EP4225036A1 - Antivirale reinigungszusammensetzung, verfahren zur herstellung und verwendung davon - Google Patents

Antivirale reinigungszusammensetzung, verfahren zur herstellung und verwendung davon

Info

Publication number
EP4225036A1
EP4225036A1 EP20956890.6A EP20956890A EP4225036A1 EP 4225036 A1 EP4225036 A1 EP 4225036A1 EP 20956890 A EP20956890 A EP 20956890A EP 4225036 A1 EP4225036 A1 EP 4225036A1
Authority
EP
European Patent Office
Prior art keywords
absorbent material
cleaning composition
virus
granular absorbent
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP20956890.6A
Other languages
English (en)
French (fr)
Inventor
Walter Hawkins
James W. Lillard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Morehouse School of Medicine Inc
Innovative Environmental Companies Inc IEC
Devmar Products LLC
Original Assignee
Morehouse School of Medicine Inc
Innovative Environmental Companies Inc IEC
Devmar Products LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morehouse School of Medicine Inc, Innovative Environmental Companies Inc IEC, Devmar Products LLC filed Critical Morehouse School of Medicine Inc
Publication of EP4225036A1 publication Critical patent/EP4225036A1/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/12—Powders or granules
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
    • C11D17/0039—Coated compositions or coated components in the compositions, (micro)capsules
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
    • C11D17/04—Detergent materials or soaps characterised by their shape or physical properties combined with or containing other objects
    • C11D17/049—Cleaning or scouring pads; Wipes
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/02—Inorganic compounds ; Elemental compounds
    • C11D3/12—Water-insoluble compounds
    • C11D3/124—Silicon containing, e.g. silica, silex, quartz or glass beads
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • the present application generally relates to a cleaning compositions and methods and, in particular, relates to a cleaning composition and method for cleaning up a virus, or other pathogens, on a surface, such as disinfecting, or removing viral particles from, a public area.
  • One aspect of the present application is directed to a method of formulating a cleaning composition to decontaminate surfaces contaminated by a virus, comprising the steps of: coating a granular absorbent material with a coating agent to produce a coated absorbent material; and mixing the coated absorbent material with a sanitation agent, wherein the coated absorbent material absorbs the sanitation agent to form the cleaning composition, wherein the sanitation agent comprises a surfactant.
  • the granular absorbent material is coated with a layer of surface bonded biocide by vapor deposition, pressure micro droplet spray or fuming or fogging nozzle.
  • the granular absorbent material is selected from the group consisting of ceramic minerals, zeolite, activated carbon, fumed silica, processed clays, cellulosic absorbents, fibrous absorbents and combinations thereof.
  • the granular absorbent material comprises ceramic minerals.
  • the ceramic minerals comprise perlite and/or vermiculite.
  • the coating agent comprises a biocide.
  • the coating agent forms a surface bonded film on the granular absorbent material.
  • the sanitation agent is an anionic surfactant.
  • Another aspect of the application is a method for prevention and/or decontamination of a surface from a virus, comprising: applying an effective amount of cleaning composition on said surface, wherein said cleaning composition comprises an granular absorbent material coated with a biocide; and a sanitation agent absorbed in said granular absorbent material, wherein said sanitation agent comprises a surfactant.
  • the virus is norovirus, HIV, rotavirus, adenovirus, astrovirus, coronavirus, hepatitis virus, ebola or norovirus, arenaviruses, bunyaviruses, filoviruses, arenaviruses, Nipah virus or hantavirus.
  • the coronavirus is SARS-CoV-2.
  • a cleaning composition for decontamination against viruses comprising: a granular absorbent material coated with a biocide; and a sanitation agent absorbed in said granular absorbent material, wherein said sanitation agent comprises a surfactant.
  • the granular absorbent material is selected from the group consisting of ceramic minerals, zeolite, activated carbon, fumed silica, processed clays, cellulosic absorbents, fibrous absorbents and combinations thereof.
  • the granular absorbent material comprises ceramic minerals.
  • the ceramic minerals comprise perlite and/or vermiculite.
  • the biocide forms a surface bonded film on the granular absorbent material.
  • Another aspect of the application is a sanitation method for decontamination against viruses, comprising the step of: applying an effective amount of a cleaning composition a cleaning composition for decontamination against viruses, comprising: an granular absorbent material coated with a biocide; and a sanitation agent absorbed in said granular absorbent material, wherein said sanitation agent comprises a surfactant to a surface in need of sanitation; and removing the cleaning composition after a period of time.
  • a cleaning composition for decontamination against viruses comprising: applying an effective amount of a cleaning composition a cleaning composition for decontamination against viruses, comprising: an granular absorbent material coated with a biocide; and a sanitation agent absorbed in said granular absorbent material, wherein said sanitation agent comprises a surfactant to a surface in need of sanitation; and removing the cleaning composition after a period of time.
  • a cleaning kit for decontaminating against viruses comprising: a cleaning composition a cleaning composition for decontamination against viruses, comprising: an granular absorbent material coated with a biocide; and a sanitation agent absorbed in said granular absorbent material, wherein said sanitation agent comprises a surfactant, and instructions on how to use the cleaning composition.
  • a cleaning composition for decontamination against viruses, comprising: an granular absorbent material coated with a biocide; and a sanitation agent absorbed in said granular absorbent material, wherein said sanitation agent comprises a surfactant, and instructions on how to use the cleaning composition.
  • a cleaning composition for decontamination against viruses comprising: an granular absorbent material coated with a biocide; and a sanitation agent absorbed in said granular absorbent material, wherein said sanitation agent comprises a surfactant, and instructions on how to use the cleaning composition.
  • said sanitation agent comprises a surfactant
  • Ranges may be expressed herein as from “about” one particular value, and/or to “about” another particular value. When such a range is expressed, another embodiment includes from the one particular value and/or to the other particular value. Similarly, when values are expressed as approximations, by use of the antecedent “about,” it is understood that the particular value forms another embodiment. It is further understood that the endpoints of each of the ranges are significant both in relation to the other endpoint, and independently of the other endpoint. It is also understood that there are a number of values disclosed herein, and that each value is also herein disclosed as “about” that particular value in addition to the value itself. For example, if the value “10” is disclosed, then “about 10” is also disclosed.
  • This application describes a novel, effective and low cost cleaning composition that can be used for rapid and safe clean-up of a surface contaminated by viruses through biohazard spills (vomit / urine / blood and feces) in hospitals, urgent care facilities, medical offices, nursing homes, prisons, schools and the hospitality industry. Viruses may have also contaminated the environment though coughing, sneezing, spitting, or other sources of respiratory droplets carrying viral load. References to pathogens herein should be understood to encompass viruses.
  • the cleaning composition of the present application is a multi-phase product that can be used to kill viruses through a number of different mechanisms by either disrupting the viral proteins, or in certain instances the viral envelope.
  • the composition is a doped granular ceramic disinfectant which combines a surface area static disinfectant or biocide coating with a chemical phase primary disinfectant (e.g. surfactant) or biocide absorbed in the ceramic particles.
  • the multi-phase product provides an effective means to decontaminate surfaces of viruses by acting as a delivery platform for a multi-pronged attack on the integrity of the virus.
  • the cleaning composition of the present application and the method of use thereof are designed to kill or inactivate enveloped viruses, such as coronaviruses.
  • Viruses may include viruses that can effect one or more of the nervous system, musculo-skeletal system, digestive system, hematological systems, immune systems, or respiratory systems.
  • viruses include, but are not limited to, influenza viruses, herpesviruses, polioviruses, noroviruses, gastrointestinal tract-related (Gl-related) viruses, retroviruses, human immunodeficiency virus type 1 and type 2 (HIV-1 and HIV-2), human T- cell lymphotropic virus type I and type II (HTLV-I and HTLV-II), hepatitis A virus, hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis delta virus (HDV), hepatitis E virus (HEV), hepatitis G virus (HGV), parvovirus B19 virus, transfusion transmitted virus (TTV), Epstein- Barr virus, human cytomegalovirus type 1 (HCMV-1), human herpesvirus type 6 (HHV-6), human
  • Examples of microbes caused causing gastroenteritis in man and animals include, viruses, bacteria, parasites and fungus. Viruses cause ⁇ 7-% of infectious diarrhea. Viral infections causing gastroenteritis can be attributed to rotavirus, adenovirus, norovirus, astrovirus, and coronavirus.
