EP4143836A1

EP4143836A1 - Secure system for monitoring and dispensing doses of active substances pre-determined by an expert and customised for users

Info

Publication number: EP4143836A1
Application number: EP21721524.3A
Authority: EP
Inventors: Adrien Plecis
Original assignee: Linkedtech
Current assignee: Linkedtech
Priority date: 2020-04-28
Filing date: 2021-04-27
Publication date: 2023-03-08
Also published as: US20230187044A1; FR3109664B1; WO2021219660A1; FR3109664A1

Abstract

The invention relates to a secure system for dispensing customised mixtures to different users, the system being capable of regularly collecting qualified data on the user and on previously mixed dispensed doses to enable the mixture to be adapted to changes in one or more specific parameters of the user. The system comprises a remote server comprising a remote central unit (31) associated with a remote database (32), at least one remote interface (40) for an expert (41), and at least one local automatic dispenser capable of dispensing a customised mixture of products, the dispenser comprising a local data display and data collection interface, and a transmitter/receiver capable of communicating with the remote database.

Description

SECURE SYSTEM FOR MONITORING AND DISTRIBUTION OF DOSES OF ACTIVE INGREDIENTS PRE-DETERMINED BY AN EXPERT AND PERSONALIZED FOR USERS

The invention relates to a secure system for monitoring and extemporaneous distribution of doses of personalized predetermined mixtures of active ingredients for users, for example, but not exclusively, in the fields of pharmaceuticals, cosmetics and food supplements.

[0002] Healthcare and cosmetics manufacturers are increasingly tending to favor the personalization of product compositions according to the end user. This tendency is for example observed for the preparation of pharmaceutical treatments specifically adapted to the patient according to his sex, his age, his genetic heritage, and the specificities of his disease, such as his cancer or the viral strain.

This type of concern also concerns the field of food supplements in order to optimize the effectiveness of these supplements while limiting negative effects and / or overdoses, and by adapting the composition of the solution to the actual needs of the patient or of the consumer.

[0004] There are standard doses or dosages (which, by the way, change depending on the country).

However, these standard doses are not suitable for all users. Indeed, we know that the physiological state, the genetic heritage and the medical history of the patient must be taken into account in the dosage. In addition, these needs depend on the evolution of the symptoms, the condition, the environment and the behavior of the patient. For all these reasons, tailoring the dosage of a treatment individually to the user's actual needs is becoming increasingly complex and requires expert intervention. The problem is that the more the treatment is personalized and the dosage adapted to the patient and his evolution, the greater the risk of non-compliance (by forgetting or misinterpreting the dosage). There is therefore today a limitation in offering sufficiently personalized treatments linked to the risk of non-compliance with the dosage rules associated with the risk posed by a personalized treatment that is too complex to retain or follow for the patient.

[0005] In order to allow such personalized preparation, automatic dispensers have already been proposed comprising at least two cartridges of different components and a mechanical (syringe type) or pneumatic pumping mechanism. [0006] The patent document US6782307 describes a system with a database and internet access for asking a customer about his preferences and his personal data and automatically generating a personalized formulation sent to a production system which will send the personalized preparation to the user, which makes it possible to adjust the active ingredients to the actual needs of the patient. However, this system is not on the user's premises so that the socket is offset from its manufacture and may be irregular, without the system being able to verify good treatment compliance. In addition, this system does not allow any security of the dispensation in the sense that it is not able to ensure that the user who has identified himself is indeed the one who must receive the personalized product or that the user who will take the individualized preparation is indeed the one who has fulfilled his personal data and preferences. Finally, this system does not make it possible to adapt the dosage of the patient on a daily basis.

[0007] Document US20110247718 is also known which describes a cosmetic product dispensing system equipped with an automatic environmental data capture tool and which adapts the composition of the cosmetic product according to the environmental data. However, this system is not secure, as it does not prevent overuse or verify good treatment compliance, or ensure who is taking the product. In addition, it does not take into account the physiological state of the user, only weather data.

[0008] Document US 10022741 describes a dispenser making it possible to dispense on demand from several cartridges. The user chooses the products he wants on the interface and the distributor dispenses them to him when he detects the presence of a receptacle (any container or directly a hand) to receive the mixture of products.

[0009] However, this device is not secure, because not only does it allow the dispensing of product at the request of any user, but in addition it allows the dispensation of any mixture. It therefore does not ensure the delivery of a truly suitable mixture, or avoid overconsumption or verify good treatment compliance, or ensure who is taking the product. In addition, it does not take into account the physiological state of the user.

Document US20150291411 is also known which describes a personalized dispensing system which is able to take personalized mixture composition instructions from the user himself, directly on the machine or via a mobile application on a mobile phone, or to automatically personalize the exemption according to models accessible in a database. However, it does not make it possible to avoid overconsumption or to verify good treatment compliance, nor to ensure that the user who has identified himself is the one who should receive the personalized product.

[0011] Finally, the entry of this information is not a condition for obtaining an exemption. Thus, the management of personalized treatment conditioned on the immediate condition of the patient cannot be achieved.

[0012] Thus, the object of the invention is to provide a system making it possible to secure for an expert (doctor, nutritionist, etc.) the treatment that he prescribes to a patient at a distance, while ensuring compliance. of the treatment, that is to say by ensuring that the patient's behavior matches the prescribed treatment (intake of the doses of the mixture prescribed in the prescribed dosage (quantity, frequency of intake)), in ensuring who is taking the dose, and allowing patient monitoring to enable effective treatment updating.

One of the problems that the invention proposes to solve is therefore to provide a system for monitoring and dispensing doses of personalized mixtures of products capable of ensuring secure compliance with a personalized treatment by a patient in improving the regularity of taking the mixture doses and informing the expert.

In the remainder of the text, a "personalized mixture of products" will be understood to mean a personalized mixture of active ingredients in the therapeutic, cosmetic or physiological sense, whether or not there is in the composition of the mixture one or more excipients , that is to say elements without therapeutic, cosmetic or physiological effect. An excipient within the meaning of the invention can be, for example, a masker or a flavor enhancer, a liquid carrier such as water, a fruit juice or a syrup. The objective of the invention is therefore to provide a system for dispensing personalized mixtures of products that is secure and controlled, that is to say that the mixture of active principles cannot be distributed to just any user, and that the user cannot receive just any mix.

Another object of the invention is to improve the personalization of processing by periodically, preferably every day, and in a secure manner, recovering data relating to each user, and returning them to an expert in charge of develop a personalized mix of products and / or a decision support algorithm in addition to the expert. Another object of the invention is to provide a system for dispensing personalized mixtures of products contained in several cartridges, to different users without risk of confusion between said users, in a secure and controlled manner, that is to say that the mixture of active principles cannot be distributed to just any user, and that the user cannot receive just any mixture. Thus, the object of the invention is to allow the distribution of different and personalized mixtures to different users, while ensuring compliance with the treatment, who is taking the dose, and by allowing patient monitoring to allow a effective update of treatment.

