EP4125711A1 - Greffon tissulaire modifié et procédés et appareil de création d'un greffon tissulaire modifié - Google Patents

Greffon tissulaire modifié et procédés et appareil de création d'un greffon tissulaire modifié

Info

Publication number
EP4125711A1
EP4125711A1 EP21775343.3A EP21775343A EP4125711A1 EP 4125711 A1 EP4125711 A1 EP 4125711A1 EP 21775343 A EP21775343 A EP 21775343A EP 4125711 A1 EP4125711 A1 EP 4125711A1
Authority
EP
European Patent Office
Prior art keywords
graft
tissue
tissue graft
layer
modified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21775343.3A
Other languages
German (de)
English (en)
Other versions
EP4125711A4 (fr
Inventor
Barry Markman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Markman Biologics Corp
Original Assignee
Markman Biologics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US16/831,169 external-priority patent/US11877921B2/en
Priority claimed from US17/146,305 external-priority patent/US20210128290A1/en
Application filed by Markman Biologics Corp filed Critical Markman Biologics Corp
Publication of EP4125711A1 publication Critical patent/EP4125711A1/fr
Publication of EP4125711A4 publication Critical patent/EP4125711A4/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
    • A61F2002/0081—Special surfaces of prostheses, e.g. for improving ingrowth directly machined on the prosthetic surface, e.g. holes, grooves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0076—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof multilayered, e.g. laminated structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2240/001—Designing or manufacturing processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/003—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time
    • A61F2250/0031—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time made from both resorbable and non-resorbable prosthetic parts, e.g. adjacent parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir

Definitions

  • the present invention relates to tissue grafts.
  • FIGURE 1 is a side view of a tissue graft having various surface patterns in accordance with an embodiment of the invention, which patterns may be used to contain or retain medicants, tissues or other materials in accordance with other embodiments of the invention;
  • FIGURES 2A and 2B illustrate configurations of die cuts made to alter a tissue graft in accordance with embodiments of the invention;
  • FIGURES 3A and 3B illustrate a top and bottom, respectively, of a tissue graft having patterns in accordance with the invention
  • FIGURES 3C, 3D, 3E and 3F illustrate tissue grafts modified to have different areas with different surface patterns in accordance with embodiments of the invention
  • FIGURES 6A, 6B, and 6C illustrate a method of modifying a tissue graft with a template to create a modified tissue graft having one or more surface patterns and associating one or more medicants with said surface patterns in accordance with an embodiment of the invention;
  • FIGURES 6D and 6E illustrate additional embodiments of a modified tissue graft in accordance with the invention;
  • FIGURES 7A-7D illustrate one embodiment of a tissue graft cutting die in accordance with an embodiment of the invention;
  • FIGURE 9 illustrates aspects of a method of forming a multi-layer modified tissue graft in accordance with the present invention
  • the invention is configured to, and an advantage of the invention comprises, reducing stress in grafts subject to continuous motion, such as, in the knee, hip, and cervical region due to targeted resurfacing.
  • the invention is configured to, and an advantage of the invention comprises, reducing stress in grafts subject to increased pressure gradients such as in the abdominal wall, inguinal hernia, and arterial grafts.
  • the invention is configured to, and an advantage of the invention comprises, allowing for selective expandability (such as via partial or non-through expansion incisions and/or through expansion incisions of various thicknesses in the graft) in order to achieve better contour and external appearance due to targeted resurfacing.
  • the invention is configured to, and an advantage of the invention comprises, allowing for selective expandability (such as via partial or non-through expansion incisions and/or through expansion incisions of various thicknesses in the graft) in order to achieve better outflow of blood in venous grafts due to targeted resurfacing.
  • the invention is configured to, and an advantage of the invention comprises, allowing for selective traction or adhesion points of tissue grafts to key anatomic areas when needed in order to increase fixation at insertions and origins to reduce slippage due to targeted resurfacing of the graft.
  • the invention is configured to, and an advantage of the invention comprises, allowing for an increase in the period of time of utilization and longevity of the modified tissue graft.
  • Another embodiment of the invention comprises methods and apparatus for creating a medicated graft, such as a tissue graft which includes a medicant, such as antibiotics, growth factors, or chemotherapeutics, or other tissues (such as stem cells), due to targeted resurfacing.
  • a medicated graft such as a tissue graft which includes a medicant, such as antibiotics, growth factors, or chemotherapeutics, or other tissues (such as stem cells), due to targeted resurfacing.
  • one or more templates or dies are used to modify the surface of a tissue graft, such as to remove material from the graft, compress areas of the graft, cut areas of the graft, or otherwise alter at least a surface of the graft.
  • modifications are made to an initial tissue graft to create a modified tissue graft having certain characteristics or properties.
  • the particular modifications and the areas where the modifications are made may be selected to achieve particular characteristics or properties in different areas of the modified tissue graft, such as based upon the desired use, including the particular anatomical location at which the modified tissue graft is to be used, as well as the functional and medical purpose the modified tissue graft is to serve.
  • Another embodiment of the invention comprises a multi-layer, medicated, reconstructive tissue graft.
  • a graft may comprise a base tissue graft having a top surface and a bottom surface, the base tissue graft modified by compressing, cutting and/or removing one or more portions of either or both the top surface and the bottom surface to create one or more designed surface features, a second graft layer or sheet applied to either or both the top surface and the bottom surface of the base tissue graft, and one or more medicants associated with the multi-layer reconstructive graft.
  • the medicants may be associated with the designed surface features of the base graft and then the second graft layer is placed over the designed surface features.
  • the medicants are associated with the second graft layer or sheet itself.
  • the medicants are injected or inserted into the base tissue graft through the second graft layer or sheet, such as using a needle.
  • Additional aspects of the invention comprise a method and system for associating secondary materials, such as medicants and/or one or more secondary tissues, with a tissue graft.
  • the secondary materials may be associated with the tissue graft by spraying or rolling, before or after the base tissue graft has been modified.
  • the secondary material may form a secondary tissue layer on the base tissue graft and/or may otherwise associate secondary materials with the base tissue graft, including the designed surface features thereof.
