual volumes. When entering the volume, the pipetting device must always check whether the maximum volume of the pipetting device is not being exceeded; if necessary, a warning message is output. After all parameters have been entered, the pipetting device takes up the total volume after the first type of operating device has been actuated, and an individual volume in each case after the second type of operating device has been actuated. All other processes are preferably like normal dispensing.

An application scenario preferably relates to the "sequential pipetting" (SeqP) of samples. Assigned pipetting parameters are preferably: Number of samples (preferably up to a fixed maximum number Nmax of preferably 5 <= Nmax <= 15, preferably Nmax = 10); individual volume of the individual samples; recording speed; speed of delivery. This function is used for pipetting a maximum of Nmax freely selectable volumes that are programmed before the start and are fixed in their sequence. The speed is preferably the same for all samples. However, the speed can also be set differently. The function sequence corresponds to the pipetting sequence. The previously entered volumes are processed in the programmed order. After dispensing, a decision is made by operating an operating element, e.g. pressing a button, whether the next sample should be taken or before the next one first a "blowout", i.e. a complete, safe blowing out of the sample still contained in the pipetting container by means of overstroke, and/or whether the pipetting container is to be changed.

An application scenario preferably relates to the "reverse pipetting" (rPip) of samples. Associated pipetting parameters are each preferably: the volume of the individual sample; the speed of recording; the speed of delivery; Activation of the counter. With this "rPip" function, more than the volume to be dosed is taken up. This is achieved by the piston being moved down before the liquid is taken up, namely by actuation of the second type, i.e., e.g. by pressing a button or "rocker down", to the lower position of a blowout, i.e. an overstroke of the piston, which exceeds the position of the piston during a pipetting stroke. When the volume recording starts, the pipetting device records the volume of the blowout and the set volume. In order to take out the play in the drive in the dispensing direction, the pipetting device performs an additional stroke, which is released again immediately. This is similar to dispensing, but is preferably done with automatic dispensing of the discard stroke at maximum speed.

In the execution of the "rPip" application scenario, the following preferably happens: the piston of the pipetting device (or the dispenser tip) automatically moves to the blowout and remains in the lower position. Secondly, the first type of operating device is actuated: the piston moves upwards by the blowout distance and by the stroke for the pipetting volume. Thirdly, a second type of operating device is actuated: the piston moves the stroke for the pipetting volume down and remains in front of the stand blowout. Fourth, two actuations of the second type of operating device take place: the piston carries out the blowout and remains in the lower position. As an alternative to “fourth”, the operating device is actuated in the first way: the piston moves the pipetting stroke up. The "rPip" mode is particularly suitable for pipetting plasma, sera and other liquids with a high protein content. The "pipette" mode is particularly suitable for aqueous solutions. The "rPip" mode is particularly suitable for solutions containing wetting agents in order to minimize foaming when dispensing into the target vessel. The liquid is taken up in particular with an overstroke (blowout volume). In this case, the overflow typically does not belong to the delivery volume and is preferably not delivered into the target vessel. Especially when the same sample is reused, the overtravel can remain in the tip. If another liquid is used, the overflow and/or preferably the pipetting container is preferably discarded.

An operating program, in particular a control program for carrying out the desired pipetting process, is preferably controlled by a set of pipetting parameters. The control program can be in the form of electrical circuits of the control device and/or can be in the form of an executable program code that is suitable for controlling a control device that can be controlled by program code and is preferably programmable.

The pipetting device or an external data processing device is preferably designed to automatically check the values of the pipetting parameters entered by the user (pipetting parameter values) and to compare them with a permitted range of the respective pipetting parameter. If the pipetting parameter value entered by the user is outside the permissible range, the input is either not accepted, a warning is issued on the screen and/or acoustically, or it is set to a default value, which is e.g. the minimum value or the maximum value or the last permissible value entered can be, or an automatically corrected value is used.

The pipetting device preferably has at least one touch-sensitive or non-touch-sensitive screen and/or preferably a number of at least partially predefined display pages (also referred to as “screen pages”) that are stored in the pipetting device in the form of display page data and that can be displayed on one screen or distributed over several screens, preferably to fill the entire screen. The screen area is preferably essentially rectangular, possibly also square. In the case of a non-square rectangle, it is particularly preferred that the shorter side of the rectangle is arranged perpendicular to the longitudinal axis A of the pipetting device. In this way, a list of entries standing one below the other, in particular lines, can be longer. In the case of a non-square rectangle, it is also preferred that the longer side of the rectangle is arranged perpendicularly to the longitudinal axis A of the pipetting device. In this way, an array of adjacent entries, particularly columns, could be longer.

The data processing device is preferably programmed to display a graphical user interface (GUI) on the screen. In the description of the GUI, the phrase “the data processing device is programmed to” is sometimes omitted below and only the GUI and how it works is described, which always means that the data processing device is programmed to implement the corresponding GUI and how it works. This implementation is a routine activity for those skilled in the art.

The GUI at least preferably contains the display of a screen page (in particular: “home screen”) on the screen, in which pipetting parameters of a parameter set of pipetting parameters are displayed. The data processing device is accordingly programmed so that a screen page is displayed on the screen, in which pipetting parameters of a parameter set of pipetting parameters are displayed. The expression "a pipetting parameter is displayed on the screen" means that the currently set value of the pipetting parameter is displayed on the screen. In addition, a description of the pipetting parameter can be displayed, in particular a text description, a characteristic pictogram, or a physical unit of the quantity described by the pipetting parameter, if the pipetting parameter relates to such a parameter, eg "pL" for a volume. However, the person skilled in the art can also know or learn from the context to which pipetting parameter a displayed value is assigned, even if a description is missing on the screen.

The data processing device is programmed in particular to display the screen page, a start screen, synonymously referred to as the home screen (analogous to the homepage in Internet browsers). It is preferred that a plurality or multitude of user inputs on the GUI lead back to this home screen. This home screen can advantageously be used to display the entire parameter set of a user-defined pipetting process—or one taken from a previously saved application scenario—and to enable settings for the associated pipetting parameters. The home screen is displayed in particular after the pipetting devices are switched on, in particular immediately after switching on, it being possible for purely informative pages to be displayed before the home screen, e.g. a company logo, device information, etc. Switching on can be done via user operation of the display or of an actuating element, or can be caused by the measurement of a sensor, e.g. an acceleration sensor, motion sensor, proximity sensor, etc. Such a home screen has proven to be the center of the operating concept of the pipetting device that can be intuitively grasped by the user.

The home screen preferably shows the pipetting parameters of the currently valid parameter set as a standard selection (=default selection). In addition, the data processing device can be programmed in particular to carry out one, several or all of the following displays for the home screen:

• After switching on the pipetting device, the pipetting parameters of a basic parameter set are displayed;

• After switching on the pipetting device, the pipetting parameters of the basic parameter set set last are displayed;

• After the pipetting device is switched on, the pipetting parameters of the last basic parameter set set are displayed, which were at least partially or completely executed or which were only set but not executed;

• After a period of inactivity of the pipetting device -especially after a possible standby mode - the pipetting parameters of a basic parameter set are displayed; this basic parameter set is in particular the pipetting parameter set displayed after switching on the pipetting device; "Inactivity" can mean that no user operation or display touch was detected on the device for a predefined time - predefined according to the factory setting or defined by the user - and/or that an optionally available sensor (e.g. an acceleration sensor, motion sensor, proximity sensor) of the pipetting device did not Movement and / or approach of a user has detected. Standby mode may be automatically activatable after a predetermined period of inactivity.

• After a period of inactivity of the pipetting device - especially after a possible standby mode - the pipetting parameters of the basic parameter set set last are displayed;

• After a period of inactivity of the pipetting device—particularly after a possible standby mode—the pipetting parameters of the basic parameter set set last are displayed, which were at least partially or completely executed or which were set but not executed.

The screen page preferably contains at least one first input tile that displays the value of at least one—or exactly one—first pipetting parameter of a parameter set, in particular a basic parameter set, which defines a pipetting process, in particular a basic pipetting process. The number of input fields displayed on the screen preferably corresponds to the number of pipetting parameters in the parameter set. The basic parameter set preferably contains at least or exactly one pipetting parameter, preferably contains at least or exactly two pipetting parameters, preferably contains at least or exactly three pipetting parameters, preferably contains at least or exactly four pipetting parameters, preferably contains at least or exactly five pipetting parameters, preferably contains at least or exactly up to ten Pipetting parameters, or more pipetting parameters. In particular, the data processing device is programmed to start the pipetting process associated with the set of pipetting parameters if the user -when shown screen or home screen-a-particularly any-actuating element actuated.

Touching an input tile on a screen page, in particular the first input tile, preferably opens an input interface that allows the user to input the value of the associated pipetting parameter, in particular the at least one first pipetting parameter.

An input tile is understood to mean a marked input area of the screen page displayed on the touchscreen, touching which represents an input, with the programming preferably starting a subsequent action as a result of this touch, in particular the display of an input interface. It may be that the detection area, which is evaluated by the control program as input for this input tile, deviates from the marked area, eg is larger, but preferably the marked area, ie the visible input tile, corresponds to the detection area. If the detection area is larger than the marked area, incorrectly located touches will also be detected as input. If the detection area is smaller than the marked area, the user is trained to correctly locate the touch of the input tiles, and the distance between adjacent input tiles can be reduced without increasing the number of incorrect localizations, thus making better use of the available area for input/output . These tolerance solutions are acceptable or promote user satisfaction as long as the touch does not hit the capture area of another input tile or field on the screen. The visible input tile is preferably a substantially rectangular area, since rectangles make the best use of the available area for inputs and outputs on a substantially rectangular display. However, such a region can also be different, for example: hexagonal, in the shape of a segment of a circle, polygonal and/or rounded. The width b of an input tile preferably extends over a proportion X of the entire width B of the screen—viewed in particular perpendicularly to a longitudinal axis A through the pipetting device. In this case, preferably 0.8<x<1, preferably 0.9<x<1, preferably 0.95<x<1. The input is comfortable due to the large width of the input tiles. This means that b=B*x. Preferably, the background of an input tile is light, specifically white, and the information shown on it is dark, specifically blue or black. However, it can also be the other way around, for example in a night mode of the display, in which the background is then dark and the information is presented in a lighter color. There is preferably sufficient contrast to the background to keep the information legible for the user in any standard lighting, from darkness to direct sunlight. The pipetting device preferably has a light-sensitive photo sensor. The control device, in particular the data processing device, is preferably set up or programmed to keep the screen brightness of the screen in a predetermined relationship to the light intensity received by the photo sensor, which can mean that the screen brightness is increased when the intensity of the outside light increases, and in particular the screen brightness is lowered with a falling intensity of the outside light. However, the screen brightness can also be constant, can in particular be preset at the factory, can be automatically adjustable depending on other parameters—for example depending on a loaded application scenario or a loaded user profile, and/or can be adjustable by the user.

The screen page, in particular the home screen, preferably has at least one input field which, when touched, enables the user to select at least one second pipetting parameter. In order to implement these input options, several advantageous solutions were found in this pipetting device. In a first solution, the input field is a marked area on an edge of the screen page, in particular the home screen, in particular in a lower or upper edge area, so as not to interrupt the list of input fields that is preferably displayed there. The special position of this input field compared to the input tiles displayed there then clarifies the special function, namely the opening of a new screen for the selection and/or deselection of new pipetting parameters (also: selection screen") that are to be added (or deselected) to the current parameter set. After closing the selection screen, the at least one selected pipetting parameter is added to the current parameter set and on the screen page displayed. In a second solution for selecting/deselecting pipetting parameters, the screen page has a size, in particular length or width, that exceeds the display area available on the screen for displaying the screen page. Input tiles can be provided in this initially invisible area of the screen page, each of which in particular describes a value or information describing the value of the pipetting parameter belonging to the input tile - e.g. a switch that shows the "on/off" of a specific pipetting parameter, in particular the "on /off" of the function represented by this pipetting parameter.

