EP4208044A1 - Compositions and methods - Google Patents

Compositions and methods

Info

Publication number
EP4208044A1
EP4208044A1 EP21773497.9A EP21773497A EP4208044A1 EP 4208044 A1 EP4208044 A1 EP 4208044A1 EP 21773497 A EP21773497 A EP 21773497A EP 4208044 A1 EP4208044 A1 EP 4208044A1
Authority
EP
European Patent Office
Prior art keywords
amorphous solid
aerosol
slurry
gelling agent
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21773497.9A
Other languages
German (de)
English (en)
French (fr)
Inventor
Walid Abi Aoun
John Paul Mua
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nicoventures Trading Ltd
Original Assignee
Nicoventures Trading Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicoventures Trading Ltd filed Critical Nicoventures Trading Ltd
Publication of EP4208044A1 publication Critical patent/EP4208044A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/12—Chemical features of tobacco products or tobacco substitutes of reconstituted tobacco
    • A24B15/14—Chemical features of tobacco products or tobacco substitutes of reconstituted tobacco made of tobacco and a binding agent not derived from tobacco
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B13/00—Tobacco for pipes, for cigars, e.g. cigar inserts, or for cigarettes; Chewing tobacco; Snuff
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
    • A24B15/302—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances by natural substances obtained from animals or plants
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
    • A24B15/302—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances by natural substances obtained from animals or plants
    • A24B15/303—Plant extracts other than tobacco
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
    • A24B15/32—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances by acyclic compounds
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
    • A24B15/36—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances containing a heterocyclic ring
    • A24B15/40—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances containing a heterocyclic ring having only oxygen or sulfur as hetero atoms
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
    • A24B15/36—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances containing a heterocyclic ring
    • A24B15/40—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances containing a heterocyclic ring having only oxygen or sulfur as hetero atoms
    • A24B15/403—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances containing a heterocyclic ring having only oxygen or sulfur as hetero atoms having only oxygen as hetero atoms
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/42—Treatment of tobacco products or tobacco substitutes by chemical substances by organic and inorganic substances
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B3/00—Preparing tobacco in the factory
    • A24B3/14—Forming reconstituted tobacco products, e.g. wrapper materials, sheets, imitation leaves, rods, cakes; Forms of such products
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
    • A24D1/00—Cigars; Cigarettes
    • A24D1/18—Selection of materials, other than tobacco, suitable for smoking
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
    • A24D1/00—Cigars; Cigarettes
    • A24D1/20—Cigarettes specially adapted for simulated smoking devices
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/20—Devices using solid inhalable precursors

Definitions

  • the present invention relates to aerosol generation for delivery of constituents, derivatives or extracts of cannabis.
  • the present invention also relates to compositions for oral delivery of constituents, derivatives or extracts of cannabis. Background
  • Smoking articles such as cigarettes, cigars and the like burn tobacco during use to create tobacco smoke.
  • Alternatives to these types of articles release an inhalable aerosol or vapour by releasing compounds from a substrate material by heating without burning.
  • These may be referred to as non-combustible smoking articles, aerosol generating assemblies or non-combustible aerosol provision systems.
  • a heating device which release compounds by heating, but not burning, a solid aerosolisable material.
  • This solid aerosolisable material may, in some cases, contain a tobacco material.
  • the heating volatilises at least one component of the material, typically forming an inhalable aerosol.
  • These products may be referred to as heat-not-burn devices, tobacco heating devices or tobacco heating products (THP).
  • THP tobacco heating products
  • e-cigarette / tobacco heating product hybrid devices also known as electronic tobacco hybrid devices.
  • These hybrid devices contain a liquid source (which may or may not contain nicotine) which is vaporised by heating to produce an inhalable vapour or aerosol.
  • the device additionally contains a solid aerosolisable material (which may or may not contain a tobacco material) and components of this material are entrained in the inhalable vapour or aerosol to produce the inhaled medium.
  • an amorphous solid for use in aerosol generation comprising: about 1 to about 12 wt% constituent, derivative or extract of cannabis; about 10 to about 80 wt% aerosol-former material; gelling agent; and optionally filler, wherein the amount of gelling agent and optional filler taken together is from about 10 to about 60 wt%; wherein the wt% values are calculated on a dry weight basis.
  • an aerosol-generating material comprising the amorphous solid of the first aspect.
  • a consumable for use in a non-combustible aerosol provision device comprising the aerosol-generating material of the second aspect.
  • a non-combustible aerosol provision system comprising the consumable of the third aspect and a non-combustible aerosol provision device.
  • a composition for oral delivery of a constituent, derivative or extract of cannabis comprising an amorphous solid, the amorphous solid comprising: about 1 to about 12 wt% constituent, derivative or extract of cannabis; about 10 to about 80 wt% humectant; gelling agent; and optionally filler, wherein the amount of gelling agent and optional filler taken together is from about 10 to about 60 wt%; wherein the wt% values are calculated on a dry weight basis.
  • amorphous solid of the first aspect or as defined in the fifth aspect comprising:
  • a slurry comprising: about 1 to about 12 wt% constituent, derivative or extract of cannabis; about 10 to about 80 wt% humectant; gelling agent; and optionally filler, wherein the amount of gelling agent and optional filler taken together is from about 10 to about 60 wt%; wherein the wt% values are calculated on a dry weight basis; and a solvent.
  • the aerosol-former material in the amorphous solid for use in aerosol generation is the same as the humectant in the amorphous solid for use in aerosol generation for oral delivery of constituent(s), derivative(s) or extract(s) of cannabis.
  • Figure 1 shows a section view of an example of a consumable.
  • Figure 2 shows a perspective view of the consumable of Figure 1.
  • Figure 3 shows a sectional elevation of an example of a consumable.
  • Figure 4 shows a perspective view of the consumable of Figure 3.
  • Figure 5 shows a perspective view of an example of a non-combustible aerosol provision system.
  • Figure 6 shows a section view of an example of a non-combustible aerosol provision system.
  • Figure 7 shows a perspective view of an example of a non-combustible aerosol provision system.
  • an amorphous solid for use in aerosol generation comprising: about 1 to about 12 wt% constituent, derivative or extract of cannabis; about 10 to about 80 wt% aerosol-former material; gelling agent; and optionally filler, wherein the amount of gelling agent and optional filler taken together is from about 10 to about 60 wt%; wherein the wt% values are calculated on a dry weight basis.
  • compositions for oral delivery of a constituent, derivative or extract of cannabis comprising an amorphous solid, the amorphous solid comprising: about 1 to about 12 wt% constituent, derivative or extract of cannabis; about 10 to about 80 wt% humectant; gelling agent; and optionally filler, wherein the amount of gelling agent and optional filler taken together is from about 10 to about 60 wt%; wherein the wt% values are calculated on a dry weight basis.
  • the amorphous solid may form part of an aerosol-generating material.
  • An aerosol-generating material is a material that is capable of generating aerosol, for example when heated, irradiated or energized in any other way.
  • the amorphous solid may alternatively be referred to as a “monolithic solid” (i.e. non-fibrous).
  • the amorphous solid may be a dried gel.
  • the amorphous solid is a solid material that may retain some fluid, such as liquid, within it.
  • the retained fluid may be water (such as water absorbed from the surroundings of the amorphous solid) or the retained fluid may be solvent (such as when the amorphous solid is formed from a slurry).
  • the solvent may be water.
  • the aerosol-generating material may for example comprise from about 50 wt%, 60 wt% or 70 wt% of amorphous solid, to about 90 wt%, 95 wt% or 100 wt% of amorphous solid, based on the weight of the aerosolgenerating material.
  • WWB wet weight basis
  • the aerosol-generating material consists of the amorphous solid.
  • the amorphous solid and/or the aerosol generating material consists essentially of, or consists of, gelling agent; solvent; aerosol-former material; constituent, derivative or extract of cannabis; and optionally a flavour and/or optionally an additional active substance and/or optionally a filler.
  • the amorphous solid and/or the aerosol generating material consists essentially of, or consists of, gelling agent; solvent; aerosol-former material; and constituent, derivative or extract of cannabis.
  • the amorphous solid and/or the aerosol generating material consists essentially of, or consists of, gelling agent; solvent; aerosol-former material; cannabinoid; and optionally a flavour and/or optionally an additional active substance and/or optionally a filler.
  • the amorphous solid and/or the aerosol generating material consists essentially of, or consists of, gelling agent; solvent; aerosol-former material; and cannabinoid.
  • the amorphous solid and/or the aerosol generating material consists essentially of, or consists of, gelling agent; water; aerosol-former material; constituent, derivative or extract of cannabis; and optionally a flavour and/or optionally an additional active substance and/or optionally a filler.
  • the amorphous solid and/or the aerosol generating material consists essentially of, or consists of, gelling agent; water; aerosol-former material; and constituent, derivative or extract of cannabis.
  • the amorphous solid and/or the aerosol generating material consists essentially of, or consists of, gelling agent; water; aerosol-former material; cannabinoid; and optionally a flavour and/or optionally an additional active substance and/or optionally a filler.
  • the amorphous solid and/or the aerosol generating material consists essentially of, or consists of, gelling agent; water; aerosol-former material; and cannabinoid.
  • the amorphous solid is a hydrogel and comprises less than about 20 wt% of water calculated on a wet weight basis. In some cases, the hydrogel may comprise less than about 15 wt%, 12 wt% or 10 wt% of water calculated on a wet weight basis (WWB). In some cases, the hydrogel may comprise at least about 1 wt%, 2 wt% or at least about 5 wt% of water (WWB).
  • the amorphous solid may contain less than about 20 wt%, such as less than about 15 wt%, 12 wt% or 10 wt% of water calculated on a wet weight basis (WWB).
  • WWB wet weight basis
  • the amorphous solid may contain about 1-15 wt% of water, such as 3-12 wt% of water (WWB).
  • the amorphous solid may contain about 1-5 wt% of water (WWB).
  • the amorphous solid may comprise from about 1 to about 12 wt% of one or more constituents, derivatives or extracts of cannabis, for example from about 1.5 wt% or 2 wt% to about 10 wt%, 8 wt%. 7 wt% or 6 wt% of constituent(s), derivative(s) or extract(s) of cannabis (all calculated on a dry weight basis).
  • the amorphous solid may comprise about 1.5-10 wt%, about 1.5-8 wt%, about 2-8 wt%, or about 2-6 wt% constituent(s), derivative(s) or extract(s) of cannabis.
  • any compound or mixture of compounds which may be obtained from cannabis may be a constituent, derivative or extract thereof, including synthetic versions of such compound(s) or such compound(s) derived from other natural sources.
  • the constituent(s), derivative(s) or extract(s) of cannabis comprises, or is, one or more compounds selected from: cannabinoids, optionally phytocannabinoids that may optionally be THC and/or CBD; terpenes, optionally triterpenes; alkaloids; and flavonoids.
  • the constituent(s), derivative(s) or extract(s) of cannabis comprises one or more compounds selected from: cannabinoids, optionally phytocannabinoids; or terpenes, optionally triterpenes.
  • the constituent(s), derivative(s) or extract(s) of cannabis comprises one or more cannabinoids, optionally phytocannabinoids.
