EP4122483A4 - Oral pharmaceutical composition - Google Patents

Oral pharmaceutical composition Download PDF

Info

Publication number
EP4122483A4
EP4122483A4 EP21772438.4A EP21772438A EP4122483A4 EP 4122483 A4 EP4122483 A4 EP 4122483A4 EP 21772438 A EP21772438 A EP 21772438A EP 4122483 A4 EP4122483 A4 EP 4122483A4
Authority
EP
European Patent Office
Prior art keywords
pharmaceutical composition
oral pharmaceutical
oral
composition
pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21772438.4A
Other languages
German (de)
French (fr)
Other versions
EP4122483A1 (en
Inventor
Ling Fu
Shunhong WANG
Dong REN
Xiaoping Li
Yi MO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xizang Haisco Pharmaceutical Co Ltd
Original Assignee
Xizang Haisco Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xizang Haisco Pharmaceutical Co Ltd filed Critical Xizang Haisco Pharmaceutical Co Ltd
Publication of EP4122483A1 publication Critical patent/EP4122483A1/en
Publication of EP4122483A4 publication Critical patent/EP4122483A4/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
EP21772438.4A 2020-03-18 2021-03-17 Oral pharmaceutical composition Pending EP4122483A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202010179149 2020-03-18
CN202110268405 2021-03-12
PCT/CN2021/081224 WO2021185265A1 (en) 2020-03-18 2021-03-17 Oral pharmaceutical composition

Publications (2)

Publication Number Publication Date
EP4122483A1 EP4122483A1 (en) 2023-01-25
EP4122483A4 true EP4122483A4 (en) 2024-03-27

Family

ID=77770153

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21772438.4A Pending EP4122483A4 (en) 2020-03-18 2021-03-17 Oral pharmaceutical composition

Country Status (5)

Country Link
US (1) US20230172866A1 (en)
EP (1) EP4122483A4 (en)
CN (1) CN115209910A (en)
TW (1) TW202143997A (en)
WO (1) WO2021185265A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240207353A1 (en) * 2021-04-12 2024-06-27 Xizang Haisco Pharmaceutical Co., Ltd. Use of peptide amide compound in preparation of drug for treating pruritus
TW202337460A (en) * 2022-03-23 2023-10-01 大陸商江蘇恩華藥業股份有限公司 Polyamide compounds, method for preparing same, and medical use thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090263479A1 (en) * 2008-04-22 2009-10-22 Solvay Phamaceuticals Gmbh Formulations for poorly permeable active pharmaceutical ingredients
CN101574343A (en) * 2008-05-07 2009-11-11 吉林大学 Medicament composition for treating sugar diabetes
WO2010020978A1 (en) * 2008-08-18 2010-02-25 Oramed Pharmaceuticals Ltd Methods and compositions for oral administration of proteins
WO2019015644A1 (en) * 2017-07-21 2019-01-24 四川海思科制药有限公司 Peptide amide compound and preparation method and medical use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020094346A1 (en) * 1995-05-17 2002-07-18 M. D. Henry C. Lin Method and compositions for improving digestion and absorption in the small intestine
BRPI0718651B8 (en) * 2006-11-10 2021-05-25 Cara Therapeutics Inc synthetic peptide amides
EP3359181A1 (en) * 2015-10-07 2018-08-15 Cyprumed GmbH Pharmaceutical formulations for the oral delivery of peptide drugs
CA3033259A1 (en) * 2016-08-17 2018-02-22 Entera Bio Ltd. Formulations for oral administration of active agents
WO2019042247A1 (en) * 2017-08-28 2019-03-07 江苏恒瑞医药股份有限公司 Pharmaceutical composition of cyp17 inhibitor and preparation method therefor