The Screen Page may be larger than the display area available on the Screen for displaying the Screen Page; in this case the screen page may be scrollable, e.g. vertically scrollable. However, it can also be scrollable, in that tapping on a screen area or swiping the screen - based on the well-known "Wsche" input gesture - leads to scrolling of the screen content, i.e. to the display of that area of the screen page that is below, above or to the side of the current one displayed area of the screen follows.

The term “selection” refers in particular to the activation of a pipetting parameter from a predetermined total set of pipetting parameters that can be stored in the data storage device of the pipetting device. Activating the pipetting parameter can have the direct consequence that it is added to the current parameter set, but a confirmation dialog can also be interposed, with which the user confirms - or prevents - this addition. The "deselection" is defined accordingly: deactivation of the activated pipetting parameter - and corresponding change of the user-defined user parameter set)

The data processing device is preferably programmed to, after detection of this user-actuated selection of a pipetting parameter, in particular a second pipetting parameter, that

• the at least one - in particular second - pipetting parameter the at least one first pipetting parameter of the parameter set, in particular a base pa- rameter set, is added in order to use this at least one first pipetting parameter to form the pipetting parameters of a user parameter set that define a user-defined pipetting process, and

• this selection of the at least one second pipetting parameter is displayed to the user on the screen page, in particular the home screen.

It is considered to be an independent invention that the data processing device of the pipetting device is programmed to display a graphical user interface (GUI) on the screen, the GUI containing at least the following: display of a screen page, in particular a home screen, on the screen in which pipetting parameters of a parameter set of Pipetting parameters are displayed, the screen page containing at least one first input tile which displays the value of at least one first pipetting parameter of a parameter set, in particular a basic parameter set, which defines a pipetting process, in particular a basic pipetting process, and touching which opens an input interface which allows the user to enter the value of the at least one first pipetting parameter, the screen page having at least one input field which, when touched, allows the user to select at least one second pipetting parameter allows, the data processing device being programmed to, after detection of this user-actuated selection, that the at least one second pipetting parameter is added to the at least one first pipetting parameter of the parameter set, in particular the basic parameter set, in order to form the pipetting parameters of a user parameter set with this at least one first pipetting parameter, which define a user-defined pipetting process, and this selection of the at least one second pipetting parameter is displayed to the user on the screen page, in particular the home screen.

The invention mentioned represents a particularly advantageous aspect of the innovative operating concept of a pipetting device. The inventors learned from user studies that a significant fraction of users can achieve a more efficient workflow with a pipetting device in which the user selects the desired pipetting pipetting processes are usually defined according to their own wishes by adding pipetting parameters, i.e. functions or features, to an existing parameter set, for example a proven parameter set or a basic parameter set. Obviously, this approach efficiently leads to the goal of defining an individually desired pipetting process. In particular, if a basic parameter set is provided on a screen, in particular the home screen, which can be executed immediately, a sense of achievement is immediately offered during operation without the need for lengthy study of operating instructions. Within a short training period, users can orientate themselves in the list of possible pipetting parameters and thus exploit the potential of the great functionality of an electric pipetting device more efficiently. This applies in particular to the large group of users who, with known pipetting devices of the prior art, have difficulties in learning existing—more or less complex— operating modes that represent application scenarios and are then satisfied with the simplest operating modes. The new concept invites inexperienced users to learn functions and offers experienced users full flexibility.

It should be noted that the aforementioned approach of defining a user parameter set does not exclude the possibility that - for example by means of separate screen pages - other, in particular more complex, parameter sets intended for selection by the user can also be offered, which represent certain predefined application scenarios that are saved by the user are parameter sets, or which are automatically saved parameter sets from a list of previously applied parameter sets (this list is also referred to as parameter set history), or which statistically are the most frequently executed parameter sets, or a user-determined favorite list of parameter sets.

Such separate screen pages form part of the GUI, which, like any other screen page, are displayed on the screen in particular according to a program or program code stored in a data storage device, in particular an operating program or control program. Examples of such screen pages, which are preferably part of the GUI, are the following: A favorites screen page is preferably provided, in which one or more, optionally limited to a maximum total number M1, of pipetting parameter sets are displayed, in particular listed, that were previously created by the user or that were loaded by the user from another screen page, and which the user can use an input option have been marked as a favorite, for example by touching an input field which can be provided in a menu and/or navigation bar arranged in particular on the edge of the screen, in particular an input field with a star-shaped pictogram or another appearance.

A history screen page is preferably provided, in which one or more, optionally up to a maximum total number M2, of pipetting parameter sets are displayed, each of which is formed by a historical pipetting parameter set that was executed in the past and in particular was automatically saved, which simulates a historical pipetting process.

A program set screen page is preferably provided, in which one or more pipetting parameter sets, optionally limited to a maximum total number M3, are displayed, in particular listed, which were created by programming by the user. This programming can be done in particular on a programming screen page, on which the user assembles program steps step by step from predefined program steps according to a modular system, the sequence of a pipetting process that can be defined by pipetting parameters in program steps, with these inputs being checked for consistency, in particular by the control program or another program, and the corresponding one being derived from this programmed pipetting parameter set is created and, in particular according to the user's specifications, is added to the program set screen page, that is to say it is in particular saved. Programming can also take place on an external data processing device, in which case the externally created programmed set of pipetting parameters is transmitted to the latter by means of a communication device of the pipetting device. The programming is carried out in particular by means of a programming (macro) language implemented in the pipetting device, which a person skilled in the art can suitably provide, in particular through input fields, text descriptions and pictograms that can be optionally selected in the GUI, which the user then adds together step by step. However, a program (macro) code is preferably generated by the recorder function, which can then be edited again by the user, in particular in the programming screen page.

An auto program set screen page is preferably provided, in which one or more pipetting parameter sets, optionally limited to a maximum total number M4, are displayed, in particular listed, which have previously been manually set and executed by the user from setting steps of pipetting parameters and/or pipetting processes by a recorder function of the pipetting device , i.e. essentially without user intervention, were derived and then stored in particular in the data storage device. Typically, this recorder function is triggered by the user touching an input field of the GUI that defines the start of the recording of the recorder function, and in particular this recorder function is terminated by the user touching an input field of the GUI that defines the end of the recording of the Recorder function defined. To create the steps of a desired pipetting program, starting from a home screen with any desired pipetting parameters, the values of these pipetting parameters are specified and the actuating elements are actuated in order to carry out the aspiration or dispensing of sample volumes in the desired way - simulated or not, which means that the movement element moved by the motor either preferably cannot move or preferably can move after actuation of the actuating elements. This "teach-in" property of the recorder function, while the pipette is being set up and the pipetting is being carried out, the associated pipetting parameter set can be created and saved, in particular without the user having to deal with a programming (macro) language implemented in the pipetting device. However, a program (macro) code is preferably generated by the recorder function, which can then be edited again by the user, in particular in the programming screen page.

A scenario screen page is preferably provided in which one or more pipetting parameter sets, optionally limited to a maximum total number M5, are provided displayed, in particular listed, which were provided in particular by the manufacturer. These sets of pipetting parameters can define one, several or all of the application scenarios described at the outset. The corresponding set of pipetting parameters is selected by touching the input field or the input tile that stands for the corresponding application scenario and has a corresponding abbreviation.

A pipetting parameter set on one of the mentioned screen pages can be represented by an input field, in particular an input tile, which can be touched by the user in order to make the corresponding pipetting parameter set the current pipetting parameter set, whose pipetting parameters are then on the (main) screen page -according to the patent claim-, in particular the home screen, or a separate screen page. The transfer of the pipetting parameter set directly to the central screen page, in particular the home screen, is also referred to as quick selection. When transferred to the separate screen page, input options can be provided in particular in order to create a new program with the pipetting parameters of the selected pipetting parameter set, to edit the pipetting parameter set and to delete this or parts of it.

The total number M1, M2, M3, M4, M5 mentioned can in particular be selectable or can be fixed, e.g. to any number between 1 to 50, in particular 2 to 30, in particular 5 to 25.

The basic parameter set can in particular include three pipetting parameters, in particular the pipetting parameters volume V, speed v (two-component, vectorial parameter: the intake/release), number of repeat steps n (this intake or release). The volume is in particular a volume to be sucked into the pipetting container or a volume to be dispensed from it in the event of a single intake and/or dispensing. For the volume, information about the physical unit is preferably also displayed in the input tile, eg mL or pL. The speed is, in particular, a vectorial value that contains the two semantically related information on the speed of recording the pipetting speed liquid in the sample container and the rate of delivery from the sample container. The numerical values associated with the speed can be proportional to the rate of the liquid volume exchanged between the pipetting container and the environment (alternative: non-proportional relationship). User-selectable speeds can be specified by speed levels, which can be represented by ordinal numbers, for example 1 ... 10 or letters A ... J or other symbols, where level 4 does not have to represent twice the speed compared to level 2, but can. A basic parameter set is selected in particular in such a way that it defines an executable pipetting process, as is the case in particular in the example (V,v,n) mentioned.

An input field is preferably provided as an extra button, in particular only a single input field is provided, which is designed as an extra button, which in particular has a different shape and/or color and/or background color than the input tiles displayed on the screen, and/or a marginal position in the Screen. Touching the extra button preferably causes the display of a selection screen, instead of the screen, home screen, and as the latter superimposed screen (overlay)), in particular a predetermined selection of available pipetting parameters, i.e. those stored in a data storage device, in the form of a selection list, which information, in particular Contains short descriptions (to identify the content of the pipetting parameter) about selectable second pipetting parameters from which the user can select the at least one second pipetting parameter.

Preferably, after the selection of the at least one second pipetting parameter has been completed, the selection screen or the selection list is closed and the screen page, in particular the home screen, is displayed again, which now also displays at least one second input tile in addition to the at least one first input tile, which shows the selection and/or a value of the at least one second pipetting parameter or information representing this value about this at least one second pipetting parameter. The wording “at least one first input tile” means in particular that, for example, exactly three “first input tiles” can be provided, so that the “at least one second input tile” that may have been added is the fourth of the four input tiles that are now displayed.

It is preferably provided that, if the at least one second pipetting parameter can assume a value that can be selected by the user, touching the at least one second input tile - within the selection screen/selection list or after closing the selection screen/selection list- opens an input interface, which allows the user to enter the value of the at least one second pipetting parameter.

According to the second solution for the selection of further pipetting parameters for the current parameter set, a number N>=1 of input fields, in particular input tiles, is preferably displayed on the screen page, in particular as a scrollable or pageable list of input tiles, with each input field having information, in particular a brief description, a pictogram and/or a physical unit is assigned and displayed via a second pipetting parameter that can be selected using the input field.

Preferably, after the user-actuated selection of the at least one second pipetting parameter from the set N of input fields, the selection and/or a value or information representing this value of the at least one second pipetting parameter is displayed.

It is preferably provided that, if the at least one second pipetting parameter can assume a value that can be selected by the user, touching the at least one second input tile, which is now displayed on the screen/home screen, allows the user to enter the value of the at least one second pipetting parameter allows.

