EP3989955A1 - Method for caring for the skin or coat of animals - Google Patents

Method for caring for the skin or coat of animals

Info

Publication number
EP3989955A1
EP3989955A1 EP20734055.5A EP20734055A EP3989955A1 EP 3989955 A1 EP3989955 A1 EP 3989955A1 EP 20734055 A EP20734055 A EP 20734055A EP 3989955 A1 EP3989955 A1 EP 3989955A1
Authority
EP
European Patent Office
Prior art keywords
skin
foam
composition
shampoo
application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP20734055.5A
Other languages
German (de)
French (fr)
Inventor
Mélanie ROUGIER
Claudine ZEMIRLINE
Elodie OLIVIER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ceva Sante Animale SA
Original Assignee
Ceva Sante Animale SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ceva Sante Animale SA filed Critical Ceva Sante Animale SA
Publication of EP3989955A1 publication Critical patent/EP3989955A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/133—Amines having hydroxy groups, e.g. sphingosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A61K9/0017—Non-human animal skin, e.g. pour-on, spot-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/12—Preparations containing hair conditioners

Definitions

  • the invention relates to a process for caring for the skin or the coat of pets, comprising the application of a composition of rinse-out shampoo type, followed by at least four consecutive applications of a composition in the form of non-rinsed foam.
  • the invention also relates to a kit, in particular intended for implementing the method of caring for the skin and / or the coat of pets and in particular for helping to reduce their itching, comprising said compositions in compartments.
  • atopic dermatitis is a chronic, itchy inflammatory dermatosis of multifactorial origin. This disorder results from complex interactions between genetic predisposing factors and environmental factors. The first signs of this disorder in dogs or cats usually appear between 6 months and 3 years old. Lesions mainly involve the face, extremities, major folds and abdomen. Atopic dermatitis or pruritus-like disorders associated with allergic dermatitis are most often treated with antipruritics, antihistamine agents, anti-inflammatory drugs or immunomodulators, such as ciclosporin, corticosteroids or oclacitinib. These treatments are usually accompanied by supportive or care treatments, such as shampoo treatments, to obtain better, faster results or to prevent or delay recurrence.
  • the Applicant has developed a specific protocol for the application of compositions for the skin or the coat of pets that is simple to implement since it only comprises a single application of a rinse-off shampoo during said protocol, this single application of shampoo being followed by applications of compositions which do not require rinsing.
  • This protocol provides very satisfactory results, especially in terms of reducing itching, while making the treatment easier to use and more attractive to owners, thus improving treatment compliance.
  • the invention relates to a method of caring for the skin or the coat of an animal, preferably a pet, comprising the application to the skin or the coat of a shampoo to be rinsed out, followed by at least four consecutive applications to the skin or coat of a composition in the form of a leave-in foam.
  • the process comprises the application of a rinse-out shampoo, followed by 5, 6, 7 or 8 consecutive applications of a composition in the form of a leave-in foam.
  • the shampoo and the composition in the form of a leave-in foam are compositions comprising at least one compound intended to reduce the itching of animals and in particular of pets, such dogs or cats.
  • the invention also relates to a kit, comprising in one or more compartment (s) at least one rinse-out shampoo and at least one composition in the form of a leave-in foam, and optionally an instruction leaflet detailing the method of use of said shampoo. and composition in the form of a leave-in foam, as defined in the present invention.
  • FIG 1 shows the "control" protocol (A) and the protocol according to the invention (B) implemented in Example 1
  • Figure 2 shows the results of studies (A) and (B) in the example (mean CADESI scores).
  • the horizontal lines represented by dashes (-) correspond to the values delimiting the degree of severity (in remission / medium / moderate).
  • the curve represented by broken lines (.7) is that of group (A).
  • the horizontal line represented by dashes ( ⁇ -.) Corresponds to a threshold score of 40%.
  • the curve represented by broken lines (.%) is that of group (A).
  • the curve with a solid line (_) is that of group (B).
  • the present invention therefore relates to a method for caring for the skin or coat of animals, in particular pets, comprising the application of a rinse-off shampoo to the skin or coat of an animal, followed by at least four consecutive applications to the skin or coat of said animal of a composition in the form of a leave-in foam.
  • the method applied to the skin or coat of animals according to the invention can be carried out before, during or after treatment of animals exhibiting skin or coat disorders, and in particular disorders of the atopic dermatitis or pruritus or hyperseborrhea.
  • the method of the invention can therefore be a treatment accompanying or supporting a therapeutic treatment, in particular treatments with antipruritic agents, antihistamine agents, anti-inflammatory agents or immunomodulatory agents, such as corticosteroids, cyclosporine or oclacitinib.
  • the animals to be treated according to the method of the present invention may have previously been diagnosed atopic. They may possibly be in remission of clinical signs of atopic dermatitis. They may be being treated for their atopic condition, in particular being treated with antipruritic agents, antihistamine agents, anti-inflammatory agents or immunomodulatory agents.