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090263479A1 (en) * 2008-04-22 2009-10-22 Solvay Phamaceuticals Gmbh Formulations for poorly permeable active pharmaceutical ingredients
CN101574343A (en) * 2008-05-07 2009-11-11 吉林大学 Medicament composition for treating sugar diabetes
WO2010020978A1 (en) * 2008-08-18 2010-02-25 Oramed Pharmaceuticals Ltd Methods and compositions for oral administration of proteins
WO2019015644A1 (en) * 2017-07-21 2019-01-24 四川海思科制药有限公司 Peptide amide compound and preparation method and medical use thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CAROLINE TWAROG ET AL: "Intestinal Permeation Enhancers for Oral Delivery of Macromolecules: A Comparison between Salcaprozate Sodium (SNAC) and Sodium Caprate (C10)", PHARMACEUTICS, vol. 11, no. 2, 13 February 2019 (2019-02-13), pages 78, XP055634457, DOI: 10.3390/pharmaceutics11020078 *
DOI NOBUYUKI ET AL: "Absorption Enhancement Effect of Acylcarnitines through Changes in Tight Junction Protein in Caco-2 Cell Monolayers", DRUG METABOLISM AND PHARMACOKINETICS, vol. 26, no. 2, 1 January 2011 (2011-01-01), JP, pages 162 - 170, XP093129477, ISSN: 1347-4367, DOI: 10.2133/dmpk.DMPK-10-RG-071 *
MORTEN ASSER KARSDAL ET AL: "Lessons learned from the clinical development of oral peptides", BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, BLACKWELL SCIENTIFIC PUBL, GB, vol. 79, no. 5, 22 April 2015 (2015-04-22), pages 720 - 732, XP071601829, ISSN: 0306-5251, DOI: 10.1111/BCP.12557 *
See also references of WO2021185265A1 *

Also Published As

Publication number Publication date
CN115209910A (en) 2022-10-18
US20230172866A1 (en) 2023-06-08
WO2021185265A1 (en) 2021-09-23
EP4122483A1 (en) 2023-01-25
TW202143997A (en) 2021-12-01

Similar Documents

Publication Publication Date Title
GB202019241D0 (en) Pharmaceutical composition
EP4135699A4 (en) Pharmaceutical compositions
EP4221714A4 (en) Oral liquid compositions including chlorpromazine
EP4132511A4 (en) Pharmaceutical compositions comprising meloxicam
EP4122483A4 (en) Oral pharmaceutical composition
IL290469A (en) Oral pharmaceutical composition
EP4110301A4 (en) Pharmaceutical composition for oral administration
EP4129413A4 (en) Composition for oral cavity
EP3845230A4 (en) Pharmaceutical composition for oral administration
EP3979980A4 (en) Oral care composition
EP4032535A4 (en) Pharmaceutical composition
EP3941422A4 (en) Oral care composition
EP3984549A4 (en) Medicinal composition
EP3964264A4 (en) Novel pharmaceutical composition
EP3949952A4 (en) Medicinal composition
EP4129276A4 (en) Pharmaceutical composition
AU2021900367A0 (en) Oral composition
AU2020901334A0 (en) Pharmaceutical composition
AU2023901609A0 (en) Pharmaceutical composition
EP4176868A4 (en) Stable pharmaceutical composition
EP4106716A4 (en) Oral care composition
AU2021410896A9 (en) Oral solid preparation
AU2020903780A0 (en) Pharmaceutical formulations
AU2020903781A0 (en) Pharmaceutical formulations
EP4034072A4 (en) Oral care composition

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20220907

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: XIZANG HAISCO PHARMACEUTICAL CO., LTD.

REG Reference to a national code

Ref country code: DE

Ref legal event code: R079

Free format text: PREVIOUS MAIN CLASS: A61K0038070000

Ipc: A61K0009000000

A4 Supplementary search report drawn up and despatched

Effective date: 20240222

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 31/438 20060101ALI20240216BHEP

Ipc: A61K 9/08 20060101ALI20240216BHEP

Ipc: A61K 47/18 20170101ALI20240216BHEP

Ipc: A61P 25/04 20060101ALI20240216BHEP

Ipc: A61K 47/20 20060101ALI20240216BHEP

Ipc: A61K 9/48 20060101ALI20240216BHEP

Ipc: A61K 9/20 20060101ALI20240216BHEP

Ipc: A61K 38/07 20060101ALI20240216BHEP

Ipc: A61K 9/00 20060101AFI20240216BHEP