  • aspects of the invention comprise methods of modifying a tissue graft to create a modified tissue graft, which tissue graft may have features which are selected to address particular objectives relative to a particular anatomical site; modified grafts, including modified tissue grafts which have features which are designed for particular medical indications and/or for a particular anatomical site; and methods of making one or more templates which are usable to modify a tissue graft to create a modified tissue graft, such as by cutting or removing portions of the tissue graft or otherwise create surface patterns or other features.
  • tissue grafts are modified by cutting the graft, removing material from the graft, compressing one or more areas of the graft or otherwise altering the surface(s) of the graft to create a modified tissue graft.
  • Such modifications may, as detailed below, be accomplished in various manners, including via the use of templates such as dies, cutting devices including interval cutting devices, or the like, which may be used to create such modifications.
  • FIG. 1 illustrates a tissue graft 20 in accordance with an embodiment of the invention.
  • the tissue graft 20 comprises a modified tissue graft where cutting, compression and/or removal of segments of graft material (such as spaced or separated by various distances between them) creates recessed expansion patterns (including slots, slits, depressions or openings) of various depths and shapes 22, adhesion projections of various heights and shapes 24, and through holes or openings 26 (including where the shape, location and/or orientation of the feature(s) is selected to achieve certain characteristics, such as expansion in certain directions, stress reduction in certain directions, etc.) ⁇
  • the modifications may be partial depth or thickness and full or “through” depth or thickness.
  • FIGS 2A and 2B illustrate additional examples of tissue grafts 20 which have been modified in particular exemplary manners.
  • the tissue graft 20 has been modified to include a plurality of cuts or slits 30 at one or more portions of a surface thereof, such as a top surface.
  • the cuts 30 are rows of offset cut segments which are aligned with one another. Such a configuration may be referred to as “linear” modification.
  • This configuration might be achieved, for example, using a die having a plurality of blades which, when pressed into a tissue graft, form a modified tissue graft having the cuts or slits 30 as illustrated (wherein, as described below, the die may have blades with adjacent lateral flat stmts or base surfaces which control the depth of cut).
  • a tissue graft may be modified to include one or more curved or curvilinear cuts or modifications.
  • Figure 3B illustrates, in the right-hand comer thereof, modification of a tissue graft to include non-linear cuts or modifications.
  • Such a configuration may be achieved, for example, by use of a die having a plurality of curvilinear blades which, when passed into a tissue graft, form a modified tissue graft having curvilinear cuts or slits 30 (wherein, as describe below, the die may have blades with adjacent lateral flat struts or base surfaces which control the depth of cut).
  • the blades might have various curved shapes, including semi-circular and irregular curved shapes, as well as in forms having combinations of linear and curved portions.
  • FIGS 3A and 3B illustrate one example of patterns of adhesion features 22 and expansion features 24 relative to a top (in Figure 3A) and bottom (in Figure 3B) of a tissue graft 20, which patterns may be used to generate a tissue graft having particular desired characteristics for a particular application, such as described in more detail below relative to Figures 4 and 5 below.
  • aspects of the present invention comprise modified tissue grafts and methods of making the same so that the modified tissue graft has particular characteristics for addressing particular anatomical regions/issues and medical conditions.
  • Such characteristics may comprise one or more of enhanced expansion, flexibility and/or stretch (such as when the tissue graft is to be wrapped about or around an anatomical area or part), traction, glide, adhesion, to reduce stress (such as shear forces), interaction of critical cells (between the graft and site tissue, such as increasing the depth and speed of penetration of the site tissue into the graft) or period of utilization in anatomic areas where it is placed.
  • a step S102 desired characteristics for the graft are identified, such as based upon the anatomical region, characteristics of the injury or wound or the like. Such characteristics might comprise, but are not limited to stress reduction, glide, adhesion, traction, scar reduction, osseous healing and/or integration, disease control, increased rate of healing, etc.
  • a step S103 one or more types of graft modifications are identified, along with regions of the graft to be modified, to achieve the desired characteristics.
  • the graft modifications might comprise one or more of forming cuts, pockets, folds, voids, slots, slits, or other modifications or changes to the graft. Further, the regions might comprise the front and/or back of the graft, or any portions thereof.
  • the graft is modified to create a modified graft. This step might comprise a step S 104A in which one or more dies or templates are obtained or created, such as described herein, which may be used to create the desired graft modifications.
  • One or more dies may then be used to resurface the ends of the graft to create a modified graft as illustrated, such as where the one or more dies are used to create cuts or slits in multiple directions, such as illustrated in Figure 2B.
  • the front and back of a graft might be modified in different manners to achieve different characteristics on each side of the graft.
  • FIG. 7A-D One embodiment of a template or die is illustrated in Figures 7A-D.