  • the method according to the invention can be implemented on animals exhibiting itching or having exhibited itching, optionally independently of a therapeutic treatment, in particular by the systemic route or in particular by injection or by the oral route, in particular with agents. antipruritics, antihistamines, anti-inflammatories or immunomodulators. Itching animals may be very mild or episodic, mild or somewhat more frequent, moderate or present with regular episodes, severe or present with prolonged episodes, or extremely severe or present almost continuously.
  • the method of the invention makes it possible to reduce the itching of animals (or also called non-human mammals), in particular of pets, such as dogs or cats.
  • the method according to the invention is characterized in that each application (subsequent to the first application) is carried out at least 24 hours or preferably at least 48 hours apart from the previous application.
  • the method is implemented such that each of the foam applications consecutive and subsequent to the first application of the rinse-out shampoo is carried out between 24 h and 72 h after the previous application.
  • each of the foam applications consecutive to and subsequent to the first application of the rinse-out shampoo is carried out between 36 hours and 72 hours, and in particular between 48 hours and 72 hours after the previous application.
  • the time intervals between each application of non-rinsed foams can therefore vary between 24 hours and 72 hours, in particular between 36 hours and 72 hours, and more particularly between 48 hours (2 days) and 72 hours (3 days). In particular, it may be the protocol as described in Figure 1.
  • the method according to the invention comprises the following steps: application of the shampoo (J1), application of the composition in the form of a leave-in foam (J3) carried out 48 hours from the shampoo (J1), followed by '' an application of the composition in the form of a leave-in foam (D6) carried out 72 hours after D3, followed by an application of the composition in the form of a leave-in foam (D8) carried out 48 hours after D6, followed by an application of the composition in the form of a leave-in foam (D10) produced 48 hours after D8, followed by an application of the composition in the form of a leave-in foam (D13) carried out 72 hours after D10, followed by an application of the composition in the form of of leave-in foam (D15) carried out 48 hours after D13, followed by an application of the composition in the form of a leave-in foam (D17) carried out 48 hours after D15, followed by an application of the composition in the form of a leave-in foam (D20) carried out 72 hours after D 17.
  • the method comprises the application of a rinse-out shampoo, followed by 4, 5, 6, 7 or preferably 8 consecutive applications of a composition in the form of a leave-in foam.
  • the 4, 5, 6, 7 or preferably 8 consecutive applications of leave-in foam according to the invention are not interrupted by an application of shampoo.
  • the process according to the invention can be spread over a period of approximately 18 to 21 days. It can be repeated one, two or three times, or even more, if necessary.
  • the method further comprises, after said at least 4, 5, 6, 7 or 8 consecutive applications of composition in the form of a leave-in foam, as defined above, at least one step consisting of an application of a rinse-off shampoo, said application of shampoo possibly being followed by consecutive applications of composition in the form of a leave-in foam, in particular said application of shampoo being able to be followed by at least 4 consecutive applications of composition in the form of non-rinsed foam, as described in the present invention.
  • this additional step can be repeated several times, in particular one, two or three times.
  • shampoo includes any composition intended to clean the hair or skin of non-human mammals and requires rinsing with water after application to the animal.
  • shampoos have certain essential characteristics.
  • the shampoos used in the present invention must of course be well tolerated compositions intended for topical application in non-human mammals.
  • a shampoo has wetting, foaming and detergent properties to ensure satisfactory cleansing of the coat or skin.
  • a shampoo composition of the invention contains surfactants, preferably at least one anionic, cationic, amphoteric or polar nonionic surfactant, or else a mixture of these.
  • anionic surfactants there may be mentioned in particular: alkylsulphates (such as magnesium or sodium laurylsulphates), alkylethersulphates (such as laurylethersulphate), alkyl polyethersulphates, alkylsulphonates (alkyl groups having 8 to 18 carbon atoms). carbon), fatty acid soaps, fatty alcohol monosulfosuccinates, condensation products of fatty acids with isethionic acid, condensation products of fatty acids with methyltaurine, condensation products of fatty acids with sarcosine and condensation products of fatty acids with a protein hydrolyzate.
  • alkylsulphates such as magnesium or sodium laurylsulphates
  • alkylethersulphates such as laurylethersulphate
  • alkyl polyethersulphates such as laurylethersulphate
  • alkylsulphonates alkyl groups having 8 to 18 carbon atoms). carbon
  • fatty acid soaps such as magnesium or sodium laurylsulphates
  • cationic surfactants there may be mentioned in particular: long-chain quaternary ammonium compounds, esters of fatty acids and of amino alcohols and polyetheramines.
  • esters of polyols and sugars condensation products of ethylene oxide with acids fatty, with fatty alcohols, with long chain alkylphenols, with long chain mercaptans and with long chain amides, and polyethers of polyhydric fatty alcohols.