  • Enveloped viruses are usually inactivated by effective surface cleaning and disinfection. Enveloped viruses possess an envelope composed of a lipid layer (fat-like substance that is water insoluble) that forms an outer coating. The virus envelope is required for attachment of the virus to a target cell. The lipid layers in cellular membranes are impermeable to most polar or charged solutes but are permeable to apolar compounds, such as the lipids making up a viral envelope. Individual enveloped viruses have differing modes of transmission; however, typical routes of transmission are via indirect or direct bodily contact with infectious virus particles, such as by inhalation or contact with respiratory droplets carrying a viral load.
  • enveloped viruses are more readily inactivated by most chemical disinfectants than are nonenveloped viruses. Although the mechanisms of virus inactivation by chemicals is poorly understood, lipophilic disinfectants and chaotropic agents should have little difficulty in breaching a normal lipid bilayer. Thus, it is likely that the infectivity of enveloped viruses could be destroyed with little or no direct damage to the protein or nucleic acid of the virus. However, it is not known how much damage must be done to the virus envelope before virus infection is prevented. At high surfactant concentrations, damage to the proteins and nucleic acids of the virion is also likely.
  • One aspect of the present application is directed to a method of making a cleaning composition.
  • the method comprises the steps of coating a granular absorbent material with a coating agent to produce a coated absorbent material; and mixing the coated absorbent material with a sanitation agent, wherein the coated absorbent material absorbs the sanitation agent to form a coated and absorbed absorbent material.
  • the method further comprises the step of grinding an absorbent material to produce the granular absorbent material used in the coating step.
  • the method further comprises the step of adding one or more modifying agent to the coated and absorbed absorbent material in amounts sufficient to achieve desired physical characteristics (e.g, non-dusty and clump, ease of pick up, liquid loading capacity, etc.).
  • the cleaning composition may be used to eradicate, eliminate, inactivate, inhibit the activity of, or reduce the amount of pathogens on a surface.
  • the cleaning composition is especially for the clean-up of biohazard spills, such as vomit, urine, blood and feces in hospitals, urgent care facilities, medical offices, nursing homes, prisons, schools and the hospitality industry.
  • the cleaning composition of the present application is also ideally suited for clean-up of common, highly hazardous spills in these environments, such as spills of chemotherapy drugs.
  • the Granular Absorbent Material can be any solid material with desired surface area, granulation, and absorbent characteristics.
  • the term “absorbent” or “adsorbent” is understood to mean a material that is capable of imbibing and holding onto aqueous fluids.
  • Suitable granular absorbent material include, but are not limited to, expanded and optimized ceramic minerals such perlite and vermiculite, zeolite, activated carbon, cellulosic absorbents and fibrous absorbents.
  • the granular absorbent material contains activated carbon, fumed silica, fine perlite, zeolites, processed clays or combinations thereof.
  • the adsorbent/absorbent will exhibit clumping or matting characteristics for best performance and be well de-dusted.
  • the granular absorbent material preferably has a surface area per mass or volume ratio. In some embodiments, the granular absorbent material has a surface area per mass ratio in the range of 100-10,000 m 2 /g, 100-9,000 m 2 /g, 100-8,000 m 2 /g, 300-8,000 m 2 /g, 1,000-8,000 m 2 /g, 2,000-8,000 m 2 /g, 3,000-8,000 m 2 /g, 4,000-8,000 m 2 /g, 5,000-8,000 m 2 /g, 6,000-8,000 m 2 /g, 7,000-8,000 m 2 /g, 100-7,000 m 2 /g, 300-7,000 m 2 /g, 1,000- 7,000 m 2 /g, 2,000-7,000 m 2 /g, 3,000-7,000 m 2 /g, 4,000-7,000 m 2
  • the granular absorbent material has a surface area per mass ratio up to 10,000 m 2 /g. In some embodiments, the granular absorbent material has a surface area per mass ratio up to 9,000 m 2 /g. In some embodiments, the granular absorbent material has a surface area per mass ratio up to 8,000 m 2 /g. In some embodiments, the granular absorbent material has a surface area per mass ratio up to 7,000 m 2 /g. In some embodiments, the granular absorbent material has a surface area per mass ratio up to 6,000 m 2 /g.
  • the granular absorbent material has a surface area per mass ratio of 100 m 2 /g or greater. In some embodiments, the granular absorbent material has a surface area per mass ratio of 300 m 2 /g or greater. In some embodiments, the granular absorbent material has a surface area per mass ratio of 1,000 m 2 /g or greater. In some embodiments, the granular absorbent material has a surface area per mass ratio of 2,000 m 2 /g or greater. In some embodiments, the granular absorbent material has a surface area per mass ratio of 3,000 m 2 /g or greater.
  • the granular absorbent material has a surface area per mass ratio of 4,000 m 2 /g or greater. In some embodiments, the granular absorbent material has a surface area per mass ratio of 5,000 m 2 /g or greater.
  • the granular absorbent material has a surface area per mass ratio in the range of 1000-6,000 m 2 /g. [0027] In some embodiments, the granular absorbent material contains ceramic minerals.
  • the granular absorbent material contains perlite and/or vermiculite.
  • the granular absorbent material has a surface area per volume ratio in the range of 100-5,000 m 2 /ml, 300-5,000 m 2 /ml, 1,000-5,000 m 2 /ml, 2,000-5,000 m 2 /ml, 3,000-5,000 m 2 /ml, 4,000-5,000 m 2 /ml, 100-4,000 m 2 /ml, 300-4,000 m 2 /ml, 1,000-4,000 m 2 /ml, 2,000-54,000 m 2 /ml, 3,000-4,000 m 2 /ml, 100-3,000 m 2 /ml, 300-3,000 m 2 /ml, 1,000- 3,000 m 2 /ml, 2,000-3,000 m 2 /ml, 100-2,000 m 2 /ml, 300-2,000 m 2 /ml, or 1,000-2,000 m 2 /ml.
  • the granular absorbent material has a surface area per volume ratio up to 5,000 m 2 /ml. In some embodiments, the granular absorbent material has a surface area per volume ratio up to 4,000 m 2 /ml. In some embodiments, the granular absorbent material has a surface area per volume ratio up to 3,000 m 2 /ml.
  • the granular absorbent material has a surface area per volume ratio of 100 m 2 /ml or greater. In some embodiments, the granular absorbent material has a surface area per volume ratio of 300 m 2 /ml or greater. In some embodiments, the granular absorbent material has a surface area per volume ratio of 1,000 m 2 /ml or greater. In some embodiments, the granular absorbent material has a surface area per volume ratio of 2,000 m 2 /ml or greater. In some embodiments, the granular absorbent material has a surface area per volume ratio in the range of 1000-3,000 m 2 /ml.
  • ceramics shall mean compounds of nonmetallic elements possessing in general hardness, compressive strength, elastic modulus, thermal expansion and density.
  • Exemplary ceramics include, but are not limited to, materials used in pottery, bricks, tiles, cements and glass, barium titanate, strontium titanate, bismuth strontium calcium copper oxide, boron oxide, boron nitride, earthenware, ferrite, lead zirconate titanate, magnesium diboride, porcelain, sialon, silicon carbodie, silicon nitride, steatite, titanium carbide, uranium oxide, yttrium barium copper oxide, zinc oxide, zirconium dioxide, and partially stabilized zirconia.
  • Ceramics may be oxides (aluminia, beryllia, ceria, zirconia), nonoxides (carbide, boride, nitride, silicide) or composite materials (combinations of oxides and onoxides).
  • Perlite is a naturally occurring form of obsidian characterized by spherulites formed by cracking of volcanic glass during cooling. Perlite typically comprises a mix of silicon dioxide, aluminium oxide, sodium oxide, potassium oxide, iron oxide, magnesium oxide and calcium oxide. Potential substitutes for perlite include, but are not limited to, diatomite, expanded clay, shale, pumice, slag or vermiculite. Vermiculite is a naturally occurring hydrous phyllosilicate material, which is 2:1 clay. [0034] As used herein, the term “zeolite” shall mean any of a large group of minerals comprising hydrated aluminosilicates of sodium, potassium, calcium and barium.
  • Zeolite can occur naturally, but is also artificially synthesized.
  • exemplary zeolites include, but are not limited to, analcime, chabazite, clinoptilolite, heulandite, natrolite, phillipsite, and stilbite.
  • activate carbon shall mean a form of carbon processed to have small, low-volume pores that increase the surface area available for adsorption or chemical reactions.
  • a synonym for activate carbon is “activated charcoal.”
  • cellulosic absorbents shall mean cellulose and cellulose derivatives that can provide structure, bulk, water-holding capacity and channeling of fluids over a wide dimensional range.
  • fibrous absorbents refers to a fibrous structure with high void volume, a hydrophilic nature, and wet resiliency.
