EP4100523A4 - Compositions et procédés pour l'expression d'arn circulaire - Google Patents
Compositions et procédés pour l'expression d'arn circulaire Download PDFInfo
- Publication number
- EP4100523A4 EP4100523A4 EP21750796.1A EP21750796A EP4100523A4 EP 4100523 A4 EP4100523 A4 EP 4100523A4 EP 21750796 A EP21750796 A EP 21750796A EP 4100523 A4 EP4100523 A4 EP 4100523A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- compositions
- methods
- rna expression
- circular rna
- circular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091028075 Circular RNA Proteins 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/532—Closed or circular
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14171—Demonstrated in vivo effect
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202062969758P | 2020-02-04 | 2020-02-04 | |
PCT/US2021/025463 WO2021159129A2 (fr) | 2020-02-04 | 2021-04-01 | Compositions et procédés pour l'expression d'arn circulaire |
Publications (2)
Publication Number | Publication Date |
---|---|
EP4100523A2 EP4100523A2 (fr) | 2022-12-14 |
EP4100523A4 true EP4100523A4 (fr) | 2024-03-06 |
Family
ID=77199626
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP21750796.1A Pending EP4100523A4 (fr) | 2020-02-04 | 2021-04-01 | Compositions et procédés pour l'expression d'arn circulaire |
Country Status (6)
Country | Link |
---|---|
US (1) | US20230072954A1 (fr) |
EP (1) | EP4100523A4 (fr) |
JP (1) | JP2023530379A (fr) |
AU (1) | AU2021216593A1 (fr) |
CA (1) | CA3168840A1 (fr) |
WO (1) | WO2021159129A2 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2024121339A1 (fr) * | 2022-12-07 | 2024-06-13 | Circio Ab | Construction d'expression d'arncirc |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107447033A (zh) * | 2017-09-15 | 2017-12-08 | 东南大学 | 一种结直肠癌诊断生物标志物及其应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7385282B2 (ja) * | 2017-11-07 | 2023-11-22 | ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | 環状rna分子のための方法及び組成物 |
-
2021
- 2021-04-01 WO PCT/US2021/025463 patent/WO2021159129A2/fr unknown
- 2021-04-01 AU AU2021216593A patent/AU2021216593A1/en active Pending
- 2021-04-01 CA CA3168840A patent/CA3168840A1/fr active Pending
- 2021-04-01 JP JP2022547232A patent/JP2023530379A/ja active Pending
- 2021-04-01 US US17/796,874 patent/US20230072954A1/en active Pending
- 2021-04-01 EP EP21750796.1A patent/EP4100523A4/fr active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107447033A (zh) * | 2017-09-15 | 2017-12-08 | 东南大学 | 一种结直肠癌诊断生物标志物及其应用 |
Also Published As
Publication number | Publication date |
---|---|
US20230072954A1 (en) | 2023-03-09 |
CA3168840A1 (fr) | 2021-08-12 |
WO2021159129A2 (fr) | 2021-08-12 |
JP2023530379A (ja) | 2023-07-18 |
WO2021159129A3 (fr) | 2021-10-07 |
AU2021216593A1 (en) | 2022-08-25 |
EP4100523A2 (fr) | 2022-12-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP4114939A4 (fr) | Compositions oligonucléotidiques et méthodes associées | |
EP3956449A4 (fr) | Procédés et compositions pour éditer des arn | |
EP3917497A4 (fr) | Compositions oligonucléotidiques et procédés associés | |
IL288284A (en) | Circular Rana preparations and methods | |
EP3691747A4 (fr) | Compositions et procédés d'édition des arn | |
EP4121522A4 (fr) | Méthodes et compositions pour l'édition génomique dirigée | |
IL308746A (en) | Cyclic RNA compositions and methods | |
EP4114360A4 (fr) | Compositions et méthodes d'administration ciblée d'arn | |
EP4153567A4 (fr) | Procédés et compositions pour le ciblage de pd-l1 | |
EP3976798A4 (fr) | Compositions et procédés de régulation sélective de gènes | |
EP4090752A4 (fr) | Procédés et compositions de thérapie génique basée sur la plakophiline 2 | |
EP3980004A4 (fr) | Compositions de tributyrine et procédés associés | |
EP3959334A4 (fr) | Compositions d'hybridation et leurs procédés de fabrication et d'utilisation | |
EP4138879A4 (fr) | Méthodes et compositions | |
EP4114176A4 (fr) | Compositions de stérilisation et leurs procédés d'utilisation | |
EP4100523A4 (fr) | Compositions et procédés pour l'expression d'arn circulaire | |
EP4037709A4 (fr) | Conjugués knottine-immunostimulant et compositions et méthodes associées | |
EP4003003A4 (fr) | Méthodes et compositions de production d'hépatocytes | |
EP3987024A4 (fr) | Compositions et méthodes pour l'édition génomique améliorée | |
AU2022344251A1 (en) | Serpina-modulating compositions and methods | |
AU2022342169A1 (en) | Hbb-modulating compositions and methods | |
EP4100416A4 (fr) | Compositions et procédés pour l'adénylation et le séquençage rapide d'arn | |
EP4149450A4 (fr) | Compositions et procédés de durcissement | |
EP3976787A4 (fr) | Procédés et compositions pour l'administration microbienne d'arn double brin | |
EP3917320A4 (fr) | Compositions et procédés bactéricides |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
17P | Request for examination filed |
Effective date: 20220902 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 40088880 Country of ref document: HK |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20240202 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12N 15/85 20060101ALI20240129BHEP Ipc: C12N 15/79 20060101ALI20240129BHEP Ipc: C12N 15/13 20060101ALI20240129BHEP Ipc: C12N 15/11 20060101AFI20240129BHEP |