[0017] Another object of the invention is to provide a distribution system for personalized mixtures of products capable of regularly collecting qualified data concerning the user and past mixing dispensations to allow adaptation, by an expert, of the mixture to the evolution of one or more specific parameters of the user.

[0018] The subject of the invention is also a system for the distribution of personalized mixtures of products capable of ensuring that information is collected from different users without the risk of confusion between said users.

More specifically, the invention relates to a secure system for monitoring and distributing doses of mixtures of active ingredients predetermined by an expert and personalized for users, the system comprising: a remote server comprising an associated remote central unit to a remote database comprising status information of each user, at least one predetermined composition of a personalized mixture of active ingredients for each user, and dosage information comprising information of authorized periodic dose for each active ingredient and / or an authorized time slot; at least one remote interface capable of allowing an expert to develop personalized mixture compositions and capable of communicating in transmission and in reception with the remote database in order to store there at least one composition predetermined by the expert for each user and at least one dosage information item comprising periodical dose information authorized for each active principle and / or an authorized intake time slot, and able to communicate with at least one local automatic distributor (10) of products capable of generating a personalized mixture of products for at least one user of the dispenser, the or each local automatic dispenser comprising: reservoirs of active ingredients a local interface for displaying and collecting data entered by the or each user of the dispenser; a transmitter / receiver capable of communicating with the remote database; a local central unit programmed to selectively actuate each reservoir of active principle as a function of an instruction for preparing a predetermined mixture; and a local memory.

[0020] According to particular embodiments:

• the system may also include a clock, the local central unit and / or the remote central unit being connected to the clock and programmed to record in the local memory and / or in the remote database, a distribution timestamp of each dose, and to prohibit a distribution of a new dose or an active ingredient in the event of an authorized periodic dose being exceeded and / or a non-compliant distribution timestamp at the authorized outlet time slot stored in memory;

• the remote database may further include temporal data for compliance with the distribution of personalized predetermined mixtures, the local central unit or the remote central unit being programmed to transmit an alert message to the remote interface. for the expert if the user has not ordered the distribution of a mixture of products for a predetermined period of time or during the authorized intake time slot, and / or to be able to transmit the compliance data on request from the expert;

• the remote database and / or in local memory may / may include several different custom mixes for a user, as well as rules for selecting a composition of a custom mix based on status information from the user and / or time stamps of dose taking, the remote central unit or local central unit being programmed to compare the patient status information and / or the time stamps with the selection rules to select the personalized mixture suitable for the patient. situation among several mixtures predetermined by the expert;

• the distribution system may further include an alert device detectable by a user, the local central unit or the remote central unit being programmed to actuate the alert device if the user has not commanded the distribution of a mixture of products during a predetermined period of time, or during the authorized setting time slot;

• the warning device can be chosen from among a visual device, an audible device and a haptic device;

• the alert device can be chosen from a device worn by the dispenser or a device carried by a personal object worn by G user;

• the dispenser may also include a presence sensor, the local central unit or the remote central unit being programmed to activate the alert device if the user has not ordered the distribution of a mixture of products during a predetermined period of time or during the authorized setting time slot, and if the user's presence is detected by the presence sensor;

A personal object of the user and the local vending machine can each comprise a geolocation beacon generating respectively a piece of information on the geolocation of the personal object of the user and a piece of information on the geolocation of the distributor, the local central unit or the remote central unit being programmed to compare the geolocation information of the personal object of the user and the geolocation information of the dispenser, and to activate the alert device if the personal object of the user and the dispenser are spaced apart by a distance greater than a threshold distance;

• the local display and data collection interface can be carried by the distributor;

• the local central unit and / or the remote central unit can / can be programmed, in addition, to display before, during and / or after a distribution of a personalized mixture, on the local interface, questions determined by the expert and to transmit the data relating to the responses to the remote central unit and to the remote interface;

• the data relating to the user's answers can be chosen from the answers themselves, the time of entry of the data entered by the user, data relating to the response time to each question and a combination of these- this ;

• the remote interface may be able to allow an authorized modification of the predetermined composition of the personalized mixture of products for the user in order to obtain an adapted composition of the personalized mixture of products for the user as a function of the data relating to the responses of the user. the user ;

• the local central unit can be programmed to display questions determined by the expert on the local display and data collection interface before dispensing a dose of personalized mixture, so as not to authorize the dispensation of a dose of product mixture only if the user has answered all the questions beforehand, and to transmit to the remote central unit data relating to the user's answers;

• the remote database can include identifying information for each user, and the local distributor comprises a device for identifying a personalized security key of a user, the identification device being connected to the local central unit, the latter being programmed to verify the authenticity of the key personalized security key, to identify the user associated with this personalized security key, and if the personalized security key is authentic, to communicate user identification data to the remote server and to receive distribution instructions from the remote server a personalized predetermined mix of products and for controlling the dispensing of said personalized predetermined mix of products;

The local central unit can be programmed to store, in addition, in a local memory, the identification information, said at least one predetermined composition of a personalized mixture of products for each user, the data entered by the or each distributor user and the status information of each user, and to authorize the dispensation in the event of disconnection from the communication network, then to transmit the information to the database when the connection is reestablished;

• the local central unit can also be programmed to transmit distribution order information to the remote database when a personalized security key is identified by the distributor;

• the personalized security key can be an alphanumeric code and the identification device can be a physical or numeric input keyboard arranged on the local interface and connected to the central unit;

• the personalized security key can be carried by a personal object of the user and the identification device is able to identify the personalized security key and to communicate it to the remote central unit;

• the personalized security key can be a visual code and the identification device is a scanner connected to the central unit;

• the personalized security key can be a biometric characteristic and the identification device is a corresponding biometric sensor;

• the personalized security key can be a wireless digital signal emitted by a transmitter carried by the user's personal object, and the identification device is a wireless receiver connected to the central unit for identification;

• the digital wireless signal can be a proximity radio signal, the local central unit or the remote central unit being programmed to identify the digital wireless signal, to assess the strength of said signal picked up by the wireless receiver, and to authorize a distribution of a personalized mixture only if the strength of said signal picked up is greater than a threshold force; • the digital wireless signal can be a geolocation information of the transmitter carried by the personal object of the user, the local vending machine itself comprising a geolocation beacon connected to the local central unit and giving information of geolocation of the distributor, G local central unit or G remote central unit being programmed to compare the geolocation information of the transmitter carried by the personal object of the user and the geolocation information of the distributor, and not to authorize a dispensing a personalized mixture only if the transmitter carried by the personal object of the user and the dispenser are spaced a distance less than a threshold distance; and or

• the user's personal object can be chosen from a mobile phone, a connected watch and a personalized preparation collection object.