  • Cannabinoids are a class of natural or synthetic chemical compounds which act on cannabinoid receptors (i.e. , CB1 and CB2) in cells that repress neurotransmitter release in the brain.
  • Cannabinoids may be naturally occurring (phytocannabinoids) from plants such as cannabis, from animals (endocannabinoids), or artificially manufactured (synthetic cannabinoids).
  • Cannabis species express at least 85 different phytocannabinoids, and are divided into subclasses, including cannabigerols, cannabichromenes, cannabidiols, tetrahydrocannabinols, cannabinols and cannabinodiols, and other cannabinoids.
  • Cannabinoids found in cannabis include, without limitation: cannabigerol (CBG), cannabichromene (CBC), cannabidiol (CBD), tetrahydrocannabinol (THC), cannabinol (CBN), cannabinodiol (CBDL), cannabicyclol (CBL), cannabivarin (CBV), tetrahydrocannabivarin (THCV), cannabidivarin (CBDV), cannabichromevarin (CBCV), cannabigerovarin (CBGV), cannabigerol monomethyl ether (CBGM), cannabinerolic acid, cannabidiolic acid (CBDA), cannabinol propyl variant (CBNV), cannabitriol (CBO), tetrahydrocannabmolic acid (THCA), and tetrahydrocannabivarinic acid (THCV A).
  • CBD cannabigerol
  • the cannabinoids are phytocannabinoids.
  • the terpenes are triterpenes.
  • the constituent, derivative or extract of cannabis comprises, or is, tetrahydrocannabinol (THC) and/or cannabidiol (CBD).
  • THC tetrahydrocannabinol
  • CBD cannabidiol
  • the constituent, derivative or extract of cannabis comprises, or is, THC.
  • the constituent, derivative or extract of cannabis comprises, or is, CBD.
  • constituents, derivatives or extracts of cannabis such as CBD may have limited solubility in solutions used in liquid vaping delivery systems, meaning that such systems may not be able to deliver high levels of such materials.
  • Use of amorphous solids may allow for incorporation of higher levels of constituents, derivatives or extracts of cannabis, and hence delivery of higher amounts of constituents, derivatives or extracts of cannabis to the user.
  • the aerosol-former material may comprise one or more constituents capable of forming an aerosol.
  • the amorphous solid may comprise from about 10 wt% to about 80 wt% of aerosol-former material (calculated on a dry weight basis), for example about 20 wt%, 30 wt% or 40 wt% to about 80 wt%, 75 wt%, 60 wt% or 50 wt%.
  • the amorphous solid may comprise from about 20-80 wt% aerosolformer material.
  • the amorphous solid may comprise about 50 to 80 wt%, such as about 60 to 80 wt% aerosol-former material.
  • the amorphous solid may comprise from about 30 to 40 wt% aerosolformer material.
  • the aerosol-former material may comprise one or more of glycerol, propylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, 1,3-butylene glycol, erythritol, meso- Erythritol, ethyl vanillate, ethyl laurate, a diethyl suberate, triethyl citrate, triacetin, a diacetin mixture, benzyl benzoate, benzyl phenyl acetate, tributyrin, lauryl acetate, lauric acid, myristic acid, and propylene carbonate.
  • glycerol propylene glycol
  • diethylene glycol triethylene glycol
  • tetraethylene glycol 1,3-butylene glycol
  • erythritol meso- Erythritol
  • ethyl vanillate ethyl laurate
  • the aerosol-former material may comprise one or more of erythritol, propylene glycol, glycerol, and triacetin. In some cases, the aerosol-former material comprises, consists essentially of or consists of glycerol, or a mixture of glycerol and propylene glycol. In some embodiments, the aerosol-former material comprises a mixture of glycerol and propylene glycol in a weight ratio of glycerol to propylene glycol of about 3:1 to 1:3, about 2:1 to 1:2, about 1.5: 1 to 1 : 1.5, about 55:45 to 45:55, or about 45:55.
  • the aerosol-former material may act as a plasticiser. If the content of the plasticiser is too high, the amorphous solid may absorb water resulting in a material that does not create an appropriate consumption experience in use. If the plasticiser content is too low, the amorphous solid may be brittle and easily broken.
  • the plasticiser content specified herein provides an amorphous solid flexibility which allows a sheet of the amorphous solid or aerosol-generating material to be wound onto a bobbin, which is useful in manufacture of aerosol generating articles (consumables).
  • the amorphous solid comprises from about 10 wt% to about 60 wt% gelling agent, for example from about 10 wt%, 15 wt%, 20 wt%, or 25 wt% to about 60 wt%, 50 wt%, 45 wt%, 40 wt%, 35 wt% or 30 wt% of a gelling agent (all calculated on a dry weight basis).
  • the amorphous solid may comprise about 10-50 wt%, 15-45 wt%, 20-45 wt%, 15-40 wt%, or 20-30 wt% of the gelling agent.
  • the amorphous solid may comprise about 15-35 wt% of the gelling agent.
  • the gelling agent comprises a hydrocolloid.
  • the gelling agent comprises (or is) one or more compounds selected from polysaccharide gelling agents, such as alginate, pectin, starch or a derivative thereof, cellulose or a derivative thereof, pullulan, carrageenan, agar and agarose; gelatin; gums, such as xanthan gum, guar gum and acacia gum; silica or silicone compounds, such as PDMS and sodium silicate; clays, such as kaolin; and polyvinyl alcohol.
  • polysaccharide gelling agents such as alginate, pectin, starch or a derivative thereof, cellulose or a derivative thereof, pullulan, carrageenan, agar and agarose
  • gelatin such as xanthan gum, guar gum and acacia gum
  • silica or silicone compounds such as PDMS and sodium silicate
  • clays such as kaolin
  • polyvinyl alcohol polyvinyl alcohol
  • the gelling agent comprises (or is) one or more polysaccharide gelling agents.
  • the polysaccharide gelling agent is selected from alginate, pectin, starch or a derivative thereof, or cellulose or a derivative thereof. In some embodiments the polysaccharide gelling agent is selected from alginate and a cellulose derivative. In some embodiments, the gelling agent is a polysaccharide gelling agent, optionally wherein the polysaccharide gelling agent is selected from alginate and a cellulose derivative.
  • the alginate is sodium alginate.
  • the polysaccharide gelling agent is a cellulose derivative. Without wishing to be bound by theory, the inventors believe that such gelling agents do not react with calcium ions to form crosslinks.
  • the polysaccharide gelling agent is alginate.
  • the gelling agent is not crosslinked.
  • the absence of crosslinks in the gelling agent facilitates quicker delivery of the constituent, derivative or extract of cannabis (and any optional additional active substances and/or flavours) from the amorphous solid.
  • cellulosic gelling agents include, but are not limited to, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethylcellulose (CMC), hydroxypropyl methylcellulose (HPMC), methyl cellulose, ethyl cellulose, cellulose acetate (CA), cellulose acetate butyrate (CAB), and cellulose acetate propionate (CAP).
  • the cellulose or derivative thereof is selected from hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethylcellulose (CMC), hydroxypropyl methylcellulose (HPMC), methyl cellulose, ethyl cellulose, cellulose acetate (CA), cellulose acetate butyrate (CAB), and cellulose acetate propionate (CAP).
  • CMC carboxymethylcellulose
  • HPMC hydroxypropyl methylcellulose
  • CAP cellulose acetate propionate
  • the cellulose derivative is CMC.
  • the gelling agent comprises (or is) one or more of alginate, pectin, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethylcellulose, pullulan, xanthan gum guar gum, carrageenan, agarose, acacia gum, fumed silica, PDMS, sodium silicate, kaolin and polyvinyl alcohol.
  • the gelling agent comprises (or is) one or more of hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethylcellulose, guar gum, acacia gum, alginate and/or pectin.
  • the gelling agent comprises (or is) alginate and/or pectin, and may be combined with a setting agent (such as a calcium source) during formation of the amorphous solid.
  • a setting agent such as a calcium source
  • the amorphous solid may comprise a calcium- crosslinked alginate and/or a calcium-crosslinked pectin.
  • the gelling agent comprises (or is) alginate, optionally wherein the alginate is present in the amorphous solid in an amount of from about 15-40 wt%, for example about 15-25 wt%, of the amorphous solid (calculated on a dry weight basis).
  • alginate is the only gelling agent present in the amorphous solid.
  • the gelling agent comprises alginate and at least one further gelling agent, such as pectin.
  • the gelling agent is carboxymethylcellulose, optionally wherein the carboxymethylcellulose (CMC) is present in an amount of about 15-50 wt%, for example about 20-40 wt% or about 30 wt%. In some embodiments, CMC is the only gelling agent present in the amorphous solid.
  • CMC carboxymethylcellulose
  • the aerosol-generating material may further comprise a filler.
  • a filler may help to reduce tackiness of the amorphous solid, for example if high levels of aerosol-former material are present.
  • the amorphous solid comprises from about 10 wt% to about 60 wt% gelling agent and any optional filler.
  • the amorphous solid may comprise less than about 50 wt% of a filler, such as from about 1 wt% to 50 wt%, or 5 wt% to 40 wt%, or 5 wt% to 30 wt%, or 10 wt% to 20 wt%.
  • the amorphous solid comprises less than 20 wt%, suitably less than 10 wt% or less than 5 wt% of a filler. In some cases, the amorphous solid comprises less than 1 wt% of a filler, and in some cases, comprises no filler.
  • the filler may comprise one or more inorganic filler materials, such as calcium carbonate, perlite, vermiculite, diatomaceous earth, colloidal silica, magnesium oxide, magnesium sulphate, magnesium carbonate, and suitable inorganic sorbents, such as molecular sieves.
  • the filler may comprise one or more organic filler materials such as wood pulp; tobacco pulp; hemp fibre; starch and starch derivatives, such as maltodextrin; chitosan; and cellulose and cellulose derivatives, such as ground cellulose, microcrystalline cellulose and nanocrystalline cellulose.
  • the amorphous solid comprises no calcium carbonate such as chalk.
  • microcrystalline cellulose may be formed by depolymerising cellulose by a chemical process (e.g. using an acid or enzyme).
  • a chemical process e.g. using an acid or enzyme.
  • One examplary method for forming microcrystalline cellulose involves acid hydrolysis of cellulose, using an acid such as HCI. The cellulose produced after this treatment is crystalline (i.e. no amorphous regions remain). Suitable methods and conditions for forming microcrystalline cellulose are well- known in the art.
  • the filler is fibrous.
  • the filler may be a fibrous organic filler material such as wood pulp, tobacco pulp, hemp fibre, cellulose or cellulose derivatives.
  • the fibrous organic filler material may be wood pulp, hemp fibre, cellulose or cellulose derivatives.
  • the fibrous filler is wood pulp.
  • the gelling agent is CMC and is used together with wood pulp as a filler.
  • the aerosol-generating material may further comprise one or more other functional material(s).
  • the amorphous solid may further comprise one or more additional active substances and/or flavours, and optionally one or more other functional material.
  • constituent(s), derivative(s) or extract(s) of cannabis is or are the only active(s) present in the amorphous solid.
  • constituent(s), derivative(s) or extract(s) of cannabis is or are the only active(s) present in the aerosol-generating material.
  • the amorphous solid and/or the aerosol-generating material may further comprise additional active ingredients.