  • amphoteric surfactants there may be mentioned in particular: amino acid derivatives, such as asparagine derivatives, condensation products of monochloroacetic acid with imidazolines and alkylaminopropionates, more specifically derivatives of betaine or of imidazoline.
  • amino acid derivatives such as asparagine derivatives, condensation products of monochloroacetic acid with imidazolines and alkylaminopropionates, more specifically derivatives of betaine or of imidazoline.
  • the concentration of surfactants is preferably between 5 and 50% by weight relative to the total weight of the composition.
  • the shampoos according to the invention can also contain other ingredients conventionally used in such compositions, such as agents which increase the viscosity, in particular acrylate / methacrylate copolymers, oils, waxes, plant extracts, emollients, agents. carbomers, gums, in particular xanthan gum, polyethylene glycols, cyclomethicones, conditioners, preservatives, such as methyl para-hydroxybenzoate or propyl parahydroxybenzoate, dyes, perfumes or mixtures thereof.
  • Leave-in foams are therefore suitable for a leave-in application, ie the compositions are not removed by rinsing, and in particular by rinsing with water, after their application.
  • Leave-in foams generally comprise a low concentration of surfactants, generally from 1 to 10%, and preferably from 2 to 4%, by weight relative to the total weight of the composition.
  • the leave-in foams used in the present invention should of course be well-tolerated compositions intended for topical application in the non-human mammal.
  • the leave-in foams that can be used in the present invention can be of different types. These may include:
  • Aerosols in which the foam is generated by a propellant gas, so-called aerosol or spray foams,
  • Foaming formulas not very rich in foaming surfactants but packaged in a packaging fitted with a mechanical foam generating system (pump with pulvorex type grid).
  • non-human mammals or “animals” include all mammals except humans.
  • non-human mammals are companion animals, including, without limitation, domestic animals such as especially dogs, cats, rabbits, ferrets and hamsters.
  • the non-human mammals are cats and preferably dogs.
  • compositions, shampoo and / or leave-in foam compositions used according to the invention are intended for cleaning or washing the skin and / or the coat. They can be used to maintain the health of the skin or coat of animals, in particular by maintaining the skin balance, by maintaining or improving the hydration of the skin, by soothing the skin, or by reducing or soothing the sensations of itching or irritation.
  • the method for caring for the skin or coat of animals according to the invention is a method for cleaning or washing the skin and / or the coat, for maintaining the health of the skin or the coat of animals, to maintain the skin balance, to maintain or improve the hydration of the skin, to soothe the skin, or to reduce or soothe the sensations of itching or irritation.
  • the compositions, shampoo and / or leave-in foam compositions used according to the invention further comprise at least one compound intended to treat or care for the skin or the coat of animals. It may in particular be at least one compound with moisturizing or restructuring properties, a compound intended to improve the barrier effect of the skin or restore its barrier effect, or intended to eliminate or reduce dandruff or excess sebum. , or even intended to reduce itching or help reduce dermatitis in animals, in particular pets.
  • the leave-in compositions, shampoo and / or foam compositions used according to the invention can comprise, as active compounds, antimicrobials (compounds limiting the proliferation of bacteria, yeasts or fungi) or disinfectants, such as chlorhexidine.
  • the compounds intended for treating or helping to care for the skin or the coat of animals can also be, for example, compounds of sphingoid base type or else compounds extracted from plants.
  • the active compounds present in the compositions of the process according to the invention, shampoo and leave-in foam compositions are identical or different, preferably they are identical.
  • the concentration of active compound intended to treat or help care for the skin or the coat is preferably between 0.001 and 30% by weight relative to the total weight. of the composition. More preferred concentrations may vary from 0.005 to 20% by weight%, 0.01 to 10% by weight%, 0.02-5% by weight% or 0.05 to 3% by weight%.
  • Compounds obtained from a plant capable of acting on various factors of animal atopic dermatitis are particularly suitable for helping to reduce itching in animals. It is in particular a compound obtained from Ophiopogon japonicus, as described in particular in patent application WO2017121965. This compound is particularly suitable for use, in topical application to the skin or coat of animals, in an accompanying treatment for the care of atopic animals. It can be used on atopic skin in particular to help decrease or delay the rate of relapse, decrease the severity score of atopic dermatitis in animals (CADESI score), reduce the intensity and / or frequency of itching or pruritus, and more generally to improve the quality of life of the animal and / or its owner.
  • CADESI score severity score of atopic dermatitis in animals
  • active compound obtained from Ophiopogon japonicus within the meaning of the invention is meant any molecule or mixture of molecules obtained from Ophiopogon japonicus. They may be molecules native to the plant or molecules obtained by any type of transformation of the native molecules of the plant, for example by hydrolysis.
  • the active compound according to the invention is preferably a hydrolyzate.