The data processing device is preferably programmed to display a screen page on the screen, in particular a home screen, which contains at least one first input tile which contains the value of at least one first pipetting parameters and touching which opens an input interface that allows the user to enter the value of the at least one first pipetting parameter.

This input interface is preferably a screen area in which a number block is displayed, the number keys of which can be touched individually and can be used by the user to enter a sequence of numbers that defines the value of the at least one first pipetting parameter. The screen area can also be the screen area of a new screen that replaces the current screen. The input interface may also include a scrollable list of choices, or other input such as an input roller, of possible numeric values or other selectable fields provided with information, or a parallel display of a plurality of possible selectable numeric values. The input interface preferably has an input field in which the user confirms the value change previously made. The input interface preferably has an input field in which the input or value setting is canceled and the screen page, in particular the home screen, is returned to. The input interface, preferably the screen page, in particular the home screen, preferably has an input field, touching which removes the pipetting parameter last added to the parameter set by selection, in particular the at least one second pipetting parameter, from the parameter set, or which removes the last change made to the value of a pipetting parameter (“undo” function) or which resets the parameter selection to a default selection, in particular to a basic parameter set.

In particular, the input interface can have a numeric keypad, at least one selection field for selection from a list, in particular a pull-down menu, at least one selection wheel (“picker wheel”) and other means for changing a numerical value of a To effect parameters, in particular pipetting parameters.

The data processing device is preferably programmed in such a way that when the value entered by a user via an input interface for a pipetting parameter is not allowed, some information is displayed on the screen and preferably

• at least one correction button is displayed, touching which automatically executes at least one correction process instead of the value entered by the user, which can have the following configurations:

A valid value is automatically set instead of the invalid value;

At least one pipetting parameter that is an alternative to the pipetting parameter mentioned is selected and in particular assigned the value of the user or another suitable value;

The user's input is undone and, in particular, a new input is made possible;

And or

• An error message is issued;

And or

• The change in the previously current value is ignored and the previously current value is retained;

And or

• Another non-combinable pipetting parameter that represents a non-combinable function is automatically deselected.

The data processing device is preferably programmed to display a screen page on the screen, in particular the home screen, which contains a list of essentially rectangular input tiles which are arranged in particular one below the other and in particular extend essentially over the entire screen page. In this way, the available space is optimally used and operation is ergonomic.

The data processing device is preferably programmed to display a start screen page (home screen) on the screen, which is in particular this screen page for displaying the pipetting parameters of a parameter set of pipetting parameters, and which is replaced by a second image by a laterally or vertically directed swipe gesture. screen page and which is replaced by a third screen page by a laterally or vertically opposite swipe gesture. This does not preclude other screen pages from being able to be displayed by further swipe gestures, starting from the second or third screen page.

The data processing device is preferably programmed in such a way that the second screen page has a list of input fields, each input field having an abbreviated designation and touching the input field loads a predetermined set of parameters that defines a predetermined pipetting process, with another screen page in particular after touching this input field as the start screen page is displayed, or, alternatively, the start screen page is displayed again with the input tiles of the predetermined parameter set.

At least one screen page is preferably provided, which provides the following special function of the pipetting device: the pipetting parameter of a target volume is required, which can be entered or changed via an input field. By continuously actuating an actuating element, liquid is taken up into the pipetting container until the target volume is reached. Analogously or alternatively, the special function for dispensing a target volume of liquid is optionally provided: liquid is dispensed from the pipetting container by continuously actuating an actuating element until the target volume is reached. This imitation of the functioning of a conventional mechanical pipette gives users a certain additional control, for example to interrupt a pipetting process for a short time and in particular to pipette in a more controlled manner.

The data processing device is preferably programmed in such a way that the third screen page has a list of input fields, with each input field having an abbreviation and with touching the input field loading one of the following parameter sets: a historical parameter set used in the past and automatically saved, the one historical pipetting process defined; parameter sets that represent certain predefined application scenarios; parameter sets, which are parameter sets saved by the user;

parameter sets that were statistically executed most frequently;

parameter sets belonging to a user-determined favorite list of parameter sets;

Parameter sets that were created by programming by the user or were automatically created by a recorder function of the pipetting device implemented by means of a program code - which can in particular be part of the control program of the pipetting device - from individual setting steps set manually by the user or pipetting processes carried out; in particular, after touching this input field, a screen page other than the start screen page is displayed, or, alternatively, the start screen page with the input tiles of the predetermined parameter set is displayed again.

The screen (also referred to as "display") is a touch-sensitive screen (also referred to as "touch screen"). It is preferably a color display.

A touch screen can serve as an input medium, a non-touch-sensitive screen can at least serve as an output medium for outputting information, or can serve as an input medium in combination with (one) control element(s) arranged next to the screen, especially if screen areas have the function of the inform each control element, which is then designed as a so-called soft key, which can perform a variable function in particular.

The screen is preferably substantially rectangular. In this way, the screen area can be optimally used by using essentially rectangular input tiles and/or rectangular information fields displayed on the screen.

The screen is preferably substantially planar. This can improve readability, since the user can choose the most reflective alignment angle to the light source len in a laboratory can choose to perform the operation, while curved screens capture light from a larger solid angle and reflect it into the user's eye.

A planar screen is preferably aligned with planar sections of a housing front in which the screen is placed. This makes it easier to touch areas of the touchscreen that are close to the edge if it is protected all around by the front of the housing.

Preferably, according to a particular inventive embodiment variant of the operating concept, the data processing device is programmed to display a screen page, in particular an output screen page, which contains a separate input area, in particular also referred to as a special button, touching which closes the output screen page and displays the Causes the input screen page or another screen page on the screen, and this other screen page can also enable the editing of parameter values contained in the pipetting parameter set. Touching the special button can also cause a running pipetting process to be aborted, it being possible for this abort to have to be confirmed by the user with a security query. The termination of a completed pipetting process also leads in particular to an input screen page being displayed again instead of the output screen page, without it being necessary to touch the special button, with information about the successfully completed pipetting process being able to be output before/after this. It does not have to be exactly the previous input screen page to which you return using the special button, e.g. if the speed is to be adjusted quickly when the pipetting sequence ("do") has already started. It can be provided that after the pipetting process has started, not all parameter values can be changed/corrected, but only certain parameter values of the current pipetting parameter set.

The distinction of the input mode represented by the input screen ("set") and the output mode ("do") defined by the output screen prevents inadvertent changing of parameter values while the "do" mode is running, which could destroy a lab work and result in a significant loss of value. On the other hand, changing from "set" to "do" mode by actuating the operating element means considerable convenience for the user and is intuitively understandable. This also contributes significantly to ergonomics and an efficient workflow. The distinction between the input screen and the output screen can be made using one or more of the following definitions. In each case, the definition particularly preferably relates to the state of the pipetting device in which the pipetting process was started and the electrically controlled movement element is moved; it may then be the case that the definition does not apply if the pipetting device is in the state in which the pipetting process was started and the electrically controlled moving element is not being moved. This makes it possible, for example in the case of a multi-step pipetting process, after a completed pipetting process or a completed partial step of a multi-step pipetting process, to display an output screen page which allows a pipetting parameter of the parameter set to be changed, but preferably not all pipetting parameters of the parameter set that can be changed in the previously displayed input screen were changeable, in particular the input screen displayed immediately before starting the pipetting step. It can be useful, for example, in a multi-step pipetting process, to give the user the option of changing one or more individual pipetting parameters, in particular those that do not critically affect the successful execution of the ongoing pipetting process. The aspirating and/or dispensing speed, also referred to as pipetting speed, can be such a pipetting parameter whose change does not necessarily change the result of the pipetting process and which can therefore be adapted to the user's needs - in the meantime or between completed partial steps of the pipetting process. The possible definitions:

Preferably, the output screen page, but not the input screen page, the input field known as a special button, touching which closes the (Output) screen page and the display of this input screen page or another input screen page on the screen.

If the output screen has the modifier, it is clear that the input screen, specifically the home screen, does not have the modifier, since the modifier is defined as closing the output screen, which must therefore be currently displayed.

Preferably, the input screen, but not the output screen, has an input field called an extra button, touching which opens up the possibility for the user to change the set of pipetting parameters of the parameter set, which is subsequently displayed in the input screen. Preferably, the input screen page, but not the output screen page, has an input field called an extra button, touching which causes a selection screen to be displayed, which in particular displays a predefined selection of available pipetting parameters, i.e. those stored in a data storage device, in the form of a selection list, which information, in particular contains brief descriptions (to identify the content of the pipetting parameter) about selectable second pipetting parameters from which the user can select the at least one second pipetting parameter; in this context, “first pipetting parameters” are understood to be those that have already been displayed previously in the input screen page, while “second pipetting parameters” are understood to be those that are added to the first pipetting parameters.

Preferably, the input screen page, but not the output screen page, has an input field that displays a pipetting parameter, in particular its numerical value, and touching it immediately, i.e. in particular without any significant delay and in particular without requiring any further user action, opens an input interface with which the user can change the value of the displayed pipetting parameter.

The output screen page and/or a further output screen page displayed following the output screen page preferably has no possibility of to change the, in particular more than half, in particular all of the pipetting parameters previously displayed in the input screen and changeable by input. Preferably, the output screen page and/or a further output screen page displayed following the output screen page does not have the possibility of displaying the total number or a part f (in particular: f > % or f > 2/3 or f > 1/2 or f > 1/ 3 or f > 1/4) or to change at least one of the pipetting parameters previously displayed in the input screen page and changeable by input.

Preferably, the output screen and/or a further output screen displayed after the output screen has no possibility, in particular no input field, to change at least one predetermined pipetting parameter previously displayed in the input screen and changeable by input, in particular to change it directly and/or indirectly. This at least one predetermined pipetting parameter is preferably selected from the following list of possible pipetting parameters:

{a volume to be aspirated or dispensed during pipetting; a number of partial steps, in particular the total number, in a pipetting process comprising several partial steps, in particular a number (greater than zero) of pre-wetting steps in a pipetting process, during a pre-wetting step a liquid is sucked into the pipetting container and released again, in particular around the inner surface of a to wet the pipetting container before the start of the actual pipetting process; a time parameter, in particular a duration of a pipetting process or a sub-step of a multi-step pipetting process, or a latency time between pipetting processes or between sub-steps of a multi-step pipetting process; a parameter relating to the automatic execution/non-execution of a complete delivery of a residual volume remaining in the pipetting container after the pipetting process has been carried out ("auto blow off" function activated or deactivated); a speed parameter relating to the speed of a pipetting process, in particular the speed of aspirating or dispensing sample volumes into/from the pipetting container, in particular during partial steps of a multi-step pipetting process, in particular dispensing process}

The pipetting volume can be a volume that is to be sucked into the pipetting container during the pipetting process or during a sub-step of a multi-step pipetting process, or it can be a volume that is to be released from the pipetting container during the pipetting process or during a sub-step of a multi-step pipetting process, in particular during volume to be dispensed in a multi-step dispensing process.

Preferably, the output screen page or a subsequently displayed output screen page, in particular apart from the special button, has no input field, in particular no input field, touching which results in a, in particular immediate, change in the content of the output screen page and/or a, in particular immediate, change in the started pipetting process Has.

Preferably, the output screen or a subsequently displayed output screen, in particular apart from the special button, has no input field for changing one of the pipetting parameters that were displayed in the previously displayed input screen and could be changed there by an input.