  • this template may comprise a cutting die 700.
  • the cutting die 700 has a base 702 with a top surface having a cutting grid 704 extending therefrom.
  • the cutting grid 704 may define a grid of cutting surfaces or blades 706.
  • the cutting surfaces or blades 706 may comprise rows and columns of cutting blades that insect, thus forming a grid of generally quadrilateral (such as rectangular, but potentially square) cutting elements.
  • the base 802 may be constructed of a polymeric material, although other materials might be used.
  • the base 802 might comprise a generally solid piece of DuPont Delrin®.
  • the cutting grid 804 may be constructed from 301 stainless steel.
  • the templates of the invention and/or other apparatus may be used to place such medicants or other materials.
  • one template may be used to modify the tissue graft, such as by creating the surface patterns, while other apparatus or devices may be used to associate the medicants or other materials (such as a medicant implanter, etc.).
  • these functions may be combined (such as by having the template modify the graft and place the medicants or other materials or facilitate their placement by associated apparatus).
  • a base tissue graft 900 may be created as described above, wherein the graft is modified to include one or more medicant retaining or associating features 902 (and may be modified to include other features or enhancements as detailed above, such as to have specific characteristics for a particular anatomical region or medical condition).
  • One or more medicants 904 may then be associated with the base graft 900, such as illustrated in Figure 6C.
  • at least one secondary layer of tissue 906, such as an amnion membrane allograft may be placed thereover, such as illustrated in Figure 9. This creates a multi-layer modified tissue graft 910. In this manner, the medicants are trapped or retained in the base tissue graft.
  • abase tissue graft 1000 may be created as described above, wherein the base graft is modified to include one or more features or enhancements as detailed above (and not shown in Figure 10A).
  • At least one secondary layer of tissue 1006 such as an amnion membrane allograft or a medicant containing sheet, may be placed onto the base tissue graft (again, at one or both sides), such as illustrated in Figure 10A.
  • the secondary tissue layer(s) may be connected to the base tissue graft in various manners.
  • the secondary tissue layer(s) may also be modified to include features or enhancements like the base tissue graft.
  • the base tissue graft 900 might be provided (including as modified with medicant retaining or associating features 902).
  • the medicants 904 might then be applied to the base tissue graft 900, such as by spraying the medicant onto the base tissue graft 900.
  • the at least one secondary layer of tissue 906 might be applied by spraying it onto the base tissue graft 900.
  • a combined solution of medicant and secondary tissue might be applied, such as by spraying or rolling, onto the base tissue graft 900 (whereby the medicant and secondary tissue are applied together).
  • multiple materials might be applied in successive applications of rolling, spraying, etc.
  • a base tissue graft 1100 may be placed on or into a jig 1102 (the shape of which may vary, such as by providing a square support or base for square tissue grafts, by being circular, etc.).
  • the base tissue graft 1100 may be held in a fixed position, such as by connecting it to one or more barbs 1110 (which catch the tissue graft, such as by pressing the graft downwardly onto an upstanding barb) or via other means for securing or connecting.
  • the jib 1102 is thus useful in maintaining a position of a tissue graft 1100, such as in a fixed and stretched position, such as for modification (such as cutting by a die), association of secondary materials, etc.
  • a cover 1104 might be located over the jig 1102 and associated base tissue graft 1100.
  • the cover 1104 may support one or more sprayers or nozzles 1106.
  • multiple nozzles 1106 may be spaced apart over the tissue graft 1110.
  • Secondary material such as medicant, secondary tissue or the like, may be supplied from a supply, such as via a delivery or distribution system from one or more sources. The system may be configured to deliver the secondary material under pressure.
  • materials may be applied in a controlled manner, such as via a metered sprayer, e.g. which permits control over the rate of application.
  • a metered sprayer e.g. which permits control over the rate of application.
  • the amount of medication applied to a tissue graft may be controlled.
  • the amount of medication might also be controlled in additional or other manners, such as by control over the concentration of medicant (or the active ingredient) in a solution being applied, etc.
  • multiple sprayers 1106 might be used to ensure that an even amount of material is distributed across the surface of the tissue graft 1100.
  • different amounts of material might be distributed by different nozzles or sprayers 1106 (such as based upon nozzle size, pressure, etc.) to cause different amounts of material to be distributed to different areas of the tissue graft 1100.
  • One aspect of the invention is a solution comprising a tissue material, such as an amnion fluid or amnion preserved fluid (such as a solution comprising amnion membrane material as a solute in a solvent).
  • a tissue material such as an amnion fluid or amnion preserved fluid (such as a solution comprising amnion membrane material as a solute in a solvent).
  • the solution might comprise a chorion membrane material or other tissue material as described herein as the solute.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Prostheses (AREA)

