EP4144745A4 - Sequencing method, analysis method therefor and analysis system thereof, computer-readable storage medium, and electronic device - Google Patents

Sequencing method, analysis method therefor and analysis system thereof, computer-readable storage medium, and electronic device Download PDF

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Publication number
EP4144745A4
EP4144745A4 EP21797265.2A EP21797265A EP4144745A4 EP 4144745 A4 EP4144745 A4 EP 4144745A4 EP 21797265 A EP21797265 A EP 21797265A EP 4144745 A4 EP4144745 A4 EP 4144745A4
Authority
EP
European Patent Office
Prior art keywords
analysis
computer
electronic device
storage medium
readable storage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21797265.2A
Other languages
German (de)
French (fr)
Other versions
EP4144745A1 (en
Inventor
Jicai FAN
Huan JIN
Fang Chen
Lei Sun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genemind Biosciences Co Ltd
Original Assignee
Genemind Biosciences Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN202010865293.5A external-priority patent/CN113593636B/en
Application filed by Genemind Biosciences Co Ltd filed Critical Genemind Biosciences Co Ltd
Publication of EP4144745A1 publication Critical patent/EP4144745A1/en
Publication of EP4144745A4 publication Critical patent/EP4144745A4/en
Pending legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/20—Sequence assembly
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/30—Detection of binding sites or motifs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N7/00—Computing arrangements based on specific mathematical models
    • G06N7/01—Probabilistic graphical models, e.g. probabilistic networks
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
    • G16B35/10—Design of libraries
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Theoretical Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Biochemistry (AREA)
  • Evolutionary Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Data Mining & Analysis (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Software Systems (AREA)
  • Artificial Intelligence (AREA)
  • Evolutionary Computation (AREA)
  • Library & Information Science (AREA)
  • Mathematical Optimization (AREA)
  • Mathematical Analysis (AREA)
  • Plant Pathology (AREA)
  • Probability & Statistics with Applications (AREA)
  • Algebra (AREA)
  • Computational Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Mathematical Physics (AREA)
EP21797265.2A 2020-04-30 2021-04-30 Sequencing method, analysis method therefor and analysis system thereof, computer-readable storage medium, and electronic device Pending EP4144745A4 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN202010362587 2020-04-30
CN202010867569 2020-08-25
CN202010865293.5A CN113593636B (en) 2020-04-30 2020-08-25 Sequencing result analysis method, sequencing result analysis system, computer-readable storage medium and electronic device
PCT/CN2021/091279 WO2021219114A1 (en) 2020-04-30 2021-04-30 Sequencing method, analysis method therefor and analysis system thereof, computer-readable storage medium, and electronic device

Publications (2)

Publication Number Publication Date
EP4144745A1 EP4144745A1 (en) 2023-03-08
EP4144745A4 true EP4144745A4 (en) 2024-02-21

Family

ID=78243116

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21797265.2A Pending EP4144745A4 (en) 2020-04-30 2021-04-30 Sequencing method, analysis method therefor and analysis system thereof, computer-readable storage medium, and electronic device

Country Status (4)

Country Link
US (1) US20230178183A1 (en)
EP (1) EP4144745A4 (en)
CN (1) CN113593637B (en)
WO (1) WO2021219114A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024093421A1 (en) * 2022-10-31 2024-05-10 深圳市真迈生物科技有限公司 Surface treatment method, sequencing method, and kit

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007123744A2 (en) * 2006-03-31 2007-11-01 Solexa, Inc. Systems and devices for sequence by synthesis analysis
WO2017136059A1 (en) * 2016-02-03 2017-08-10 Verinata Health, Inc. Using cell-free dna fragment size to determine copy number variations
WO2019109086A1 (en) * 2017-12-01 2019-06-06 Illumina, Inc. Methods and systems for determining somatic mutation clonality

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0718409A3 (en) * 1994-12-22 1999-02-03 Hitachi, Ltd. DNA preparation method
CN102296065B (en) * 2011-08-04 2013-05-15 盛司潼 System and method for constructing sequencing library
CN103543270B (en) * 2012-07-09 2015-07-08 国家纳米科学中心 Protein in situ expression chip and preparation method and application thereof
WO2014093709A1 (en) * 2012-12-12 2014-06-19 The Broad Institute, Inc. Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
CN105624272B (en) * 2014-10-29 2019-08-09 深圳华大基因科技有限公司 The construction method and device in genome presumptive area nucleic acid sequencing library
WO2016095736A1 (en) * 2014-12-18 2016-06-23 深圳华大基因研究院 Target region enrichment method based on multiplex pcr, and reagent
CN107227344B (en) * 2017-05-16 2019-09-24 北京量化健康科技有限公司 A kind of high density, nucleic acid chip of high stability and preparation method thereof
CN109207571B (en) * 2017-06-30 2022-01-04 深圳华大生命科学研究院 Method for detecting endonuclease cleavage site
CN108165618B (en) * 2017-12-08 2021-06-08 东南大学 DNA sequencing method containing nucleotide and 3' end reversible closed nucleotide
CN113913945A (en) 2018-10-12 2022-01-11 深圳市真迈生物科技有限公司 Method for preparing chip, chip and method for fixing biological molecule

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007123744A2 (en) * 2006-03-31 2007-11-01 Solexa, Inc. Systems and devices for sequence by synthesis analysis
WO2017136059A1 (en) * 2016-02-03 2017-08-10 Verinata Health, Inc. Using cell-free dna fragment size to determine copy number variations
WO2019109086A1 (en) * 2017-12-01 2019-06-06 Illumina, Inc. Methods and systems for determining somatic mutation clonality

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO2021219114A1 *
TIMOTHY D. HARRIS ET AL: "Single-Molecule DNA Sequencing of a Viral Genome", SCIENCE, vol. 320, no. 5872, 4 April 2008 (2008-04-04), US, pages 106 - 109, XP055412280, ISSN: 0036-8075, DOI: 10.1126/science.1150427 *

Also Published As

Publication number Publication date
US20230178183A1 (en) 2023-06-08
WO2021219114A1 (en) 2021-11-04
CN113593637A (en) 2021-11-02
EP4144745A1 (en) 2023-03-08
CN113593637B (en) 2024-05-03

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