EP4157453A4 - Methods and compositions for preventing and treating myopia with levocabastine, a selective histamine h1-receptor antagonist, and derivatives thereof - Google Patents

Methods and compositions for preventing and treating myopia with levocabastine, a selective histamine h1-receptor antagonist, and derivatives thereof Download PDF

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Publication number
EP4157453A4
EP4157453A4 EP21816939.9A EP21816939A EP4157453A4 EP 4157453 A4 EP4157453 A4 EP 4157453A4 EP 21816939 A EP21816939 A EP 21816939A EP 4157453 A4 EP4157453 A4 EP 4157453A4
Authority
EP
European Patent Office
Prior art keywords
levocabastine
derivatives
compositions
preventing
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21816939.9A
Other languages
German (de)
French (fr)
Other versions
EP4157453A1 (en
Inventor
Andrei V. Tkatchenko
Tatiana V. TKATCHENKO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Columbia University in the City of New York
Original Assignee
Columbia University in the City of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Columbia University in the City of New York filed Critical Columbia University in the City of New York
Publication of EP4157453A1 publication Critical patent/EP4157453A1/en
Publication of EP4157453A4 publication Critical patent/EP4157453A4/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
EP21816939.9A 2020-06-02 2021-06-02 Methods and compositions for preventing and treating myopia with levocabastine, a selective histamine h1-receptor antagonist, and derivatives thereof Pending EP4157453A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063033291P 2020-06-02 2020-06-02
PCT/US2021/035344 WO2021247635A1 (en) 2020-06-02 2021-06-02 Methods and compositions for preventing and treating myopia with levocabastine, a selective histamine h1-receptor antagonist, and derivatives thereof

Publications (2)

Publication Number Publication Date
EP4157453A1 EP4157453A1 (en) 2023-04-05
EP4157453A4 true EP4157453A4 (en) 2024-06-19

Family

ID=78829881

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21816939.9A Pending EP4157453A4 (en) 2020-06-02 2021-06-02 Methods and compositions for preventing and treating myopia with levocabastine, a selective histamine h1-receptor antagonist, and derivatives thereof

Country Status (7)

Country Link
EP (1) EP4157453A4 (en)
JP (1) JP2023529374A (en)
KR (1) KR20230051130A (en)
CN (1) CN115835905A (en)
CA (1) CA3181292A1 (en)
IL (1) IL298796A (en)
WO (1) WO2021247635A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116270442A (en) * 2021-12-21 2023-06-23 浙江瑞瞳生物科技有限公司 Ophthalmic preparation for correcting near vision

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017140846A1 (en) * 2016-02-19 2017-08-24 D'ambrosio Enzo Maria Combination of an antiallergic agent with muscarinic antagonist and/or dopaminergic agonist for use in preventing/stopping of axial myopia in human
WO2019104191A1 (en) * 2017-11-21 2019-05-31 Sydnexis, Inc. Ophthalmic composition and delivery device thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010095478A1 (en) * 2009-02-20 2010-08-26 株式会社シード Sustainedly drug-releasing hydrogel contact lens, and drug releasing method using sustainedly drug-releasing hydrogel contact lens
US9827250B2 (en) * 2012-07-31 2017-11-28 Johnson & Johnson Vision Care, Inc. Lens incorporating myopia control optics and muscarinic agents
US10945980B2 (en) * 2016-06-21 2021-03-16 The University Of Newcastle Treatment for myopia
KR20200007769A (en) * 2017-02-21 2020-01-22 싱가포르 헬스 서비시즈 피티이 엘티디 Compositions and methods for preventing or delaying the development of myopia comprising atropine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017140846A1 (en) * 2016-02-19 2017-08-24 D'ambrosio Enzo Maria Combination of an antiallergic agent with muscarinic antagonist and/or dopaminergic agonist for use in preventing/stopping of axial myopia in human
WO2019104191A1 (en) * 2017-11-21 2019-05-31 Sydnexis, Inc. Ophthalmic composition and delivery device thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2021247635A1 *

Also Published As

Publication number Publication date
CN115835905A (en) 2023-03-21
KR20230051130A (en) 2023-04-17
JP2023529374A (en) 2023-07-10
EP4157453A1 (en) 2023-04-05
CA3181292A1 (en) 2021-12-09
IL298796A (en) 2023-02-01
WO2021247635A1 (en) 2021-12-09

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