Preferably, the output screen page or a subsequently displayed output screen page, in particular apart from the special button, does not have an input field for changing a pipetting parameter, touching which, in particular directly or indirectly, enables one or more or all pipetting parameters of the parameter set of pipetting parameters entered by means of the input screen page to be changed. in particular in order to change at least one predetermined pipetting parameter previously displayed in the input screen page and changeable by input, and/or in particular to change one of the pipetting parameters of an ongoing pipetting process. "Change immediately" means in particular that after touching the input field, an input interface opens immediately in which the user can change the value of the displayed pipetting parameter. "Change indirectly" means in particular that an input screen page with at least one input field opens first, touching it immediately opens an input interface where the user can change the value of the displayed pipetting parameter.

The change of at least one, several or all changeable pipetting parameters of a parameter set of pipetting parameters is preferably provided only in the input screen, in particular in the home screen, but not in the output screen. In particular, only an input screen page, but not the / an output screen page, contains an input field, in particular at least one first input tile, which in particular displays the value of at least one first pipetting parameter of a parameter set, in particular a basic parameter set, which defines a pipetting process, in particular basic pipetting process, and touching them - namely without a further user input following this touching - opens an input interface which allows the user to input the value of the at least one first pipetting parameter. These pipetting parameters of the parameter set of pipetting parameters can in particular be selected from the above list of possible “predetermined operating parameters”.

Preferably, the output screen page, but not the input screen page, displays different content, preferably depending on the sub-step of an automated multi-step pipetting process that is currently taking place, in particular the values of the pipetting parameters that define the currently running sub-step, e.g. the delivery of a partial volume Vt with a specific delivery rate v2, as a sub-step i of a total of N steps of the pipetting process. This can be the case, for example, in the "Dis" application scenario.

Preferably, the output screen page, but not the input screen page, displays a progress indicator, which contains information about the progress of the multi-step pipetting process, preferably depending on the partial step of an automated multi-step pipetting process that is currently taking place.

The output screen preferably shows, but not the input screen, preferably depending on the sub-step of an automated process that is currently taking place multi-step pipetting process, a variable display element, in particular a display wheel or a display roller, as will be explained below.

The distinction between the input screen page and the output screen page can be made in particular by the above definitions.

The start of a pipetting process can satisfy different start conditions or can be fixed. It can take place immediately by (first) actuating an actuating element, or, in the sense of a security query or for other reasons, in a second actuation immediately following this first actuation (i.e. in particular without the special button being touched), possibly a third actuation of a Actuator done, which is different from the touch screen. The data processing device is preferably programmed to display the input screen page, in particular the home screen, for the display and input of pipetting parameters of a parameter set of pipetting parameters, and if the actuation of the at least one actuating element (different from the screen) is detected, an output screen page is displayed on the screen instead of the input screen page (abbreviated: "do") to display pipetting parameters of the parameter set defined in the input screen page, and in particular to start the pipetting process triggered by this actuation or by a subsequent actuation of one of the operating elements (different from the screen), or in particular if these the actuation of the at least one actuating element causing the display of the output screen page is detected or upon the subsequent actuation of one of these actuating elements, the according to this Pipetti to start the pipetting process defined in the parameter set. The data processing device is preferably programmed in such a way that the start conditions mentioned can be selected by the user on the pipetting device via an input interface of the GUI.

The input screen page preferably differs from the, in particular each, output screen page, preferably in its graphic representation; in particular, the output screen page has a different color scheme and/or a different arrangement of markings and/or information fields. In particular, the output screen page will display different content, preferably depending on the partial step of an automated multi-step pipetting process currently taking place, in particular the values of the pipetting parameters currently defining the partial step, e.g. the delivery of a partial volume Vt with a specific delivery speed v2 as partial step i of the total N steps of the pipetting process. This can be the case, for example, in the "Dis" application scenario. The concept of distinguishing between an input screen page and an output screen page, which is implemented in particular by an external distinction, forms a significant ergonomic advantage in operation, since the user recognizes with minimal effort whether he is currently in a - possibly interrupted - on an operation awaiting pipetting or in a setup mode. The concept of the input screen and the output screen thus implies such an input mode and output mode of the pipetting device that are easily distinguishable for the user. Preferably just touching the separate input area—or a completed pipetting process that can bring about an automatic return to an input screen page, in particular the home screen—allows the user to change parameter values or make a new parameter selection. In particular, this separation prevents parameter values from being accidentally changed while the "do" mode is running, which could destroy a laboratory work and result in a significant loss of value. On the other hand, changing from "set" to "do" mode by actuating the operating element means considerable convenience for the user and is intuitively understandable. This also contributes significantly to ergonomics and an efficient workflow.

In particular, the at least one actuating element is not part of the touch-sensitive screen. The at least one actuating element is preferably designed as a push button, namely as a component that can be actuated by the user, which can be actuated in particular with the thumb when the user holds the hand-held pipetting device in the intended manner with one hand, the hand gripping the housing, which serves in particular as a handle, and doing so in particular a hand rest of the housing rests on an index finger. The touch screen is operated in particular by a finger of the hand that is not holding the pipetting device. The data processing device can be programmed so that the actuation of an ejection button (to eject a pipette tip) of the pipetting device while an output screen is being displayed, i.e. in particular in the output mode of the pipetting device, in some scenarios or in principle leads to the input screen page, in particular home screen, instead of the output screen page , or another input screen is displayed and/or the pipetting process is stopped or aborted.

A pipetting program that is defined by the pipetting parameters of a parameter set can have several temporal phases, e.g. if repetitively or cyclically determined sequences of steps or partial steps are repeated. For example, if a pipetting process includes 10 sequences of steps, the output screen preferably shows for each step that is executed which of the 10 sequences of steps is currently being executed and/or how many sequences of steps remain. In addition, the pipetting parameter(s) of the current (active) step can be displayed. The output screen preferably shows the active parameter settings so that it is clear what happens next when the actuator is pressed, e.g. pipetting step 3 of 3 with 150 pL and speed X.

The output screen page preferably displays different content, preferably depending on the sub-step of an automated multi-step pipetting process that is currently taking place, in particular the values of the pipetting parameters that define the currently running sub-step, e.g. the dispensing of a partial volume Vt with a specific dispensing speed v2, as sub-step i of a total of N steps of the pipetting process. This can be the case, for example, in the "Dis" application scenario.

In order to indicate the progress of the multi-step pipetting process, the output screen page preferably has a display element, in particular a one-part or multi-part output tile. The display element displays various contents, preferably depending on the partial step currently taking place of an automated multi-step pipetting process, in particular the values of the pipetting parameters which define the currently running sub-step. In particular, the display element occupies a variable or constant area of the output screen page.

The first view of the display element in a first state, in which it displays sub-step i (i is a counting index that counts the sub-steps running in particular sequentially), preferably differs from a second view in a second state in that sub-step i+ 1 indicates. The difference in the view can be that in the first state a counting index i and in the second state a counting index i+1 is displayed in the output screen page, in particular in the display element. In addition, the difference in the view can consist in the fact that in the first state and in the second state different values of pipetting parameters are displayed in the output screen page, in particular in the display element, which are used in the respective partial step.

Preferably, the display element has a first output tile, in which one or more values of one or more pipetting parameters are displayed, which are used in sub-step i currently running. The display element preferably also has a second output tile, in which one or more values of one or more pipetting parameters are displayed, which will be used in sub-step i+1 to be executed in the future. This gives the user a better overview and better control over working with the pipetting device. The display element preferably has a different second output tile or a third output tile in which one or more values of one or more pipetting parameters are displayed that were used in the previous sub-step i-1. This also gives the user a better overview and better control over the work with the pipetting device. Analogously, further output tiles with successively planned future partial steps (eg i+2, i+3, etc. until i=N) can be displayed at least partially and simultaneously. Analogously, further output tiles with successively past partial steps (eg i-2, i-3, etc. up to i=0) can be displayed at least partially and simultaneously. Depending in particular on sub-step i, the display element can contain the first output tile and one or more of the second and/or third output tiles.

Preferably, at least during a sub-step i, the display element has said first output tile, said second output tile and said third output tile. The first output tile is preferably arranged spatially between the second and the third output tile. In this arrangement, the indicator element is also referred to as an indicator wheel or indicator roller. The display roller preferably has at least three positions (e.g. middle, left, right; or: middle, top, bottom), which can be occupied by output tiles characterizing a respective part of the journey. The progression of the multi-step pipetting process, counted by the index counter i, is illustrated by rotating the output tiles of the display roller, since, for example, in a ten-step (N=10) pipetting process (e.g. dispensing process) at the beginning of the pipetting process (i=1), the sub-step i =1 associated output tile is in the middle roller position, while an output tile associated with substep i=0 does not exist; or exists and is displayed to the side (left, right, top, bottom) of the middle position and displays information about the entire pipetting process or other or no information; and while the output tile associated with the future sub-step i=2 is to the side of the middle roller position and opposite the first position (e.g. right, left, bottom, top). After completion of sub-step i=1, the first output tile changes from the middle position to a lateral position and the second output tile relating to sub-step i=2 now running switches to the middle position, while the third output tile relating to sub-step i=3 now in the future changes is displayed in the other lateral position of the indicator roller.

A progress indicator, which contains information about the progress of the multi-step pipetting process, is preferably displayed in the output screen page, in particular in the display element, in particular in at least one output tile of the display element. In particular, the counting index i and additionally the value N of the total number of partial steps of the multi-step pipetting process can be displayed, for example in the form of a text output “i of N” or “i/N”. The progress indicator can additionally or alternatively contain a non-numerical and graphical representation of the progress, in particular a progress bar, or a route representing the successively running sub-steps 1...N with a graphically highlighted position of the currently running sub-step i.

If a display element has several output tiles depending on the sub-step, e.g. in the case of a display roller, provision can be made to show the change from the first view to a second view of the display element in an animated manner. In addition, the lateral positions of an indicator roller can be shown in shaded or brightened order, in particular, to simulate or show a three-dimensional object (roller, wheel) and/or to simulate or show perspective. This makes working with the pipetting device even more intuitive.

The data processing device is preferably programmed so that the pipetting device has exactly one first and one second actuating element, which can be actuated separately from one another, in particular by a rocker switch. Irrespective of this, an ejection button for ejecting a pipette container, in particular a pipette tip, can be provided. This makes operation intuitive and ergonomic.

