EP4235179A3 - Nachweis, quantifizierung und/oder isolierung zirkulierender tumorzellen mittels der expression des cd321-markers - Google Patents

Nachweis, quantifizierung und/oder isolierung zirkulierender tumorzellen mittels der expression des cd321-markers Download PDF

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Publication number
EP4235179A3
EP4235179A3 EP23172591.2A EP23172591A EP4235179A3 EP 4235179 A3 EP4235179 A3 EP 4235179A3 EP 23172591 A EP23172591 A EP 23172591A EP 4235179 A3 EP4235179 A3 EP 4235179A3
Authority
EP
European Patent Office
Prior art keywords
detection
tumor cells
marker
circulating tumor
quantification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP23172591.2A
Other languages
English (en)
French (fr)
Other versions
EP4235179A2 (de
Inventor
Cédric BLANPAIN
Panagiota SOTIROPOULOU
Ievgenia PASTUSHENKO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universite Libre de Bruxelles ULB
Original Assignee
Universite Libre de Bruxelles ULB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universite Libre de Bruxelles ULB filed Critical Universite Libre de Bruxelles ULB
Publication of EP4235179A2 publication Critical patent/EP4235179A2/de
Publication of EP4235179A3 publication Critical patent/EP4235179A3/de
Pending legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70589—CD45
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/54—Determining the risk of relapse

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP23172591.2A 2017-03-16 2018-03-16 Nachweis, quantifizierung und/oder isolierung zirkulierender tumorzellen mittels der expression des cd321-markers Pending EP4235179A3 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17161411 2017-03-16
PCT/EP2018/056760 WO2018167312A1 (en) 2017-03-16 2018-03-16 Detection, quantification and/or isolation of circulating tumor cells based on the expression of cd321 marker
EP18710884.0A EP3596467B1 (de) 2017-03-16 2018-03-16 Nachweis, quantifizierung und/oder isolierung zirkulierender tumorzellen mittels der expression des cd321-markers

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP18710884.0A Division EP3596467B1 (de) 2017-03-16 2018-03-16 Nachweis, quantifizierung und/oder isolierung zirkulierender tumorzellen mittels der expression des cd321-markers
EP18710884.0A Division-Into EP3596467B1 (de) 2017-03-16 2018-03-16 Nachweis, quantifizierung und/oder isolierung zirkulierender tumorzellen mittels der expression des cd321-markers

Publications (2)

Publication Number Publication Date
EP4235179A2 EP4235179A2 (de) 2023-08-30
EP4235179A3 true EP4235179A3 (de) 2023-11-15

Family

ID=58387669

Family Applications (2)

Application Number Title Priority Date Filing Date
EP23172591.2A Pending EP4235179A3 (de) 2017-03-16 2018-03-16 Nachweis, quantifizierung und/oder isolierung zirkulierender tumorzellen mittels der expression des cd321-markers
EP18710884.0A Active EP3596467B1 (de) 2017-03-16 2018-03-16 Nachweis, quantifizierung und/oder isolierung zirkulierender tumorzellen mittels der expression des cd321-markers

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP18710884.0A Active EP3596467B1 (de) 2017-03-16 2018-03-16 Nachweis, quantifizierung und/oder isolierung zirkulierender tumorzellen mittels der expression des cd321-markers

Country Status (8)

Country Link
US (1) US20210190787A1 (de)
EP (2) EP4235179A3 (de)
JP (1) JP7278595B2 (de)
KR (1) KR102583603B1 (de)
AU (1) AU2018235021B2 (de)
CA (1) CA3054915A1 (de)
IL (1) IL269315A (de)
WO (1) WO2018167312A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102019202788A1 (de) * 2019-03-01 2020-09-03 Robert Bosch Gmbh Verfahren zum Zählen von Zelltypen oder Zellmarkern in einer Probe, insbesondere in einer Blutprobe
JP2020144054A (ja) * 2019-03-07 2020-09-10 学校法人昭和大学 末梢血循環癌細胞の検出方法及び検出装置
KR102654518B1 (ko) * 2020-05-26 2024-04-04 가톨릭대학교 산학협력단 Lsp1 결핍 t 세포
CN113009135B (zh) * 2021-02-19 2024-04-02 山东省大健康精准医疗产业技术研究院 一种检测cd47的管式磁微粒化学发光免疫定量试剂盒及其制备方法与应用
WO2023044118A1 (en) * 2021-09-20 2023-03-23 Droplet Biosciences, Inc. Methods for disease assessment using drain fluid