  • hydrolyzate means any extract derived from Ophiopogon japonicus, obtained with a process comprising at least one enzymatic or chemical hydrolysis step of Ophiopogon japonicus, preferably at least one enzymatic hydrolysis step.
  • Ophiopogon japonicus is meant all or part of the plant. It can be the whole plant or part of the plant. Preferably, they are tubers of Ophiopogon japonicus.
  • Ophiopogon japonicus is a perennial, low and abundant herbaceous species with a rhizome of the Liliaceae family.
  • the sphingoid base is preferably selected from the group consisting of sphingosine, sphinganine and phytosphingosine. Phytosphingosine is more particularly preferred. Suitable examples of sphingoid base derivatives include N-lactyloyl-phytosphingosine, N-salicyloyl-phytosphingosine or N-retinoylphytosphingosine, i.e. compounds which are N-substituted.
  • sphingoid base derivatives include salts of sphingoid bases.
  • the anion of the salt can be derived from any suitable acid, i.e., those acids which, when mixed with the sphingoid base in a suitable solid, produce a salt with improved water solubility. Acids which are themselves effective when applied to the coat or skin are preferred.
  • Preferred salts of the sphingoid base for use in the composition of the present invention are the salts obtainable with acids which, when mixed with the above-mentioned sphingoid base in a suitable solvent, produce a salt having increased water solubility over the water solubility of the sphingoid base as such.
  • Phytosphingosine salts are preferred for better solubility and better bioavailability.
  • the acid is a hydrophilic acid capable of delivering the sphingoid base salt to the aqueous phase of the veterinary composition.
  • Suitable hydrophilic acids include a-hydroxy alkanoic acid, an (hydroxy-3-alkanoic acid, an ⁇ , p-dihydroxy alkanoic acid, an alkanedioic acid or a mineral acid.
  • Examples of preferred hydrophilic organic acids are. lactic acid, glycolic acid, malic acid, pyruvic acid, succinic acid, fumaric acid, ascorbic acid, gluconic acid and / or pyroglutamic acid, examples of acids preferred minerals are hydrochloric acid, nitric acid and / or phosphoric acid.
  • the acid is a lipophilic organic acid to enable the effectiveness of the lipophilic acid and the sphingoid base in the sphingoid base salt to be increased.
  • the method according to the invention may comprise one or more steps additional to those mentioned above, for example previous or subsequent steps. It is also possible to envisage repeating the successive steps of the process according to the invention. Thus, the protocol detailed in Figure 1 (B) can be repeated as many times as necessary, without requiring any downtime if deemed appropriate.
  • An additional object according to the invention is a kit comprising in one or more compartment (s) at least one rinse-out shampoo and at least one composition in the form of a leave-in foam, and optionally an instruction manual detailing the method of use. of said shampoo and composition, as defined in the present invention.
  • the composition in the form of a rinse-off foam can be presented in a single compartment or in several compartments. In the latter case, each compartment preferably comprises a composition in the form of a leave-in foam corresponding to each of the at least four consecutive applications.
  • the kit has at least four compartments each comprising a composition in the form of a leave-in foam and another compartment comprising the shampoo to be rinsed out.
  • Example 1 Treatment of dogs according to the present invention compared to a conventional protocol
  • the aim of this study was to evaluate the effectiveness of a combination of shampoo and foam comprising phytosphingosine, from the range of products (Douxo Calm®, sold by the company Ceva Santé Animale) during a relapse crisis of atopic dermatitis in dogs.
  • Douxo Calm® sold by the company Ceva Santé Animale
  • the treatment consisted for the study (A) (control) of applications of a shampoo on D1, D8 and D15, and twice weekly applications of a leave-in foam between the applications of shampoo D1, D8 and J15 ( Figure 1 (A).
  • Figure 2A shows the average changes in the CADESI score for each of the studies (A) and (B).
  • a decrease in the CADESI score was observed during treatment ( Figure 2A).
  • the mean percentage decrease was close to the expected threshold of -40% for group (A) and below the threshold of -40% for group (B), which means that in general after 21 days of treatment, CADESI is reduced on average by less than 40% ( Figure 2B).
  • the mean percentages of CADESI change are -39.8 ⁇ 23.1% for group (A) and -75.6 ⁇ 19.0% for group (B).
  • the primary endpoint was based on the percentage decrease in CADESI between D0 and D21. Thus, a higher percentage obtained can be used as the main criterion distinguishing the groups tested. Different percentages were tested (see Table 1). Table 1 provides information on the number of dogs that achieved the specific percentage decrease in CADESI. The 50% threshold corresponds to the level of difference observed between the two protocols, in fact only one dog reached this threshold for group (A), while 6 out of 7 dogs reached it in group (B).