The data processing device is preferably programmed to detect the actuation of an actuation element, in particular the first actuation element, by the user and to start the pipetting process defined according to the parameter set depending on the actuation of the actuation element. It is possible for the pipetting process to start immediately after the actuation element has been actuated, or for one or two intermediate processes to take place before the start, e.g. a blow-out, i.e. ejection of the residual liquid in a pipetting container by means of an overstroke, or pre-wetting the pipette tip by a single or multiple aspiration and dispensing of a pre-wetting volume of the sample before the start of the further steps of the pipetting process, or a mixing step can take place which provides for the aspiration and dispensing of a mixture volume before the start of the further steps of the pipetting process. The pipetting device preferably has a first and a second actuating element, which are each separately arranged buttons. Preferably, the pipetting device has an operating rocker and a first and a second actuating element, which can be actuated separately from one another by the operating rocker, in that pressing a first pressure surface of the operating rocker actuates the first actuating element and pressing a second pressure surface of the operating rocker actuates the second actuating element, wherein the first and second pressure surfaces are haptically distinguishable. In particular, the first and second pressure surfaces can be distinguished with regard to the following haptically perceptible and distinguishable external features: * the direction of the optional curvature of the first and second pressure surfaces, in particular in that the first pressure surface is concave and the second pressure surface is convex; * the surface structures of the first and the second pressure surfaces; * the materials of the first and second printing surfaces. In predetermined situations of the operation of the pipetting device, eg after starting an execution mode by pressing one of the actuating elements in the setting mode, the first actuating element can in particular cause the sample to be picked up and the second actuating element can in particular cause the sample to be dispensed. Alternatively, the second actuation element can in particular cause the sample to be taken up, and the first actuation element can in particular cause the sample to be dispensed

Preferably, the pipetting device has a housing which is arranged as a handle for holding the pipetting device with a single hand of the user and which has an axial section containing the piston, along whose longitudinal axis A the piston runs, and wherein the pipetting device has a first and a second actuating element, which can be actuated separately from one another by an operating rocker, which is mounted on a plateau surface of the pipetting device, in particular a thumb rest surface, which is arranged at an angle 80 < a < 180° to the longitudinal axis and which preferably slopes downwards. The “down” direction designates the direction of gravity when the longitudinal axis of the pipetting device is arranged parallel to gravity. Here is the Plateau area arranged in particular so that the user's thumb rests on the thumb support surface when holding the pipetting device with one hand essentially without tiring ("sweet spot" of the gripping hand).

The pipetting device preferably has a housing which has plastic or consists of plastic.

Preferably, the plateau surface is perpendicular to a plane that runs through the longitudinal axis and perpendicular to a surface of the screen.

The pipetting device preferably has a housing with an axial section containing the movement element, in particular a piston or a piston rod, along whose longitudinal axis the movement element runs, and a head section which has a front surface inclined to the longitudinal axis, which extends through the surface of the screen and preferably a this enclosing frame is formed, the screen occupying at least 70%, preferably at least 80% or even at least 90% of the front surface; and in particular wherein a frame front surface lies in a first plane and the screen lies in a second plane identical to or parallel to the first plane.

The pipetting device preferably has a housing with a connecting section for at least one pipetting container and with an ejection button, the contact surface of which can be moved along a path into the housing by pressing the ejection button, with the pipetting device being set up such that when the end of this path is reached, the ejection of the at least one pipette container, in particular the pipette tip, or that an electrical signal is generated which triggers the ejection of the at least one pipette container, in particular the pipette tip. The eject button can be spring loaded. The ejection can also be purely mechanical, with the energy required for the ejection being applied by the user, directly during the ejection or indirectly by tensioning a spring element when the pipette tip is put on. The invention also relates to a system for entering pipetting parameters, having the hand-held pipetting device according to the invention, and an external data processing device, in particular a smartphone or tablet PC, which has an external screen, ie a screen that is not part of the pipetting device, and a data processing device that is is programmed to display an external input screen page (“set”) in the external screen for displaying and entering the pipetting parameters of a parameter set of pipetting parameters, the external input screen page and the input screen page of the pipetting device essentially having the same content, i.e. the screen page has the same functionality , In particular the input screen page of the pipetting device, the system being set up to transmit the pipetting parameters defined on the external data processing device to the pipetting device and there to To use the definition of a pipetting process, and or to transmit the pipetting parameters defined on the pipetting device to the external data processing device and to store them there.

The invention also relates to a computer program code for providing an input screen page on the screen of a hand-held pipetting device, which is used for pipetting at least one liquid sample and has a connecting section for connecting at least one pipetting container, an electrically controlled movement element, in particular a piston, a piston rod or another Element, for aspirating the at least one sample into the at least one pipetting container, for holding the sample in the at least one pipetting container and for dispensing the sample from the at least one pipetting container when performing a pipetting process, and a touch-sensitive screen for entering the parameter values of user-definable pipetting parameters, wherein a parameter set of pipetting parameters completely defines the pipetting process, and the pipetting device has an electrical control device with data processing has a line device which is programmed to control the movement element as a function of the at least one pipetting parameter, and at least one actuating element which can be actuated by a user's finger pressure, in particular thumb pressure, and the actuation of which starts the pipetting process defined according to the parameter set, with the result that the program code, when it is executed by the data processing device of the hand-held pipetting device, has the result that a) a Input screen page (“set”) for displaying and entering pipetting parameters of a parameter set of pipetting parameters is displayed, b) if actuation of the at least one actuating element is detected, an output screen page (“do”) for displaying pipetting parameters of the parameter set is displayed on the screen and optionally: with this actuation or a subsequent actuation of an actuation element, the pipetting process is also started according to the current pipetting parameter set, and c) a special button is displayed in the output screen page, touching which closes the output bi ld screen page and the display of the input screen page on the screen, or wherein the program code, when executed by the data processing device of the hand-held pipetting device, results in a graphical user interface (GUI) being displayed on the screen, the GUI containing at least the following: Display of a screen page, in particular a home screen, on the screen in which pipetting parameters of a parameter set of pipetting parameters are displayed, the screen page containing at least one first input tile that displays the value of at least one first pipetting parameter of a parameter set, in particular a basic parameter set, which displays a Defined pipetting process, in particular basic pipetting process, and touching which opens an input interface that allows the user to enter the value of the at least one first pipetting parameter, the screen page containing at least one egg specification field, touching which enables the selection of at least one second pipetting parameter by the user, the data processing device being programmed to, after detection of this user-actuated selection, add the at least one second pipetting parameter to the at least one first pipetting parameter of the parameter set, in particular the basic parameter set, to use this at least one first pipetting parameter to form the pipetting parameters of a user parameter set that define a user-defined pipetting process, and this selection of the at least one second pipetting parameter is displayed to the user on the screen page, in particular the home screen.

The pipetting device or an external data processing device preferably has a data storage device. This preferably has at least one data memory, in particular a hardware data memory, in particular non-volatile data memory, in particular an EPROM or FLASH memory. It can also have volatile data storage.

The electrical control device of the pipetting device or of an external data processing device, also referred to as control device or control device for short, preferably has a data processing device, which in particular has at least one central processor (CPU). The data processing device can contain a microcontroller. The control device preferably has a microcontroller. The control device preferably has at least one memory device or a data memory for storing data, in particular pipetting parameters and/or one or more computer programs or computer program codes.

The control device preferably contains at least one piece of control software or a control program which uses this at least one pipetting parameter in order to automatically carry out at least one function of the pipetting process or a part of the pipetting process or the pipetting process. The control software or the control program is used in particular by the data processing device Executed control device, in particular by a CPU of the data processing device. The control software or the control program is stored in particular in a data storage device of the device. This data storage device is preferably a non-volatile memory.

The pipetting device or an external data processing device can have a sensor device, e.g. a sensor for detecting an environmental parameter, in particular the temperature, the humidity or the pressure, the motor current used for the piston drive of the pipetting device. In particular, the motor current can be used to determine the viscosity of the pipetted liquid and thus to identify the liquid. The sensor device can also be designed to carry out a measurement with which a parameter, in particular pipetting parameters, in particular the type of a pipetting container connected to the pipetting device, in particular the maximum filling volume of the pipetting container, in particular a pipette tip, can be determined. The pipetting device or an external data processing device can be designed to automatically determine at least one pipetting parameter as a function of the measured value of the sensor device. This improves the optimization of the pipetting parameters required for precise pipetting.

The pipetting device and/or an external data processing device is preferably operated independently of the mains. In particular, the respective device can be provided with a chargeable voltage source, for example one or more rechargeable batteries. In this case, the device can have a charging interface connected to the chargeable voltage source.

Pipette tips are, in particular, disposable products and are preferably made of plastic. Depending on the required maximum volume of liquid, different pipette tips are used with the piston pipette. Typical nominal volumes of commercially available pipette tips are, for example, 10 pL, 20 pL, 100 pL, 200 pL, 300 pL, 1000 pL, 1250 pL, 2500 pL, 5 mL, 10 mL (pL: microliter; mL: milliliter). A pipette tip generally has a cone-shaped container that is elongated along a longitudinal axis, which has a liquid exchange opening at the lower end, and which has a conical and tubular end section at the upper end which is open at the top and which can be plugged onto a connecting section designed as a working cone of the pipetting device designed as an air-cushion pipette. The liquid is sucked into the pipette tip by means of a negative pressure in the interior of the pipette tip, which in the case of the pipetting device designed as an air cushion pipette is generated by a movement of the moving element of the pipetting device designed as a piston, by generating a negative pressure in the air space above the sample in the pipette tip . The interior of the pipette tip is in a pipetting position, also known as the plug-on position, in which the pipette tip is connected to the connecting section of the piston-operated pipette, fluidically connected to the pipetting channel of the piston-operated pipette, which is connected to the negative pressure/ overpressure is applied.

A dispenser tip is used with positive displacement devices in which there is essentially no air cushion between the piston and the liquid sample during pipetting. The plunger is part of the dispenser tip here. This has a container part functioning as a piston cylinder with a container mouth and a container opening into which the piston engages in order to be displaceably arranged in the piston cylinder and to be able to displace the entire aspirated liquid content in an end position. When connecting the dispenser tip to the pipetting device designed as a positive displacement device, the container part is connected to the connecting section of the pipetting device, in particular by screwing it on, and the piston is coupled to the moving element by a coupling device. Dispenser tips are, in particular, disposable products and are preferably made of plastic. Depending on the required maximum liquid volume, different dispenser tips are used with the positive displacement. Typical nominal volumes of commercial dispenser tips are e.g. 100 pL, 200 pL, 500 pL, 1 mL, 2.5 mL, 5 mL, 10 mL, 25 mL, 50 mL.

The invention relates to a hand-held pipetting device, a data processing device that interacts with it, a system and a computer program or a Computer program code, which can be stored in particular on a data storage medium. The possible and preferred configurations of each of these objects result from the description of all configurations of the respective other objects, in particular configuration options for the hand-held piston-operated pipette result from the description of the method, the—in particular external—data processing device, the system and the computer program.

Further preferred configurations of the method according to the invention, the hand-held piston-operated pipette, the data processing device interacting with it, the system and the computer program result from the following description of the exemplary embodiments in connection with the figures and their description. Identical components of the exemplary embodiments are essentially identified by the same reference symbols, unless this is described differently or the context does not indicate otherwise. Show it:

1a shows a schematic side view of an exemplary embodiment of a pipetting device according to the invention, here an air-cushion pipette.

FIG. 1b shows a detail of the operating rocker of the pipetting device from FIG. 1a.

FIG. 1c shows a view of the pipetting device from FIG. 1a rotated slightly about the longitudinal axis A. FIG.

FIG. 1d shows a detail of the pipetting device from FIG. 1a in a perspective side view, with a visible touchscreen.

1e schematically shows a system according to the invention according to the exemplary embodiment. 2a uses two images of the header area of a pipetting device according to the exemplary embodiment to show the functionality of the GUI of the pipetting device to switch between two main types of screen pages, namely between an input screen page and an output screen page.

2b shows input screen pages of the GUI and below it (symbolically) an actuating element of the pipetting device starting from an input screen page (“set”), which is replaced by an output screen page by actuating the actuating element. the content of which changes successively in the dispensing pipetting process ("Dis") shown here.

2c shows an input screen page of the GUI, with a list of abbreviations for the list of pipetting parameters currently selected for the pipetting parameter set, the list of abbreviations being implemented in the form of “tags” arranged at the top edge of the screen, each of which shows an abbreviation of the selected pipetting parameters ; this means that the user has an overview of the pipetting parameters that have already been selected, even if he does not see the entire (scrollable) selection list.