  • fibrous absorbents include, but are not limited to, cotton fiber based absorbents, com fiber based absorbents and hemp based absorbents.
  • the granular absorbent material constitutes 10-70% (w/w), 10-60% (w/w), 10-50% (w/w), 10-40% (w/w), 10-30% (w/w), 10-20% (w/w), 20-70% (w/w), 20-60% (w/w), 20-50% (w/w), 20-40% (w/w), 20-30% (w/w), 30-70% (w/w), 30-60% (w/w), 30-50% (w/w), 30-40% (w/w), 40-70% (w/w), 40-60% (w/w), 40-50% (w/w), 50-70% (w/w), 50-70% (w/w) or 60-70% (w/w) of the final product.
  • the granular absorbent material constitutes 25-30% (w/w) of the final product. In some embodiments, the granular absorbent material constitutes about 27% (w/w) of the final product.
  • the coating agent can be any biocide capable of forming a coating layer on the surface of the granular absorbent material of the present application.
  • the coating agent contains one or more agents selected from the group consisting of silanes, siloxanes, aminopropyltrimethoxysilane, quaternary amines, fumed metal hydroxides, solutions of silver, solutions of copper and combinations thereof.
  • the coating agent is a biocide that forms a surface bonded film on the granular absorbent material.
  • the static surface bonded biocide film provides a long term inactivation or inhibition of pathogens in contact with the cleaning composition of the present invention, thus providing a long term assurance of the effectiveness of the cleaning effect.
  • the coating agent is applied to the granular absorbent material by vapor deposition. In some embodiments, the vapor deposition is performed by thermal heating the coating agent and the granular absorbent. [0041] In some embodiments, the coating agent is applied to the granular absorbent material by pressure micro droplet spray.
  • the coating agent is applied to the granular absorbent material by a fuming or fogging nozzle.
  • the coating agent is applied to the granular absorbent material by a deposition technique commonly used for metal plating.
  • biocide refers to any material that destroys, inactivates, eliminates, deters, inhibits the growth of, or otherwise render harmless and/or prevent damage or infection of a pathogen or a microorganism.
  • biocide includes, but are not limited to, silanes, siloxanes, aminopropyltrimethoxysilane, quaternary amines, fumed metal hydroxides, silver and salts or solutions thereof, copper and salts or solutions thereof, formaldehyde; bronopol; chlorocresol; peracetic acid; chloroxylenol; biphenyl-2-ol; hexa-2,4-dienoic acid/scorbutic acid; glutaral; clorofen; 2-phenoxy ethanol; cetylpyridinium chloride; tosylchloramide sodium; sodium 2-biphenylate; phthalaldehyde; N-(3-aminopropyl)- N-dodecylpropan-l,3-diamine; troclosen sodium; sodium dichloroisocyanurate dihydrate; didecyldimethylammonium chloride; iodine; sodium hypochlorite; hydrogen peroxide; calcium hypo
  • silanes refers chemical compounds with four substituents on silicon, including an organosilicon compound.
  • exemplary silanes include, but are not limited to, trichlorosilane (SiHCh), tetramethylsilane (Si(CH3)4) and tetraethoxysilane (Si(OC 2 H 5 )4).
  • siloxanes refers to chemical compounds that contain a functional group in organosilicon chemistry with the Si-O-Ai linkage.
  • exemplary siloxanes include, but are not limited to, poly dimethylsiloxane or cyclomethicones.
  • pathogen includes, but is not limited to, viruses, bacteria, yeast, protozoan, or other pathogenic microorganisms. Definitions and description of pathogens that may be eliminated, killed, inactivated or inhibited by administering the cleaning composition of the present application are described below. One of ordinary skill will understand that the described pathogens herein are not limiting.
  • the biocide and/or the cleaning composition of the present application can address such critical pathogen families as norovirus, HIV, MRS A, C. Diff, hepatitis, ebola, Gl-related viruses of many sorts or targeted bioterror agents, amongst others defined and described below.
  • Bacterial infections leading to gastroenteritis can be caused by Campylobacter, Escherichia coli, Salmonella, Shigella, Staphylococcus aureus, and Clostridum bacterial species.
  • Protozoa infections leading to gastroenteritis can be a result of Giardia, Entamoeba, and Cryptosporidium species.
  • bacteria shall mean members of a large group of unicellular microorganisms that have cell walls but lack organelles and an organized nucleus. Synonyms for bacteria include the terms “microorganisms”, “microbes”, “germs”, “bacilli”, “pathogens”, and “prokaryotes.” Exemplary bacteria include, but are not limited to Mycobacterium species, including M. tuberculosis,' Staphylococcus species, including S. epidermidis, S. aureus, and methicillin-resistant S. aureus,' Streptococcus species, including S. pneumoniae, S. pyogenes, S. mutans, S.
  • Corynebacterium species including C. diphtheriae, C. ulcerans, C. pseudotuberculosis, C. pseudodiphtheriticum, C. urealyticum, C. hemolyticum, C. equi; Listeria monocytogenes, Nocardia asteroides, Bacteroides species, Actinomycetes species, Treponema pallidum, Leptospirosa species, Klebsiella pneumoniae; Proteus sp., including Proteus vulgaris,' Serratia species, Acinetobacter , Yersinia species, including Y. pestis and Y. pseudotuberculosis,' Francisella tularensis, Enterobacter species, Bacteriodes species, Legionella species, Borrelia burgdorferi, and the like.
  • MRSA methicillin-resistant Staphylococcus aureus
  • C. Diff shall mean a species of gram-positive sporeforming bacterium known as Clostridium difficile, or C. difficile, or C. diff or sometimes CDF/cdf Clostridium difficile infection (CDI) is a symptomatic infection caused by this bacteria which can cause C. difficile associated diarrhea or Clostridum difficile colitis.
  • CDI Clostridium difficile infection
  • fungi shall mean any member of the group of saprophytic and parasitic spore-producing eukaryotic typically filamentous organisms formerly classified as plants that lack chlorophyll and include molds, rusts, mildews, smuts, mushrooms, and yeasts.
  • Exemplary fungi include, but are not limited to, Aspergillus species, Dermatophytes, Blastomyces derinatitidis , Candida species, including C. albicans and C.
  • T. schoenleinii T. megninii, T. soudanense, T. equinum, T. erinacei, and T. verrucosum
  • Mycoplasma genitalia Microsporum species, including M. audouini, M. ferrugineum, M. cants, M. nanum, M. distortum, M. gypseum, M. fulvum, and the like.
  • protozoans shall mean any member of a diverse group of eukaryotes that are primarily unicellular, existing singly or aggregating into colonies, are usually nonphotosynthetic, and are often classified further into phyla according to their capacity for and means of motility, as by pseudopods, flagella, or cilia.
  • Exemplary protozoans include, but are not limited to Plasmodium species, including P. falciparum, P. vivax, P. ovale, and P. malariae; Leishmania species, including L. major, L. tropica, L. donovani, L. infantum, L. chagasi, L. mexicana, L. panamensis, L. braziliensis and L. guyanensi; Cryptosporidium, Isospora belli, Toxoplasma gondii, Trichomonas vaginalis, and Cyclospora species.
  • targeted bioterror agents includes, but is not limited to, anthrax (Bacillus anthracis), botulism (Clostridium botulinum toxin), plague (Yersinia pestis). smallpox (Variola virus), tularemia (Franciscella tularensis) and viral hemorrhagic fever (arenaviruses, bunyaviruses, filoviruses, and arenaviruses), or other CDC Category A Agents.
  • Brucella species Clostrodium perfringens, Salmonella species, Escherichia coli, and Shigella species, Burkholderia mallei, Burkholderia pseudomallei, Chlamydia psittaci, Coxiella brunetii, Ricinus communis, Rickettsia prowazekii, Vibrio cholera, and Cryptosporidium parvum, and alphaviruses, e.g., Venezuelan equine encephalitis, eastern equine encephalitis, and western equine encephalitis viruses and other CDC Category B Agents. Emerging infectious disease infectious agents such as Nipah virus, hantavirus and other CDC Category C Agents.
  • the coating agent is added in an amount that constitutes 0.1 to 10% (w/w), 0.1 to 5% (w/w), 0.1 to 2% (w/w), 0.1 to 1% (w/w), 0.1 to 0.5% (w/w), 0.3 to 10% (w/w), 0.3 to 5% (w/w), 0.3 to 2% (w/w), 0.3 to 1% (w/w), 1 to 10% (w/w), 1 to 5% (w/w), 1 to 2% (w/w), 3 to 10% (w/w) or 3 to 5% (w/w) of the final product.