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Abstract

The invention concerns a method for caring for the skin or coat of animals, comprising the application of a rinse-off shampoo, followed by at least four consecutive applications of a composition in the form of a non-rinse-off foam. The invention also concerns a kit, in particular intended to implement a method for caring for the skin or coat of animals and, more specifically, to help reduce their itching.

Description

PROCEDE DE SOIN DE LA PEAU OU DU PELAGE D’ANIMAUX PROCEDURE FOR CARING FOR THE SKIN OR COAT OF ANIMALS
DOMAINE DE L’INVENTION FIELD OF THE INVENTION
L’invention est relative à un procédé de soin de la peau ou du pelage d’animaux de compagnie, comprenant l’application d’une composition de type shampooing à rincer, suivie d’au moins quatre applications consécutives d’une composition sous forme de mousse non rincée. L’invention a trait également à un kit, en particulier destiné à mettre en oeuvre le procédé de soin de la peau et/ou du pelage des animaux de compagnie et en particulier pour aider à diminuer leurs démangeaisons, comprenant lesdites compositions dans des compartiments. The invention relates to a process for caring for the skin or the coat of pets, comprising the application of a composition of rinse-out shampoo type, followed by at least four consecutive applications of a composition in the form of non-rinsed foam. The invention also relates to a kit, in particular intended for implementing the method of caring for the skin and / or the coat of pets and in particular for helping to reduce their itching, comprising said compositions in compartments.
PRESENTATION DE L’ETAT DE LA TECHNIQUE PRESENTATION OF THE STATE OF THE ART
Les animaux de compagnie, tels que les chiens et les chats, ont fréquemment des problèmes de peau et de pelage ou des troubles cutanés ou du pelage, tels que : peau sèche, desquamation, prurit, démangeaisons, irritation de la peau, perte excessive de poils et pelage terne. Les problèmes de démangeaisons de la peau varient entre des démangeaisons très légères ou épisodiques à des démangeaisons extrêmement sévères ou presque continues. Pets, such as dogs and cats, frequently have skin and coat problems or skin or coat disorders, such as: dry skin, peeling, pruritus, itching, skin irritation, excessive loss of hair and coat dull. Itchy skin problems vary from very mild or episodic itching to extremely severe or almost continuous itching.
Chez l'animal, la dermatite atopique est une dermatose inflammatoire chronique et prurigineuse d'origine multifactorielle. Ce désordre résulte d'interactions complexes entre les facteurs de prédisposition génétique et des facteurs environnementaux. Les premiers signes de ce désordre chez les chiens ou les chats apparaissent généralement entre 6 mois et 3 ans. Les lésions impliquent principalement la face, les extrémités, les grands plis et l'abdomen. Les désordres de type dermatite atopique ou de prurit associé à des dermatites allergiques sont la plupart du temps traités par des antiprurigineux, des agents antihistaminiques, des antiinflammatoires ou des immunomodulateurs, tels que la ciclosporine, des corticoïdes ou l’oclacitinib. Ces traitements sont généralement accompagnés de traitements de soutien ou de soin, tels que des traitements par shampooings, pour obtenir des résultats meilleurs, plus rapides ou pour prévenir ou retarder les récidives. In animals, atopic dermatitis is a chronic, itchy inflammatory dermatosis of multifactorial origin. This disorder results from complex interactions between genetic predisposing factors and environmental factors. The first signs of this disorder in dogs or cats usually appear between 6 months and 3 years old. Lesions mainly involve the face, extremities, major folds and abdomen. Atopic dermatitis or pruritus-like disorders associated with allergic dermatitis are most often treated with antipruritics, antihistamine agents, anti-inflammatory drugs or immunomodulators, such as ciclosporin, corticosteroids or oclacitinib. These treatments are usually accompanied by supportive or care treatments, such as shampoo treatments, to obtain better, faster results or to prevent or delay recurrence.
Toutefois, de manière générale, il est constaté que les traitements d’accompagnement au soin par shampooing sont peu suivis par les propriétaires d’animaux car leur mise en oeuvre n’est pas pratique puisqu’ils nécessitent un rinçage des shampooings, ce qui peut être particulièrement éprouvant lorsque les animaux ont de longs poils ou sont de nature nerveuse. L’application répétée de shampooings à rincer peut également réduire l’efficacité de traitements topiques contre les tiques et les puces, en particulier si un décalage temporel entre l’application de l’anti-parasitaire et le soin cutané n’est pas respecté. However, in general, it is observed that the treatments accompanying care by shampooing are little followed by the owners of animals because their implementation is not practical since they require rinsing of the shampoos, which can be especially taxing when animals have long hair or are nervous in nature. Repeated application of rinse-out shampoos may also reduce the effectiveness of topical treatments for ticks and fleas, particularly if a time lag between the application of the anti-parasitic and the skin care is not respected.
