EP4049035A4 - Functional derivatives of maleimide copolymers for nanodisc production - Google Patents

Functional derivatives of maleimide copolymers for nanodisc production Download PDF

Info

Publication number
EP4049035A4
EP4049035A4 EP20878138.5A EP20878138A EP4049035A4 EP 4049035 A4 EP4049035 A4 EP 4049035A4 EP 20878138 A EP20878138 A EP 20878138A EP 4049035 A4 EP4049035 A4 EP 4049035A4
Authority
EP
European Patent Office
Prior art keywords
nanodisc
production
functional derivatives
maleimide copolymers
maleimide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP20878138.5A
Other languages
German (de)
French (fr)
Other versions
EP4049035A1 (en
Inventor
Michael Overduin
Mansoore ESMAILI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Alberta
Original Assignee
University of Alberta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Alberta filed Critical University of Alberta
Publication of EP4049035A1 publication Critical patent/EP4049035A1/en
Publication of EP4049035A4 publication Critical patent/EP4049035A4/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/12—Hydrolysis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F212/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring
    • C08F212/02—Monomers containing only one unsaturated aliphatic radical
    • C08F212/04—Monomers containing only one unsaturated aliphatic radical containing one ring
    • C08F212/06—Hydrocarbons
    • C08F212/08—Styrene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • C08F8/32—Introducing nitrogen atoms or nitrogen-containing groups by reaction with amines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/34—Introducing sulfur atoms or sulfur-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/48—Isomerisation; Cyclisation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Peptides Or Proteins (AREA)
EP20878138.5A 2019-10-23 2020-10-23 Functional derivatives of maleimide copolymers for nanodisc production Pending EP4049035A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962925086P 2019-10-23 2019-10-23
PCT/US2020/057069 WO2021081329A1 (en) 2019-10-23 2020-10-23 Functional derivatives of maleimide copolymers for nanodisc production

Publications (2)

Publication Number Publication Date
EP4049035A1 EP4049035A1 (en) 2022-08-31
EP4049035A4 true EP4049035A4 (en) 2023-12-06

Family

ID=75620288

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20878138.5A Pending EP4049035A4 (en) 2019-10-23 2020-10-23 Functional derivatives of maleimide copolymers for nanodisc production

Country Status (3)

Country Link
US (1) US20220347114A1 (en)
EP (1) EP4049035A4 (en)
WO (1) WO2021081329A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2613819B (en) * 2021-12-15 2024-08-07 Univ Stellenbosch Terpolymers for lipid nanodisc formation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050032929A1 (en) * 2001-09-26 2005-02-10 Bryan Greener Polymers with structure-defined functions
US20190154698A1 (en) * 2017-11-22 2019-05-23 The Regents Of The University Of Michigan Polymer-Based Lipid Nanodiscs And Macrodiscs

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2426703B (en) * 2005-05-31 2007-09-19 Malvern Cosmeceutics Ltd Compositions
JP2012532853A (en) * 2009-07-08 2012-12-20 ザ ユニバーシティ オブ バーミンガム Solubilization of membrane proteins
US9937152B2 (en) * 2013-11-19 2018-04-10 Hiroshi Maeda Derivative of styrene-maleic acid copolymer
WO2019046573A1 (en) * 2017-08-31 2019-03-07 Texas Tech University System Polymer-encased nanodiscs with improved buffer compatibility

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050032929A1 (en) * 2001-09-26 2005-02-10 Bryan Greener Polymers with structure-defined functions
US20190154698A1 (en) * 2017-11-22 2019-05-23 The Regents Of The University Of Michigan Polymer-Based Lipid Nanodiscs And Macrodiscs

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GRUNDKE K. ET AL: "Wettability of Maleimide Copolymer Films:? Effect of the Chain Length of n -Alkyl Side Groups on the Solid Surface Tension", MACROMOLECULES, vol. 34, no. 19, 17 August 2001 (2001-08-17), US, pages 6768 - 6775, XP093096624, ISSN: 0024-9297, DOI: 10.1021/ma0021592 *
SAVAGE ALICE M. ET AL: "A review of semi-rigid, stilbene-containing alternating copolymers", APPLIED PETROCHEMICAL RESEARCH, vol. 5, no. 1, 16 April 2014 (2014-04-16), pages 27 - 33, XP093096431, ISSN: 2190-5525, Retrieved from the Internet <URL:http://link.springer.com/content/pdf/10.1007/s13203-014-0055-0.pdf> DOI: 10.1007/s13203-014-0055-0 *
See also references of WO2021081329A1 *
SOER W J ET AL: "Surfactant-free artificial latexes from modified styrene-maleic anhydride (SMA) copolymers", POLYMER, ELSEVIER, AMSTERDAM, NL, vol. 47, no. 22, 18 October 2006 (2006-10-18), pages 7621 - 7627, XP028061138, ISSN: 0032-3861, [retrieved on 20061018], DOI: 10.1016/J.POLYMER.2006.09.007 *

Also Published As

Publication number Publication date
US20220347114A1 (en) 2022-11-03
EP4049035A1 (en) 2022-08-31
WO2021081329A1 (en) 2021-04-29

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