  • the coating agent is added in an amount that constitutes 0.5 to 3.5% (w/w) or 1 to 3% (w/w) of the final product. In some embodiments, the coating agent is added in an amount that constitutes about 2% (w/w) of the final product.
  • the sanitation agent can be any agent having biocide activity and can be absorbed by the coated granular absorbent of the present application.
  • the sanitation agent comprise an active substance designed to destroy, inhibit, reduce activity, inhibit grow or otherwise render harmless harmful organisms or toxic chemicals.
  • the sanitation agent is a liquid phase agent.
  • the sanitation agent is a liquid phase biocide.
  • the sanitation agent is a liquid phase chemical that inactivates or removes toxic chemicals, such as chemo therapy drugs.
  • the liquid phase biocide is added at an application site to provide chemical disinfection for immediate response.
  • liquid phase biocide examples include, but are not limited to, chlorine bleach solutions, hydrogen peroxide solutions, peracetic acid, quaternary amine solutions, alcohol solutions, periodine solutions, dimethyl benzyl ammonium chloride, dimethyl ethybenzyl ammonium chloride and mixtures thereof.
  • liquid phase chemicals that can be used to inactivate or remove toxic chemicals include, but are not limited to, anionic surfactants such as soap, sulfonates and sulfates. In some embodiments, large quantities of water is used to dilute the toxic chemicals.
  • the sanitation agent is added in an amount that constitutes 0.1 to 10% (w/w), 0.1 to 3% (w/w), 0.1 to 1% (w/w), 0.1 to 0.3% (w/w), 0.3 to 10% (w/w), 0.3 to 3% (w/w), 0.3 to 1% (w/w), 1 to 10% (w/w), 1 to 3% (w/w) or 3 to 10% (w/w) of the final product.
  • the sanitation agent comprises dimethyl benzyl ammonium chloride or dimethyl ethybenzyl ammonium chloride. In some embodiments, the sanitation agent comprises a mixture of dimethyl benzyl ammonium chloride or dimethyl ethybenzyl ammonium chloride. In some embodiments, the sanitation agent is a 1 : 1 mixture of dimethyl benzyl ammonium chloride or dimethyl ethybenzyl ammonium chloride.
  • the sanitation agent is a quatanary amine and is added in an amount that constitutes 0.3 to 3% (w/w), 0.5 to 2% (w/w) or 0.5 to 1.5% (w/w) of the final product. In some embodiments, the sanitation agent is a quatanary amine and is added in an amount that constitutes about 1% (w/w) of the final product.
  • CMC critical micelle concentration
  • Anionic surfactants at low concentrations reduce the magnitude of the apparent capsid surface charge enough to induce particle aggregation for capsids with a net negative surface charge.
  • concentration of charged surfactant As the concentration of charged surfactant is increased beyond its CMC, the micelles can solubilize capsid protein dimers and therefore disassemble the capsid structure.
  • surfactants are efficient in disrupting the virus structure only above their CMC, this should be taken into account when formulating virus cleaning and disinfectant systems with surfactants.
  • Surfactant micellization results in the ability of strong surfactants to disrupt interactions between virus capsid proteins and solubilize individual proteins or dimers.
  • Virus particle disassembly by surfactant is likely to lead to complete loss of infectivity, which can also be severely disrupted by the dramatic apparent surface charge alteration and aggregation caused by ionic surfactant.
  • Low concentrations of ionic surfactants (below CMC) are likely to disrupt the virus infectivity much less.
  • anionic surfactants are used as a sanitation agent to destroy viruses.
  • Typical anionic surfactants include soaps, sodium dodecylsulfate (SDS), alkylbenzene sulfonates, alkyl sulfonates, alkyl sulfonates, alkyl sulfates, salts of fluorinated fatty acids, silicones, fatty alcohol sulfates, polyoxyethylene fatty alcohol ether sulfates, a-olefin sulfonate, polyoxyethylene fatty alcohol phosphates ether, alkyl alcohol amide, alkyl sulfonic acid acetamide, alkyl succinate sulfonate salts, amino alcohol alkylbenzene sulfonates, naphthenates, alkylphenol sulfonate and polyoxyethylene monolaurate.
  • SDS sodium dodecylsulfate
  • alkylbenzene sulfonates alky
  • SDS is used as a sanitation agent absorbed in the granular ceramic material.
  • SDS sodium lauryl sulfate (SLS)
  • chemical formula NaChLLSSCL IUPAC, 2014
  • SDS possesses a zwitterionic form in aqueous solution with two distinct portions, polar and apolar, at opposite ends of a single molecule. The polar end is formed by a sulfate group while the opposite end, apolar, is composed by a long chain hydrocarbon, which may be linear, branched or aromatic according to the diluent solution.
  • the chemical nature of SDS provides adequate ionic balance, solubilizing fats and oils, and the formation of microemulsions, hence it is suitable as an ingredient in cleaning products.
  • SDS Sud contact of SDS with cells will cause physical and biochemical effects.
  • SDS is able to undo the barrier capacity of the cellular membrane due to its effect on lipids.
  • the effects of SDS depend on absolute concentrations and lipid/surfactant molar ratios.
  • cell membranes lose their barrier capacity increasing permeability.
  • equal or superior surfactant/lipid ratios cause cell lysis. If levels of surfactant (SDS) exceed cytolytic concentrations, the lamellar structure of the membrane is solubilized releasing proteins, lipoproteins and micelles, resulting in a complete cell lysis.
  • SDS surfactant
  • anionic surfactants are effective at breaking up the lipid envelope, and thereby ending viral infectivity.
  • the Modifying Agent is added to the coated granular absorbent or the absorbed- and-coated granular absorbent in an amount to achieve desired physical characteristics (e.g., non-dusty and clump, ease of pick up, liquid loadability, etc.) in the final product.
  • desired physical characteristics e.g., non-dusty and clump, ease of pick up, liquid loadability, etc.
  • the modifying agent include, but are not limited to, thickening agents, gums, absorbent polymers, tackifiers, and combinations thereof.
  • thickening agent may include any material known or otherwise effective in providing suspending, gelling, viscosifying, solidifying or thickening properties to the composition or which otherwise provide structure to the final product form.
  • thickening agents may include gelling agents, polymeric or nonpolymeric agents, inorganic thickening agents, or viscosifying agents. The amount and type of the thickening agent may vary depending upon the desired characteristics of the final product.
  • tackifier refers to polymeric adhesives which increase the tack, i.e., the inherent stickiness or self-adhesion, of the compositions so that after a short period of gentle pressure they adhere firmly to surfaces.
  • suitable tackifiers comprise high-flexibility resins such as, but not limited to, homopolymers of alkyl(meth)acrylates, especially alkyl acrylates, such as poly(isobutyl acrylate) or poly(2- ethylhexyl acrylate), linear polyesters, as commonly used for coil coating, linear difunctional oligomers, curable with actinic radiation, with a number average molecular weight of more than 2000, in particular from 3000 to 4000, based on polycarbonatediol or polyester-diol, linear vinyl ether homopolymers or copolymers based on ethyl, propyl, isobutyl, butyl and/or 2-ethylhexyl vinyl ether, or nonreactive urethane urea oligomers, which are prepared from bis(4,4- isocyanatophenyl)methane, N,N-dimethylethanolamine or diols such as propanediol,
  • the modifying agent comprises a high-molecular substance that absorbs liquids, preferably water, swells, and finally is converted to a viscous true or colloidal solution.
  • the modifying agent comprises one or more silicone gums.
  • silicone gum means a silicone polymer having a degree of polymerization sufficient to provide a silicone having a gum-like texture. In certain cases the silicone polymer forming the gum may be crosslinked.
  • the modifying agent comprises a polymer.
  • the polymers include, but is not limited to, natural and synthetic polymers such as polyacrylamide (ACAM) and carboxymethyl cellulose.
  • the polymers of the present application includes, but are not limited to, polyacrylates such as sodium polyacrylates, and carboxymethyl cellulose.
  • the modifying agent comprises one or more superabsorbent polymer.
  • superabsorbent polymer is understood to mean hydrophilic polymer structure capable of absorbing water or saline solution at greater than 10g of pure water/saline per gram of dry-based material (> lOg/g). Examples of super-absorbent polymers include, but are not limited to, sodium polyacrylates and carboxymethyl cellulose.
  • the one or more modifying agents further comprise one or more additives selected from the group comprising denaturing agents, colorant agents, odor correctors, and/or pH regulators.