Ainsi, il subsiste un besoin de mettre au point des protocoles de soin de la peau ou du pelage des animaux de compagnie faciles à mettre en oeuvre tout en étant aussi actifs voire plus actifs que les protocoles connus à ce jour. Thus, there remains a need to develop protocols for caring for the skin or the coat of pets that are easy to implement while being as active or even more active than the protocols known to date.
La Demanderesse a mis au point un protocole particulier d’application de compositions pour la peau ou le pelage des animaux de compagnie simple à mettre en oeuvre puisqu’il ne comprend qu’une seule application d’un shampooing à rincer au cours dudit protocole, cette unique application de shampooing étant suivie d’applications de compositions qui ne nécessitent pas de rinçage. Ce protocole permet d’obtenir des résultats très satisfaisants, notamment en terme de diminution des démangeaisons, tout en rendant le traitement plus facile à l’usage et plus attrayant pour les propriétaires, améliorant ainsi l’observance du traitement. The Applicant has developed a specific protocol for the application of compositions for the skin or the coat of pets that is simple to implement since it only comprises a single application of a rinse-off shampoo during said protocol, this single application of shampoo being followed by applications of compositions which do not require rinsing. This protocol provides very satisfactory results, especially in terms of reducing itching, while making the treatment easier to use and more attractive to owners, thus improving treatment compliance.
RESUME DE L’INVENTION SUMMARY OF THE INVENTION
L’invention a pour objet un procédé de soin de la peau ou du pelage d’un animal, de préférence un animal de compagnie, comprenant l’application sur la peau ou le pelage d’un shampooing à rincer, suivie d’au moins quatre applications consécutives sur la peau ou le pelage d’une composition sous forme de mousse non rincée. The invention relates to a method of caring for the skin or the coat of an animal, preferably a pet, comprising the application to the skin or the coat of a shampoo to be rinsed out, followed by at least four consecutive applications to the skin or coat of a composition in the form of a leave-in foam.
En particulier, le procédé comprend l’application d’un shampooing à rincer, suivie de 5, 6, 7 ou 8 applications consécutives d’une composition sous forme de mousse non rincée. Dans certains modes de réalisation, le shampooing et la composition sous forme de mousse non rincée sont des compositions comprenant au moins un composé destiné à diminuer les démangeaisons des animaux et en particulier des animaux de compagnie, tels chiens ou chats. In particular, the process comprises the application of a rinse-out shampoo, followed by 5, 6, 7 or 8 consecutive applications of a composition in the form of a leave-in foam. In certain embodiments, the shampoo and the composition in the form of a leave-in foam are compositions comprising at least one compound intended to reduce the itching of animals and in particular of pets, such dogs or cats.
L’invention concerne aussi un kit, comprenant dans un ou plusieurs compartiment(s) au moins un shampooing à rincer et au moins une composition sous forme de mousse non rincée, et éventuellement une notice d’instructions détaillant le procédé d’utilisation desdits shampooing et composition sous forme de mousse non rincée, tel que défini dans la présente invention. The invention also relates to a kit, comprising in one or more compartment (s) at least one rinse-out shampoo and at least one composition in the form of a leave-in foam, and optionally an instruction leaflet detailing the method of use of said shampoo. and composition in the form of a leave-in foam, as defined in the present invention.
FIGURES FIGURES
La Figure 1 présente le protocole « témoin » (A) et le protocole selon l’invention (B) mis en oeuvre à l’exemple 1 Figure 1 shows the "control" protocol (A) and the protocol according to the invention (B) implemented in Example 1
La Figure 2 montre les résultats des études (A) et (B) de l’exemple (scores moyens CADESI). A) Score moyen CADESI des deux études. - CADESI-04 en % de changement par rapport à JO -moyenne avec Intervalle de confiance (IC) à 95%). Les lignes horizontales représentées par des tirets ( - ) correspondent aux valeurs délimitant le degré de sévérité (en rémission / moyen / modéré). La courbe représentée par des traits discontinus ( .... ) est celle du groupe (A). La courbe représentée par un trait continuFigure 2 shows the results of studies (A) and (B) in the example (mean CADESI scores). A) Average CADESI score of the two studies. - CADESI-04 in% change relative to OJ -mean with 95% Confidence Interval (CI)). The horizontal lines represented by dashes (-) correspond to the values delimiting the degree of severity (in remission / medium / moderate). The curve represented by broken lines (....) is that of group (A). The curve represented by a continuous line
( _ ) est celle du groupe (B). B) Les scores CADESI des deux groups (A) et (B) des études de l’exemple sont présentés sous forme de pourcentages de changements ((Jx-(_) is that of group (B). B) The CADESI scores of the two groups (A) and (B) of the studies in the example are presented in the form of percentages of changes ((Jx-
J0/J0)X100). La ligne horizontale représentée par des tirets (·- . ) correspond à un score seuil de 40%. La courbe représentée par des traits discontinus ( .... ) est celle du groupe (A). La courbe par un trait continu ( _ ) est celle du groupe (B). J0 / J0) X100). The horizontal line represented by dashes (· -.) Corresponds to a threshold score of 40%. The curve represented by broken lines (....) is that of group (A). The curve with a solid line (_) is that of group (B).
