EP4096571A4 - Methods of making delmopinol and salts thereof - Google Patents

Methods of making delmopinol and salts thereof Download PDF

Info

Publication number
EP4096571A4
EP4096571A4 EP21748011.0A EP21748011A EP4096571A4 EP 4096571 A4 EP4096571 A4 EP 4096571A4 EP 21748011 A EP21748011 A EP 21748011A EP 4096571 A4 EP4096571 A4 EP 4096571A4
Authority
EP
European Patent Office
Prior art keywords
delmopinol
salts
making
methods
making delmopinol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21748011.0A
Other languages
German (de)
French (fr)
Other versions
EP4096571A1 (en
Inventor
Venkataramana Reddy YEMIREDDY
Balraju VADLA
Vijaya Kumar KONGARA
Vidya Sagar GOTTAM
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
You First Services Inc
Original Assignee
You First Services Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by You First Services Inc filed Critical You First Services Inc
Publication of EP4096571A1 publication Critical patent/EP4096571A1/en
Publication of EP4096571A4 publication Critical patent/EP4096571A4/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
EP21748011.0A 2020-01-31 2021-02-01 Methods of making delmopinol and salts thereof Pending EP4096571A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062968730P 2020-01-31 2020-01-31
PCT/US2021/016040 WO2021155350A1 (en) 2020-01-31 2021-02-01 Methods of making delmopinol and salts thereof

Publications (2)

Publication Number Publication Date
EP4096571A1 EP4096571A1 (en) 2022-12-07
EP4096571A4 true EP4096571A4 (en) 2024-03-06

Family

ID=77079984

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21748011.0A Pending EP4096571A4 (en) 2020-01-31 2021-02-01 Methods of making delmopinol and salts thereof

Country Status (7)

Country Link
US (2) US11780818B2 (en)
EP (1) EP4096571A4 (en)
JP (1) JP7424685B2 (en)
CN (1) CN115315231B (en)
CA (1) CA3169675C (en)
IL (1) IL295228B2 (en)
WO (1) WO2021155350A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4096571A4 (en) * 2020-01-31 2024-03-06 You First Services, Inc. Methods of making delmopinol and salts thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990014342A1 (en) * 1989-05-24 1990-11-29 Pharmacia Ab Substituted isoxazolidines and isoxazolines
WO2007091009A2 (en) * 2006-02-07 2007-08-16 Sinclair Pharmaceuticals Limited Preparation of delmopinol
WO2018115096A1 (en) * 2016-12-23 2018-06-28 Lundbeck Pharmaceuticals Italy S.P.A. Method for the manufacturing of delmopinol
WO2018115111A1 (en) * 2016-12-23 2018-06-28 Lundbeck Pharmaceuticals Italy S.P.A. Method for the manufacturing of 2-(3-(alkyl and alkenyl)morpholino)-ethan-1-ols
WO2018115116A1 (en) * 2016-12-23 2018-06-28 Lundbeck Pharmaceuticals Italy S.P.A. Method for the manufacturing of delmopinol intermediates

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3598814A (en) 1970-01-21 1971-08-10 Carter Wallace 3,3a-dihydro-2h,9h-isoxazolo(3,2-b)(1,3) benzoxazin-9-ones
US5212305A (en) 1989-05-24 1993-05-18 Kabi Pharmacia Aktibolag Process for preparing delmopinol via the intermediates isoxazolidines and isoxazolines
US5085850A (en) * 1990-11-09 1992-02-04 Warner-Lambert Company Anti-plaque compositions comprising a combination of morpholinoamino alcohol and metal salts
GB0502046D0 (en) 2005-02-01 2005-03-09 Sinclair Pharmaceuticals Ltd Method
GB0523435D0 (en) 2005-11-17 2005-12-28 Sinclair Pharmaceuticals Ltd Process
GB0604018D0 (en) 2006-02-28 2006-04-05 Sinclair Pharmaceuticals Ltd Method
GB0615814D0 (en) 2006-08-09 2006-09-20 Sinclair Pharmaceuticals Ltd Medicament
GB0625841D0 (en) 2006-12-22 2007-02-07 Sinclair Pharmaceuticals Ltd Composition
JP2019507193A (en) 2016-03-04 2019-03-14 ジェームズ・エム・ライナーソン Method for treating ocular disorders by inhibiting or interfering with bacterial biofilm formation
IT201700076821A1 (en) 2017-08-24 2019-02-24 Lundbeck Pharmaceuticals Italy S P A NEW SALT OF DELMOPINOL
CN112585690A (en) * 2018-06-21 2021-03-30 阿奎斯蒂弗医疗股份有限公司 System and method for producing individualized individual unit doses containing a pharmaceutically active substance
US20200345624A1 (en) 2019-05-03 2020-11-05 Lee Edward Hudson Nanopore Delivery Device
EP4096571A4 (en) * 2020-01-31 2024-03-06 You First Services, Inc. Methods of making delmopinol and salts thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990014342A1 (en) * 1989-05-24 1990-11-29 Pharmacia Ab Substituted isoxazolidines and isoxazolines
WO2007091009A2 (en) * 2006-02-07 2007-08-16 Sinclair Pharmaceuticals Limited Preparation of delmopinol
WO2018115096A1 (en) * 2016-12-23 2018-06-28 Lundbeck Pharmaceuticals Italy S.P.A. Method for the manufacturing of delmopinol
WO2018115111A1 (en) * 2016-12-23 2018-06-28 Lundbeck Pharmaceuticals Italy S.P.A. Method for the manufacturing of 2-(3-(alkyl and alkenyl)morpholino)-ethan-1-ols
WO2018115116A1 (en) * 2016-12-23 2018-06-28 Lundbeck Pharmaceuticals Italy S.P.A. Method for the manufacturing of delmopinol intermediates

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2021155350A1 *

Also Published As

Publication number Publication date
CN115315231B (en) 2024-03-22
US20240092743A1 (en) 2024-03-21
CN115315231A (en) 2022-11-08
WO2021155350A1 (en) 2021-08-05
CA3169675C (en) 2024-05-28
JP7424685B2 (en) 2024-01-30
IL295228A (en) 2022-10-01
US11780818B2 (en) 2023-10-10
US20230094524A1 (en) 2023-03-30
JP2023508602A (en) 2023-03-02
IL295228B2 (en) 2023-09-01
CA3169675A1 (en) 2021-08-05
EP4096571A1 (en) 2022-12-07
IL295228B1 (en) 2023-05-01

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