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006130737A1 (en) * 2005-06-02 2006-12-07 Immunivest Corporation A method for assessing metastatic carcinomas from circulating endothelial cells and disseminated tumor cells
WO2007056049A2 (en) * 2005-11-02 2007-05-18 The Regents Of The University Of Michigan Molecular profiling of cancer
EP1813945A1 (de) * 2005-12-30 2007-08-01 Centocor, Inc. Verfahren zur Bestimmung des Phänotyps von Zellen
EP2199798A1 (de) * 2008-12-18 2010-06-23 Universite Libre De Bruxelles Diagnoseverfahren und Kit zur Zirkulierung von Tumorzellen
EP2455403A1 (de) * 2010-11-23 2012-05-23 Pierre Fabre Medicament Homogene humanisierte Antikörper gegen JAM-A die Proliferation inhibieren
WO2013148450A1 (en) * 2012-03-30 2013-10-03 The Board Of Trustees Of The Leland Stanford Junior University Use of jam-a in diagnosing and treating leukemia
WO2014120265A1 (en) * 2013-02-02 2014-08-07 Duke University Method of isolating circulating tumor cells

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5270163A (en) 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
US8980568B2 (en) * 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
EP1706720A4 (de) 2003-10-31 2007-02-28 Vitatex Inc Bluttest-prototypen und verfahren zum nachweis zirkulierender tumor- und endothelzellen
GB0808413D0 (en) 2008-05-09 2008-06-18 Univ Nottingham Stabilisation of blood cell conjugates
WO2010037134A2 (en) 2008-09-29 2010-04-01 Stemlifeline, Inc. Multi-stage stem cell carcinogenesis
CN111729090A (zh) 2013-12-20 2020-10-02 通用医疗公司 与循环肿瘤细胞相关的方法和测定法
CN107430116B (zh) 2015-01-21 2020-11-03 新加坡科技研究局 用于基于大小回收稀有细胞的以柱为基础的装置和方法，及其用途

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006130737A1 (en) * 2005-06-02 2006-12-07 Immunivest Corporation A method for assessing metastatic carcinomas from circulating endothelial cells and disseminated tumor cells
WO2007056049A2 (en) * 2005-11-02 2007-05-18 The Regents Of The University Of Michigan Molecular profiling of cancer
EP1813945A1 (de) * 2005-12-30 2007-08-01 Centocor, Inc. Verfahren zur Bestimmung des Phänotyps von Zellen
EP2199798A1 (de) * 2008-12-18 2010-06-23 Universite Libre De Bruxelles Diagnoseverfahren und Kit zur Zirkulierung von Tumorzellen
EP2455403A1 (de) * 2010-11-23 2012-05-23 Pierre Fabre Medicament Homogene humanisierte Antikörper gegen JAM-A die Proliferation inhibieren
WO2013148450A1 (en) * 2012-03-30 2013-10-03 The Board Of Trustees Of The Leland Stanford Junior University Use of jam-a in diagnosing and treating leukemia
WO2014120265A1 (en) * 2013-02-02 2014-08-07 Duke University Method of isolating circulating tumor cells

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CARLA KANTARA ET AL: "Methods for detecting circulating cancer stem cells (CCSCs) as a novel approach for diagnosis of colon cancer relapse/metastasis", LABORATORY INVESTIGATION, vol. 95, no. 1, 27 October 2014 (2014-10-27), The United States and Canadian Academy of Pathology, Inc., pages 100 - 112, XP055741024, ISSN: 0023-6837, DOI: 10.1038/labinvest.2014.133 *
ELAINE A. MCSHERRY ET AL: "JAM-A expression positively correlates with poor prognosis in breast cancer patients", INTERNATIONAL JOURNAL OF CANCER, vol. 125, no. 6, 15 September 2009 (2009-09-15), US, pages 1343 - 1351, XP055241503, ISSN: 0020-7136, DOI: 10.1002/ijc.24498 *
JEROEN F VAN VELZEN ET AL: "Multicolor flow cytometry for evaluation of platelet surface antigens and activation markers", THROMBOSIS RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 130, no. 1, 21 February 2012 (2012-02-21), pages 92 - 98, XP028518186, ISSN: 0049-3848, [retrieved on 20120229], DOI: 10.1016/J.THROMRES.2012.02.041 *
JUSTIN D. LATHIA ET AL: "High-Throughput Flow Cytometry Screening Reveals a Role for Junctional Adhesion Molecule A as a Cancer Stem Cell Maintenance Factor", CELL REPORTS, vol. 6, no. 1, 1 January 2014 (2014-01-01), US, pages 117 - 129, XP055469072, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2013.11.043 *

Also Published As

Publication number Publication date
EP4235179A2 (de) 2023-08-30
KR20190142330A (ko) 2019-12-26
IL269315A (en) 2019-11-28
KR102583603B1 (ko) 2023-10-05
JP7278595B2 (ja) 2023-05-22
AU2018235021A1 (en) 2019-09-12
EP3596467A1 (de) 2020-01-22
WO2018167312A1 (en) 2018-09-20
EP3596467C0 (de) 2023-09-27
US20210190787A1 (en) 2021-06-24
JP2020512549A (ja) 2020-04-23
EP3596467B1 (de) 2023-09-27
AU2018235021B2 (en) 2024-07-11
CA3054915A1 (en) 2018-09-20

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