Other characteristics of the invention will be set out in the detailed description below given with reference to the appended figures, given by way of example, and which represent, respectively:

[0022] [Fig. 1], a schematic view of a dispensing system for personalized predetermined mixtures of products according to the invention;

[0023] [Fig. 2], a graph showing the data recovery rate as a function of the local interface used;

[0024] [Fig. 3], a schematic perspective view of a vending machine equipped with a socket alert device;

[0025] [Fig. 4], two graphics illustrating a process of modifying the personalized composition according to a parameter A; and

[0026] [Fig. 5], a schematic perspective view of a vending machine equipped with a personalized key detector carried by three embodiments of personal identification objects.

As illustrated in Figure 1, the invention provides a system for dispensing personalized predetermined mixtures of products to users. The system 100 comprises one or more automatic dispensers 10 of products, the dispenser (s) 10 being able to generate a personalized mixture of products for at least one user U of the dispenser.

These distributors are qualified as premises, because they are located near the users: home, office, training room, etc. Each product distributor 10 is able to communicate (in transmission and in reception as shown diagrammatically by the two-way arrows in FIG. 1) via a telecommunications network 20, such as the Internet, with a remote server 30 comprising a remote central unit 31 associated with a remote database 32. The latter comprises at least one predetermined composition of a personalized mixture of products for each user U, information on the authorized intake time slot and / or dosage information comprising periodic dose information authorized for each active principle and / or a time slot for authorized intake and, advantageously, information identifying each user U.

The remote database 32 also includes status information for each user, obtained from the user himself following a series of questions which are asked to him through a local interface 12 in the form of 'a screen 12a carried by the product dispenser.

[0030] Optionally, the remote database 32 can also include information obtained by one or more sensors worn by the users (connected watch, sports activity sensor, heart rate sensor for example).

[0031] Status information may vary depending on the user and, in particular, the reasons for taking the Custom Mix. For example, if the user is taking a mixture to improve their sleep, status information may include, but are not limited to, tracking sleep phases or self-assessment of user fatigue. If he is taking a mixture to help relieve the functioning of his liver, status information may include tracking the composition of his meals and his alcohol consumption. If he is taking a mixture aimed at restoring his intestinal balance (his microbiota), status information may include monitoring symptoms of gas or constipation and his consumption of products rich in fiber. In another field, the status information can include, for example, questions relating to the side effects of a treatment (for example during chemotherapy) to adjust the active ingredients or to warn the expert of a problem and of the need for a counter-visit.

More generally, the status information relates to at least one parameter such as a physiological, physical or psychological parameter of each user.

The system according to the invention also comprises at least one local interface 40 for an expert 41, capable of allowing the expert 41 to develop compositions of mixtures personalized, and capable of communicating in transmission and reception with the remote database 32 to store there at least one predetermined composition prepared by the expert for each user and at least one dosage information comprising information on the authorized periodic dose for each active principle and / or an authorized taking time slot, and able to communicate, directly or indirectly (via the network 20 and / or via the remote server 30), with at least one local vending machine 10.

The system according to the invention therefore secures the distribution of the mixture, because it is a human expert 41 who is in charge of developing one or more personalized mixtures of products. In a particular embodiment, the system according to the invention can also include a decision support algorithm 42 programmed to make a proposal to the human expert 41 via the remote interface 40, the expert being able to either validate the decision. proposal is to modify it via the remote interface 40. This algorithm is advantageously based on an artificial intelligence which automatically develops a proposal for modification of the personalized mixture from data received from the local automatic distributor 10, as described below. The remote interface 40 is able to communicate in transmission and in reception through the communication network 20 with the remote database 32 in order to store there at least one composition determined by the expert for each user, and able to communicate with at least one local automatic product distributor so that the latter can generate a personalized mix of products for at least one user of the distributor.

If the system includes a decision support algorithm 42, the latter can be programmed either directly in the server 31, or in an independent server capable of communicating in transmission and reception through the communication network 20 with the remote database 32.

The or each local vending machine comprises a frame provided with N locations (not shown) for product reservoirs (active ingredients and, optionally, excipients), for example cartridges of fluid products or in the form of pills, powder or paste, N being an integer greater than or equal to 2. The dispenser 10 according to the invention also comprises a motor (not illustrated) capable of generating a force sufficient to selectively actuate the cartridges and generate the dispensing.

Of course, the advantage for the invention is to provide a large number of tank locations to be able to use more different products and allow the dispenses with a large number of combinations of mixtures. Thus, N is advantageously chosen between 3 and 8. The number of tank locations is limited by the size of the machine, the power of the motor, and the size of the cartridges which must remain reasonable, especially if the dispenser is intended for use. home use.

Advantageously, each reservoir of active ingredients (or cartridge) comprises an identification means, such as an electronic identification chip, and the dispenser comprises a reading means of each cartridge identification means, such as 'a sensor capable of reading the identification chips. The dispenser 10 (or the remote server 30) can thus identify each reservoir and know its location in the dispenser.

[0039] In addition, the distributor 10 according to the invention comprises a central unit 11 programmed to selectively actuate each tank location according to a determined preparation instruction of a mixture.

When the reservoirs are provided with product identification chips, the local central unit 11 is programmed to selectively actuate each reservoir of active principle identified by its chip according to the identification information captured and a instruction for preparing a predetermined mixture.

Thanks to these means of identifying the cartridges, and therefore the products contained in the cartridges, the system according to the invention makes it possible to manage any interactions between products, in particular harmful interactions by avoiding mixtures of incompatible products. between them. For example, certain nutrients may have opposite effects (stimulating or relaxing) and it is desirable to be able to prevent the delivery of these nutrients concomitantly, which the invention allows. Thus, the local central unit 11 and / or the remote central unit 31 is / are programmed to compare the prescription with a list of interactions stored in the local memory 18 and / or the remote memory 32, and to prohibit the distribution. one or more active ingredients in the event of incompatibility. Advantageously, in this case, the system warns the 4L expert

According to the invention, the or each local vending machine also comprises a local interface 12, for displaying and collecting data entered by the or each user of the distributor, and comprises a transmitter / receiver 13 capable of communicating with the remote database 32 via the telecommunications network 20. As described above, the local interface 12 is advantageously and preferably a screen 12a carried directly by the dispenser, that is to say forming an integral part of the dispenser, without the possibility of removing it from the dispenser.