DESCRIPTION DETAILLEE DE L’INVENTION DETAILED DESCRIPTION OF THE INVENTION
La présente invention a donc trait à un procédé de soin de la peau ou du pelage d’animaux, en particulier d’animaux de compagnie, comprenant l’application d’un shampooing à rincer sur la peau ou le pelage d’un animal, suivie d’au moins quatre applications consécutives sur la peau ou le pelage dudit animal d’une composition sous forme de mousse non rincée. The present invention therefore relates to a method for caring for the skin or coat of animals, in particular pets, comprising the application of a rinse-off shampoo to the skin or coat of an animal, followed by at least four consecutive applications to the skin or coat of said animal of a composition in the form of a leave-in foam.
Le procédé appliqué à la peau ou au pelage d’animaux selon l’invention peut être mis en oeuvre avant, pendant ou après un traitement d’animaux présentant des troubles cutanés ou du pelage, et en particulier des désordres de type dermatite atopique ou de prurit ou d’hyperseborrhée. Le procédé de l’invention peut donc être un traitement d’accompagnement ou de soutien à un traitement thérapeutique, notamment des traitements avec des agents antiprurigineux, des agents antihistaminiques, des agents antiinflammatoires ou des agents immunomodulateurs, tels que les corticoïdes, la ciclosporine ou l’oclacitinib. Ainsi, les animaux à traiter selon le procédé de la présente invention peuvent avoir été précédemment diagnostiqués atopiques. Ils peuvent être éventuellement en période de rémission des signes cliniques de dermatite atopique. Ils peuvent être en cours de traitement de leur condition atopique, notamment traités avec des agents antiprurigineux, des agents antihistaminiques, des agents antiinflammatoires ou des agents immunomodulateurs. The method applied to the skin or coat of animals according to the invention can be carried out before, during or after treatment of animals exhibiting skin or coat disorders, and in particular disorders of the atopic dermatitis or pruritus or hyperseborrhea. The method of the invention can therefore be a treatment accompanying or supporting a therapeutic treatment, in particular treatments with antipruritic agents, antihistamine agents, anti-inflammatory agents or immunomodulatory agents, such as corticosteroids, cyclosporine or oclacitinib. Thus, the animals to be treated according to the method of the present invention may have previously been diagnosed atopic. They may possibly be in remission of clinical signs of atopic dermatitis. They may be being treated for their atopic condition, in particular being treated with antipruritic agents, antihistamine agents, anti-inflammatory agents or immunomodulatory agents.
Le procédé selon l’invention peut être mis en oeuvre sur des animaux présentant des démangeaisons ou ayant présenté des démangeaisons, éventuellement indépendamment d’un traitement thérapeutique, en particulier par voie systémique ou en particulier par injection ou par voie orale, notamment avec des agents antiprurigineux, antihistaminiques, antiinflammatoires ou immunomodulateurs. Les démangeaisons des animaux peuvent être très légères ou épisodiques, légères ou un peu plus fréquentes, modérées ou présentes à épisodes réguliers, sévères ou présentes à épisodes prolongés, ou extrêmement sévères ou présentes de manière presque continue. The method according to the invention can be implemented on animals exhibiting itching or having exhibited itching, optionally independently of a therapeutic treatment, in particular by the systemic route or in particular by injection or by the oral route, in particular with agents. antipruritics, antihistamines, anti-inflammatories or immunomodulators. Itching animals may be very mild or episodic, mild or somewhat more frequent, moderate or present with regular episodes, severe or present with prolonged episodes, or extremely severe or present almost continuously.
Selon un mode particulier, le procédé de l’invention permet de diminuer les démangeaisons des animaux (ou encore appelés mammifères non humains), en particulier des animaux de compagnie, tels que chiens ou chats. According to a particular mode, the method of the invention makes it possible to reduce the itching of animals (or also called non-human mammals), in particular of pets, such as dogs or cats.