Figure 2d shows an input screen, in particular the home screen, of the GUI and a parameter selection screen which is overlaid on the input screen when a separate input field on the input screen is touched.

2e shows an output screen page of the pipetting device according to the invention according to the exemplary embodiment, in a multi-step dispensing process, in a first state in partial step i=2 and a second state in partial step i=3.

2f shows an output screen page of the pipetting device according to the invention according to the exemplary embodiment, in a multi-step pipetting process. 3a uses two images of the header area of a pipetting device according to the exemplary embodiment to show further functionalities of the GUI of the pipetting device, namely adding further pipetting parameters or functions to the current parameter set via a selection list in the selection screen starting from a home screen.

3b uses two images of an inventive pipetting device according to an exemplary embodiment to show further functionalities of the GUI of the pipetting device, namely adding further pipetting parameters or functions to the current parameter set starting from a home screen with scrollable content or a scrollable selection list.

4 uses several images of the screen of a pipetting device according to the exemplary embodiment to show the functionality of the GUI of the pipetting device to switch between the display of different screen pages.

5a shows, based on several images of the screen of a pipetting device according to the exemplary embodiment, the functionality of the GUI of the pipetting device for setting pipetting parameter values using an input mask.

5b uses two images of the screen of a pipetting device according to the invention according to the exemplary embodiment to show the functionality of the GUI of the pipetting device to call up a historical list of pipetting parameters or to use an optional menu bar with input fields or, as a navigation aid, information fields that do not serve as input fields.

6 shows the functionality of the GUI of the pipetting device, based on several images of the screen of a pipetting device according to the invention, for selecting predetermined parameter sets representing certain application scenarios. 7a shows, based on two images of the screen of a pipetting device according to the exemplary embodiment, the functionality of the GUI of the pipetting device to mark a current parameter set as a favorite, which is then saved as a favorite and in particular in a favorites screen page as a selectable list entry, namely as a correspondingly informative input tile. is shown.

7b uses two images of the screen of a pipetting device according to the invention according to the exemplary embodiment to show the functionality of the GUI of the pipetting device, that the input tile identifying a favorite parameter set has an input field in the favorites screen page, touching which transfers the parameters of the favorite parameter set to a separate screen, which is then displayed , in which the parameter values and/or the parameter selection of the favorite parameter set can be changed.

8a and 8b belong together and use a sequence of numerous images of the screen with the actuating element of a pipetting device according to the embodiment shown below (symbolically) to show the functionality of the GUI of the pipetting device to define the pipetting parameters of a user-defined pipetting process using a recorder function of the pipetting device.

9 uses a sequence of numerous images of the screen with the actuating element of a pipetting device shown below (symbolically) according to the exemplary embodiment, showing the functionality of the GUI of the pipetting device for selecting a parameter set created by a user-defined recorder function and editing it for change purposes.

1a shows the hand-held pipetting device according to the invention for pipetting at least one liquid sample, here an air-cushion pipette 1. This has: a connecting section 2 for connecting at least one pipetting container 19, here one Pipette tip, with a movement element electrically controlled by the control device 5, here the piston 3, for sucking in the at least one sample into the at least one pipetting container 19, holding the sample in the at least one pipetting container and dispensing sample from the at least one pipetting container when carrying out a pipetting process , with a touch-sensitive screen 4 on the front surface 14a of the head section 14 of the pipetting device, for entering the parameter values of user-definable pipetting parameters, a parameter set of pipetting parameters completely defining the pipetting process, the electrical control device 5 having a data processing device 6 which is used to control the moving element 3 is programmed as a function of the at least one pipetting parameter, as well as a data memory 7 and a communication unit 8 for wireless communication with an external data processing device a ufweis, with exactly two controls (synonymous: actuating elements) 9a and 9b, which can be actuated by the user using a rocker switch 10. Each of these actuating elements can be set by actuating the pipetting device from an input mode (“set”), in which an input screen page 100, 100′ is shown on the screen, e.g. the home screen shown in FIG. 1d, into an output mode (“do”) , in which an output screen is displayed on the screen. This advantageous aspect of the operating concept is also explained with reference to the further FIGS. 2a, 2b and 4. The actuation of the ejection button 15 and a (not shown) “power on/off” button of the pipetting device, on the other hand, does not bring about the change between “set” and “do” mode. The list of pipetting parameters associated with the parameter set can be edited by means of the input field 101′ provided with a “+” sign here in FIG. 1d, also referred to as an “extra button”.

The rocker switch has a lower portion 10b which is concave and actuation of which actuates button 9b and in particular causes sample delivery, and an upper section 10a which is convex and actuation of which actuates button 9a and in particular causes sample collection. The rocker switch sits on one by one Housing section formed plateau, which occupies an angle of approximately a = 130-140 ° with the longitudinal axis A of the pipetting device. Due to the hand rest 16 arranged perpendicular to the longitudinal axis next to the plateau, the pipetting device lies ergonomically in the hand and the thumb can rest on the rocker 10 since the hand position allows the thumb to rest on a "sweet spot" of the hand. The screen 4 is arranged in a head housing section 14 of the pipetting device.

The pipetting device has an electric motor 18 which is fed by an accumulator 17 and which moves the piston rod or the piston 3 within the cylinder piston 12 so that in the pipetting channel 13 a suction pressure or a discharge pressure is the result. The electronic control allows precise dosing. An ejection button 15 is provided, which allows the pipette tip 19 to be ejected from the connecting section 2 by means of an ejection sleeve of the pipetting device. In particular, the data processing device is programmed to interrupt an ongoing pipetting process if the release button 15 is actuated and to replace any output screen page that may still be displayed with an input screen page 100, 100'.

The pipetting process defined according to the current parameter set would be started by the user actuating one of the two actuating elements 9a, 9b. The selection of the pipetting parameters of a parameter set that defines the desired semi-automated pipetting process and the setting of the values of these pipetting parameters takes place using a GUI that implements the special operating concept according to the invention. This operating concept is explained using the following figures.

The data processing device 6 is programmed (see FIG. 2a) to display an input screen page 100, 100′ (“set”, see the content of the rectangle enclosed by the dashed line) on the screen 4 for the display and input of pipetting parameters of a parameter set of pipetting parameters. and, if an actuation of at least one of the actuation elements 9a or 9b is detected, display an output screen 200 ("do") on the screen 4 for displaying pipetting parameters of the parameter set defined in the input screen, and also if these Actuation of the at least one actuating element is detected or, upon the subsequent actuation (in the sense of an optional security query) of one of these actuating elements, to start the pipetting process defined according to this pipetting parameter set, with output screen page 200, or another output screen page displayed after output screen page 200, having an as Special button 201 (here labeled with the information “back”) has an input area, here at the bottom edge of the screen, which touches the closing of output screen page 200 and the display of input screen page 100 or another screen page, in particular input screen page, on screen 4. In particular, in the case of a second actuation of one of the actuation elements 9a, 9b (different from the screen) following this first actuation, the pipetting process defined according to the current pipetting parameter set is started.

Said other screen page can in particular enable the editing of parameter values contained in the pipetting parameter set. It does not have to be exactly the previous input screen page 100 if, for example, the speed is only to be adjusted quickly when the pipetting sequence ("do") has already begun. It can be provided that after the pipetting process has started, not all parameter values can be changed/corrected, but only certain parameter values of the current pipetting parameter set.

The input screen page 100 and the output screen page 200 differ in their graphic and/or textual or numerical representation, in particular in the coloring: the input fields of the input screen page 100 are mostly with black information (letters, numerical values, input field color) on a light or white background , and the display fields of the output screen page 200 are kept mostly with blue information on a light or white background. The black input field 101 (also referred to as an extra button) of the input screen, which calls up the selection screen for selecting pipetting parameters, does not exist in the output screen.

In particular, the output screen page 200, preferably depending on the straight partial step of an automated multi-step pipetting process taking place, display various contents, in particular the values of the pipetting parameters currently defining the partial step, e.g. the dispensing of a partial volume Vt with a specific dispensing speed v2 as partial step i of a total of N steps of the pipetting process. This can be the case, for example, in the "Dis" application scenario, which is shown in FIG. 2b.

In FIG. 2b, an input screen page 100_1 is first displayed, which contains the set of pipetting parameters for a dispensing process that runs partially automatically; the extra button 101_1, which is slightly different graphically compared to the extra button 101, enables the pipetting parameter list to be processed analogously. The actuation of the actuating element, namely here the switch 9a or the first pressure surface 10a of the operating rocker 10, leads the pipette device from the "set" mode to the "do" mode, the output screen page 200_1 is now displayed, which contains the special button 201_1. which is graphically modified compared to the special button 201 and otherwise has an analogous effect. After an aspiration process has been carried out, e.g. after a period of 2 seconds here, in which the partial step of aspirating 360 pl of solution into the pipetting container is carried out, the output screen belonging to the partial step of dispensing the first partial dispensing volume of 120 pl is displayed in output screen page 200_1. Actuation of the actuating element, here the second pressure surface 10b of the operating rocker 10, initiates the delivery of the partial volume, each further actuation of the pressure surface 10b leads to the next partial delivery step. The partial dispensing steps are counted by index counter i=1 ...3, the progress display i / N (i=1 ...3; N=3) shows the progress of the semi-automatic dispensing process in an output field of the output screen page. To make progress even more intuitive for the user, a variable indicator can be used, such as the indicator roller shown in Figures 2e and 2f. The output screen page 200_1 does not have such a changeable display element, the output tiles are always in the same position on the output screen page 200_1 here, only the numerical display of the parameter values and the progress display change.

FIG. 2e shows an output screen page 200′ of the pipetting device according to the invention according to the exemplary embodiment, in a multi-step dispensing process, in one first state in substep i=2 (left side of the figure) and a second state in substep i=3 (right side of the figure). The output screen page has a variable display element 203', which is designed as a display roller. In the case of a variable display element which has at least one output tile, the position of at least one output tile within the display element changes in particular. The display roller 203' has a middle output tile 203a', which shows the pipetting parameter "partial dispensing volume" with the value 200 pl of a (N=6)-step dispensing process, the dispensing speed "8" and a numerical progress indicator ("2/6" ) indicates. Above the middle output tile 203a', the upper output tile 203b' is displayed, which indicates "Dispense 200pl" of the previous dispensing sub-step (i=1), and below the middle output tile 203a', the lower output tile 203c' is displayed, which " Dispense 200pl” of the dispensing sub-step (i=3) immediately following the current sub-step i=2. On the right side of the picture is shown the same output screen page 200' that will be displayed during the next delivery sub-step with i=3. Above the middle output tile 203a', the upper output tile 203b' is displayed, which indicates "Dispense 200pl" of the previous dispensing sub-step (i=2), and below the middle output tile 203a', the lower output tile 203c' is displayed, which " Dispense 200pl” of the dispensing sub-step (i=4) immediately following the current sub-step i=3. The transition of the view of indicator 203' from i=2 to i=3 (left to right) may be animated to illustrate the dynamics of progress. Due to the changeable display element, the perception of the multi-stage pipetting process and the operation of the pipetting device are more intuitive. In the case of the last partial delivery step (i=N; here i=6), either information about reaching the end or other information is displayed in the lower position 203c' of the display roller, nothing is displayed, or the corresponding output tile 203c' is then done not displayed. The same can be provided in the first partial delivery step i=1 for the upper output tile 203b′, which then either shows nothing or is omitted, for example.