  • the amorphous solid may comprise from about 1 wt%, 5 wt%, 10 wt%, 15 wt%, 20 wt% or 25 wt% to about 65wt%, 60 wt%, 50 wt%, 45 wt%, 40 wt%, 35 wt%, or 30 wt% (calculated on a dry weight basis) of another active substance in addition to constituent(s), derivative(s) or extract(s) of cannabis.
  • the additional active substance as used herein may be a physiologically active material, which is a material intended to achieve or enhance a physiological response.
  • the additional active substance may for example be selected from nutraceuticals, nootropics and psychoactives.
  • the additional active substance may be naturally occurring or synthetically obtained.
  • the additional active substance may comprise for example nicotine, caffeine, taurine, theine, vitamins such as B6 or B12 or C, melatonin, or constituents, derivatives, or combinations thereof.
  • the additional active substance may comprise one or more constituents, derivatives or extracts of tobacco or another botanical.
  • the additional active substance comprises nicotine.
  • the additional active substance comprises caffeine, melatonin or vitamin B12.
  • the additional active substance may comprise or be derived from one or more botanicals or constituents, derivatives or extracts thereof.
  • botanical includes any material derived from plants including, but not limited to, extracts, leaves, bark, fibres, stems, roots, seeds, flowers, fruits, pollen, husk, shells or the like.
  • the material may comprise an active compound naturally existing in a botanical, obtained synthetically.
  • the material may be in the form of liquid, gas, solid, powder, dust, crushed particles, granules, pellets, shreds, strips, sheets, or the like.
  • Example botanicals are tobacco, eucalyptus, star anise, hemp, cocoa, coffee, fennel, lemongrass, peppermint, spearmint, rooibos, chamomile, flax, ginger, ginkgo biloba, hazel, hibiscus, laurel, licorice (liquorice), matcha, mate, orange skin, papaya, rose, sage, tea such as green tea or black tea, thyme, clove, cinnamon, coffee, aniseed (anise), basil, bay leaves, cardamom, coriander, cumin, nutmeg, oregano, paprika, rosemary, saffron, lavender, lemon peel, mint, juniper, elderflower, vanilla, Wintergreen, beefsteak plant, curcuma, turmeric, sandalwood, cilantro, bergamot, orange blossom, myrtle, cassis, valerian, pimento, mace, damien, marjoram, olive, lemon
  • the mint may be chosen from the following mint varieties: Mentha Arventis, Mentha c.v., Mentha niliaca, Mentha piperita, Mentha piperita citrata c.v., Mentha piperita c.v., Mentha spicata crispa, Mentha cardi folia, Mentha longifolia, Mentha suaveolens variegata, Mentha pulegium, Mentha spicata c.v. and Mentha suaveolens.
  • the additional active substance comprises or is derived from one or more botanicals or constituents, derivatives or extracts thereof and the botanical is tobacco. In some embodiments, the additional active substance comprises or derived from one or more botanicals or constituents, derivatives or extracts thereof and the botanical is selected from eucalyptus, star anise, cocoa and hemp. In some embodiments the additional active substance comprises (or is) a botanical selected from eucalyptus, star anise, cocoa and hemp.
  • the additional active substance comprises or derived from one or more botanicals or constituents, derivatives or extracts thereof and the botanical is selected from rooibos and fennel. In some embodiments, the additional active substance comprises (or is) a botanical selected from rooibos and fennel.
  • the amorphous solid additionally comprises a tobacco material and/or nicotine.
  • the amorphous solid may comprise 5-60 wt% (calculated on a dry weight basis) of a tobacco material and/or nicotine.
  • the amorphous solid may comprise from about 1 wt%, 5 wt%, 10 wt%, 15 wt%, 20 wt% or 25 wt% to about 65 wt%, 60 wt%, 50 wt%, 45 wt%, 40 wt%, 35 wt%, or 30 wt% (calculated on a dry weight basis) of a tobacco material.
  • the amorphous solid may comprise up to about 50 wt% of a tobacco material.
  • the amorphous solid may comprise about 10-50 wt%, 15-40 wt% or 20-35 wt% of a tobacco material.
  • the amorphous solid may comprise from about 1 wt%, 2 wt%, 3 wt% or 4 wt% to about 20 wt%, 18 wt%, 15 wt% or 12 wt% (calculated on a dry weight basis) of nicotine.
  • the amorphous solid may comprise about 1-20 wt%, 2-18 wt% or 3-12 wt% of nicotine.
  • the amorphous solid comprises an additional active substance such as tobacco extract.
  • the amorphous solid may comprise 5-60 wt% (calculated on a dry weight basis) of tobacco extract.
  • the amorphous solid may comprise from about 5 wt%, 10 wt%, 15 wt%, 20 wt% or 25 wt% to about 60 wt%, 50 wt%, 45 wt%, 40 wt%, 35 wt%, or 30 wt% (calculated on a dry weight basis) tobacco extract.
  • the amorphous solid may comprise about 10-50 wt%, 15-40 wt% or 20-35 wt% of tobacco extract.
  • the tobacco extract may contain nicotine at a concentration such that the amorphous solid comprises about 1 wt% 1.5 wt%, 2 wt% or 2.5wt% to about 6 wt%, 5 wt%, 4.5 wt% or 4 wt% (calculated on a dry weight basis) of nicotine. In some cases, there may be no nicotine in the amorphous solid other than that which results from any tobacco extract.
  • the amorphous solid in the aerosol-generating material comprises no tobacco material but does comprise nicotine.
  • the amorphous solid may comprise from about 1 wt%, 2 wt%, 3 wt% or 4 wt% to about 20 wt%, 18 wt%, 15 wt% or 12 wt% (calculated on a dry weight basis) of nicotine.
  • the amorphous solid may comprise about 1-20 wt%, 2-18 wt% or 3-12 wt% of nicotine.
  • the amorphous solid and the aerosol-generating material do not contain any tobacco material (including tobacco extract) or nicotine.
  • the amorphous solid does not comprise tobacco fibres. In particular embodiments, the amorphous solid does not comprise fibrous material.
  • the aerosol-generating material does not comprise tobacco fibres. In particular embodiments, the aerosol-generating material does not comprise fibrous material.
  • the amorphous solid and/or the aerosol-generating material may optionally comprise a flavour.
  • the amorphous solid may comprise up to about 65 wt%, 55 wt%, 50 wt% or 45 wt% of a flavour.
  • the amorphous solid may comprise at least about 0.1 wt%, 1 wt%, 10 wt%, 20 wt%, 30 wt%, 35 wt% or 40 wt% of a flavour (all calculated on a dry weight basis).
  • the amorphous solid may comprise 1-65 wt%, 10-65 wt%, 20-50 wt%, or 30-40 wt% a flavour.
  • flavour and “flavourant” refer to materials which, where local regulations permit, may be used to create a desired taste, aroma or other somatosensorial sensation in a product for adult consumers. They may include naturally occurring flavour materials, botanicals, extracts of botanicals, synthetically obtained materials, or combinations thereof (e.g., tobacco, cannabis, licorice (liquorice), hydrangea, eugenol, Japanese white bark magnolia leaf, chamomile, fenugreek, clove, maple, matcha, menthol, Japanese mint, aniseed (anise), cinnamon, turmeric, Indian spices, Asian spices, herb, Wintergreen, cherry, berry, red berry, cranberry, peach, apple, orange, mango, clementine, lemon, lime, tropical fruit, papaya, rhubarb, grape, durian, dragon fruit, cucumber, blueberry, mulberry, citrus fruits, Drambuie, bourbon, scotch,
  • the flavour comprises menthol, spearmint and/or peppermint.
  • the flavour comprises flavour components of cucumber, blueberry, citrus fruits and/or redberry.
  • the flavour comprises eugenol.
  • the flavour comprises flavour components extracted from tobacco.
  • the flavour comprises flavour components extracted from cannabis.
  • the flavour may comprise a sensate, which is intended to achieve a somatosensorial sensation which are usually chemically induced and perceived by the stimulation of the fifth cranial nerve (trigeminal nerve), in addition to or in place of aroma or taste nerves, and these may include agents providing heating, cooling, tingling, numbing effect.
  • a suitable heat effect agent may be, but is not limited to, vanillyl ethyl ether and a suitable cooling agent may be, but not limited to eucolyptol or WS-3 (/V-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide).
  • the amorphous solid may additionally comprise an emulsifying agent, which emulsifies molten flavour during manufacture.
  • the amorphous solid may comprise from about 5 wt% to about 15 wt% of an emulsifying agent (calculated on a dry weight basis), suitably about 10wt%.
  • the emulsifying agent may comprise acacia gum.
  • the total content of additional active substance and/or flavour may be at least about 0.1 wt%, 1 wt%, 5 wt%, 10 wt%, 20 wt%, 25 wt% or 30 wt%. In some cases, the total content of additional active substance and/or flavour may be less than about 60 wt%, 50 wt% or 40 wt% (all calculated on a dry weight basis).
  • the total content of tobacco material, nicotine and/or flavour may be at least about 0.1 wt%, 1 wt%, 5 wt%, 10 wt%, 20 wt%, 25 wt% or 30 wt%. In some cases, the total content of tobacco material, nicotine and/or flavour may be less than about 60 wt%, 50 wt% or 40 wt% (all calculated on a dry weight basis).
  • the one or more other functional materials may comprise one or more of pH regulators, colouring agents, preservatives, stabilizers, and/or antioxidants.
  • the amorphous solid is formed as a sheet.
  • the amorphous solid sheet may be incorporated into the non-combustible aerosol provision system or consumable in sheet form.
  • the amorphous solid sheet may be incorporated as a planar sheet, as a gathered or bunched sheet, as a crimped sheet, or as a rolled sheet (i.e. in the form of a tube).
  • the amorphous solid of these embodiments may be included in the system/consumable as a sheet, such as a sheet circumscribing a rod of aerosolisable material (e.g. tobacco).
  • the amorphous solid sheet may be formed on a wrapping paper which circumscribes an aerosolisable material such as tobacco.
  • the sheet may be shredded and then incorporated into the assembly, suitably mixed into an aerosolisable material such as cut rag tobacco.
  • the amorphous solid may be in the form of a sheet or layer having a thickness of about 0.015 mm to about 1.0 mm.
  • the thickness may be in the range of about 0.05 mm, 0.1 mm or 0.15 mm to about 0.5 mm or 0.3 mm, for example 0.1-3 mm or 0.15-3 mm.
  • a material having a thickness of 0.2 mm may be particularly suitable.
  • the amorphous solid may comprise more than one layer, and the thickness described herein refers to the aggregate thickness of those layers.
  • the amorphous solid is too thick, then heating efficiency may be compromised. This adversely affects the power consumption in use. Conversely, if the amorphous solid is too thin, it may be difficult to manufacture and handle; a very thin material is harder to cast and may be fragile, compromising aerosol formation in use.
  • the thickness stipulated herein is a mean thickness for the material. In some cases, the amorphous solid thickness may vary by no more than 25%, 20%, 15%, 10%, 5% or 1%.
