EP4022097A4 - Réactifs et procédés de détection d'excrétion de virus adéno-associé - Google Patents
Réactifs et procédés de détection d'excrétion de virus adéno-associé Download PDFInfo
- Publication number
- EP4022097A4 EP4022097A4 EP20856734.7A EP20856734A EP4022097A4 EP 4022097 A4 EP4022097 A4 EP 4022097A4 EP 20856734 A EP20856734 A EP 20856734A EP 4022097 A4 EP4022097 A4 EP 4022097A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- shedding
- reagents
- methods
- aav
- detecting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962893486P | 2019-08-29 | 2019-08-29 | |
PCT/US2020/048654 WO2021042004A1 (fr) | 2019-08-29 | 2020-08-29 | Réactifs et procédés de détection d'excrétion de virus adéno-associé |
Publications (2)
Publication Number | Publication Date |
---|---|
EP4022097A1 EP4022097A1 (fr) | 2022-07-06 |
EP4022097A4 true EP4022097A4 (fr) | 2022-12-14 |
Family
ID=74686060
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP20856734.7A Pending EP4022097A4 (fr) | 2019-08-29 | 2020-08-29 | Réactifs et procédés de détection d'excrétion de virus adéno-associé |
Country Status (4)
Country | Link |
---|---|
US (1) | US20220349017A1 (fr) |
EP (1) | EP4022097A4 (fr) |
CN (1) | CN114302968A (fr) |
WO (1) | WO2021042004A1 (fr) |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA01011635A (es) * | 1999-05-14 | 2003-09-10 | Entpr Ireland Haciendo Negocio | Ensayos diagnosticos basados en sondas de acidos nucleicos para organismos procarioticos y eucarioticos.. |
EP1472335A4 (fr) * | 2001-11-08 | 2005-12-28 | Univ Johns Hopkins | Procedes et systemes pour le sequencage d'acides nucleiques |
US7179629B2 (en) * | 2002-05-15 | 2007-02-20 | Bayer Healthcare Ag | Regulation of human serine/threonine kinase |
US20110129925A1 (en) * | 2008-06-13 | 2011-06-02 | Yushan Yan | Zeolite and bone mimetic zeolite based coatings for bioimplants |
JP2012524540A (ja) * | 2009-04-24 | 2012-10-18 | プロセンサ テクノロジーズ ビー.ブイ. | Dmdを処置するためのイノシンを含むオリゴヌクレオチド |
US9309565B2 (en) * | 2010-05-14 | 2016-04-12 | Life Technologies Corporation | Karyotyping assay |
EP2500434A1 (fr) * | 2011-03-12 | 2012-09-19 | Association Institut de Myologie | Vecteurs AAV sans capside, compositions et procédés pour la production des vecteurs et la thérapie génique |
US10030268B2 (en) * | 2014-11-11 | 2018-07-24 | Abbott Molecular Inc. | Hybridization probes and methods |
TWI707951B (zh) * | 2015-04-08 | 2020-10-21 | 美商健臻公司 | 過大腺相關載體之製造 |
US10799566B2 (en) * | 2015-06-23 | 2020-10-13 | The Children's Hospital Of Philadelphia | Modified factor IX, and compositions, methods and uses for gene transfer to cells, organs, and tissues |
CA2971303A1 (fr) * | 2016-06-21 | 2017-12-21 | Bamboo Therapeutics, Inc. | Genes de mini-dystrophine optimises et cassettes d'expression et leur utilisation |
CA3056638A1 (fr) * | 2017-03-17 | 2018-09-20 | Research Institute At Nationwide Children's Hospital | Administration par vecteur a virus adeno-associe de micro-dystrophine specifique du muscle pour traiter la dystrophie musculaire |
-
2020
- 2020-08-29 US US17/597,826 patent/US20220349017A1/en active Pending
- 2020-08-29 EP EP20856734.7A patent/EP4022097A4/fr active Pending
- 2020-08-29 WO PCT/US2020/048654 patent/WO2021042004A1/fr active Search and Examination
- 2020-08-29 CN CN202080060875.4A patent/CN114302968A/zh active Pending
Non-Patent Citations (5)
Title |
---|
CHRISTINE AURNHAMMER ET AL: "Universal Real-Time PCR for the Detection and Quantification of Adeno-Associated Virus Serotype 2-Derived Inverted Terminal Repeat Sequences", HUMAN GENE THERAPY METHODS, vol. B 23, 1 February 2012 (2012-02-01), pages 18 - 28, XP055346603, ISSN: 1946-6536, DOI: 10.1089/hgtb.2011.034 * |
ROHR ULRICH-PETER ET AL: "Fast and reliable titration of recombinant adeno-associated virus type-2 using quantitative real-time PCR", JOURNAL OF VIROLOGICAL METHODS, vol. 106, no. 1, 1 October 2002 (2002-10-01), NL, pages 81 - 88, XP055977623, ISSN: 0166-0934, DOI: 10.1016/S0166-0934(02)00138-6 * |
See also references of WO2021042004A1 * |
SUSAN D'COSTA ET AL: "Practical utilization of recombinant AAV vector reference standards: focus on vector genomes titration by free ITR qPCR", MOLECULAR THERAPY- METHODS & CLINICAL DEVELOPMENT, vol. 3, 1 January 2016 (2016-01-01), GB, pages 16019, XP055730397, ISSN: 2329-0501, DOI: 10.1038/mtm.2016.19 * |
WANG Z ET AL: "Development of a universal extraction protocol for multiple AAV-based gene therapy shedding assays Concurrent muscle and liver transduction imposes immune tolerance for muscle rAAV gene transfer", HUMAN GENE THERAPY, vol. 30, no. 11, 22 October 2019 (2019-10-22), pages A114, XP055977521 * |
Also Published As
Publication number | Publication date |
---|---|
EP4022097A1 (fr) | 2022-07-06 |
CN114302968A (zh) | 2022-04-08 |
US20220349017A1 (en) | 2022-11-03 |
WO2021042004A1 (fr) | 2021-03-04 |
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Legal Events
Date | Code | Title | Description |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
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17P | Request for examination filed |
Effective date: 20220328 |
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AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
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DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20221111 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12Q 1/70 20060101AFI20221107BHEP |