In combination, and for security, the system may further include a local backup interface (in the event of a problem encountered by the screen 12a of the dispenser), such as the screen 12b of the mobile phone of the user or his personal computer, provided that he is programmed to communicate (in transmission and in reception) with the distributor 10 and / or the remote server 30 in order to display information and collect it. In the event of a problem encountered by the distributor's screen 12a concomitant with a loss of Internet connection from the distributor 10, then the screen 12b must be programmed to necessarily communicate (in transmission and in reception) with the distributor 10.

Alternatively, G local central unit 11 and the local transceiver 13 can be programmed to communicate with the user's mobile phone, itself programmed to share its connection and allow the local central unit 11 to communicate with the remote central unit 31 via the user's mobile phone. In this case, the local interface remains the screen 12a carried directly by the distributor.

[0046] Figure 2 illustrates the effect obtained through a local interface 12 in the form of a screen 12a worn directly on the dispenser. Indeed, the first hatched bar C corresponds to the rate of recovery of patient status information with a local interface formed by the screen 12b of a cell phone. This rate is less than 50%, which is very little. This means either that users do not enter any information (wrong amount of information), or that the information entered is irrelevant (poor quality of information). On the contrary, the use of a screen 12a carried directly by the dispenser (dotted bar D) ensures a recovery rate of patient status information greater than 75%. This means that users are more likely to respond, and they respond better.

This rate even goes beyond 90% when the distribution of the personalized mixture is conditioned on the recovery of patient status information. Indeed, in this case, the user is obliged to answer the questions to obtain the mixture, and the answers must be of good quality. Thus, the user is more inclined to answer questions asked about his distributor than about his mobile phone. The number of responses, as well as the quality of responses obtained, have a direct and significant effect on treatment adherence. by the user, on the quality of the mixture composed by the expert and on the reactivity of the modification of the mixture by the expert.

[0048] Thus, the fact that the screen is worn by the dispenser makes it possible to ensure that the user who answers the questions is near the dispenser and that it is he who takes the dispensed mixture.

This allows a multi-user implementation of the dispenser, ensuring a distribution of personalized mixtures of products contained in several cartridges, to different users without risk of confusion between said users, in a secure and controlled manner. Thus, the personalized mixture of active ingredients cannot be distributed to just any user, and the user cannot receive any mixture, while ensuring adherence to the treatment, from who takes the medication. dose, and allowing patient monitoring to enable effective treatment updating.

[0050] In order to ensure the safety of the user, the system according to the invention makes it possible to avoid any overconsumption or any improper intake of one or more active ingredients.

[0051] To this end, the invention provides that the remote database 32 may further include timing data of dispensing adherence of personalized predetermined mixtures. To this end, the remote server 30 and / or the local distributor 10 is / are also provided with a clock 33 respectively 19. The local central unit 11 and / or the remote central unit 31 are connected to the clock 19, 33 and is / are programmed to record in local memory 18 and / or in remote database 32, a time and date of delivery of each dose.

Thus, the system 100 being provided with a clock 19-33, the local central unit 11 and / or the remote central unit 31 is / are also programmed to record a delivery time stamp of each dose (the time and date of the dispensing of each dose) and to prohibit the dispensing of a new dose or of an active ingredient of the dose in case of exceeding a periodic dose (for example daily, weekly, monthly, or other) ) authorized by the expert 41, and / or a distribution timestamp that does not comply with the authorized outlet time slot previously defined by the expert and stored in the remote database 32 and / or in the local memory 18.

For example, the distribution of melatonin (active principle) can be blocked if the setting time is early in the morning. Also for example the distribution of a stimulant (such as turmeric which stimulates the secretion of serotonin and dopamine) can be blocked if the time of intake is in the evening.

In the pharmaceutical field, it is known, for example, that for an active principle such as paracetamol, an overdose can cause serious damage to the liver. The dosage in terms of dose per dose and frequency of intake therefore depends on the weight and age of the patient. However, it is common for users to mistake the dosage or forget the time of the last dose. A device according to the invention will allow the user not to be mistaken about the doses and will automatically block the resumption of this anti-inflammatory when the attempts to take it are too close together, which will make it possible to avoid the harmful side effects associated with non-compliance with the strict dosage.

In the cosmetic field, for the application of topical agents, for example calcipotriol in the form of a cream (used in the treatment of plaque psoriasis affecting up to 40% of the body surface), systemic effects ( hypercalcemia and hypercalciuria) have been reported: the risk of experiencing systemic effects increases if the total dose increases, but the therapeutic effect increases with the increase in the locally received dose. It is therefore necessary, for an expert, to assess the right dose of cream and active principle to be administered to the user according to the severity of the psoriasis, the surface to be covered by the treatment and the risk incurred by it. user to develop systemic effects. With the system according to the invention, the dosage of the cream can be systematically carried out in line with the recommendations of the expert. In the event that the user presents areas of psoriasis with different levels of severity, a system according to the invention will make it possible to provide several dispensations and to independently adapt the dosage of the active principle to the quantity of total cream. The system according to the invention will even be able, at the end of the questions put to the user, to gradually adjust the dosage of the active principle downwards according to the evolution of the psoriasis reported by the user according to each treated area. .

In general, other dosage rules can be collected by the system according to the invention and used to automatically adjust the dosage according to clearly identified cases. For example, it will be possible to define minimum setting intervals. In the case of an active principle such as paracetamol, the expert will be able to define, instead of a given and fixed setting time slot, a minimum setting interval (for example at least equal to 4 hours). Thus the system according to the invention will allow the delivery of the personalized mixture at the most suitable time according to the symptoms felt by the user (fever in the example of paracetamol) and will block any dispensation until the minimum intake interval has been observed.

Advantageously, an alert message is displayed on the local interface 12a to warn the user that the periodic dose has been exceeded. This can be useful, for example, for users with poor memory.

[0058] It may also be useful to program the system to allow for a crash procedure in the event that, for example, the user spills the dose before swallowing it. Indeed, in this case, the periodic dose of intake is not exceeded, but the periodic dose of distribution may be. In an exemplary embodiment, the local central unit is programmed to display on the local interface 12a a request for an incident report. Once this request has been selected by the user, the local central unit 11 sends an incident alert to the remote server which in return sends a warning message of the overrun and informing the user of the cause for confirmation on the local interface 12a. Once the declaration of incident and declaration of assumption of responsibility by the user has been confirmed and sent back to the remote server 30, the latter authorizes a new distribution of a dose. Advantageously, the authorization of a new distribution can take into account the time between the moment of the first normal dose distribution, and the moment of the presentation of the incident report. Thus, if the incident report occurs after a predetermined period of time after the normal issue, the re-issue is refused for safety.