  • the one or more modifying agents are added in an amount that constitute 0.1 to 5% (w/w), 0.1 to 2% (w/w), 0.1 to 1% (w/w), 0.1 to 0.3% (w/w), 0.3 to 5% (w/w), 0.3 to 2% (w/w), 0.3 to 1% (w/w), 1 to 5% (w/w), 1 to 2% (w/w) or 2 to 5% (w/w) of the final product.
  • the cleaning composition contains an granular absorbent material coated with a coating agent.
  • the coating agent contains a biocide.
  • the biocide comprises an agent selected from the group consisting of silanes, siloxanes, aminopropyltrimethoxysilane, quaternary amines, fumed metal hydroxides, silver and salts of silver, copper and salts of copper.
  • the biocide forms a static film on the surface of the granular absorbent material.
  • the granular absorbent material contains activated carbon, fumed silica, fine perlite, zeolites, processed clays or combinations thereof.
  • the coating agent constitutes 0.1 to 5% (w/w), 0.1 to 2% (w/w), 0.1 to 1% (w/w), 0.1 to 0.3% (w/w), 0.3 to 5% (w/w), 0.3 to 2% (w/w), 0.3 to 1% (w/w), 1 to 5% (w/w), 1 to 2% (w/w) or 2 to 5% (w/w) of the cleaning composition.
  • the granular absorbent material contains ceramic minerals. In some embodiments, the granular absorbent material contains perlite and/or vermiculite. In some embodiments, the granular absorbent material has a surface area per mass ratio in the range of 100-10,000 m 2 /g, 100-9,000 m 2 /g, 100-8,000 m 2 /g, 300-8,000 m 2 /g, 1,000-8,000 m 2 /g, 2,000-8,000 m 2 /g, 3,000-8,000 m 2 /g, 4,000-8,000 m 2 /g, 5,000-8,000 m 2 /g, 6,000-8,000 m 2 /g, 7,000-8,000 m 2 /g, 100-7,000 m 2 /g, 300-7,000 m 2 /g, 1,000-7,000 m 2 /g, 2,000-7,000 m 2 /g, 3,000- 7,000 m 2 /g, 4,000-7,000 m 2 /g, 5,000-7,000 m 2 /g, 5,000-7,000
  • the granular absorbent material has a surface area per mass ratio up to 10,000 m 2 /g. In some embodiments, the granular absorbent material has a surface area per mass ratio up to 9,000 m 2 /g. In some embodiments, the granular absorbent material has a surface area per mass ratio up to 8,000 m 2 /g. In some embodiments, the granular absorbent material has a surface area per mass ratio up to 7,000 m 2 /g. In some embodiments, the granular absorbent material has a surface area per mass ratio up to 6,000 m 2 /g.
  • the granular absorbent material has a surface area per mass ratio of 100 m 2 /g or greater. In some embodiments, the granular absorbent material has a surface area per mass ratio of 300 m 2 /g or greater. In some embodiments, the granular absorbent material has a surface area per mass ratio of 1,000 m 2 /g or greater. In some embodiments, the granular absorbent material has a surface area per mass ratio of 2,000 m 2 /g or greater. In some embodiments, the granular absorbent material has a surface area per mass ratio of 3,000 m 2 /g or greater.
  • the granular absorbent material has a surface area per mass ratio of 4,000 m 2 /g or greater. In some embodiments, the granular absorbent material has a surface area per mass ratio of 5,000 m 2 /g or greater.
  • the granular absorbent material has a surface area per mass ratio in the range of 1000-6,000 m 2 /g.
  • the granular absorbent material has a surface area per volume ratio in the range of 100-5,000 m 2 /ml, 300-5,000 m 2 /ml, 1,000-5,000 m 2 /ml, 2,000-5,000 m 2 /ml, 3,000-5,000 m 2 /ml, 4,000-5,000 m 2 /ml, 100-4,000 m 2 /ml, 300-4,000 m 2 /ml, 1,000-4,000 m 2 /ml, 2,000-54,000 m 2 /ml, 3,000-4,000 m 2 /ml, 100-3,000 m 2 /ml, 300-3,000 m 2 /ml, 1,000- 3,000 m 2 /ml, 2,000-3,000 m 2 /ml, 100-2,000 m 2 /ml, 300-2,000 m 2 /ml, or 1,000-2,000 m 2 /ml.
  • the granular absorbent material has a surface area per volume ratio up to 5,000 m 2 /ml. In some embodiments, the granular absorbent material has a surface area per volume ratio up to 4,000 m 2 /ml. In some embodiments, the granular absorbent material has a surface area per volume ratio up to 3,000 m 2 /ml.
  • the granular absorbent material has a surface area per volume ratio of 100 m 2 /ml or greater. In some embodiments, the granular absorbent material has a surface area per volume ratio of 300 m 2 /ml or greater. In some embodiments, the granular absorbent material has a surface area per volume ratio of 1,000 m 2 /ml or greater. In some embodiments, the granular absorbent material has a surface area per volume ratio of 2,000 m 2 /ml or greater. In some embodiments, the granular absorbent material has a surface area per volume ratio in the range of 1000-3,000 m 2 /ml.
  • the granular absorbent material constitutes 10-70% (w/w), 10-60% (w/w), 10-50% (w/w), 10-40% (w/w), 10-30% (w/w), 10-20% (w/w), 20-70% (w/w), 20-60% (w/w), 20-50% (w/w), 20-40% (w/w), 20-30% (w/w), 30-70% (w/w), 30-60% (w/w), 30-50% (w/w), 30-40% (w/w), 40-70% (w/w), 40-60% (w/w), 40-50% (w/w), 50-70% (w/w), 50-70% (w/w) or 60-70% (w/w) of the cleaning composition.
  • the granular absorbent material constitutes 25-30% (w/w) of the final product. In some embodiments, the granular absorbent material constitutes about 27% (w/w) of the cleaning composition.
  • the cleaning composition further comprises a sanitation agent absorbed in the coated granular absorbent material.
  • a sanitation agent absorbed in the coated granular absorbent material. Examples of the sanitation agent have been described above.
  • the sanitation agent comprise an active substance designed to destroy, inhibit, reduce activity, inhibit grow or otherwise render harmless harmful organisms or toxic chemicals.
  • the sanitation agent is a liquid phase agent.
  • the sanitation agent is a liquid phase biocide.
  • the sanitation agent is a liquid phase chemical that inactivates toxic chemicals, such as chemo therapy drugs.
  • liquid phase biocide examples include, but are not limited to, chlorine bleach solutions, hydrogen peroxide solutions, peracetic acid, quaternary amine solutions, periodine, alcohol solutions, dimethyl benzyl ammonium chloride, dimethyl ethybenzyl ammonium chloride and mixtures thereof.
  • liquid phase chemicals that can be used to inactivate or remove toxic chemicals include, but are not limited to, anionic surfactants such as soap, sulfonates and sulfates. In some embodiments, large quantities of water is used to dilute the toxic chemicals.
  • the sanitation agent constitutes 0.1 to 10% (w/w), 0.1 to 3% (w/w), 0.1 to 1% (w/w), 0.1 to 0.3% (w/w), 0.3 to 10% (w/w), 0.3 to 3% (w/w), 0.3 to 1% (w/w), 1 to 10% (w/w), 1 to 3% (w/w) or 3 to 10% (w/w) of the cleaning composition.
  • the sanitation agent comprises dimethyl benzyl ammonium chloride or dimethyl ethybenzyl ammonium chloride. In some embodiments, the sanitation agent comprises a mixture of dimethyl benzyl ammonium chloride or dimethyl ethybenzyl ammonium chloride. In some embodiments, the sanitation agent is a 1 : 1 mixture of dimethyl benzyl ammonium chloride or dimethyl ethybenzyl ammonium chloride.
  • the cleaning composition further comprises one or more modifying agent.
  • the modifying agent comprises a thickening agent, a tackifier, a gum, an absorbent polymers or combinations thereof.
  • the one or more modifying agents comprise a carboxymethyl cellulose (CMC)-derived polymer and/or a hierarchically porous carbons (HPC)-derived polymer.
  • the one or more modifying agents further comprise one or more additives selected from the group comprising denaturing agents, colorant agents, odor correctors, and/or pH regulators.
  • the one or more modifying agents constitute 0.1 to 5% (w/w), 0.1 to 2% (w/w), 0.1 to 1% (w/w), 0.1 to 0.3% (w/w), 0.3 to 5% (w/w), 0.3 to 2% (w/w), 0.3 to 1% (w/w), 1 to 5% (w/w), 1 to 2% (w/w) or 2 to 5% (w/w) of the cleaning composition.