  • the amorphous solid in sheet form may have a tensile strength of from around 200 N/m to around 2000 N/m. In some examples, the amorphous solid in sheet form may have a tensile strength of from around 200 N/m to around 900 N/m. In some examples, such as where the amorphous solid does not comprise a filler, the amorphous solid in sheet form may have a tensile strength of from around 200 N/m to around 400 N/m, or around 200 N/m to around 300 N/m, or about 250 N/m.
  • Such tensile strengths may be particularly suitable for embodiments wherein the amorphous solid and/or the aerosol-generating material is formed as a sheet and then shredded and incorporated into a consumable.
  • the amorphous solid may have a tensile strength of from around 600 N/m to around 900 N/m, or from around 700 N/m to around 900 N/m, or around 800 N/m.
  • Such tensile strengths may be particularly suitable for embodiments wherein the amorphous solid and/or the aerosol-generating material is included in a consumable/non-combustible aerosol provision system as a rolled sheet, suitably in the form of a tube.
  • the aerosol-generating material comprising the amorphous solid may have any suitable area density, such as from 30 g/m 2 to 120 g/m 2 .
  • the aerosol-generating material may have a mass per unit area of 80-120 g/m 2 , or from about 70 to 110 g/m 2 , or particularly from about 90 to 110 g/m 2 , or suitably about 100 g/m 2 (so that it has a similar density to cut rag tobacco and a mixture of these substances will not readily separate).
  • Such area densities may be particularly suitable where the aerosol-generating material is included in assembly consumable/system in sheet form, or as a shredded sheet (described further hereinbelow).
  • the aerosol-generating material may have a mass per unit area of about 30 to 70 g/m 2 , 40 to 60 g/m 2 , or 25-60 g/m 2 and may be used to wrap an aerosolisable material such as tobacco.
  • the amorphous solid for use in aerosol generation may be present on or in a support, to form a substrate.
  • the support may, for example, be or comprise paper, card, paperboard, cardboard, reconstituted material, a plastics material, a ceramic material, a composite material, glass, a metal, or a metal alloy.
  • the support comprises a susceptor.
  • the susceptor is embedded within the material. In some alternative embodiments, the susceptor is on one or either side of the material.
  • the aerosol-generating material may comprise a carrier on which the amorphous solid is provided.
  • the carrier functions as a support on which the amorphous solid layer forms, easing manufacture.
  • the carrier may provide tensile strength to the amorphous solid layer, easing handling.
  • the carrier may be formed from materials selected from metal foil, paper, carbon paper, greaseproof paper, ceramic, carbon allotropes such as graphite and graphene, plastic, cardboard, wood or combinations thereof.
  • the carrier may comprise or consist of a tobacco material, such as a sheet of reconstituted tobacco.
  • the carrier may be formed from materials selected from metal foil, paper, cardboard, wood or combinations thereof.
  • the carrier itself be a laminate structure comprising layers of materials selected from the preceding lists.
  • the carrier may also function as a flavour carrier.
  • the carrier may be impregnated with a flavour or with tobacco extract.
  • the carrier may be magnetic. This functionality may be used to fasten the carrier to the non-combustible aerosol provision device in use, or may be used to generate particular amorphous solid shapes.
  • the aerosolgenerating material may comprise one or more magnets which can be used to fasten the material to an induction heater in use.
  • the carrier may be substantially or wholly impermeable to gas and/or aerosol. This prevents aerosol or gas passage through the carrier layer, thereby controlling the flow and ensuring it is delivered to the user. This can also be used to prevent condensation or other deposition of the gas/aerosol in use on, for example, the surface of a heater provided in an aerosol generating assembly. Thus, consumption efficiency and hygiene can be improved in some cases.
  • the surface of the carrier that abuts the amorphous solid may be porous.
  • the carrier comprises paper.
  • a porous carrier such as paper has been found to be particularly suitable; the porous (e.g. paper) layer abuts the amorphous solid layer and forms a strong bond.
  • the amorphous solid may be formed by drying a gel and, without being limited by theory, it is thought that the slurry from which the gel is formed partially impregnates the porous carrier (e.g. paper) so that when the gel sets, the carrier is partially bound into the gel. This provides a strong binding between the gel and the carrier (and between the dried gel and the carrier).
  • the amorphous solid may be laminated to a carrier, such as a paper sheet.
  • the layer of slurry may be formed on a carrier, such as a paper sheet.
  • surface roughness may contribute to the strength of bond between the amorphous material and the carrier.
  • the inventors have found that the paper roughness (for the surface abutting the carrier) may suitably be in the range of 50-1000 Bekk seconds, suitably 50-150 Bekk seconds, suitably 100 Bekk seconds (measured over an air pressure interval of 50.66-48.00 kPa).
  • a Bekk smoothness tester is an instrument used to determine the smoothness of a paper surface, in which air at a specified pressure is leaked between a smooth glass surface and a paper sample, and the time (in seconds) for a fixed volume of air to seep between these surfaces is the "Bekk smoothness”.
  • the surface of the carrier facing away from the amorphous solid may be arranged in contact with the heater, and a smoother surface may provide more efficient heat transfer.
  • the carrier is disposed so as to have a rougher side abutting the amorphous material and a smoother side facing away from the amorphous material.
  • the carrier may be a paper-backed foil; the paper layer abuts the amorphous solid layer and the properties discussed in the previous paragraphs are afforded by this abutment.
  • the foil backing is substantially impermeable, providing control of the aerosol flow path.
  • a metal foil backing may also serve to conduct heat to the amorphous solid.
  • the foil layer of the paper-backed foil abuts the amorphous solid.
  • the foil is substantially impermeable, thereby preventing water provided in the amorphous solid from being absorbed into the paper which could weaken its structural integrity.
  • the carrier is formed from or comprises metal foil, such as aluminium foil.
  • a metallic carrier may allow for better conduction of thermal energy to the amorphous solid.
  • a metal foil may function as a susceptor in an induction heating system.
  • the carrier comprises a metal foil layer and a support layer, such as cardboard.
  • the metal foil layer may have a thickness of less than 20 pm, such as from about 1 pm to about 10 pm, suitably about 5 pm.
  • the carrier may have a thickness of between about 0.010 mm and about 2.0 mm, suitably from about 0.015 mm, 0.02 mm, 0.05 mm or 0.1 mm to about 1.5 mm, 1.0 mm, or 0.5 mm.
  • a consumable for use in a non-combustible aerosol provision device comprising an aerosolgenerating material, wherein the aerosol-generating material comprises an amorphous solid, the amorphous solid comprising: about 1 to about 12 wt% constituent, derivative or extract of cannabis; about 10 to about 80 wt% aerosol-former material; gelling agent; and optionally filler, wherein the amount of gelling agent and optional filler taken together is from about 10 to about 60 wt%; wherein the wt% values are calculated on a dry weight basis.
  • the disclosure relates to consumables comprising aerosol-generating material and configured to be used with non-combustible aerosol provision devices. These consumables are sometimes referred to as articles throughout the disclosure.
  • the consumable may be used with any suitable non-combustible aerosol provision device.
  • a consumable is an article comprising or consisting of aerosol-generating material, part or all of which is intended to be consumed during use by a user.
  • a consumable may comprise one or more other components, such as an aerosolgenerating material storage area, an aerosol-generating material transfer component, an aerosol generation area, a housing, a wrapper, a mouthpiece, a filter and/or an aerosol-modifying agent.
  • a consumable may also comprise an aerosol generator, such as a heater, that emits heat to cause the aerosol-generating material to generate aerosol in use.
  • the heater may, for example, comprise combustible material, a material heatable by electrical conduction, or a susceptor.
  • a susceptor is a material that is heatable by penetration with a varying magnetic field, such as an alternating magnetic field.
  • the susceptor may be an electrically-conductive material, so that penetration thereof with a varying magnetic field causes induction heating of the heating material.
  • the heating material may be magnetic material, so that penetration thereof with a varying magnetic field causes magnetic hysteresis heating of the heating material.
  • the susceptor may be both electrically-conductive and magnetic, so that the susceptor is heatable by both heating mechanisms.
  • the device that is configured to generate the varying magnetic field is referred to as a magnetic field generator, herein.
  • An aerosol-modifying agent is a substance, typically located downstream of the aerosol generation area, that is configured to modify the aerosol generated, for example by changing the taste, flavour, acidity or another characteristic of the aerosol.
  • the aerosol-modifying agent may be provided in an aerosol-modifying agent release component that is operable to selectively release the aerosolmodifying agent.
  • the aerosol-modifying agent may, for example, be an additive or a sorbent.
  • the aerosol-modifying agent may, for example, comprise one or more of a flavourant, a colourant, water, and a carbon adsorbent.
  • the aerosol-modifying agent may, for example, be a solid, a liquid, or a gel.
  • the aerosol-modifying agent may be in powder, thread or granule form.
  • the aerosol-modifying agent may be free from filtration material.
  • An aerosol generator is an apparatus configured to cause aerosol to be generated from the aerosol-generating material.
  • the aerosol generator is a heater configured to subject the aerosol-generating material to heat energy, so as to release one or more volatiles from the aerosol-generating material to form an aerosol.
  • the aerosol generator is configured to cause an aerosol to be generated from the aerosol-generating material without heating.
  • the aerosol generator may be configured to subject the aerosol-generating material to one or more of vibration, increased pressure, or electrostatic energy.
  • a non-combustible aerosol provision system comprising the consumable described herein and a non- combustible aerosol provision device.
  • a “non-combustible” aerosol provision system is one where a constituent aerosol-generating material of the aerosol provision system (or component thereof) is not combusted or burned in order to facilitate delivery of at least one substance to a user.
  • the delivery system is a non-combustible aerosol provision system, such as a powered non-combustible aerosol provision system.
  • the non-combustible aerosol provision system is an aerosol-generating material heating system, also known as a heat-not-burn system.
  • a heat-not-burn system is a tobacco heating system.
  • the non-combustible aerosol provision device is a heat-not-burn device.
  • the non-combustible aerosol provision system is a hybrid system to generate aerosol using a combination of aerosol-generating materials, one or a plurality of which may be heated.
  • the hybrid system comprises the aerosol-generating material described herein comprising or consisting of the amorphous solid and an additional liquid or gel aerosol-generating material.
  • the non-combustible aerosol provision device is an electronic tobacco hybrid device.
  • the non-combustible aerosol provision system may comprise a non- combustible aerosol provision device and a consumable for use with the non- combustible aerosol provision device.
  • the non-combustible aerosol provision system such as a non-combustible aerosol provision device thereof, may comprise a power source and a controller.
  • the power source may, for example, be an electric power source or an exothermic power source.
  • the exothermic power source comprises a carbon substrate which may be energised so as to distribute power in the form of heat to an aerosol-generating material or to a heat transfer material in proximity to the exothermic power source.
  • the non-combustible aerosol provision system such as a non-combustible aerosol provision device thereof, may comprise an area for receiving the consumable, an aerosol generator, an aerosol generation area, a housing, a mouthpiece, a filter and/or an aerosol-modifying agent.
  • the non-combustible aerosol provision system or device may comprise a heater configured to heat but not burn the aerosol generating substrate.
  • the heater may be, in some cases, a thin film, electrically resistive heater. In other cases, the heater may comprise an induction heater or the like. In yet further cases, the heater may be a combustible heat source or a chemical heat source which undergoes an exothermic reaction to produce heat in use. In some cases, the heater may heat but not burn the aerosolisable material(s) to between 120°C and 350°C in use. In some cases, the heater may heat but not burn the aerosolisable material(s) to between 140°C and 250°C in use.