In combination, the local central unit 11 and / or the remote central unit 31 are also programmed to transmit data on compliance with the intake of the mixture to the expert 41 via its interface 40 and, optionally, to the decision support algorithm 42, and to send an alert message if the user has not ordered the distribution of a mixture of products during a predetermined period of time or during the authorized setting time slot. Alternatively or in combination, the remote central unit 31 can also be programmed to transmit an alert message to a referenced and authorized third party (for example a caregiver or a close relative) if the user has not ordered the distribution of a mixture of products during a predetermined period of time or during the authorized intake time slot, for example in the case of a prescription for an elderly person.

[0060] Alternatively or in combination, the dosage information recorded by the expert 41 via his remote interface 40 in the remote database 32 may include information on minimum periodic dose for at least some of the active ingredients. Of this In this way, when the user has not taken a prescribed dose, the system can increase the amount of one or more active principle (s) in the next dose. For example, when the doctor prescribes a dose of magnesium in the morning and evening to distribute the doses and the user forgets to take his dose in the morning, the system according to the invention can automatically deliver a double amount of magnesium in the evening dose. .

[0061] Alternatively or in combination, in an advantageous embodiment of the invention, illustrated in FIG. 3, the system according to the invention comprises an alert device 16 detectable by a user U.

In the embodiment illustrated in Figure 3, the warning device 16 is carried by the dispenser. In addition, the local distributor 10 is provided with a clock 19 and the local central unit 11 is programmed to activate the warning device 16 if the user has not ordered the distribution of a mixture of products during a period of time. predetermined period of time or during the authorized setting time slot.

[0063] In this way, when the user passes near the dispenser, he thinks of ordering his personalized mixture and of answering the questions asked.

[0064] The alert device can be selected from a visual device, a sound device and a haptic device or a combination thereof.

Advantageously, the alert device can be active as long as the person has not entered their data and taken their food supplements.

In an advantageous embodiment, the dispenser 10 further comprises a presence sensor 17, the local central unit 11 being programmed to actuate the warning device 16 if the user has not ordered the distribution of a mixture of products during a predetermined period of time or during the authorized setting time slot and if the presence of the user U is detected by the presence sensor 17.

[0067] Alternatively or in combination, the system can assess the distance between the user and the dispenser and activate the alert device if the user leaves without having taken the prescribed dose.

To this end, a personal object 15a, 15b, 15c (see FIG. 5) of the user and the local vending machine each comprise a geolocation beacon generating information on the geolocation of the personal object 15a, 15b, 15c user and distributor 10. The local central unit 11 or the remote central unit 31 is then programmed to compare the geolocation information of the personal object 15a, 15b, 15c of the user and the geolocation information of the distributor 10, and to activate the alert device 16 if the personal object 15a, 15b, 15c of the user (and therefore the user himself) and the dispenser 10 are spaced apart by a distance greater than a threshold distance. For example, it helps remind a user that they forgot to take their personalized product mix before they leave their home for good.

[0069] Alternatively or in combination, the alert device can be included in an object worn by the user, such as his mobile phone, for example. In this case, the phone rings, vibrates or flashes when the user has not ordered the dispensing of a mixture of products for a predetermined period of time or during the authorized pick-up time slot. Also in this case, the alert device can be triggered if the phone, and therefore its user, moves away from the dispenser by comparing the geo-positioning data of the phone and the dispenser. The invention also enables efficient and safe adaptation of the device. mixing during processing allowing the collection of quality information at regular intervals.

To this end, the local central unit 11 is programmed to display on the local interface 12a, before, during and / or after a distribution of a personalized mixture, questions predetermined by the expert 40 and to transmit responses to the remote central unit 31.

Preferably, the local central unit 11 can be programmed to authorize the dispensation of a mixture of products only if the user has answered all the questions beforehand. To this end, the local central unit 11 is programmed to display questions determined by the expert 41 on the local display and data collection interface 12a a distribution of a dose of personalized mixture, so as not to allow dispensing with a dose of product mixture only if the user has answered all the questions beforehand, and to transmit to the remote central unit 31 data relating to the user's responses.

The data relating to the user's responses can be the responses themselves, but also advantageously, thanks to the clock 19 (or 33), data relating to the response time to each question, or even the response time to allow an analysis of the rhythm of life and a possible adaptation of the mixture by the expert. It is in fact possible to characterize physical, physiological or mental states as a function of the time taken by the user to answer a given question. Data relating to user responses can also be comparisons of response times to the same question at different intervals in order to deduce therefrom an evolution of the response time over time as a function of the treatment.

The system according to the invention is thus able to allow a modification of the predetermined composition of personalized mixture of products for G user in order to obtain an adapted composition of personalized mixture of products for the user as a function of the data relating to the products. user responses.

The remote central unit 31 can be programmed to transmit to the expert 41 via its remote interface 40 and, optionally, to the decision support algorithm 42, the data relating to the user's responses for that the expert can decide to modify or not the mixture, in what proportions and in what dosage (quantity and frequency or time of taking), possibly with the help of proposals formulated by the decision support algorithm.

These modifications authorized by the expert are stored in the local memory 18 and / or in the remote database 32, and the local central unit 11 is programmed to selectively actuate each reservoir of active principle according to a instruction for the preparation of a predetermined mixture including these authorized modifications according to the data relating to the questions entered by the user

In an example of a personalized food supplement, the user has a distributor 10 at his home, the programming of which has been carried out remotely by his expert nutritionist 4L In a standard operating mode, the user has two dispensations per day, one in the morning and one in the evening to accompany it during the day and at night.

[0077] In order to tailor the user's schedule, the nutritionist needs to know if the user is getting restful sleep and if the user is stressed. When dispensing their food supplement in the morning, the machine asks the user via its touchscreen interface 12 to rate the quality of their sleep from 1 to 10 the previous night. Likewise, when dispensing their dietary supplement in the evening, the interface asks the user to note their stress level for that day.

The user's data is stored in the remote database 31, and at the end of his first month of treatment, during his visit to his expert nutritionist, the user allows the latter to have access to this health information to adjust its recommendation via a web or mobile interface. By observing the evolution of the quality of sleep and the amount of stress felt by the user, the healthcare professional will be able to adjust the personalized program by increasing or decreasing the quantity of certain food supplements. These new recommendations are stored in the remote database 31 in order to be queried by the automatic distributor.

[0079] For example, if the stress has not diminished sufficiently, it may increase the doses of certain plants, such as Rhodiola, known for its de-stressing properties.

Conversely, if the quality of sleep has returned to normal, it may decrease or even stop the use of certain food supplements such as melatonin.

Advantageously, the expert 41 can define several compositions of mixtures personalized for a user stored in the remote database 32 and / or in the local memory 18, as well as rules for selecting a composition of a mixture. personalized according to the data relating to the user's state information (for example the user's answers to the questions asked) and / or the time-stamps of the doses taken.