  • the cleaning composition has a liquid loading capability in the range of 10-50% by volume, 15-45% by volume, 20-40% by volume, 25-35% by volume, or 25-30% by volume. In other embodiments, the cleaning composition has a liquid loading capability of 100-400% by mass addition, 150-350% by mass addition, or 200-300% by mass addition. In some embodiments, the cleaning composition of the present application is capable of absorbing liquid at a liquid loading of 25-30% by volume or 200-300% by mass addition.
  • the cleaning composition is specifically designed to kill or inactivate enveloped viruses, such as coronaviruses.
  • the cleaning composition comprises ethyl alcohol, isopropyl alcohol, chlorine or hypochlorites, chlorine dioxide, sodium dichloroisocyanurate, and chloramine-T, formaldehyde, glutaraldehyde, hydrogen peroxide, iodophors, ortho-phthalaldehyde, peracetic acid, phenolics, quaternary ammonium compounds, or in conjunction with superoxidized water.
  • Another aspect of the present application relates to a method of using the cleaning composition of the present application.
  • the method comprises the steps of applying an effective amount of the cleaning composition of the present application to a surface in need of cleaning, and remove the cleaning composition after a period of time.
  • the period of time is from 30 seconds to 30 minutes. In some embodiments, the period of time is from 1 to 30 minutes, from 1 to 20 minutes, from 1 to 10 minutes, from 2 to 30 minutes, from 2 to 20 minutes, from 2 to 10 minutes, from 5 to 30 minutes, from 5 to 20 minutes and from 5 to 10 minutes.
  • the surface in need of cleaning comprises a biohazard spill.
  • the biohazard spill is vomit, urine, blood, feces, and/or a chemo therapy drug.
  • the surface in need of cleaning is a surface in a public area and needs to be treated to prevent or reduce cross contamination or infection.
  • the term “public area” includes, but is not limited to, hospitals, doctors’ offices, urgent care facilities, nursing homes, prisons and related correction facilities, schools, buses, aircraft, airports, bars, restaurants, hotels, amusement parks, any large gathering institution facilities, veterinary facilities and drug research and development facilities.
  • the public area is located in a hotel.
  • the method further comprises the step of: washing the treated surface with a liquid or wiping the surface with a wiping material, such as paper tower or mops, after the removal of the cleaning composition.
  • a wiping material such as paper tower or mops
  • Another aspect of the present application relates to a method of disinfecting an affected area to prevent or reduce the distribution of pathogens such as viruses and bacteria.
  • the method comprises the steps of apply an effective amount of the cleaning composition of the present application to the affected area and remove the cleaning composition after a period of time, wherein the cleaning composition contains a granular absorbent material coated with a static, surface bonded film of biocide selected from the group consisting of silanes, siloxanes, aminopropyltrimethoxysilane, quaternary amines, fumed metal hydroxides, silver and salts of silver, copper and salts of copper.
  • a static, surface bonded film of biocide selected from the group consisting of silanes, siloxanes, aminopropyltrimethoxysilane, quaternary amines, fumed metal hydroxides, silver and salts of silver, copper and salts of copper.
  • the cleaning composition further comprises a sanitation agent selected from the group consisting of chlorine bleach solutions, hydrogen peroxide solutions, per acetic acid, quaternary amine solutions and alcohol solutions.
  • a sanitation agent selected from the group consisting of chlorine bleach solutions, hydrogen peroxide solutions, per acetic acid, quaternary amine solutions and alcohol solutions.
  • the sanitation agent is added to the cleaning composition immediately prior to the application to the affected area.
  • the cleaning composition of the present application is a multi-phase product that can be used to kill microbes through a number of different mechanisms.
  • the composition is a doped granular ceramic disinfectant which combines a surface area static disinfectant or biocide coating with a chemical phase primary disinfectant or biocide absorbed in the ceramic particles.
  • the term “disinfectant” describes the composition and formulations described herein for the elimination of pathogens from surfaces.
  • the term "disinfect” shall mean the elimination of many or all pathogens on a surface to which disinfectant is administered.
  • the cleaning composition of the present application is a surface area solid phase disinfectant that combines with a super absorbent polymer so that liquid loadings (e.g., 25-30% by volume/200-300% by mass addition) of available liquid can be added so as to impart chemical disinfection, to impart deodorizing chemicals or to impart a blanketing effect on the affected area so as to reduce the spread of microbe into the open air.
  • liquid loadings e.g., 25-30% by volume/200-300% by mass addition
  • the cleaning composition of the present application is a high surface area solid phase disinfectant with the addition of tackifiers, so that it lays on a bio hazard and forms a blanket which greatly reduces the release of airborne pathogens.
  • the cleaning composition is designed to be spray able on surfaces that may be contaminated with a virus.
  • the blend of a sprayable cleaning composition can depend on the dispensing form (e.g., hose or trigger spray) and according to the surface that has to be decontaminated.
  • Surfaces likely to become contaminated with viruses include medical and veterinary areas that come into contact with blood, body fluids, or internal mucosae of humans and animals. In terms of risk of virus transmission, these are considered to be critical contacts or, when only mucosae are involved, semicritical. Environmental surfaces are designated as critical only if they are in areas where highly susceptible individuals are housed, e.g., neonatal intensive care units, bum units, operating suites, nursing care homes, etc.
  • the surfaces which may be likely to carry contaminating viruses can be broadly categorized as nonporous inanimate, porous inanimate (e.g., linen), and animate (e.g., skin).
  • nonporous inanimate surfaces can be divided into instruments used for medical and veterinary procedures which are soaked in disinfectant solution between use, and environmental surfaces and objects which are usually decontaminated by wiping with towels, etc.
  • Such surface may include everything from egg shells to cement, but, in practice, stainless steel, plastics, ceramics, glass, and painted surfaces are the most likely to be treated with decontaminants regularly.
  • the cleaning composition of the present application is used in a procedure specifically designed to kill or inactivate enveloped viruses, such as coronaviruses.
  • kits can be used for cleaning up hazardous materials, such as vomit, urine, blood, feces, and/or a spill of chemo therapy drug, or disinfecting a surface.
  • the kit contains the cleaning composition of the present application and instructions on how to use the cleaning composition.
  • the kit further contains a copy of OSHA guidelines. In some embodiments, the kit further contains one or more of the following: biohazard bags, gloves, twist tie, antimicrobial hand wipe, germicidal wipe, scoop/scraper.
  • the cleaning kit can be conveniently placed in locations within quick reach of all caregivers. For example; all patient and chemotherapy rooms, case & crash carts, emergency vehicles, cafeteria, environmental services closets, and within or near first aid kits, etc.
  • EXAMPLE 1 TESTS OF THE VIRUCIDAL EFFECT OF THE CLEANING COMPOSITION OF THE PRESENT APPLICATION
  • Viral stock 1:10 dilution, 1ml virus + 9ml serum free EMEM
  • Flask 1 2ml virus + 8ml media b. Flask 2: 1.5ml virus + 8.5ml media c. Plate 1: virus + media in all 6 cells d. Plate 2
  • this test is designed to validate virucidal effectiveness claims for a product to be registered as a virucide. It determines the potential of the test agent to disinfect hard, non-porous surfaces contaminated with NOROVIRUS. This test is designed to simulate consumer use, conforms to EPA Guidelines DIS/TSS-7, November 1981, and follows the general procedure outlined in the FR notice for another surrogate virus available onlinel and Virucidal Testing Format and Statistics Primer issued by EPA (March 2000).
  • test agents Two lots of the test agents will be used to inactivate the challenge virus that has been dried on a sterile glass surface (two replicates for each batch/lot of the test agents). The test agent will be tested in a manner consistent with the label directions for use of the test agent or as specified by the Sponsor.
  • Test control and reference substances supplied by the Sponsor (see last page).
  • the test agent will be tested as supplied by the Sponsor unless directed otherwise.
  • the Sponsor before the initiation of testing, must specify all operations performed on the test agent such as dilutions of the test agent, the diluent for the test agent, or specialized storage conditions.
  • test agent must be tested for identity, strength, purity, stability and uniformity as applicable. All unused test agent will be retained for a period after completion of the test, then discarded in a manner that meets the approval of the safety officer.
  • B. Materials can include, but are not limited to:
  • CRFK Crandel Reese Feline Kidney
  • BA American Type Culture Collection, Manassas, VA; ATCC CCL-94).
  • CRFK cells will be grown in Cell Culture Media (Eagle’s Minimum Essential Media containing $5% Fetal Bovine Serum) containing Fetal Bovine Serum (FBS).