  • substantially all of the amorphous solid is less than about 4 mm, 3 mm, 2 mm or 1 mm from the heater. In some cases, the solid is disposed between about 0.017 mm and 2.0 mm from the heater, suitably between about 0.1 mm and 1.0 mm. These minimum distances may, in some cases, reflect the thickness of a carrier that supports the amorphous solid. In some cases, a surface of the amorphous solid may directly abut the heater.
  • the heater may be embedded in the aerosol-generating material.
  • the heater may be an electrically resistive heater (with exposed contacts for connection to an electrical circuit).
  • the heater may be a susceptor embedded in the aerosol-generating material, which is heated by induction.
  • the non-combustible aerosol provision system may additionally comprise a cooling element and/or a filter.
  • the cooling element if present, may act or function to cool gaseous or aerosol components. In some cases, it may act to cool gaseous components such that they condense to form an aerosol. It may also act to space the very hot parts of the apparatus from the user.
  • the filter if present, may comprise any suitable filter known in the art such as a cellulose acetate plug.
  • the non-combustible aerosol provision system may be a heat- not-burn system. That is, it may contain a solid material (and no liquid aerosolisable material).
  • a heat-not-burn device is disclosed in WO 2015/062983 A2, which is incorporated by reference in its entirety.
  • the non-combustible aerosol provision system may comprise an electronic tobacco hybrid device. That is, it may contain a solid aerosolisable material and a liquid aerosolisable material.
  • the separate aerosolisable materials may be heated by separate heaters, the same heater or, in one case, a downstream aerosolisable material may be heated by a hot aerosol which is generated from the upstream aerosolisable material.
  • An electronic tobacco hybrid device is disclosed in WO 2016/135331 A1, which is incorporated by reference in its entirety.
  • the consumable may alternatively be referred to herein as a cartridge.
  • the consumable may be adapted for use in a THP, an electronic tobacco hybrid device or another aerosol generating device.
  • the consumable may additionally comprise a filter and/or cooling element, as described previously.
  • the consumable may be circumscribed by a wrapping material such as paper.
  • the consumable may additionally comprise ventilation apertures. These may be provided in the sidewall of the article. In some cases, the ventilation apertures may be provided in the filter and/or cooling element. These apertures may allow cool air to be drawn into the article during use, which can mix with the heated volatilised components thereby cooling the aerosol.
  • the ventilation enhances the generation of visible heated volatilised components from the article when it is heated in use.
  • the heated volatilised components are made visible by the process of cooling the heated volatilised components such that supersaturation of the heated volatilised components occurs.
  • the heated volatilised components then undergo droplet formation, otherwise known as nucleation, and eventually the size of the aerosol particles of the heated volatilised components increases by further condensation of the heated volatilised components and by coagulation of newly formed droplets from the heated volatilised components.
  • the ratio of the cool air to the sum of the heated volatilised components and the cool air is at least 15%.
  • a ventilation ratio of 15% enables the heated volatilised components to be made visible by the method described above. The visibility of the heated volatilised components enables the user to identify that the volatilised components have been generated and adds to the sensory experience of the smoking experience.
  • the ventilation ratio is between 50% and 85% to provide additional cooling to the heated volatilised components. In some cases, the ventilation ratio may be at least 60% or 65%.
  • article 101 is adapted for use with a device having a power source and a heater.
  • the article 101 of this embodiment is particularly suitable for use with the device 51 shown in Figures 5 to 7, described below.
  • the article 101 may be removably inserted into the device shown in Figure 5 at an insertion point 20 of the device 51.
  • the article 101 of one example is in the form of a substantially cylindrical rod that includes a body of aerosol-generating material 103 and a filter assembly 105 in the form of a rod.
  • the aerosol-generating material comprises the amorphous solid material described herein. In some embodiments, it may be included in sheet form. In some embodiments it may be included in the form of a shredded sheet. In some embodiments, the aerosol-generating material described herein may be incorporated in sheet form and in shredded form.
  • the filter assembly 105 includes three segments, a cooling segment 107, a filter segment 109 and a mouth end segment 111.
  • the article 101 has a first end 113, also known as a mouth end or a proximal end and a second end 115, also known as a distal end.
  • the body of aerosol-generating material 103 is located towards the distal end 115 of the article 101.
  • the cooling segment 107 is located adjacent the body of aerosol-generating material 103 between the body of aerosol-generating material 103 and the filter segment 109, such that the cooling segment 107 is in an abutting relationship with the aerosol generatingmaterial 103 and the filter segment 103.
  • the filter segment 109 is located in between the cooling segment 107 and the mouth end segment 111.
  • the mouth end segment 111 is located towards the proximal end 113 of the article 101 , adjacent the filter segment 109.
  • the filter segment 109 is in an abutting relationship with the mouth end segment 111.
  • the total length of the filter assembly 105 is between 37 mm and 45 mm, more preferably, the total length of the filter assembly 105 is 41 mm.
  • the rod of aerosol-generating material 103 is between 34 mm and 50 mm in length, suitably between 38 mm and 46 mm in length, suitably 42 mm in length.
  • the total length of the article 101 is between 71 mm and 95 mm, suitably between 79 mm and 87 mm, suitably 83 mm.
  • an axial end of the body of aerosol-generating material 103 is visible at the distal end 115 of the article 101.
  • the distal end 115 of the article 101 may comprise an end member (not shown) covering the axial end of the body of aerosol-generating material 103.
  • the body of aerosol-generating material 103 is joined to the filter assembly 105 by annular tipping paper (not shown), which is located substantially around the circumference of the filter assembly 105 to surround the filter assembly 105 and extends partially along the length of the body of aerosol-generating material 103.
  • the tipping paper is made of 58GSM standard tipping base paper.
  • the tipping paper has a length of between 42mm and 50mm, suitably of 46mm.
  • the cooling segment 107 is an annular tube and is located around and defines an air gap within the cooling segment.
  • the air gap provides a chamber for heated volatilised components generated from the body of aerosolgenerating material 103 to flow.
  • the cooling segment 107 is hollow to provide a chamber for aerosol accumulation yet rigid enough to withstand axial compressive forces and bending moments that might arise during manufacture and whilst the article 101 is in use during insertion into the device 51.
  • the thickness of the wall of the cooling segment 107 is approximately 0.29mm.
  • the cooling segment 107 provides a physical displacement between the aerosol-generating material 103 and the filter segment 109.
  • the physical displacement provided by the cooling segment 107 will provide a thermal gradient across the length of the cooling segment 107.
  • the cooling segment 107 is configured to provide a temperature differential of at least 40 degrees Celsius between a heated volatilised component entering a first end of the cooling segment 107 and a heated volatilised component exiting a second end of the cooling segment 107.
  • the cooling segment 107 is configured to provide a temperature differential of at least 60 degrees Celsius between a heated volatilised component entering a first end of the cooling segment 107 and a heated volatilised component exiting a second end of the cooling segment 107.
  • This temperature differential across the length of the cooling element 107 protects the temperature sensitive filter segment 109 from the high temperatures of the aerosol-generating material 103 when it is heated by the device 51. If the physical displacement was not provided between the filter segment 109 and the body of aerosol-generating material 103 and the heating elements of the device 51 , then the temperature sensitive filter segment may 109 become damaged in use, so it would not perform its required functions as effectively.
  • the length of the cooling segment 107 is at least 15mm. In one example, the length of the cooling segment 107 is between 20mm and 30mm, more particularly 23mm to 27mm, more particularly 25mm to 27mm, suitably 25mm.
  • the cooling segment 107 is made of paper, which means that it is comprised of a material that does not generate compounds of concern, for example, toxic compounds when in use adjacent to the heater of the device 51.
  • the cooling segment 107 is manufactured from a spirally wound paper tube which provides a hollow internal chamber yet maintains mechanical rigidity. Spirally wound paper tubes are able to meet the tight dimensional accuracy requirements of highspeed manufacturing processes with respect to tube length, outer diameter, roundness and straightness.
  • the cooling segment 107 is a recess created from stiff plug wrap or tipping paper.
  • the stiff plug wrap or tipping paper is manufactured to have a rigidity that is sufficient to withstand the axial compressive forces and bending moments that might arise during manufacture and whilst the article 101 is in use during insertion into the device 51.
  • the filter segment 109 may be formed of any filter material sufficient to remove one or more volatilised compounds from heated volatilised components from the aerosol-generating material.
  • the filter segment 109 is made of a mono-acetate material, such as cellulose acetate.
  • the filter segment 109 provides cooling and irritation-reduction from the heated volatilised components without depleting the quantity of the heated volatilised components to an unsatisfactory level for a user.
  • a capsule (not illustrated) may be provided in filter segment 109. It may be disposed substantially centrally in the filter segment 109, both across the filter segment 109 diameter and along the filter segment 109 length. In other cases, it may be offset in one or more dimension.
  • the capsule may in some cases, where present, contain a volatile component such as a flavour or aerosolformer material.
  • the density of the cellulose acetate tow material of the filter segment 109 controls the pressure drop across the filter segment 109, which in turn controls the draw resistance of the article 101. Therefore the selection of the material of the filter segment 109 is important in controlling the resistance to draw of the article 101. In addition, the filter segment performs a filtration function in the article 101.
  • the filter segment 109 is made of a 8Y15 grade of filter tow material, which provides a filtration effect on the heated volatilised material, whilst also reducing the size of condensed aerosol droplets which result from the heated volatilised material.
  • the presence of the filter segment 109 provides an insulating effect by providing further cooling to the heated volatilised components that exit the cooling segment 107. This further cooling effect reduces the contact temperature of the user’s lips on the surface of the filter segment 109.
  • the filter segment 109 is between 6mm to 10mm in length, suitably 8mm.
  • the mouth end segment 111 is an annular tube and is located around and defines an air gap within the mouth end segment 111.
  • the air gap provides a chamber for heated volatilised components that flow from the filter segment 109.
  • the mouth end segment 111 is hollow to provide a chamber for aerosol accumulation yet rigid enough to withstand axial compressive forces and bending moments that might arise during manufacture and whilst the article is in use during insertion into the device 51.
  • the thickness of the wall of the mouth end segment 111 is approximately 0.29mm.
  • the length of the mouth end segment 111 is between 6mm to 10mm, suitably 8mm.
  • the mouth end segment 111 may be manufactured from a spirally wound paper tube which provides a hollow internal chamber yet maintains critical mechanical rigidity. Spirally wound paper tubes are able to meet the tight dimensional accuracy requirements of high-speed manufacturing processes with respect to tube length, outer diameter, roundness and straightness.
  • the mouth end segment 111 provides the function of preventing any liquid condensate that accumulates at the exit of the filter segment 109 from coming into direct contact with a user.
  • the mouth end segment 111 and the cooling segment 107 may be formed of a single tube and the filter segment 109 is located within that tube separating the mouth end segment 111 and the cooling segment 107.
  • FIGS 3 and 4 there are shown a partially cut-away section and perspective views of an example of an article 301.
  • the reference signs shown in Figures 3 and 4 are equivalent to the reference signs shown in Figures 1 and 2, but with an increment of 200.