The display roller here has a horizontal axis of rotation, the change in position of the output tiles runs in the vertical direction. Alternatively, a vertical axis of rotation or an inclined axis of rotation would be possible. 2f shows an output screen page 200″ of the pipetting device according to the invention according to the exemplary embodiment, in a multi-step (M=32) pipetting process, in a state in partial step i=8. A display roller 203″ is also displayed here, which has the middle output position or output tile 203a″, the upper output tile 203b″ and the lower output tile 203c″, which work analogously to the display roller 203′. In addition, the output screen page 200" has additional functionality that is achieved using additional output fields and input fields. In particular, an output screen page preferably does not have an input field that shows the value of a pipetting parameter and whose touching in the next step would enable a pipetting parameter to be changed, as is implemented in the present exemplary embodiments. In the "Do" mode that is present while an output screen page is being displayed, it is not possible to change pipetting parameters, and at most it is possible via intermediate steps, and not all pipetting parameters of the parameter set can be changed. For example, it may be possible to change the speed at which the liquid is dispensed/received during an ongoing multi-step pipetting process.

The output screen page 200” has an input field, which is arranged on the edge, here at the bottom right, which is labeled “Pause” and implements a pause function. Touching this input field pauses the multi-step pipetting process, here for example after completion of the dispensing sub-step i=1 of N=3, which is also the eighth sub-step of a total of 32-step programmed pipetting process. The input field with the exclamation mark and the surrounding arrow allows a pipetting process to be repeated in the event that the eighth sub-step just carried out has to be repeated, e.g. due to a user error. The input fields mentioned are therefore, following the logic of the GUI, not input fields which show the value of a pipetting parameter and touching which would enable a pipetting parameter to be changed in the next step.

In these exemplary embodiments of the pipetting device, "touching" an input field always results in an immediate effect, ie the effect occurs without any significant delay and preferably without a gap between the time of the Touching and the time the effect is displayed (e.g. opening an input interface) another screen page is displayed, e.g. as an information page, which indicates a delay, also referred to as the "waiting page". However, there may be GUI scenarios in which such an intermediately displayed information page makes sense.

As shown in FIG. 2f, a progress bar can be useful for a multi-step (here M=32) pipetting process, with which the progress (“8/32”), which is also displayed numerically here, is graphically illustrated. The note "Protocol Lisa 250" in output tile 222" indicates that an individually programmed pipetting process with the name "Lisa 250" specified by the user, for example, is carried out and logged at the same time, i.e. it is saved, for example, in a log file of the pipetting device. As is generally provided, the special button 201 "leads to the closing of the output screen page 200". In general, each output tile in particular is not an input tile, and therefore has no input field that would result in a function being touched, and therefore does not allow any input.

The concept of distinguishing between an input screen page and an output screen page, which is implemented by means of an external distinction, forms a significant ergonomic advantage in operation, since the user recognizes with the least effort whether he is currently in a - possibly interrupted - waiting for an operation - Pipetting process is in progress or in a setting mode. The concept of the input screen and the output screen thus implies such an input mode and output mode of the pipetting device that are easily distinguishable for the user. Preferably only touching the separate input area (special button) - or a completed pipetting process, which can bring about an automatic return to an input screen page, in particular the home screen - allow the user to change parameter values or make a new parameter selection. In particular, this separation prevents parameter values from being accidentally changed while the "do" mode is running, which could destroy a laboratory work and result in a significant loss of value. On the other hand, changing from "set" to "do" mode by pressing the operating element means one considerable comfort for the user and is intuitively understandable. This also contributes significantly to ergonomics and an efficient workflow. An output screen page (e.g. 200) is preferably fundamentally characterized in that the display fields or tiles contained in the output screen page, e.g. output tile 203, are purely informative, i.e. they do not serve as input fields and touching them in particular does not result in any action, in particular none Input option starts. This does not apply to a separate control panel of the output screen page, here the special button 201, touching which cancels the output mode and leads to the display of an input screen page on the screen and can in particular lead to the termination of a pipetting process or pipetting program that may still be running.

The pipetting device 1 has precisely a first 9a and a second actuating element 9b, which can be actuated separately from one another, in particular by means of a rocker switch 10. The data processing device 6 is programmed to detect the actuation of the first or second actuating element 9a or 9b by the user and to start the pipetting process defined according to the parameter set.

The pipetting device has the operating rocker 10 and the first 9a and the second actuating element 9b, which can be actuated separately from one another by the operating rocker 10 in that pressing a first pressure surface 10a of the operating rocker 10 actuates the first actuating element 9a and pressing a second pressure surface 10b the rocker switch actuates the second actuating element 9b, the first and the second pressure surface being haptically distinguishable. In particular, the first pressure surface 10a is convex (=curved outward), and the second pressure surface 10b is concave. As a result, the user can feel the desired operating element or the desired side (pressure surface) of the rocker switch without visual control, operation is intuitive and ergonomic.

The pipetting device 1 has a housing 11, which is designed as a handle for holding the pipetting device with a single hand of the user, and which has an axial section 11 containing the moving element, along the longitudinal axis A, the moving element 3 runs. The operating rocker is mounted on a thumb rest surface, which is arranged at an angle of 80<a<180°, namely here preferably a=100-150°, preferably 130°, to the longitudinal axis and in particular arranged inclined downwards. “Down” refers to an orientation of the pipetting device with the longitudinal axis A aligned vertically and the pipette tip 19 pointing in the direction of gravity. The angular arrangement of the plateau section of the operating rocker results in an ergonomically arranged thumb rest surface. The thumb rest surface is arranged starting from the longitudinal axis and is in particular perpendicular to a plane which runs through the longitudinal axis A and perpendicular to a surface of the planar screen 4 . The position of the plateau section, which is at the same height as the hand rest in relation to the longitudinal axis, results in the advantageous ergonomics.

The head section 14 has the front surface 14a, which is inclined relative to the longitudinal axis A and is formed by the surface of the screen 4 and a frame enclosing it, with the screen occupying approximately 80% of the front surface here; the frame front surface 14a lies in a first plane and the planar screen 4 lies in a second plane identical to the first plane. As a result, the edge areas of the screen can also be easily touched by the user, and the available area of the touchscreen 4 can thus be optimally used. At the same time, the edges of the screen are not exposed and are protected by the frame front surface 14a.

The housing 11 has the connecting section 2 (working cone) for at least one pipetting container 19 and the ejection button 15, the contact surface of which can be moved along a path into the housing by pressing the ejection button, with the pipetting device being set up such that when the end of this path is reached, the The pipetting container, in particular the pipette tip, is ejected or an electrical signal is generated which triggers the ejection of the at least one pipetting container.

Fig. 5a: The data processing device is programmed to display a screen page 102 on the screen, which contains at least one first input tile 103, here 103a, 103b, 103c, which contains the value of at least one first pipetting parameter (here: 103a: V=120pl, 103b: v= (v1 , v2) with dispensing speed v1=level 8, intake speed=level 8; number n of steps n=3) and touching them opens an input interface that allows the user to enter the value of the at least one first pipetting parameter, this input interface being a screen area in which in particular a numeric keypad is displayed whose numeric keys can be touched individually and usable by the user to enter a string of digits defining the value of the at least one first pipetting parameter. The input tiles are here white, rectangular areas of the screen, which can be recognized by corresponding drawing or contrasting with the gray background and extend with their width b over almost the entire width B of the screen 4. This results in advantageous ergonomics. Although this applies to the input tiles mentioned, it does not have to apply to all input fields of the input screen page, see FIG. 1d. The input interface here is the screen area in a new screen 100a shown on the right in FIG. Similar screen areas 100b, 100c open when the input tiles 103b, 103c of the associated pipetting parameters v=(v1, v2) and n are opened. Or a corresponding screen area with input fields in a list with possible fractions f= 0. 1 to 1.0 if instead of the absolute number the division of the total volume V (eg by dispensing steps into partial steps or partial volumes) is to be set.

3a: The data processing device 6 is particularly preferably programmed to display a screen page 100 on the screen 4, designed here as a home screen, for displaying the pipetting parameters of a parameter set of pipetting parameters, the screen page having at least a first input tile 103 (here three input tiles 103a, 103b, 103c) that displays the value of at least one first pipetting parameter of a basic parameter set (here: V, v=(v1, v2), n) and touching it an input interface, here in Fig. 5a, for example, the image area with the numeric keypad of screen page 100a , opens, which allows the user to enter the value of the at least one first pipetting parameter, screen page 100 containing an input field 101, touching which causes the display, here in a separate screen page 110, of a selection list which contains a list of brief descriptions (here : quick mix, reverse, step time, auto blow off etc.)) further selectable pipetting parameters (here qm, rev, st, abo etc.), from which the user can select at least one second pipetting parameter (here qm, rev, st, or abo etc.), which is added to the at least one first pipetting parameter of the basic parameter set in order to use this to define the pipetting parameters of the parameter set of pipetting parameters that determines the pipetting process, with the selection list being closed after the selection of the at least one second pipetting parameter has been completed and screen page 100 being displayed again, which now also displays at least one second input tile in addition to the at least one first input tile 103 , which displays the value of the at least one second pipetting parameter (here qm, rev, st, or abo etc.) and touching which opens an input interface 100d etc. which allows the user to enter the value of the at least one second pipetting parameter.

As an alternative to the display of an alternative screen page 110, in which the selectable parameters are shown, from which one returns to the home screen 100 after selecting/deselecting the desired parameters by touching the input field 104, as shown in Fig. 3b, the The content of the home screen can also be expanded, e.g. by an area 106 that is expanded downwards and by scrolling (vertical swiping or tapping on the control panel 105), or also other areas, in which the possible pipetting parameters are listed and can be selected/activated, and whose values can subsequently be edited.

The invention mentioned represents a particularly advantageous aspect of the innovative operating concept of a pipetting device. The inventors learned from user studies that a significant fraction of users can achieve a more efficient workflow with a pipetting device in which the user usually defines the desired pipetting processes as he wishes , by adding pipetting parameters, i.e. functions or features, to an existing, for example a proven parameter set or a basic parameter set. Obviously, this approach efficiently leads to the goal of defining an individually desired pipetting process. In particular, if a basic parameter set is provided on a screen, in particular a home screen, which can be executed immediately, there is an immediate sense of achievement when operating it offered without the need for lengthy study of operating instructions. Within a short training period, users can orientate themselves in the list of possible pipetting parameters and thus exploit the potential of the great functionality of an electric pipetting device more efficiently. This applies in particular to the large group of users who, with known pipetting devices of the prior art, have difficulties in learning existing—more or less complex— operating modes that represent application scenarios and are then satisfied with the simplest operating modes. The new concept invites inexperienced users to learn functions and offers experienced users full flexibility.

The data processing device 6 is preferably programmed to do this, if the value entered by a user via an input interface 100a, 100b, 100c, 100d for a pipetting parameter is not permitted, information is displayed on the screen and preferably

A valid value is automatically set instead of the invalid value;

The user's input is undone and, in particular, a new input is made possible;

And or

• An error message is issued;

And or

Another non-combinable pipetting parameter that is a non-combinable

represented by the function is automatically deselected. The data processing device 6 is preferably programmed to display a screen page 100 on the screen 4, which display a list of input tiles 103a, 103b, 103c, which in particular essentially extend over the entire screen page.