Abstract

Selon la présente invention, dans un procédé de création d'un greffon tissulaire modifié, au moins une surface extérieure d'un greffon est modifiée en comprimant, découpant et/ou retirant une ou plusieurs parties de celle-ci, par exemple à l'aide d'une matrice pour créer des éléments de surface conçus qui amènent le greffon tissulaire à présenter des caractéristiques pour une zone anatomique spécifique. Le greffon tissulaire modifié peut comprendre une greffe médicamenteuse, par exemple par association de médicaments aux éléments de surface, ou par association d'un second greffon ou d'une seconde couche avec une couche de greffon tissulaire de base modifié, des médicaments étant associés au second greffon ou à la seconde couche. Le greffon tissulaire peut être modifié en pressant un gabarit ou une matrice spécialement conçu(e), par exemple doté(e) de lames, dans le greffon tissulaire, de façon à créer un motif de découpes de profondeur partielle.
EP21775343.3A 2020-03-26 2021-03-17 Greffon tissulaire modifié et procédés et appareil de création d'un greffon tissulaire modifié Pending EP4125711A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16/831,169 US11877921B2 (en) 2010-05-05 2020-03-26 Method and apparatus for creating a modified tissue graft
US17/146,305 US20210128290A1 (en) 2010-05-05 2021-01-11 Method and apparatus for creating a modified tissue graft
PCT/US2021/022691 WO2021194817A1 (fr) 2020-03-26 2021-03-17 Greffon tissulaire modifié et procédés et appareil de création d'un greffon tissulaire modifié

Publications (2)

Publication Number Publication Date
EP4125711A1 true EP4125711A1 (fr) 2023-02-08
EP4125711A4 EP4125711A4 (fr) 2024-04-17

Family

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EP21775343.3A Pending EP4125711A4 (fr) 2020-03-26 2021-03-17 Greffon tissulaire modifié et procédés et appareil de création d'un greffon tissulaire modifié

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EP (1) EP4125711A4 (fr)
CN (1) CN115916109A (fr)
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US6962592B2 (en) * 2002-09-11 2005-11-08 Cortek, Inc. Allograft implant cutting machine
WO2004026244A2 (fr) * 2002-09-18 2004-04-01 Emiliano Ghinelli Utilisation d'une composition a base de membrane amniotique humaine dans la prophylaxie et le traitement de maladies et d'etats pathologiques de l'oeil et de la peau
JP5693475B2 (ja) * 2009-03-04 2015-04-01 ペイタント・ソリューションズ・インコーポレイテッドＰｅｙｔａｎｔ Ｓｏｌｕｔｉｏｎｓ， Ｉｎｃ． 羊膜組織を含む材料で修飾されたステント及び対応する方法
US11701213B2 (en) * 2010-05-05 2023-07-18 Markman Biologics Corporation Method and apparatus for creating a modified tissue graft
US9532866B2 (en) * 2012-03-15 2017-01-03 L&C Bio Co., Ltd. Acellular dermal graft
DK2897625T3 (da) * 2012-09-10 2019-12-16 Univ Wake Forest Health Sciences Amnionmembran og anvendelse deraf til sårheling og tissue engineering-konstrukter
US9545302B2 (en) * 2013-11-20 2017-01-17 Dermagenesis Llc Skin printing and auto-grafting
US10695463B2 (en) * 2015-09-08 2020-06-30 Clemson University Research Foundation Multi-layered biomimetic material and method of formation
MX2018004640A (es) * 2015-10-16 2018-08-01 Lifenet Health Injertos de tejido blando y metodos para la fabricacion y uso de los mismos.
US10105862B1 (en) * 2017-03-31 2018-10-23 Biocut, Llc Fenestrated graft press cutting die assembly

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CN115916109A (zh) 2023-04-04
AU2021242217A1 (en) 2022-12-01
WO2021194817A1 (fr) 2021-09-30
EP4125711A4 (fr) 2024-04-17

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