  • a ventilation region 317 is provided in the article 301 to enable air to flow into the interior of the article 301 from the exterior of the article 301.
  • the ventilation region 317 takes the form of one or more ventilation holes 317 formed through the outer layer of the article 301.
  • the ventilation holes may be located in the cooling segment 307 to aid with the cooling of the article 301.
  • the ventilation region 317 comprises one or more rows of holes, and preferably, each row of holes is arranged circumferentially around the article 301 in a cross-section that is substantially perpendicular to a longitudinal axis of the article 301.
  • each row of ventilation holes may have between 12 to 36 ventilation holes 317.
  • the ventilation holes 317 may, for example, be between 100 to 500pm in diameter.
  • an axial separation between rows of ventilation holes 317 is between 0.25mm and 0.75mm, suitably 0.5mm.
  • the ventilation holes 317 are of uniform size. In another example, the ventilation holes 317 vary in size.
  • the ventilation holes can be made using any suitable technique, for example, one or more of the following techniques: laser technology, mechanical perforation of the cooling segment 307 or preperforation of the cooling segment 307 before it is formed into the article 301.
  • the ventilation holes 317 are positioned so as to provide effective cooling to the article 301.
  • the rows of ventilation holes 317 are located at least 11mm from the proximal end 313 of the article, suitably between 17mm and 20mm from the proximal end 313 of the article 301.
  • the location of the ventilation holes 317 is positioned such that user does not block the ventilation holes 317 when the article 301 is in use.
  • Providing the rows of ventilation holes between 17mm and 20mm from the proximal end 313 of the article 301 enables the ventilation holes 317 to be located outside of the device 51, when the article 301 is fully inserted in the device 51, as can be seen in Figures 6 and 7.
  • By locating the ventilation holes outside of the device non-heated air is able to enter the article 301 through the ventilation holes from outside the device 51 to aid with the cooling of the article 301.
  • the length of the cooling segment 307 is such that the cooling segment 307 will be partially inserted into the device 51, when the article 301 is fully inserted into the device 51.
  • the length of the cooling segment 307 provides a first function of providing a physical gap between the heater arrangement of the device 51 and the heat sensitive filter arrangement 309, and a second function of enabling the ventilation holes 317 to be located in the cooling segment, whilst also being located outside of the device 51 , when the article 301 is fully inserted into the device 51.
  • the majority of the cooling element 307 is located within the device 51. However, there is a portion of the cooling element 307 that extends out of the device 51. It is in this portion of the cooling element 307 that extends out of the device 51 in which the ventilation holes 317 are located.
  • FIG. 5 to 7 there is shown an example of a device 51 arranged to heat aerosol-generating material to volatilise at least one component of said aerosol-generating material, typically to form an aerosol which can be inhaled.
  • the device 51 is a heating device which releases compounds by heating, but not burning, the aerosol-generating material.
  • a first end 53 is sometimes referred to herein as the mouth or proximal end 53 of the device 51 and a second end 55 is sometimes referred to herein as the distal end 55 of the device 51 .
  • the device 51 has an on/off button 57 to allow the device 51 as a whole to be switched on and off as desired by a user.
  • the device 51 comprises a housing 59 for locating and protecting various internal components of the device 51 .
  • the housing 59 comprises a uni-body sleeve 11 that encompasses the perimeter of the device 51 , capped with a top panel 17 which defines generally the ‘top’ of the device 51 and a bottom panel 19 which defines generally the ‘bottom’ of the device 51.
  • the housing comprises a front panel, a rear panel and a pair of opposite side panels in addition to the top panel 17 and the bottom panel 19.
  • the top panel 17 and/or the bottom panel 19 may be removably fixed to the uni-body sleeve 11 , to permit easy access to the interior of the device 51 , or may be “permanently” fixed to the uni-body sleeve 11 , for example to deter a user from accessing the interior of the device 51.
  • the panels 17 and 19 are made of a plastics material, including for example glass-filled nylon formed by injection moulding, and the uni-body sleeve 11 is made of aluminium, though other materials and other manufacturing processes may be used.
  • the top panel 17 of the device 51 has an opening 20 at the mouth end 53 of the device 51 through which, in use, the article 101 , 301 including the aerosolgenerating material may be inserted into the device 51 and removed from the device 51 by a user.
  • the housing 59 has located or fixed therein a heater arrangement 23, control circuitry 25 and a power source 27.
  • the heater arrangement 23, the control circuitry 25 and the power source 27 are laterally adjacent (that is, adjacent when viewed from an end), with the control circuitry 25 being located generally between the heater arrangement 23 and the power source 27, though other locations are possible.
  • the control circuitry 25 may include a controller, such as a microprocessor arrangement, configured and arranged to control the heating of the aerosolgenerating material in the article 101 , 301 as discussed further below.
  • the power source 27 may be for example a battery, which may be a rechargeable battery or a non-rechargeable battery.
  • suitable batteries include for example a lithium-ion battery, a nickel battery (such as a nickel-cadmium battery), an alkaline battery and/ or the like.
  • the battery 27 is electrically coupled to the heater arrangement 23 to supply electrical power when required and under control of the control circuitry 25 to heat the aerosol-generating material in the article (as discussed, to volatilise the aerosol-generating material without causing the aerosol-generating material to burn).
  • An advantage of locating the power source 27 laterally adjacent to the heater arrangement 23 is that a physically large power source 25 may be used without causing the device 51 as a whole to be unduly lengthy.
  • a physically large power source 25 has a higher capacity (that is, the total electrical energy that can be supplied, often measured in Amp-hours or the like) and thus the battery life for the device 51 can be longer.
  • the heater arrangement 23 is generally in the form of a hollow cylindrical tube, having a hollow interior heating chamber 29 into which the article 101, 301 comprising the aerosol-generating material is inserted for heating in use.
  • the heater arrangement 23 may comprise a single heating element or may be formed of plural heating elements aligned along the longitudinal axis of the heater arrangement 23.
  • the or each heating element may be annular or tubular, or at least part-annular or part-tubular around its circumference.
  • the or each heating element may be a thin film heater.
  • the or each heating element may be made of a ceramics material.
  • suitable ceramics materials include alumina and aluminium nitride and silicon nitride ceramics, which may be laminated and sintered.
  • Other heating arrangements are possible, including for example inductive heating, infrared heater elements, which heat by emitting infrared radiation, or resistive heating elements formed by for example a resistive electrical winding.
  • the heater arrangement 23 is supported by a stainless steel support tube and comprises a polyimide heating element.
  • the heater arrangement 23 is dimensioned so that substantially the whole of the body of aerosol-generating material 103, 303 of the article 101 , 301 is inserted into the heater arrangement 23 when the article 101 , 301 is inserted into the device 51.
  • the or each heating element may be arranged so that selected zones of the aerosol-generating material can be independently heated, for example in turn (over time, as discussed above) or together (simultaneously) as desired.
  • the heater arrangement 23 in this example is surrounded along at least part of its length by a thermal insulator 31.
  • the insulator 31 helps to reduce heat passing from the heater arrangement 23 to the exterior of the device 51. This helps to keep down the power requirements for the heater arrangement 23 as it reduces heat losses generally.
  • the insulator 31 also helps to keep the exterior of the device 51 cool during operation of the heater arrangement 23.
  • the insulator 31 may be a double-walled sleeve which provides a low pressure region between the two walls of the sleeve. That is, the insulator 31 may be for example a “vacuum” tube, i.e. a tube that has been at least partially evacuated so as to minimise heat transfer by conduction and/or convection.
  • Other arrangements for the insulator 31 are possible, including using heat insulating materials, including for example a suitable foam-type material, in addition to or instead of a double-walled sleeve.
  • the housing 59 may further comprises various internal support structures 37 for supporting all internal components, as well as the heating arrangement 23.
  • the device 51 further comprises a collar 33 which extends around and projects from the opening 20 into the interior of the housing 59 and a generally tubular chamber 35 which is located between the collar 33 and one end of the vacuum sleeve 31.
  • the chamber 35 further comprises a cooling structure 35f, which in this example, comprises a plurality of cooling fins 35f spaced apart along the outer surface of the chamber 35, and each arranged circumferentially around outer surface of the chamber 35.
  • the air gap 36 is around all of the circumference of the article 101, 301 over at least part of the cooling segment 307.
  • the collar 33 comprises a plurality of ridges 60 arranged circumferentially around the periphery of the opening 20 and which project into the opening 20.
  • the ridges 60 take up space within the opening 20 such that the open span of the opening 20 at the locations of the ridges 60 is less than the open span of the opening 20 at the locations without the ridges 60.
  • the ridges 60 are configured to engage with an article 101, 301 inserted into the device to assist in securing it within the device 51.
  • Open spaces (not shown in the Figures) defined by adjacent pairs of ridges 60 and the article 101, 301 form ventilation paths around the exterior of the article 101 , 301. These ventilation paths allow hot vapours that have escaped from the article 101, 301 to exit the device 51 and allow cooling air to flow into the device 51 around the article 101, 301 in the air gap 36.
  • the article 101, 301 is removably inserted into an insertion point 20 of the device 51, as shown in Figures 5 to 7.
  • the body of aerosol-generating material 103, 303 which is located towards the distal end 115, 315 of the article 101 , 301, is entirely received within the heater arrangement 23 of the device 51.
  • the proximal end 113, 313 of the article 101, 301 extends from the device 51 and acts as a mouthpiece assembly for a user.
  • the heater arrangement 23 will heat the article 101, 301 to volatilise at least one component of the aerosol-generating material from the body of aerosol-generating material 103, 303.
  • the primary flow path for the heated volatilised components from the body of aerosol-generating material 103, 303 is axially through the article 101, 301, through the chamber inside the cooling segment 107, 307, through the filter segment 109, 309, through the mouth end segment 111 , 313 to the user.
  • the temperature of the heated volatilised components that are generated from the body of aerosol-generating material is between 60°C and 250°C, which may be above the acceptable inhalation temperature for a user.
  • the heated volatilised component travels through the cooling segment 107, 307, it will cool and some volatilised components will condense on the inner surface of the cooling segment 107, 307.
  • cool air will be able to enter the cooling segment 307 via the ventilation holes 317 formed in the cooling segment 307. This cool air will mix with the heated volatilised components to provide additional cooling to the heated volatilised components.
  • a method of forming an amorphous solid comprising: about 1 to about 12 wt% constituent, derivative or extract of cannabis; about 10 to about 80 wt% aerosol-former material; gelling agent; and optionally filler, wherein the amount of gelling agent and optional filler taken together is from about 10 to about 60 wt%; wherein the wt% values are calculated on a dry weight basis; the method comprising:
  • Another aspect of the invention provides a method of making the consumable or system as previously described.
  • This method comprises a method of making the amorphous solid and incorporating the amorphous solid into the consumable or system.
  • the method may comprise (a) forming a slurry comprising components of the amorphous solid or precursors thereof, (b) forming a layer of the slurry, and (c) setting the slurry, (d) drying to form an amorphous solid, and (e) incorporating the resulting amorphous solid into the consumable or system.
  • step (a) the constituent, derivative or extract of cannabis may first be dissolved in the aerosol-former material and the resulting solution then added to the other components of the slurry.