  • the FCV will be grown by inoculating confluent cell monolayers, no more than 24-48 hours in age, using low multiplicity of infection (MOI). Briefly, a flask of host cells grown in cell culture media containing 10% fetal bovine serum (FBS) will be used. The percent FBS contained in the stock virus aliquot will be adjusted to yield a minimum of a 5% organic soil load.
  • MOI multiplicity of infection
  • CPE cytopathic effects
  • Stock virus will be prepared by collecting the supernatant culture fluid from 75-100% infected culture cells. The supernatant will be removed, aliquoted, and stored in an ultra-low temperature freezer until the day of use. On the day of use an aliquot will be removed, thawed and refrigerated until use in the assay.
  • TEST SYSTEM IDENTIFICATION All Petri dishes, dilution tube racks, and host-containing apparatus will be labeled with the following information: virus, host, test agent, and project number.
  • FCV Feline calici virus
  • the F-9 strain of Feline calici virus will be obtained from the American Type Culture Collection, Manassas, VA, (ATCC VR-782).
  • FCV Feline calici virus
  • the FCV will be grown by inoculating confluent cell monolayers, no more than 24-48 hours in age, using low multiplicity of infection (MOI). Briefly, a flask of host cells grown in cell culture media containing 10% fetal bovine serum (FBS) will be used. Cells will be washed three times with phosphate buffered saline (PBS) and inoculated with virus.
  • FBS fetal bovine serum
  • the cell monolayer will be washed once in Earle’s balanced salt solution (EBSS), re-fed with cell culture media and incubated.
  • EBSS Earle’s balanced salt solution
  • CPE cytopathic effects
  • the CPE starts to develop in 1-2 days following inoculation, and will be harvested when more than ninety percent cytopathic effects (CPE) are observed.
  • Postincubation the cells will be disrupted, with cell debris removed by centrifugation.
  • Stock virus will be prepared by collecting the supernatant culture fluid from 75- 100% infected culture cells.
  • the supernatant will be removed, aliquoted, and stored in an ultralow temperature freezer until the day of use. On the day of use an aliquot is removed, thawed and refrigerated until use in the assay.
  • the percent FBS contained in the stock virus aliquot is adjusted to yield a minimum of a 5% organic soil load. If the Sponsor chooses a soil load greater than 5%, the percent FBS contained in the stock virus aliquot will be adjusted to yield the percent soil load requested.
  • B. Carrier Preparation An aliquot of 0.2 ml stock virus will be spread uniformly over the bottoms of 100 X 15 mm sterile glass Petri dishes with a cell scraper. The virus will be air-dried at room temperature for 30-60 minutes (until visibly dry). The drying conditions (temperature and humidity) will be appropriate for the test virus to obtain maximum survival following drying. The actual drying time and temperature will be recorded. Two carriers will be prepared for each lot of test agent and plate recovery control. Additionally, one carrier per test agent lot will be prepared for the neutralizer effectiveness control using cell culture media in place of stock virus.
  • Test agent preparation The test agent will be prepared and used according to the Sponsor’s directions or proposed label claims.
  • test For each of two batches of test substance, two dried virus films will be exposed to 2.0 ml of the use dilution of the test substance, or to the amount of spray released under use conditions (spray products) for a specified exposure time and temperature. Post contact time, the test agent will be neutralized and the mixture will be scraped from the surface of the dish. This will be considered approximately one log 10 dilution.
  • FCV virusspecific cytopathic effects
  • Virus stock titer The challenge virus will be titered at the time of the test to determine the relative infectivity of the virus and to demonstrate the susceptibility of the host cells to support infection of FCV.
  • the virus inoculum will be serial diluted tenfold in cell culture media. Selected dilutions will be inoculated into four wells per dilution and incubated under the same conditions as the test.
  • Plate recovery control Two ml of cell culture media will be added to the dried virus. Post-contact time, the virus/cell culture mixture will be subjected to the identical neutralization procedure as the test agent. If columns are used, a portion of the virus/cell culture media/neutralizer mixture will be used for the column titer control (see below). This control will determine the relative loss in virus infectivity resulting from drying and neutralization alone. The results from the PRC will be compared with the test results to confirm recovery of at least four log 10 of infectious virus following drying and neutralization. Its titer will be used to compare with the titers of the test results to reach the acceptable test criteria (see below).
  • Neutralizer effectiveness control (NEC). The neutralization procedure will be dependent upon the active ingredient present in the test agent and in the internal control test agent. For this control, each lot of the test agent will be processed exactly as the test procedure, but instead of the viral inoculum, cell culture media will be added. Post neutralization, the sample will be divided into three portions [two for cytotoxicity related controls (see below) and one for neutralizer effectiveness]. [0139] If columns are used, each sample will be passed through individual columns and the eluate will be serial diluted as appropriate in cell culture media. If columns are not used, the neutralizer effectiveness samples will be serial diluted tenfold in cell culture media.
  • the diluted samples will be mixed with low titer virus, held for a period equivalent to contact time and assayed for viral infectivity and/or cytotoxicity (see below), in order to determine the dilution of test agent at which virucidal activity, if any, is retained. Then the selected dilutions will be used to inoculate host cells as described for the test procedure. Dilutions that show virucidal activity will not be considered in determining reduction of viral infectivity by the test agent.
  • CT Cytotoxicity control
  • Viral and cytotoxicity titers will be expressed as -log 10 of the 50 percent titration endpoint infectivity (TCID 50 ), respectively, as calculated by the method of Spearman Karber. st
  • the cleaning composition of the present application is tested for effectiveness according to EPA standard operating procedures to measure the effectiveness of hard surface disinfectants against Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella choleraesuis , Mycobacterium bovis, Clostridium difficile, and viruses.
  • the standard operating procedures are based on strict interpretations of AO AC International and ASTM International standard methods.
  • the cleaning composition of the present application is tested as a germicidal spray product with testing for effectiveness against Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella enterica (EPA Method ID: MB-06-08 dated 9/22/2014).
  • Test cultures of the bacterium are prepared as follows: Defrost a single cryovial at room temperature and briefly vortex to mix. Add 10 pL of the thawed frozen stock (single use) to a tube containing 10 mL of culture medium (Synthetic broth is used for 5. aureus, P. aeruginosa and S. enterica. Nutrient broth may be used for P.
  • aeruginosa.' Vortex, and incubate at 36 ⁇ 1°C for 24 ⁇ 2 h.
  • One daily transfer is required prior to the inoculation of a final test culture. Daily cultures may be subcultured for up to 5 days; each daily culture may be used to generate a test culture. For S. aureus and S. enterica only, briefly vortex the 24 h cultures prior to transfer. For the final subculture transfer, inoculate a sufficient number of 20 * 150 mm tubes containing 10 mL growth medium (e.g., synthetic broth or nutrient broth) with 10 pL per tube of the 24 h culture then vortex to mix. Incubate 48-54 h at 36 ⁇ 1°C without shaking.
  • 10 mL growth medium e.g., synthetic broth or nutrient broth
  • Carrier inoculation is carried out as follows: Inoculate approximately 80 carriers; 60 carriers are required for testing, 6 for control carrier counts, and 1 for the viability control.
  • For P. aeruginosa remove the pellicle from the broth either by decanting the liquid aseptically into a sterile tube, by gently aspirating the broth away from the pellicle using a pipette, or by vacuum removal. Avoid harvesting pellicle from the bottom of the tube. Transfer test culture after pellicle removal into sterile 25 * 150 mm test tubes (up to approximately 20 mL per tube) and visually inspect for pellicle fragments. Presence of pellicle in the final culture makes it unusable for testing.
  • the final test culture may be diluted (e.g., one part culture plus one part sterile broth) prior to the addition of the OSL to the inoculum using the sterile culture medium used to generate the final test culture (e.g, synthetic broth).
  • the diluted test culture for carrier inoculation within 30 min. Add appropriate amount of organic burden if required. Swirl to mix.
  • Enumeration of viable bacteria from carriers is conducted as follows: Assay dried carriers in 2 sets of three carriers, one set immediately prior to conducting the efficacy test and one set immediately following the test. Randomly select 6 inoculated carriers for carrier count analysis prior to efficacy testing. Place each of the inoculated, dried carriers in a 38 x 100 mm culture tube or sterile 50 mL polypropylene conical tube containing 20 mL of letheen broth. Vortex immediately - 60 ⁇ 5 seconds for P. aeruginosa or 120 ⁇ 5 seconds for S. aureus and S. enterica.