Fig. 4: The data processing device 6 is programmed to display a start screen page 100 on the screen 4, which is replaced by a laterally directed swiping gesture by a second screen page 120 and which is replaced by a laterally opposite swiping gesture by a third screen page 130, where in particular (cf. Fig. 6) the second screen page 120 has a list of input fields, each input field having an abbreviation (e.g. the input tile with the abbreviation “measure volume”) and touching the input field loads a predetermined set of parameters, which defines a predetermined pipetting process, with a further screen page 120a being displayed in particular after this input field has been touched; and where in particular the third screen page 130 has a list of input fields, with each input field having an abbreviation (here e.g. the input tile with the abbreviation "150pl steps 6" etc.) and where touching the input field has a historical one used in the past and automatically saved, loads a set of parameters that defines a historical pipetting process, with a different screen page being displayed after touching this input field in particular.

1e shows the system 300 for entering pipetting parameters, comprising the hand-held pipetting device 1, an external data processing device 50, which has an external screen 51 and a data processing device 52, which is programmed to display and input an external input screen on the external screen to display the pipetting parameters of a parameter set of pipetting parameters, the content of the external input screen and the input screen of the pipetting device being essentially the same, the system being set up to transmit the pipetting parameters defined on the external data processing device to the pipetting device and to use them there to define a pipetting process. Using two images of an input screen page 100_3 of a pipetting device according to the exemplary embodiment, Fig. 7a shows the functionality of the GUI of the pipetting device to mark a current parameter set as a favorite, which is then saved as a favorite and in particular in a favorites screen page as a selectable list entry, namely as a correspondingly informative input tile , is shown. An input field correspondingly marked with a favorites symbol (asterisk) here detects a user touch, as a result of which a pipetting parameter set defined in the input screen page 100_3 is saved as a favorite, which is illustrated by the color change of the favorites symbol.

Using two screen pages of a pipetting device according to the exemplary embodiment, Fig. 7b shows the functionality of the GUI of the pipetting device, that the input tile that characterizes a favorite parameter set has an input field in favorites screen page 121, touching which transfers the parameters of the favorite parameter set to the home screen, namely input screen page 100_4, which is then displayed, in which the parameter values and/or the parameter selection of the favorite parameter set can be changed.

8a and 8b belong together and use a sequence of numerous images of the screen with the actuating element of a pipetting device according to the embodiment shown below (symbolically) to show the functionality of the GUI of the pipetting device to define the pipetting parameters of a user-defined pipetting process using a recorder function of the pipetting device. In Figure 8a, a user programming process starts from a screen titled "Programs" which has already been described as an "Auto Program Set Screen". Another program can be created using an input field "+" on this screen page. Then, here on a subsequent screen page, an input field "record" is offered, touching which starts the recorder function or the recording. At the same time, a separate “recorder mode” of the pipetting device is started, in which, in this example, the activation of the activation elements (9a, 9b) does not lead to the electrical movement of the piston 3; rather, a pipetting process is only simulated (this could also not be simulated perform) and the program steps are recorded. A property of the recorder function is that only the actuating elements 9a, 9b, which are used for picking up and dispensing the sample, and the touch screen and its input tiles 103, which are used for setting pipetting parameter values, are required on input screen pages 100" etc. No programming using programming code is required.

During the recording, a status bar on the screen shows the information that recording is in progress ("Recording..."). There is also an input field with a stop sign that can be used to stop the recording. The automatically assigned designation "Program 2" is displayed in the program list of the "Programs" screen page as an input tile; touching them allows editing the program, in particular changing its name.

Claims

Claims Hand-held pipetting device for pipetting at least one liquid sample, with a connecting section for connecting at least one pipetting container, with an electrically controlled movement element for sucking in the at least one sample into the at least one pipetting container, holding the sample in the at least one pipetting container and dispensing samples from the at least one Pipetting container when carrying out a pipetting process, with a touch-sensitive screen for entering the parameter values of user-definable pipetting parameters, a parameter set of pipetting parameters completely defining the pipetting process, with an electrical control device that has a data processing device that is used to control the moving element depending on the at least one Pipetting parameters is programmed with at least one actuator that can be actuated by a user's finger pressure and whose actuation starts the pipetting process defined according to the parameter set, characterized in that the data processing device is programmed to display an input screen page (100; 100'; 100"; 100_1 ; 100_3;

100_4) for displaying and inputting pipetting parameters of a parameter set of pipetting parameters, and if the actuation of the at least one actuating element is detected, an output screen page on the screen instead of the input screen page

69 (200; 200';200"; 200_1) for displaying pipetting parameters of the parameter set defined in the input screen page and, if this actuation of the at least one actuating element is detected or upon the subsequent actuation of one of these actuating elements, the pipetting process defined according to this pipetting parameter set start, this or a subsequently displayed output screen page having a special button (201; 201 ';201"; 201_1), touching which causes the output screen page to be closed and this input screen page or another input screen page to be displayed on the screen. Hand-held pipetting device according to claim 1, wherein the pipetting device has precisely one first and one second actuating element, which can be actuated separately from one another, in particular by a rocker switch, the data processing device being programmed to allow the first actuating element to be actuated by the user, starting from the display of the input screen page record and start the pipetting process defined according to the parameter set. Pipetting device according to one of claims 1 or 2, wherein the pipetting device has an operating rocker, and has a first and a second actuating element which can be actuated separately from one another by the operating rocker, in that pressing a first pressure surface of the operating rocker actuates the first actuating element and pressing one second pressure surface of the rocker switch actuates the second actuating element, the first and the second pressure surface being haptically distinguishable. Pipetting device according to one of the preceding claims, wherein

70 the pipetting device has a housing which is designed as a handle for holding the pipetting device with a single hand of the user, and which has an axial section containing the moving element, along whose longitudinal axis the moving element runs, and wherein the pipetting device has a first and a second actuating element , which can be actuated separately from one another by a rocker switch, which is mounted on a thumb rest surface which is arranged at an angle of 100<a<150° to the longitudinal axis and, in particular, is arranged inclined downwards. Pipetting device according to one of the preceding claims, wherein the data processing device is programmed to execute a recorder function in which the GUI has at least one input field for starting and/or ending a recording and after the start the steps of a pipetting program for carrying out a user-defined pipetting process are recorded , wherein the user carries out these steps by actuating the at least one actuating element and by entering values of the pipetting parameters in one or more input screen pages. Pipetting device according to one of the preceding claims, wherein the pipetting device has a housing with an axial section containing the moving element, along the longitudinal axis of which the moving element runs, and a head section which has a front surface inclined to the longitudinal axis, which extends through the surface of the screen and a screen enclosing it frame is formed, with the screen occupying at least 80% of the front surface; and in particular wherein a frame front face lies in a first plane and the screen lies in a second plane identical to or parallel to the first plane

71 This is. Pipetting device according to one of the preceding claims, which has a housing with a connecting section for at least one pipetting container and with an ejection button, the contact surface of which can be moved along a distance into the housing by pressing the ejection button, the pipetting device being arranged such that when the end of the same is reached Distance of the dropping of the pipette, in particular the pipette tip takes place or that an electrical signal is generated that triggers the ejection of at least one pipette. Hand-held pipetting device according to one of the preceding claims, wherein the data processing device is programmed to display a screen page on the screen which contains at least one first input tile which displays the value of at least one first pipetting parameter and touching which opens an input interface which allows the user to enter the value of the at least one first pipetting parameter, this input interface being a screen area in which a numeric keypad is displayed, the numeric keys of which can be touched individually and can be used by the user to enter a sequence of digits which defines the value of the at least one first pipetting parameter. Hand-held pipetting device according to one of the preceding claims, wherein the data processing device is programmed to

72 display a screen page for displaying the pipetting parameters of a parameter set of pipetting parameters on the screen, the screen page containing at least one first input tile which displays the value of at least one first pipetting parameter of a basic parameter set and touching which opens an input interface which allows the user to enter the value of the at least a first pipetting parameter, the screen page containing an input field which, when touched, causes a selection list to be displayed, which contains a list of brief descriptions of further selectable pipetting parameters, from which the user can select at least one second pipetting parameter which is added to the at least one first pipetting parameter of the basic set is, in order to define with this the pipetting parameters of the pipetting process-determining parameter set of pipetting parameters, wherein after the end of the selection of the at least one second pipetting parameter, the selection list is closed and the screen page is displayed, which now, in addition to the at least one first input tile, also displays at least one second input tile, which displays the value of the at least one second pipetting parameter and touching which opens an input interface that allows the user to enter the value of the at least one second pipetting parameter. Hand-held pipetting device according to any one of the preceding claims, wherein the data processing means is programmed to, if the value entered by a user via an input interface for a pipetting parameter is invalid, information is displayed on the screen and preferably

73 • at least one correction button is displayed, touching which automatically executes at least one correction process instead of the value entered by the user, which can have the following configurations:

A valid value is automatically set instead of the invalid value;

The user's input is undone and, in particular, a new input is made possible;

And or

• An error message is issued;

And or

• Another non-combinable pipetting parameter that represents a non-combinable function is automatically deselected. Hand-held pipetting device according to one of the preceding claims, wherein the data processing device is programmed to display a screen page on the screen, which display one or more input tiles, which in particular extend substantially over the entire screen page. Hand-held pipetting device according to one of the preceding claims, wherein the data processing device is programmed to

74 display a start screen page on the screen, which is replaced by a second screen page by a sideways swipe gesture and which is replaced by a third screen page by a sideways swipe gesture in the opposite direction, the second screen page in particular having a list of input fields, each input field having an abbreviation and wherein touching the input field loads a predetermined set of parameters which defines a predetermined pipetting process, with another screen page being displayed in particular after touching this input field; and wherein in particular the third screen page has a list of input fields, each input field having an abbreviation and touching the input field loads a historical parameter set used in the past and automatically saved, which defines a historical pipetting process, whereby in particular after touching this input field another screen page is displayed. System for entering pipetting parameters, comprising the hand-held pipetting device according to one of the preceding claims, and an external data processing device which has an external screen and a data processing device which is programmed to display an external input screen page in the external screen for displaying and entering the pipetting parameters of a parameter set from Display pipetting parameters, the content of the external input screen and the input screen of the pipetting device being essentially the same, the system being set up to transmit the pipetting parameters defined on the external data processing device to the pipetting device and to use them there to define a pipetting process. Computer program code (analogous to claim l_1 ) for providing an input screen page on the screen of a hand-held pipetting device, which is used for pipetting at least one liquid sample and has a connecting section for connecting at least one pipetting container, an electrically controlled moving element for sucking the at least one sample into the at least a pipetting container, for holding the sample in the at least one pipetting container and for dispensing the sample from the at least one pipetting container when performing a pipetting process, and a touch-sensitive screen for entering the parameter values of user-definable pipetting parameters, wherein a parameter set of pipetting parameters completely defines the pipetting process, and wherein the pipetting device has an electrical control device with a data processing device which is used to control the movement element as a function t is programmed by the at least one pipetting parameter, and has at least one actuating element which can be actuated by a user pressing a finger, in particular a thumb pressure, and whose actuation starts the pipetting process defined according to the parameter set, the program code being executed by the data processing device of the hand-held pipetting device results in a) an input screen page for displaying and entering pipetting parameters of a parameter set of pipetting parameters being displayed on the screen, b) if the actuation of the at least one actuating element is detected, an output screen page for displaying pipetting parameters of the parameter set being displayed on the screen is displayed and optionally: with this actuation or a subsequent actuation of an actuating element, the pipetting process is also started according to the current pipetting parameter set, and c) a special button is displayed in the output screen page, touching which causes the output screen page to be closed and a screen page, in particular an input screen page, to be displayed on the screen.

77