EP4182928C0 - Verfahren, system und computerprogrammprodukt zur bestimmung von präsentationswahrscheinlichkeiten von neoantigenen - Google Patents

Verfahren, system und computerprogrammprodukt zur bestimmung von präsentationswahrscheinlichkeiten von neoantigenen

Info

Publication number
EP4182928C0
EP4182928C0 EP21742134.6A EP21742134A EP4182928C0 EP 4182928 C0 EP4182928 C0 EP 4182928C0 EP 21742134 A EP21742134 A EP 21742134A EP 4182928 C0 EP4182928 C0 EP 4182928C0
Authority
EP
European Patent Office
Prior art keywords
neoantigens
computer program
program product
determining presentation
presentation probabilities
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP21742134.6A
Other languages
English (en)
French (fr)
Other versions
EP4182928A1 (de
EP4182928B1 (de
Inventor
Bruno Fant
Cedric Bogaert
Mill Nil Adell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Myneo NV
Original Assignee
Myneo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Myneo NV filed Critical Myneo NV
Publication of EP4182928A1 publication Critical patent/EP4182928A1/de
Application granted granted Critical
Publication of EP4182928C0 publication Critical patent/EP4182928C0/de
Publication of EP4182928B1 publication Critical patent/EP4182928B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/30—Detection of binding sites or motifs
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis

Landscapes

  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Theoretical Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Health & Medical Sciences (AREA)
  • Evolutionary Biology (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Data Mining & Analysis (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Evolutionary Computation (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Software Systems (AREA)
  • Bioethics (AREA)
  • Public Health (AREA)
  • Artificial Intelligence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP21742134.6A 2020-07-14 2021-07-12 Verfahren, system und computerprogrammprodukt zur bestimmung von präsentationswahrscheinlichkeiten von neoantigenen Active EP4182928B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20185779 2020-07-14
PCT/EP2021/069341 WO2022013154A1 (en) 2020-07-14 2021-07-12 Method, system and computer program product for determining presentation likelihoods of neoantigens

Publications (3)

Publication Number Publication Date
EP4182928A1 EP4182928A1 (de) 2023-05-24
EP4182928C0 true EP4182928C0 (de) 2024-09-04
EP4182928B1 EP4182928B1 (de) 2024-09-04

Family

ID=71620189

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21742134.6A Active EP4182928B1 (de) 2020-07-14 2021-07-12 Verfahren, system und computerprogrammprodukt zur bestimmung von präsentationswahrscheinlichkeiten von neoantigenen

Country Status (6)

Country Link
US (1) US20230298692A1 (de)
EP (1) EP4182928B1 (de)
JP (1) JP2023534220A (de)
CN (1) CN115836350A (de)
ES (1) ES2991797T3 (de)
WO (1) WO2022013154A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230081439A1 (en) * 2021-09-10 2023-03-16 X Development Llc Generative tna sequence design with experiment-in-the-loop training
CN115512762B (zh) * 2022-10-26 2023-06-20 北京百度网讯科技有限公司 多肽序列的生成方法、装置、电子设备及存储介质
CN116013404B (zh) * 2022-12-28 2025-11-28 云南大学 一种多模态融合深度学习模型及多功能生物活性肽预测方法
CN116741275B (zh) * 2023-06-20 2025-08-19 森瑞斯生物科技(深圳)有限公司 一种基于大型预训练模型的新型抗菌肽设计方法
EP4520345A1 (de) 2023-09-06 2025-03-12 Myneo Nv Produkt
WO2025191132A1 (en) * 2024-03-15 2025-09-18 Evaxion Biotech A/S Mhc ligand identification and related systems and methods
CN118571309B (zh) * 2024-04-16 2025-04-18 四川大学华西医院 抗生素耐药基因或毒力因子的基因预测或分类方法、装置、设备
CN118898031A (zh) * 2024-09-30 2024-11-05 中国海洋大学 一种基于位置编码的抗冻肽快速预测方法及装置
CN119296653B (zh) * 2024-10-12 2025-09-16 西安电子科技大学 一种预测主要组织相容性复合体与多肽的亲和力的方法
CN120708721A (zh) * 2025-08-15 2025-09-26 北京悦康科创医药科技股份有限公司 一种肿瘤新抗原筛选方法、装置、设备、存储介质及产品

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016128060A1 (en) 2015-02-12 2016-08-18 Biontech Ag Predicting t cell epitopes useful for vaccination
CA3008641A1 (en) 2015-12-16 2017-06-22 Gritstone Oncology, Inc. Neoantigen identification, manufacture, and use
GB201607521D0 (en) 2016-04-29 2016-06-15 Oncolmmunity As Method
US10350280B2 (en) 2016-08-31 2019-07-16 Medgenome Inc. Methods to analyze genetic alterations in cancer to identify therapeutic peptide vaccines and kits therefore
KR20240165471A (ko) * 2017-06-09 2024-11-22 그릿스톤 바이오, 인코포레이티드 신생항원 동정, 제조, 및 용도

Also Published As

Publication number Publication date
US20230298692A1 (en) 2023-09-21
WO2022013154A1 (en) 2022-01-20
EP4182928A1 (de) 2023-05-24
CN115836350A (zh) 2023-03-21
EP4182928B1 (de) 2024-09-04
ES2991797T3 (es) 2024-12-04
JP2023534220A (ja) 2023-08-08

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