EP3989976A4 - Lemborexant for treating sleep issues - Google Patents

Lemborexant for treating sleep issues Download PDF

Info

Publication number
EP3989976A4
EP3989976A4 EP20832928.4A EP20832928A EP3989976A4 EP 3989976 A4 EP3989976 A4 EP 3989976A4 EP 20832928 A EP20832928 A EP 20832928A EP 3989976 A4 EP3989976 A4 EP 3989976A4
Authority
EP
European Patent Office
Prior art keywords
lemborexant
treating sleep
sleep issues
issues
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP20832928.4A
Other languages
German (de)
French (fr)
Other versions
EP3989976A1 (en
Inventor
Margaret MOLINE
Lynn Kramer
Shobha DHADDA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
Original Assignee
Eisai R&D Management Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2019/039333 external-priority patent/WO2020263253A1/en
Application filed by Eisai R&D Management Co Ltd filed Critical Eisai R&D Management Co Ltd
Priority claimed from PCT/US2020/039674 external-priority patent/WO2020264201A1/en
Publication of EP3989976A1 publication Critical patent/EP3989976A1/en
Publication of EP3989976A4 publication Critical patent/EP3989976A4/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP20832928.4A 2019-06-26 2020-06-25 Lemborexant for treating sleep issues Pending EP3989976A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US2019/039333 WO2020263253A1 (en) 2019-06-26 2019-06-26 Lemborexant for treating sleep issues
US2019006795 2019-12-20
PCT/US2020/039674 WO2020264201A1 (en) 2019-06-26 2020-06-25 Lemborexant for treating sleep issues

Publications (2)

Publication Number Publication Date
EP3989976A1 EP3989976A1 (en) 2022-05-04
EP3989976A4 true EP3989976A4 (en) 2023-07-19

Family

ID=80857396

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20832928.4A Pending EP3989976A4 (en) 2019-06-26 2020-06-25 Lemborexant for treating sleep issues

Country Status (1)

Country Link
EP (1) EP3989976A4 (en)

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MARGARETMOLINE ET AL: "EFFICACY AND TOLERABILITY OF LEMBOREXANT IN FEMALE AND MALE SUBJECTS WITH INSOMNIA EFFECT OF LEMBOREXANT ON SLEEP ARCHITECTURE IN OLDER ADULTS WITH INSOMNIA DISORDER", SLEEP, 1 January 1201 (1201-01-01), pages a150 - a151, XP093053299 *
MURPHY PATRICIA ET AL: "Lemborexant, A Dual Orexin Receptor Antagonist (DORA) for the Treatment of Insomnia Disorder: Results From a Bayesian, Adaptive, Randomized, Double-Blind, Placebo-Controlled Study", JOURNAL OF CLINICAL SLEEP MEDICINE, vol. 13, no. 11, 15 November 2017 (2017-11-15), US, pages 1289 - 1299, XP055778847, ISSN: 1550-9389, DOI: 10.5664/jcsm.6800 *
See also references of WO2020264201A1 *

Also Published As

Publication number Publication date
EP3989976A1 (en) 2022-05-04

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A4 Supplementary search report drawn up and despatched

Effective date: 20230620

RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 25/28 20060101ALI20230614BHEP

Ipc: A61P 25/20 20060101ALI20230614BHEP

Ipc: A61K 45/06 20060101ALI20230614BHEP

Ipc: A61K 31/519 20060101AFI20230614BHEP