  • Disinfectant sample preparation is conducted as follows: For aerosol cans and trigger or pump sprayers, shake the can 25 times prior to use, unless otherwise specified by the manufacturer. Spray the test substance for 10-15 seconds prior to testing to ensure sprayer is operating correctly and test substance is dispensed properly.
  • For concentrated test substances aseptically prepare the test substance use-dilution required for the test using appropriate sterile glassware or pipettes.
  • For concentrated test substances use > 1.0 mL or 1.0 g of the test substance sample to prepare the final solution to be tested.
  • the test procedure is conducted as follows: After the required carrier drying time, spray the slides sequentially for a specified time, distance, and number of pumps at timed intervals (typically 30 seconds) with the carriers in a horizontal position. Use a certified timer to time the spray interval. Spray the slide within ⁇ 5 seconds of the specified time for a contact time of 1-10 minutes or within ⁇ 3 seconds for contact times ⁇ 1 minute. After spraying, maintain the carriers in a horizontal position. Treated carriers must be kept undisturbed during the contact time. After the last slide of a set (typically 20 slides) has been sprayed with the disinfectant, and the exposure time is complete, sequentially transfer each slide into the primary subculture tube containing the appropriate neutralizer within the ⁇ 5 second time limit.
  • timed intervals typically 30 seconds
  • Results are recorded as follows: Gently shake each tube prior to recording results. Record results as + (growth) or 0 (no growth) as determined by presence or absence of turbidity. Confirm a minimum of three positive carrier sets per test. If there are less than three positive carriers, then confirm each carrier.
  • the cleaning composition of the present application is tested against the parameters set by the EPA in the Series 810 — Product Performance Test Guidelines, specifically public health uses of disinfectants (OCSPP 810.2200 (EPA-HQ-OPPT-2009-0150-0029)).
  • OCSPP 810.2200 EPA-HQ-OPPT-2009-0150-0029
  • testing is conducted against Salmonella enterica (S. enterica), formerly designated as Salmonella choleraesuis , American Type Culture Collection (ATCC) 10708 for effectiveness against Gram-negative bacteria, or Staphylococcus aureus (S. aureus) (ATCC 6538) for effectiveness against Gram-positive bacteria.
  • Three batches of the product are tested at the lower certified limit (LCL). For each batch, sixty carriers are used in the test.
  • the performance standard for 5. aureus is 0-3 positive carriers out of sixty.
  • the performance standard for 5. enterica is 0-1 positive carriers out of sixty. Contamination of one carrier (culture tube) is allowed per 60-carrier set; occurrence of more than one contaminated carrier invalidates the test results. For germicidal spray products, the product should kill the test microorganisms on 59 out of each set of 60 carriers/slides. Contamination of only one carrier (culture tube) is allowed per 60-carrier set; occurrence of more than one contaminated carrier invalidates the test results.
  • testing is conducted against S. aureus (ATCC 6538) and Pseudomonas aeruginosa (ATCC 15442).
  • ATCC 15442 For use against fungus, to demonstrate efficacy, testing is conducted against Trichophyton mentagrophytes (ATCC 9533).
  • testing is conducted against Hepatitis B virus, Hepatitis C virus, and Norovirus, the Duck Hepatitis B virus, Bovine Viral Diarrhea virus, and Feline Calicivirus, respectively, which are considered acceptable surrogates for testing.
  • Coronaviruses are enveloped viruses with a positive-sense single-stranded RNA genome and a nucleocapsid of helical symmetry. Coronavirus virions are generally considered to have on average diameters of 80-120 nm, but the size range can vary from 50 nm up to 200 nm. Characteristic surface spikes or peplomers, which appear club-like, pear-shaped, or petalshaped, project some 17-20 nm from the virion surface, having a thin base that swells to a width of about 10 nm at the distal extremity. In certain coronaviruses a second set of projections, 5- 10-nm long, forms an undergrowth beneath the major spikes.
  • Coronavirus infections begin with the binding of virions to host cellular receptors. The infection culminates in the deposition of the nucleocapsid into the cytoplasm, where the viral genome becomes available for translation.
  • the positive-sense genome which functions in effect as the first mRNA of viral infection, is translated into the enormous replicase polyprotein.
  • the replicase then uses the genome as the template for the synthesis, via negativestrand intermediates, of both new viral genomes and a set of subgenomic mRNAs. The latter are translated into structural proteins and accessory proteins.
  • the membrane-bound structural proteins, M, S, and E, are inserted into the ER, from where they transit to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC).
  • Nucleocapsids are formed from the encapsidation of progeny genomes by N protein, and these coalesce with the membrane-bound components, forming virions by budding into the ERGIC. Finally, progeny virions are exported from infected cells by transport to the plasma membrane in smooth-walled vesicles, or Golgi sacs, that remain to be more clearly defined.
  • a fraction of S protein that has not been assembled into virions ultimately reaches the plasma membrane.
  • S protein can cause the fusion of an infected cell with adjacent, uninfected cells, leading to the formation of large, multinucleate syncytia. This enables the spread of infection independent of the action of extracellular virus, thereby providing some measure of escape from immune surveillance.
  • SARS-CoV-2 coronavirus coronavirus coronavirus
  • SARS-CoV infects ciliated bronchial epithelial cells and type-II pneumocytes through angiotensin-converting enzyme 2 (ACE2) as receptor; mechanism of action for SARS-CoV-2 are still being determined.
  • ACE2 angiotensin-converting enzyme 2
  • SARS-CoV-2 has been detected in environmental samples from COVID-19 dedicated intensive care units (ICU) in hospitals. In rooms of COVID-19 patients, different levels of environmental contamination have been detected, ranging from 1 out of 13 to 13 out of 15 samples testing positive for SARS-CoV-2 prior to cleaning. One sample from an air exhaust outlet was positive indicating that virus particles may be displaced by air and deposited on surfaces, although no direct air samples tested positive. SARS-CoV-2 was also detected on objects such as the self-service printers used by patients to self-print the results of their exams, desktop keyboards and doorknobs. Virus was detected most commonly on gloves and, even rarely, on eye protection. The evidence shows the threat of contamination of SARS-CoV-2 in the environment of a COVID-19 patient, therefore reinforcing the need for decontamination of these environments.
  • the cleaning composition described herein provides an effective solution. Decontamination Protocol
  • Appropriate personal protective equipment is worn for cleaning up a body fluid spill. Gloves are worn during the cleaning and decontaminating procedures. To avoid the consequences of any splashing, the worker wears a face shield and gown. For large spills, overalls, gowns or aprons as well as boots or protective shoe covers are worn. Personal protective equipment is changed if tom or soiled, and is always removed before leaving the location of the spill, and then hands are washed.
  • the cleaning composition is applied to spill - wait at least 60 seconds.
  • Disposable towels are used to spread the cleaning composition to any areas not covered by initial application of the cleaning composition. Paper towels are disposed in plastic-lined waste receptacles
  • the surface is sprayed or wiped thoroughly with the cleaning composition -the appropriate contact time is allowed to pass in accordance with the degree of severity of the spill (typically 1 - to 5 minutes).
  • the cleaning composition is wiped up disposable paper towels. Paper towel are discarded as above. 7. Remove gloves and dispose in plastic-lined waste receptacle.
  • the following active ingredients are some of those that are incorporated in the sanitation agent in the cleaning composition in combinations of one or more ingredients for use in decontamination of areas suspected of harboring SARS-CoV-2: quaternary ammonium; isopropanol; dodecylbenzenesulfonic acid; lactic acid; hydrogen peroxide; citric acid; chlorine dioxide; sodium hypochlorite; L-lactic acid; citric acid; thymol; peroxyacetic acid; potassium peroxymonosulfate; sodium chloride; thymol; ethanol; glutaraldehyde; phenols; sodium dischloroisocyanurate dehydrate; hypochlorous acid; silver; peroxy octanoic acid; sodium carbonate peroxyhydrate; sodium dichloro-S-triazinetrione; potassium peroxymonosulfate; ethyl alcohol; octanoic acid; glycolic acid; ammonium carbonate; ammonium bicarbonate.

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EP20956890.6A 2020-10-08 2020-10-08 Antivirale reinigungszusammensetzung, verfahren zur herstellung und verwendung davon Pending EP4225036A1 (de)

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GB9818778D0 (en) * 1998-08-28 1998-10-21 Crosfield Joseph & Sons Particulate carrier for biocide formulations
US8343525B2 (en) * 2009-12-22 2013-01-01 Becton, Dickinson And Company Chlorhexidine acetate antiseptic cleaning agent
US10604729B2 (en) * 2016-09-08 2020-03-31 Morehouse School Of Medicine Liquid loading composition, method of making and use thereof
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