These rules are stored in the remote database 32 and / or in the local memory 18 by the user via the remote interface 40, and the remote central unit 31 or the local central unit 11 is programmed to comparing the patient's status information and / or the timestamps to these rules to select, according to the rules defined by the expert, the personalized mixture suited to the situation from among several mixtures predetermined by the expert.

FIG. 4 illustrates an example of rules for modifying a composition of a personalized mixture (parameter B) as a function of a parameter A, for example by adjusting the dose of certain food supplements as a function of the results of the evaluations .

For example, in FIG. 4, the scores relating to sleep (parameter A) are shown in the top graph and form the dotted curve A (t).

The local central unit 11 or the remote central unit 31 then calculates the average of the scores over seven rolling days, which generates the full line curve MA.

If the average quality of sleep MA over the last 7 days is greater than 5, the evening dose of melatonin (parameter B) will be 1 mg. If the average MA sleep quality is less than 5, the evening melatonin dose (parameter B) will be 2 mg, if the average MA sleep quality is greater than 8, the evening melatonin dose (parameter B) will be Omg. Another possible personalized composition modification process could, for example, consist in counting the number of events over a given period. By asking a user if he drank 2L of water the day before, we can ensure, for example, that he has drunk enough water to eliminate toxins from his body. Over a period of 3 consecutive days when water consumption has not been reached, it will be possible to adjust the intake of vitamins and minerals so as not to overload the kidneys.

For this, it is necessary to have regular data, otherwise the recommendation may be falsified. Indeed, if the user only completes his assessment when he has slept poorly, it will tend to increase the doses of melatonin unnecessarily, knowing that it is not medically recommended to use melatonin in very high doses for too long. .

[0089] It is therefore essential to collect information regularly. The use of the dispensing machine according to the invention with a questioning interface 12a greatly improves the information taking and the quality of the treatment. Indeed, when the user waits for his personalized dispensation, he is more inclined to respond to these assessments. As previously described, it has been noted that the use of the machine interface 12a rather than a web or mobile interface 12b greatly improves daily information retrieval.

[0090] Thus, the invention makes it possible to improve the personalization of recommendations by a professional, possibly with the help of a decision-support algorithm. In the case of items presenting a risk of overdose, these daily assessments may become essential to avoid overdoses that are harmful to the user.

The information collected daily can be declarative (evaluation, rating), extrapolated (time taken, reactivity to the interface, etc.) or captured by sensors integrated into the machine (pulse test, facial image , glucose or conductivity test).

In the case of a personalized cosmetic preparation, an example could consist in asking the user if he feels tightness in the skin (yes or no). After one month of use, the expert (the health professional) will be able to assess, possibly with the help of an algorithm, whether the tightness is occasional, regular or localized at certain periods (for example when it is cold or the day after sports activities) and can adjust the personalized program based on the analysis of this daily information obtained over a sufficiently long period. In medical use, it is possible, for example, to collect the psychological feelings of a user in order to gradually adapt the prescription of molecules, for example of anxiolytics.

In addition to securing the taking of the doses, the invention can also make it possible to secure the distribution by ensuring that the user who has identified himself is the one who should receive the personalized mixture of product,

The or each local vending machine 10 also comprises an identification device 14 of a local personalized security key 15 of a user, and the remote database 32 further comprises identification information of the user. each user U.

By local personalized security key is meant, according to the invention, a means of identification near the dispenser. Several embodiments are illustrated in FIG. 5 and will be described below.

The identification device 14 being connected to the local central unit 11, the latter is programmed to verify the authenticity of the local personalized security key, to identify the user associated with this local personalized security key, and if the local personalized security key is authentic, to communicate identification data of the user to the remote server 30 and to receive from the remote server 30 instructions for dispensing a determined personalized mixture of products and for ordering the distribution by the dispenser 10 of said personalized determined mixture of products.

To be authentic, the security key must be unique to a user / password pair.

It is of course not necessary to confuse the local personalized security key of the present invention, which is entered by the user, directly or indirectly, so that he identifies himself and that he can receive a mixture. of products predetermined by an expert, and ordering data which allows any user to compose himself and to order the distribution of the mixture he has composed, without any identification of said user.

[0100] In fact, according to the invention, the user does not have the choice of the composition of the mixture (s) of active products preprogrammed by the expert. This composition is determined or authorized by the expert, prior to the distribution, so that the distribution is safe and easy for any user, including those with no knowledge of mixing active products.

On the other hand, in an optional embodiment, the dispenser and the system according to the invention can be configured so that the user can add or remove any excipient of his choice and dispensed by the dispenser, such as, for example, a masker or flavor enhancer, a liquid carrier such as water, fruit juice or syrup, etc. In the case of cosmetics, this may for example be a pigment making it possible to color the preparation according to the skin tone of the user U.

[0102] The system according to the invention can also allow the expert to program several predefined mixtures per user (different active ingredients and / or different dosages). Indeed, it may be desirable to adapt the intake according to certain circumstances. In this case, the expert programs several predefined mixtures for the user to use depending on the circumstances. For example, if a particular event occurs (chronic symptom, fever, etc.), the user can choose from the predefined mixtures. It will be beneficial to program a question into the interface to guide the user to the most beneficial preset mix. However, while the user can choose the mixture depending on the circumstances (and possibly the excipients), he does not have the choice of the composition of active ingredients of the predefined mixture chosen. It was the expert who predetermined this composition via his interface 40.

[0103] Also according to the invention, the mixture is determined for the first time a priori, at the start of treatment, by the expert 41 via his remote interface 40, and it can be modified and adapted a posteriori, during the process. processing, by the expert 41, possibly with the help of an algorithm 42 programmed for example in the remote server 30.

[0104] For this adaptation to be effective, it is necessary for the system to retrieve data from the user, either directly or indirectly through sensors worn by the user.

To this end, the invention proposes to secure the dispensing of the mixture by ensuring that the user who has activated the dispenser is indeed the one who must receive the mixture, and to secure the collection of data to ensure that 'they are qualified, that is to say they are of good quality and accurately reflect the physiological, physical and / or mental situation of the user U. To secure the dispensation, the or each local vending machine 10 also comprises a device 14 for identifying a local personalized security key 15 of a user. Additionally, the local central processing unit is also programmed to transmit distribution control information to the remote database when the personalized security key is identified by the distributor. Alternatively or in combination, the central unit can store locally, in a local memory 18, the identification parameters, the dispensing information, the dispensing commands and the status information in order to be able to provide dispensation in the event of a momentary disconnection. to the communication network 20, and return the information subsequently to the database 32 when the connection is reestablished.