  • the step (b) in the above methods of forming a layer of the slurry may comprise spraying, casting or extruding the slurry, for example.
  • the layer is formed by electrospraying the slurry.
  • the layer is formed by casting the slurry.
  • the steps (b) and/or (c) and/or (d) may, at least partially, occur simultaneously (for example, during electrospraying). In some cases, these steps may occur sequentially.
  • a setting agent such as a calcium source
  • a setting agent may be added to the slurry before or during step (b). This is appropriate in instances where gelation occurs relatively slowly (e.g. with alginate gelling agent), and thus the slurry may be, e.g. cast, after the setting agent is added.
  • the step (c) of setting the slurry may comprise the addition of a setting agent to the slurry layer.
  • the setting agent may be sprayed onto the slurry, for example, or may be preloaded onto the surface on which the slurry is layered.
  • a setting agent comprising a calcium source (such as calcium chloride or calcium citrate), may be added to a slurry containing alginate and/or pectin to form a calcium-crosslinked alginate/pectin gel.
  • a setting agent comprising a calcium source (such as calcium chloride or calcium citrate)
  • the calcium should be added after casting (because the slurry is too viscous to cast).
  • the total amount of the setting agent such as a calcium source, may be 0.5-5 wt% (calculated on a dry weight basis). It has been found that the addition of too little setting agent may result in a gel which does not stabilise any optional flavour and results in the flavour dropping out of the gel. It has also been found that the addition of too much setting agent results in a gel that is very tacky or very brittle and consequently has poor handleability.
  • Alginate salts are derivatives of alginic acid and are typically high molecular weight polymers (10-600 kDa).
  • Alginic acid is a copolymer of p-D-mannuronic (M) and a-L-guluronic acid (G) units (blocks) linked together with (1,4)-glycosidic bonds to form a polysaccharide.
  • M p-D-mannuronic
  • G a-L-guluronic acid
  • Alginate salts with a high G monomer content may more readily form a gel on addition of the calcium source.
  • the gel-precursor may comprise an alginate salt in which at least about 40%, 45%, 50%, 55%, 60% or 70% of the monomer units in the alginate copolymer are a-L-guluronic acid (G) units.
  • G a-L-guluronic acid
  • the slurry may be warmed prior to and during casting. This can slow gelation, improving handleability and easing the casting process. Further, warming the slurry may melt optional flavour components (e.g. menthol) easing handleability.
  • optional flavour components e.g. menthol
  • menthol or other optional flavours may be distributed through the slurry in powder form.
  • menthol or other flavours may be molten in the slurry (where it is warmed).
  • an emulsifying agent such as acacia gum may be added to disperse molten menthol in the slurry.
  • the slurry may be cast onto a bandcast sheet.
  • the sheet may be loaded with a releasing agent, such as lecithin, which can aid separation of the bandcast and the amorphous solid.
  • a slurry comprising: about 1 to about 12 wt% constituent, derivative or extract of cannabis; about 10 to about 80 wt% aerosol-former material; gelling agent; and optionally filler, wherein the amount of gelling agent and optional filler taken together is from about 10 to about 60 wt%; wherein the wt% values are calculated on a dry weight basis; and a solvent.
  • the slurry solvent comprises, or is, one or more of water, ethanol, methanol, dimethyl sulfoxide, acetone, hexane, and toluene.
  • the slurry solvent may comprise water.
  • the slurry solvent may consist essentially of or consist of water.
  • the slurry may comprise from about 50 wt%, 60 wt%, 70 wt%, 80 wt% or 90 wt% of solvent (WWB).
  • the slurry has a viscosity of from about 1 to about 20 Pa-s at 46.5 °C, such as from about 10 to about 20 Pa-s at 46.5 °C, such as from about 14 to about 16 Pa-s at 46.5 °C.
  • composition for oral delivery of constituent, derivative or extract of cannabis Composition for oral delivery of constituent, derivative or extract of cannabis
  • composition for oral delivery of a constituent, derivative or extract of cannabis comprising an amorphous solid, the amorphous solid comprising: about 1 to about 12 wt% constituent, derivative or extract of cannabis; about 10 to about 80 wt% aerosol-former material; gelling agent; and optionally filler, wherein the amount of gelling agent and optional filler taken together is from about 10 to about 60 wt%; wherein the wt% values are calculated on a dry weight basis.
  • the composition for oral delivery may be provided in the form of chews, soluble strips, lozenges, gums, snus or moist snuff.
  • the composition for oral delivery further comprises one or more additives selected from sweeteners, taste modifiers, salts, buffering agents, colorants, oral care additives, preservatives, disintegration aids, emulsifiers, preservatives and antioxidants.
  • the aerosol-former material discussed above may be used as the humectant in the compositions for oral delivery.
  • the above disclosures for example those regarding the constituents, derivatives or extracts of cannabis, gelling agent, aerosolformer material [humectant], optional fillers, other optional ingredients such as additional active substances, flavours, and other functional materials, in relation to the amorphous solid for use in aerosol generation apply equally to this aspect of the invention.
  • the humectant may comprise one or more compounds selected from glycerol, propylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, 1 ,3-butylene glycol, erythritol, meso-Erythritol, ethyl vanillate, ethyl laurate, a diethyl suberate, triethyl citrate, triacetin, a diacetin mixture, benzyl benzoate, benzyl phenyl acetate, tributyrin, lauryl acetate, lauric acid, myristic acid, and propylene carbonate.
  • glycerol propylene glycol
  • diethylene glycol triethylene glycol
  • tetraethylene glycol 1 ,3-butylene glycol
  • erythritol meso-Erythritol
  • ethyl vanillate ethyl laurate
  • the humectant may comprise one or more of erythritol, propylene glycol, glycerol, and triacetin. In some cases, the humectant comprises, consists essentially of or consists of glycerol, optionally in combination with propylene glycol.
  • the amorphous solid may comprise from about 10 wt% to about 80 wt% of humectant (calculated on a dry weight basis), for example about 20 to 80 wt% or about 30 wt% or 40 wt% to about 80 wt%, 75 wt%, or 60 wt%.
  • the composition for oral delivery may comprise from about 10 to 100 wt % of the amorphous solid, or from about 20 wt%, about 30 wt%, about 40 wt%, about 50 wt%, to about 60 wt%, about 70 wt%, about 80 wt% or about 90 wt% of the amorphous solid.
  • the composition for oral delivery may comprise from about 10-60 wt%, such as about 15-50 wt%, of the amorphous solid.
  • WWB wet weight basis
  • Amorphous solids (AS) were prepared according to the following method.
  • the gelling agent CMC or alginate
  • CBD cannabidiol
  • PG propylene glycol
  • VG glycerol
  • An amorphous solid or slurry as defined in the Summary of the Disclosure comprising about 1-12 wt% constituent(s), derivative(s) or extract(s) of cannabis.
  • Embodiment 1 The amorphous solid or slurry of Embodiment 1 comprising about 1-10 wt% constituent(s), derivative(s) or extract(s) of cannabis.
  • Embodiment 3 The amorphous solid or slurry of Embodiment 2 comprising about 1-8 wt% constituent(s), derivative(s) or extract(s) of cannabis.
  • Embodiment 4 The amorphous solid or slurry of Embodiment 3 comprising about 1-7 wt% constituent(s), derivative(s) or extract(s) of cannabis.
  • Embodiment 4 The amorphous solid or slurry of Embodiment 4 comprising about 1-6 wt% constituent(s), derivative(s) or extract(s) of cannabis.
  • Embodiment 1 The amorphous solid or slurry of Embodiment 1 comprising about 1.5-12 wt% constituent(s), derivative(s) or extract(s) of cannabis.
  • Embodiment 6 The amorphous solid or slurry of Embodiment 6 comprising about 1.5-10 wt% constituent(s), derivative(s) or extract(s) of cannabis.
  • Embodiment 7 The amorphous solid or slurry of Embodiment 7 comprising about 1.5-8 wt% constituent(s), derivative(s) or extract(s) of cannabis.
  • Embodiment 8 The amorphous solid or slurry of Embodiment 8 comprising about 1.5-7 wt% constituent(s), derivative(s) or extract(s) of cannabis.
  • Embodiment 9 The amorphous solid or slurry of Embodiment 9 comprising about 1.5-6 wt% constituent(s), derivative(s) or extract(s) of cannabis.
  • the amorphous solid or slurry of Embodiment 1 comprising about 2-12 wt% constituent(s), derivative(s) or extract(s) of cannabis.
  • the amorphous solid or slurry of Embodiment 11 comprising about 2-10 wt% constituent(s), derivative(s) or extract(s) of cannabis.
  • Embodiment 13 The amorphous solid or slurry of Embodiment 12 comprising about 2-8 wt% constituent(s), derivative(s) or extract(s) of cannabis.
  • Embodiment 13 The amorphous solid or slurry of Embodiment 13 comprising about 2-7 wt% constituent(s), derivative(s) or extract(s) of cannabis.
  • Embodiment 14 The amorphous solid or slurry of Embodiment 14 comprising about 2-6 wt% constituent(s), derivative(s) or extract(s) of cannabis.
  • amorphous solid or slurry of any of any preceding Embodiment wherein the constituent(s), derivative(s) or extract(s) of cannabis comprises, or is, one or more compounds selected from: cannabinoids, terpenes, alkaloids, and flavonoids.
  • amorphous solid or slurry of any of preceding Embodiment wherein the constituent(s), derivative(s) or extract(s) of cannabis comprises, or is, one or more compounds selected from: cannabinoids or terpenes.
  • Embodiment 22 The amorphous solid or slurry of Embodiment 21 wherein the cannabinoids are selected from cannabidiol (CBD) and/or THC. 23. The amorphous solid or slurry of Embodiment 22, wherein the cannabinoid is CBD.
  • CBD cannabidiol
  • Embodiment 26 The amorphous solid or slurry of Embodiment 25 comprising about 10-45 wt% gelling agent.
  • Embodiment 27 The amorphous solid or slurry of Embodiment 26, comprising about 10-40 wt% gelling agent.
  • Embodiment 28 The amorphous solid or slurry of Embodiment 27 comprising about 10-35 wt% gelling agent.
  • Embodiment 29 The amorphous solid or slurry of Embodiment 28 comprising about 10-30 wt% gelling agent.
  • Embodiment 32 The amorphous solid or slurry of Embodiment 31, comprising about 15-50 wt% gelling agent.
  • Embodiment 33 The amorphous solid or slurry of Embodiment 32, comprising about 15-45 wt% gelling agent.
  • Embodiment 34 The amorphous solid or slurry of Embodiment 33, comprising about 15-40 wt% gelling agent.
  • Embodiment 35 The amorphous solid or slurry of Embodiment 34, comprising about 15-35 wt% gelling agent.
  • Embodiments 35 The amorphous solid or slurry of Embodiments 35, comprising about 15-30 wt% gelling agent.
  • Embodiment 39 The amorphous solid or slurry of Embodiment 38, comprising about 20-45 wt% gelling agent.
  • Embodiment 40 The amorphous solid or slurry of Embodiment 39, comprising about 20-40 wt% gelling agent.
  • Embodiment 40 The amorphous solid or slurry of Embodiment 40, comprising about 20-35 wt% gelling agent.
