EP4081232A4 - Gene therapy systems and related methods for treatment of hearing loss - Google Patents

Gene therapy systems and related methods for treatment of hearing loss

Info

Publication number
EP4081232A4
EP4081232A4 EP21750337.4A EP21750337A EP4081232A4 EP 4081232 A4 EP4081232 A4 EP 4081232A4 EP 21750337 A EP21750337 A EP 21750337A EP 4081232 A4 EP4081232 A4 EP 4081232A4
Authority
EP
European Patent Office
Prior art keywords
treatment
gene therapy
hearing loss
related methods
therapy systems
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21750337.4A
Other languages
German (de)
French (fr)
Other versions
EP4081232A1 (en
Inventor
Hinrich Staecker
Caesar James Ayala
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rescue Hearing Inc
Original Assignee
Rescue Hearing Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US16/783,148 external-priority patent/US20200181596A1/en
Application filed by Rescue Hearing Inc filed Critical Rescue Hearing Inc
Publication of EP4081232A1 publication Critical patent/EP4081232A1/en
Publication of EP4081232A4 publication Critical patent/EP4081232A4/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0541—Cochlear electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36036—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the outer, middle or inner ear
    • A61N1/36038—Cochlear stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Otolaryngology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Radiology & Medical Imaging (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP21750337.4A 2020-02-05 2021-02-04 Gene therapy systems and related methods for treatment of hearing loss Pending EP4081232A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16/783,148 US20200181596A1 (en) 2017-03-17 2020-02-05 Gene therapy systems and related methods for treatment of hearing loss
PCT/US2021/016653 WO2021158814A1 (en) 2020-02-05 2021-02-04 Gene therapy systems and related methods for treatment of hearing loss

Publications (2)

Publication Number Publication Date
EP4081232A1 EP4081232A1 (en) 2022-11-02
EP4081232A4 true EP4081232A4 (en) 2024-02-28

Family

ID=77200377

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21750337.4A Pending EP4081232A4 (en) 2020-02-05 2021-02-04 Gene therapy systems and related methods for treatment of hearing loss

Country Status (9)

Country Link
EP (1) EP4081232A4 (en)
JP (1) JP2023513116A (en)
KR (1) KR20220137652A (en)
CN (1) CN116096391A (en)
AU (1) AU2021216405A1 (en)
BR (1) BR112022015345A2 (en)
CA (1) CA3166104A1 (en)
IL (1) IL295265A (en)
WO (1) WO2021158814A1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018170402A1 (en) * 2017-03-17 2018-09-20 Rescue Hearing Inc Gene therapy constructs and methods for treatment of hearing loss

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7186699B2 (en) * 2003-06-03 2007-03-06 Cell Genesys, Inc. Method for treating cancer by vector-mediated delivery of one or more anti-angiogenic or pro-apoptotic genes
WO2007030743A2 (en) * 2005-09-08 2007-03-15 Massachusetts Eye & Ear Infirmary Cochlear implants containing biological cells and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018170402A1 (en) * 2017-03-17 2018-09-20 Rescue Hearing Inc Gene therapy constructs and methods for treatment of hearing loss

Also Published As

Publication number Publication date
WO2021158814A9 (en) 2022-09-01
AU2021216405A1 (en) 2022-09-15
JP2023513116A (en) 2023-03-30
IL295265A (en) 2022-10-01
KR20220137652A (en) 2022-10-12
CA3166104A1 (en) 2021-08-12
BR112022015345A2 (en) 2022-12-06
CN116096391A (en) 2023-05-09
WO2021158814A1 (en) 2021-08-12
EP4081232A1 (en) 2022-11-02

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Legal Events

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Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230505

A4 Supplementary search report drawn up and despatched

Effective date: 20240131

RIC1 Information provided on ipc code assigned before grant

Ipc: C12N 15/86 20060101ALI20240125BHEP

Ipc: C12N 5/074 20100101ALI20240125BHEP

Ipc: A61P 27/16 20060101ALI20240125BHEP

Ipc: A61N 1/05 20060101ALI20240125BHEP

Ipc: A61K 35/761 20150101AFI20240125BHEP