[0107] In a first embodiment, the personalized security key is an alphanumeric code and the identification device 14 is a physical or numeric input keyboard arranged on the local interface 12a connected to the central unit 11.

[0108] Thus, once the user has been identified by the remote server, the system sends the personalized security key to the mobile telephone or the user's computer in the form of an alphanumeric code to be entered on the local interface. 12a. Thus, the system according to the invention ensures that the person who entered the identification information is also the recipient of the personalized security key.

[0109] Preferred embodiments, illustrated in Figure 5, allow faster securing without active user intervention. These embodiments use a personal object for each user, the personalized security key being carried by this personal object. In a complementary manner, the identification device is able to automatically identify the personalized security key and to communicate it to the remote central unit 31.

[0110] FIG. 5 illustrates three embodiments in which the personal object of the user is respectively a container for collecting the personalized preparation 15a, a connected watch 15b and a mobile phone 15c.

The personalized security key can be a visual code 15a1 carried by the container 15a or displayed on the screen of the connected watch 15b or of the telephone 15c. It can be, for example, a bar code or a QR code. Additionally, the identification device 14 is then a scanner capable of capturing the visual code and transmitting it to the remote central unit 30 and / or to the local unit 11 in the case where the key is stored in the distributor 10 . [0112] Alternatively, the personalized security key can be a wireless digital signal (for example a near field communication signal or NFC in English, or else a Bluetooth signal, a geolocation signal, etc.) emitted by a transmitter. carried by the personal object of G user. For example, it may be an RFID chip bonded to the container or integrated into the container 15a. Additionally, the identification device 14 is a wireless receiver capable of communicating with the remote central unit 31 or the local central unit 11 for identification.

Preferably, in the embodiment in which the digital wireless signal is a proximity radio signal (NFC or Bluetooth for example), the local 11 or remote 31 central unit is programmed to identify the digital wireless signal. , but also to compare the strength of said signal picked up by the wireless receiver 13 with a threshold strength. In addition, the local central unit 11 or the remote central unit 31 is programmed to allow distribution of a personalized mixture only if the strength of said signal picked up by the identification device 14 is greater than a threshold force.

If it is the local central unit 11 which compares the strength of the signal picked up with a threshold force, it is programmed to communicate with the remote central unit 30 and control the delivery of the mixture only if the strength of said signal captured is greater than a threshold force.

If it is the remote central unit which compares the strength of the signal picked up with a threshold force, it is programmed to send the authorization to deliver the mixture to the local central unit 11 only if the strength of said signal picked up is greater than a threshold force.

[0116] Alternatively or in combination, the digital wireless signal can be a geolocation information of the transmitter carried by the personal object of the user. In this case, the local vending machine itself includes a geolocation beacon connected to the local central unit 11 or any other means of geolocation (IP address, etc.) to provide geolocation information for the distributor 10.

The local 11 or remote central unit 31 is then programmed to compare the geolocation information of the transmitter carried by the personal object 15a, 15b, 15c of the user and the geolocation information of the distributor 10, and to authorize a dispensing of a personalized mixture only if the transmitter carried by the personal object 15a, 15b, 15c of the user and the dispenser are spaced at a distance less than a threshold distance.

If it is the local central unit 11 which compares the geolocation positions, it is programmed not to communicate with the remote central unit 30 and to control the delivery of the mixture only if the transmitter carried by the personal object 15a, 15b, 15c of the user and the dispenser are spaced at a distance less than a threshold distance.

If it is the remote central unit which compares the geolocation positions, it is programmed to send the authorization to issue the mixture to the local central unit 11 only if the transmitter carried by the object The user's personnel 15a, 15b, 15c and the dispenser are spaced a distance less than a threshold distance.

[0120] Alternatively, the personalized security key can be a biometric characteristic and the identification device 14 is then a corresponding biometric sensor. For example, this biometric characteristic can be a fingerprint, a face, an iris, etc.

[0121] Alternatively, the personalized security key can be a physical security key, such as a key, a smart card, a magnetic badge. In this case, the local central unit is programmed to transmit dispensing control information to the remote database when the personalized security key is entered into the dispenser.

[0122] Alternatively, the personalized security key can be a combination of the previous security keys, which makes it possible to increase security.

[0123] Thus, the system according to the invention makes it possible to secure for an expert (doctor, nutritionist, etc.) the treatment that he prescribes to a patient remotely, by allowing him to effectively monitor compliance with the treatment, by making sure who is taking the dose, and by allowing patient follow-up to allow for personalized treatment updates.

[0124] The system according to the invention also makes it possible to improve the regularity of taking the mixture doses, by informing the expert and reminding the user to take his doses.

The system according to the invention also makes it possible to improve the personalization of the treatment by periodically recovering good quality data relating to each user, and by returning them to an expert so that he can possibly adapt the prescription to the patient. actual condition of the patient, which makes it possible to administer complex treatments without risking confusion for the user.

[0126] The invention also makes it possible to provide a system for dispensing personalized mixtures to different users which avoids the risk of confusion between said users.

Claims

[Claim 1] Secure system (100) for monitoring and distributing doses of mixtures of active ingredients predetermined by an expert and personalized for users, characterized in that it comprises: a remote server (30) comprising a remote central unit (31) associated with a remote database (32) comprising status information of each user, at least one predetermined composition of a personalized mixture of active ingredients for each user, and dosage information comprising dose information periodical authorized for each active ingredient and / or a time slot for authorized intake; at least one remote interface (40) capable of allowing an expert (41) to develop personalized mixture compositions and capable of communicating in transmission and in reception with the remote database (32) in order to store at least one composition therein predetermined by the expert for each user and at least one dose information item comprising information on the authorized periodic dose for each active principle and / or an authorized intake time slot, and capable of communicating with at least one local automatic dispenser (10) of products capable of generating a personalized mixture of products for at least one user of the dispenser, the or each local automatic dispenser (10) comprising: reservoirs of active ingredients a local interface (12, 12a, 12b) for display and collection data entered by the or each user of the distributor; a transmitter / receiver (13) able to communicate with the remote database

(32); a local central unit (11) programmed to selectively actuate each reservoir of active ingredient according to an instruction for preparing a predetermined mixture; and a local memory (18).

[Claim 2] A distribution system according to claim 1, further comprising a clock (19, 33), the local central unit (11) and / or the remote central unit (31) being connected (s) to the clock (19, 33) and programmed (s) to record in the local memory (18) and / or in the remote database (32), a dispensing timestamp of each dose, and to prohibit a dispensing of a new dose or an active ingredient in the event of exceeding an authorized periodic dose and / or a delivery time stamp that does not comply with the authorized intake time slot stored in memory.