  • Embodiment 41 The amorphous solid or slurry of Embodiment 41, comprising about 20-30 wt% gelling agent.
  • Embodiment 44 The amorphous solid or slurry of Embodiment 43, comprising about 5-40 wt% filler.
  • Embodiment 45 The amorphous solid or slurry of Embodiment 44, comprising about 10-20 wt% filler.
  • amorphous solid or slurry of any preceding Embodiment comprising about 10-75 wt% aerosol-former material/humectant.
  • Embodiment 50 The amorphous solid or slurry of Embodiment 50, comprising about 10-60 wt% aerosol-former material/humectant.
  • Embodiment 52 The amorphous solid or slurry of Embodiment 51, comprising about 10-50 wt% aerosol-former material/humectant.
  • 53 The amorphous solid or slurry of any of Embodiments 1-49, comprising about 20-80 wt% aerosol-former material/humectant.
  • Embodiment 54 The amorphous solid or slurry of Embodiment 53, comprising about 20-75 wt% aerosol-former material/humectant.
  • Embodiment 55 The amorphous solid or slurry of Embodiment 54, comprising about 20-60 wt% aerosol-former material/humectant.
  • Embodiment 56 The amorphous solid or slurry of Embodiment 55, comprising about 20-50 wt% aerosol-former material/humectant.
  • Embodiment 57 The amorphous solid or slurry of Embodiment 57, comprising about 30-75 wt% aerosol-former material/humectant.
  • Embodiment 58 The amorphous solid or slurry of Embodiment 58, comprising about 30-60 wt% aerosol-former material/humectant.
  • Embodiment 60 The amorphous solid or slurry of Embodiment 59, comprising about 30-50 wt% aerosol-former material/humectant.
  • Embodiment 61 The amorphous solid or slurry of Embodiment 61, comprising about 40-75 wt% aerosol-former material/humectant.
  • Embodiment 62 The amorphous solid or slurry of Embodiment 62, comprising about 40-60 wt% aerosol-former material/humectant.
  • Embodiment 64 The amorphous solid or slurry of Embodiment 63, comprising about 40-50 wt% aerosol-former material/humectant.
  • Embodiment 65 The amorphous solid or slurry of Embodiment 65, comprising about 60 to 80 wt% aerosol-former material/humectant.
  • Embodiment 67 The amorphous solid or slurry of Embodiment 66, comprising about 70 to 80 wt% aerosol-former material/humectant.
  • 68 The amorphous solid or slurry of any of Embodiments 1-49, comprising about 30-40 wt% aerosol-former material/humectant.
  • the aerosol-former material/humectant comprises (or is) one or more of glycerol, propylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, 1,3- butylene glycol, erythritol, meso- Erythritol, ethyl vanillate, ethyl laurate, a diethyl suberate, triethyl citrate, triacetin, a diacetin mixture, benzyl benzoate, benzyl phenyl acetate, tributyrin, lauryl acetate, lauric acid, myristic acid, and propylene carbonate.
  • Embodiment 70 The amorphous solid or slurry of Embodiment 69, wherein the aerosol-former material/humectant comprises (or is) one or more of erythritol, propylene glycol, glycerol, and triacetin.
  • Embodiment 69 or 70 The amorphous solid or slurry of Embodiment 69 or 70, wherein the aerosolformer material/humectant comprises (or is) glycerol or a combination or glycerol and propylene glycol.
  • Embodiment 72 The amorphous solid or slurry of Embodiment 71, wherein the aerosol-former material comprises a mixture of glycerol and propylene glycol in a weight ratio of glycerol to propylene glycol of about 3:1 to 1:3.
  • Embodiment 72 The amorphous solid or slurry of Embodiment 72, wherein the aerosol-former material comprises a mixture of glycerol and propylene glycol in a weight ratio of glycerol to propylene glycol of about 2:1 to 1:2.
  • Embodiment 74 The amorphous solid or slurry of Embodiment 73, wherein the aerosol-former material comprises a mixture of glycerol and propylene glycol in a weight ratio of glycerol to propylene glycol of about 1.5:1 to 1:1.5.
  • Embodiment 75 The amorphous solid or slurry of Embodiment 74, wherein the aerosol-former material comprises a mixture of glycerol and propylene glycol in a weight ratio of glycerol to propylene glycol of about 55:45 to 45:55.
  • Embodiment 75 The amorphous solid or slurry of Embodiment 75, wherein the aerosol-former material comprises a mixture of glycerol and propylene glycol in a weight ratio of glycerol to propylene glycol of about 45:55.
  • the gelling agent comprises a hydrocolloid.
  • the gelling agent comprises (or is) one or more compounds selected from polysaccharide gelling agents, such as alginate, pectin, starch or a derivative thereof, cellulose or a derivative thereof, pullulan, carrageenan, agar and agarose; gelatin; gums, such as xanthan gum, guar gum and acacia gum; silica or silicone compounds, such as PDMS and sodium silicate; clays, such as kaolin; and polyvinyl alcohol.
  • Embodiments 78-80 The amorphous solid or slurry of any of Embodiments 78-80 wherein the polysaccharide gelling agent is selected from: alginate, pectin, starch or a derivative thereof, cellulose or a derivative thereof.
  • Embodiment 81 The amorphous solid or slurry of Embodiment 81 wherein the polysaccharide gelling agent is selected from alginate and a cellulose derivative.
  • Embodiment 83 The amorphous solid or slurry of Embodiment 82 wherein the polysaccharide gelling agent is a cellulose derivative.
  • CMC carboxymethylcellulose
  • HPMC hydroxypropyl methylcellulose
  • CA cellulose acetate
  • CAB cellulose acetate butyrate
  • CAP cellulose acetate propionate
  • Embodiment 85 The amorphous solid or slurry of Embodiment 84, wherein the cellulose or the derivative thereof, or the cellulose derivative, is CMC.
  • Embodiment 87 The amorphous solid or slurry of Embodiment 82, wherein the polysaccharide gelling agent is alginate.
  • Embodiment 87 The amorphous solid or slurry of Embodiment 87, wherein alginate is the only gelling agent present in the amorphous solid.
  • the gelling agent comprises (or is) one or more of alginate, pectin, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethylcellulose, pullulan, xanthan gum guar gum, carrageenan, agarose, acacia gum, fumed silica, PDMS, sodium silicate, kaolin and polyvinyl alcohol.
  • Embodiment 90 The amorphous solid or slurry of Embodiment 78, wherein the gelling agent comprises (or is) one or more of hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethylcellulose, guar gum, acacia gum, alginate and/or pectin.
  • the gelling agent comprises (or is) one or more of hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethylcellulose, guar gum, acacia gum, alginate and/or pectin.
  • Embodiment 94 The amorphous solid or slurry of Embodiment 93, wherein the filler is wood pulp.
  • amorphous solid of any preceding Embodiment wherein the amorphous solid consists of, or consists essentially of, gelling agent, solvent such as water, aerosol-former material, constituents, derivatives or extracts of cannabis, and optionally a flavour and/or optionally an additional active substance and/or optionally a filler.
  • solvent such as water, aerosol-former material, constituents, derivatives or extracts of cannabis, and optionally a flavour and/or optionally an additional active substance and/or optionally a filler.
  • amorphous solid of any preceding Embodiment wherein the amorphous solid consists of, or consists essentially of, gelling agent, solvent such as water, aerosol-former material, and constituents, derivatives or extracts of cannabis.
  • An aerosol-generating material comprising an amorphous solid according to any preceding Embodiment. 100. The aerosol-generating material of Embodiment 99, wherein the aerosolgenerating material does not comprise tobacco fibres.
  • the aerosol-generating material of any of Embodiments 99-100 comprising from about 50-100 wt% (WWB) of the amorphous solid.
  • Embodiment 101 comprising from about 50-95 wt% (WWB) of the amorphous solid.
  • Embodiment 102 comprising from about 50-90 wt% (WWB) of the amorphous solid.
  • the aerosol-generating material of any of Embodiments 99-100 comprising from about 60-100 wt% (WWB) of the amorphous solid.
  • Embodiment 104 The aerosol-generating material of Embodiment 104, comprising from about 60-95 wt% (WWB) of the amorphous solid.
  • Embodiment 106 The aerosol-generating material of Embodiment 105, comprising from about 60-90 wt% (WWB) of the amorphous solid.
  • the aerosol-generating material of any of Embodiments 99-100 comprising from about 70-100 wt% (WWB) of the amorphous solid.
  • the aerosol-generating material of Embodiment 107 comprising from about 70-95 wt% (WWB) of the amorphous solid.
  • Embodiment 109 The aerosol-generating material of Embodiment 108, comprising from about 70-90 wt% (WWB) of the amorphous solid.
  • a consumable for use in a non-combustible aerosol provision device comprising the aerosol-generating material of any of Embodiments 99- 110.
  • a non-combustible aerosol provision system comprising the consumable of Embodiment 111 and a non-combustible aerosol provision device.
  • Embodiment 115 The method of Embodiment 115 or the slurry of any of Embodiments 1 -96 wherein the solvent consists essentially of, or consists of, water.
  • WWB solvent
  • the amorphous solid as used in the composition of the fifth aspect as defined in the Summary of the Disclosure may be an amorphous solid as defined in any of the preceding Embodiments.
  • the aerosol-generating material described herein comprises an “amorphous solid”, which may alternatively be referred to as a “monolithic solid” (i.e. non-fibrous), or as a “dried gel”.
  • amorphous solid is a solid material that may retain some fluid, such as liquid, within it.
  • tobacco material refers to any material comprising tobacco or derivatives therefore.
  • tobacco material may include one or more of tobacco, tobacco derivatives, expanded tobacco, reconstituted tobacco or tobacco substitutes.
  • the tobacco material may comprise one or more of ground tobacco, tobacco fibre, cut tobacco, extruded tobacco, tobacco stem, reconstituted tobacco and/or tobacco extract.
  • the tobacco used to produce tobacco material may be any suitable tobacco, such as single grades or blends, cut rag or whole leaf, including Virginia and/or Burley and/or Oriental. It may also be tobacco particle ‘fines’ or dust, expanded tobacco, stems, expanded stems, and other processed stem materials, such as cut rolled stems.
  • the tobacco material may be a ground tobacco or a reconstituted tobacco material.
  • the reconstituted tobacco material may comprise tobacco fibres, and may be formed by casting, a Fourdrinier-based paper making-type approach with back addition of tobacco extract, or by extrusion.

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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Botany (AREA)
  • Agronomy & Crop Science (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dental Preparations (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Manufacture Of Tobacco Products (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Adhesives Or Adhesive Processes (AREA)
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EP21773497.9A 2020-09-03 2021-09-03 Compositions and methods Pending EP4208044A1 (en)

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JP6725524B2 (ja) 2015-02-27 2020-07-22 ブリティッシュ アメリカン タバコ （インヴェストメンツ） リミテッドＢｒｉｔｉｓｈ Ａｍｅｒｉｃａｎ Ｔｏｂａｃｃｏ （Ｉｎｖｅｓｔｍｅｎｔｓ） Ｌｉｍｉｔｅｄ 吸引可能な媒体を発生させるためのカートリッジ、部品および方法
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TW202214130A (zh) 2022-04-16
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