[Claim 3] A distribution system according to claim 2, wherein the remote database further comprises timing data of distribution adherence of personalized predetermined mixtures, the local central unit (11) or the remote central unit ( 31) being programmed to transmit to the remote interface (40) an alert message for the expert (41) if the user has not ordered the distribution of a mixture of products for a predetermined period of time or during the authorized setting time slot, and / or to be able to transmit the compliance data at the request of the expert (41).

[Claim 4] A distribution system according to any one of claims 2 or 3, wherein the remote database (32) and / or in the local memory (18) comprises several different custom mixes for a user, as well as rules for selecting a composition of a personalized mixture according to the user's status information and / or the time stamps of the doses taken, the remote central unit (31) or the local central unit (11) being programmed to compare patient status information and / or time stamps to selection rules to select the custom mix suitable for the situation from among several mixes predetermined by the expert.

[Claim 5] A distribution system according to any one of claims 2 to 4, further comprising an alert device (16) detectable by a user, the local central unit (11) or the remote central unit. (31) being programmed to activate the warning device if the user has not ordered the distribution of a mixture of products for a predetermined period of time, or during the authorized setting time slot.

[Claim 6] The dispensing system of claim 5, wherein the alert device is selected from a visual device, a sound device and a haptic device.

[Claim 7] A dispensing system according to any one of claims 5 or 6, wherein the warning device is selected from a device carried by the dispenser or a device carried by a personal object (15a, 15b, 15c) carried. by the user.

[Claim 8] A dispensing system according to any one of claims 5 to 7, wherein the dispenser further comprises a presence sensor, the local central unit (11) or the remote central unit (31) being programmed to activate the warning device if the user has not ordered the dispensing of a mixture of products during a predetermined period of time or during the authorized setting time slot, and if the presence of G user is detected by the presence sensor.

[Claim 9] A distribution system according to any one of claims 5 to 8, wherein a personal object (15a, 15b, 15c) of G user and the local vending machine each comprise a geolocation beacon respectively generating geolocation information. of the personal object (15a, 15b, 15c) of the user and a geolocation information of the distributor (10), the local central unit (11) or the remote central unit (31) being programmed to compare the information for geolocation of the personal object (15a, 15b, 15c) of the user and the geolocation information of the distributor (10), and to activate the alert device (16) if the personal object (15a, 15b, 15c) of the user and the dispenser 10 are spaced apart by a distance greater than a threshold distance.

[Claim 10] The distribution system of any one of claims 1 to 9, wherein the local display and data collection interface (12a) is carried by the distributor.

[Claim 11] A distribution system according to any one of claims 1 to 10, wherein the local central unit (11) or the remote central unit (31) is further programmed to display before, during and / or after a distribution of a personalized mixture, on the local interface (12a), of the questions determined by the expert (41) and to transmit the data relating to the responses to the remote central unit (31) and to the remote interface (40).

[Claim 12] A distribution system according to claim 11, in which the data relating to the responses of the user is chosen from among the responses themselves, the time of entry of the data entered by the user, of the data relating to the user. response time to each question and a combination of them.

[Claim 13] A distribution system according to any of the claims

11 or 12, in which the remote interface (40) is adapted to allow an authorized modification of the predetermined composition of the personalized mixture of products for the user in order to obtain a suitable composition of the personalized mixture of products for the user in depending on the data relating to the user's responses.

[Claim 14] A distribution system according to any of the claims

11 to 13, in which the local central unit is programmed to display questions determined by the expert on the local display and data collection interface before a dispensing of a dose of personalized mixture, to allow the dispensation of a dose of product mixture only if the user has answered all the questions beforehand, and to transmit to the remote central unit data relating to the user's responses.

[Claim 15] A distribution system according to any one of claims 1 to 14, wherein the remote database (32) includes identification information of each user (U), and the local distributor (10) comprises a identification device (14) of a personalized security key of a user, the identification device (14) being connected to the local central unit (11), the latter being programmed to verify the authenticity of the personalized security key, to identify the user associated with this personalized security key, and if the personalized security key is authentic, to communicate identification data of the user to the remote server (30) and to receive from the remote server instructions for dispensing a personalized predetermined mix of products and for controlling the dispensing of said personalized predetermined mix of products.

[Claim 16] A distribution system according to claim 15, wherein the local central processing unit (11) is programmed to further store in a local memory (18) the identification information, said at least one predetermined composition. a personalized mix of products for each user, the data entered by the or each user of the distributor and the status information of each user, and to authorize the dispensation in the event of disconnection from the communication network (20), then for transmitting the information to the database (32) when the connection is reestablished.

[Claim 17] A distribution system according to any of the claims

15 or 16, wherein the local central unit is also programmed to transmit distribution order information to the remote database when a personalized security key is identified by the distributor.

[Claim 18] A distribution system according to any of the claims

15 to 17, in which the personalized security key is an alphanumeric code and the identification device is a physical or numeric input keyboard arranged on the local interface and connected to the central unit.

[Claim 19] A distribution system according to claim 15 to 17, in which the personalized security key is carried by a personal object of the user and the identification device is able to identify the personalized security key and to communicate it. to the remote central unit (30). [Claim 20] A dispensing system according to claim 19, wherein the personalized security key is a visual code and the identification device is a scanner connected to the central unit.

[Claim 21] The dispensing system of claim 19, wherein the personalized security key is a biometric characteristic and the identification device is a corresponding biometric sensor.

[Claim 22] The distribution system of claim 19, wherein the personalized security key is a wireless digital signal transmitted by a transmitter carried by the user's personal object, and the identification device is a wireless receiver. wire connected to the central unit for identification.

[Claim 23] A distribution system according to claim 22, wherein the digital wireless signal is a proximity radio signal, the local central unit (11) or the remote central unit (31) being programmed to identify the digital signal. wireless, to assess the strength of said signal picked up by the wireless receiver (14), and to allow delivery of a custom mix only if the strength of said picked up signal is greater than a threshold strength.

[Claim 24] A distribution system according to claim 22, in which the digital wireless signal is a geolocation information of the transmitter carried by the personal object of the user, the local vending machine itself comprising a beacon. geolocation connected to the local central unit and giving information on the geolocation of the distributor, the local central unit (11) or the remote central unit (31) being programmed to compare the geolocation information of the transmitter carried by the personal object (15a, 15b, 15c) of the user and the geolocation information of the distributor (10), and to authorize a distribution of a personalized mixture only if the transmitter carried by the personal object (15a, 15b, 15c) of the user and the dispenser are spaced a distance less than a threshold distance.

[Claim 25] A distribution system according to any of the claims

19 to 24, in which the personal object of the user is chosen from a cell phone, a connected watch and a collection object of the personalized preparation.