Selon un mode particulier, le procédé selon l’invention est caractérisé en ce que chaque application (ultérieure à la première application) est réalisée à au moins 24 heures ou de préférence au moins 48 heures d’intervalle de l’application précédente. De manière préférée, le procédé est mis en oeuvre de telle sorte que chacune des applications de mousse consécutives et ultérieures à la première application du shampooing à rincer est réalisée entre 24 h et 72h après l’application précédente. De manière encore plus préférée, chacune des applications de mousse consécutives et ultérieures à la première application du shampooing à rincer est réalisée entre 36h et 72h, et en particulier entre 48 h et 72h après l’application précédente. Les intervalles de temps entre chaque application de mousses non rincées peuvent donc varier entre 24h et 72h, en particulier entre 36h et 72h, et plus particulièrement entre 48h (2 jours) et 72h (3 jours). Il peut en particulier s’agir du protocole tel que décrit à la figure 1 . According to a particular embodiment, the method according to the invention is characterized in that each application (subsequent to the first application) is carried out at least 24 hours or preferably at least 48 hours apart from the previous application. Preferably, the method is implemented such that each of the foam applications consecutive and subsequent to the first application of the rinse-out shampoo is carried out between 24 h and 72 h after the previous application. Even more preferably, each of the foam applications consecutive to and subsequent to the first application of the rinse-out shampoo is carried out between 36 hours and 72 hours, and in particular between 48 hours and 72 hours after the previous application. The time intervals between each application of non-rinsed foams can therefore vary between 24 hours and 72 hours, in particular between 36 hours and 72 hours, and more particularly between 48 hours (2 days) and 72 hours (3 days). In particular, it may be the protocol as described in Figure 1.
Ainsi, de manière plus spécifique, le procédé selon l’invention comprend les étapes suivantes : application du shampooing (J1 ), application de la composition sous forme de mousse non rincée (J3) réalisée à 48 heures du shampooing (J1 ), suivie d’une application de la composition sous forme de mousse non rincée (J6) réalisée 72 heures après J3, suivi d’une application de la composition sous forme de mousse non rincée (J8) réalisée 48 heures après J6, suivi d’une application de la composition sous forme de mousse non rincée (J10) réalisée 48 heures après J8, suivi d’une application de la composition sous forme de mousse non rincée (J13) réalisée 72 heures après J10, suivi d’une application de la composition sous forme de mousse non rincée (J15) réalisée 48 heures après J13, suivi d’une application de la composition sous forme de mousse non rincée (J17) réalisée 48 heures après J15, suivi d’une application de la composition sous forme de mousse non rincée (J20) réalisée 72 heures après J17. Thus, more specifically, the method according to the invention comprises the following steps: application of the shampoo (J1), application of the composition in the form of a leave-in foam (J3) carried out 48 hours from the shampoo (J1), followed by '' an application of the composition in the form of a leave-in foam (D6) carried out 72 hours after D3, followed by an application of the composition in the form of a leave-in foam (D8) carried out 48 hours after D6, followed by an application of the composition in the form of a leave-in foam (D10) produced 48 hours after D8, followed by an application of the composition in the form of a leave-in foam (D13) carried out 72 hours after D10, followed by an application of the composition in the form of of leave-in foam (D15) carried out 48 hours after D13, followed by an application of the composition in the form of a leave-in foam (D17) carried out 48 hours after D15, followed by an application of the composition in the form of a leave-in foam (D20) carried out 72 hours after D 17.
Selon un mode préféré, le procédé comprend l’application d’un shampooing à rincer, suivie de 4, 5, 6, 7 ou de préférence 8 applications consécutives d’une composition sous forme de mousse non rincée. Ainsi, de manière plus spécifique, les 4, 5, 6, 7 ou de préférence 8 applications consécutives de mousse non rincée selon l’invention ne sont pas interrompues par une application de shampooing. Le procédé selon l’invention peut s’étaler sur une période de 18 à 21 jours environ. Il peut être répété une, deux ou trois fois, voire plus, si nécessaire. According to a preferred embodiment, the method comprises the application of a rinse-out shampoo, followed by 4, 5, 6, 7 or preferably 8 consecutive applications of a composition in the form of a leave-in foam. Thus, more specifically, the 4, 5, 6, 7 or preferably 8 consecutive applications of leave-in foam according to the invention are not interrupted by an application of shampoo. The process according to the invention can be spread over a period of approximately 18 to 21 days. It can be repeated one, two or three times, or even more, if necessary.
Ainsi, selon un mode particulier, le procédé comprend en outre, après lesdites au moins 4, 5, 6, 7 ou 8 applications consécutives de composition sous forme de mousse non rincée, telles que définies ci-dessus, au moins une étape consistant en une application d’un shampooing à rincer, ladite application de shampooing pouvant être suivie d’applications consécutives de composition sous forme de mousse non rincée, en particulier ladite application de shampooing pouvant être suivie d’au moins 4 applications consécutives de composition sous forme de mousse non rincée, telles que décrites dans la présente invention. Selon un mode plus particulier, cette étape supplémentaire pouvant être répétée plusieurs fois, en particulier une, deux ou trois fois. Thus, according to a particular embodiment, the method further comprises, after said at least 4, 5, 6, 7 or 8 consecutive applications of composition in the form of a leave-in foam, as defined above, at least one step consisting of an application of a rinse-off shampoo, said application of shampoo possibly being followed by consecutive applications of composition in the form of a leave-in foam, in particular said application of shampoo being able to be followed by at least 4 consecutive applications of composition in the form of non-rinsed foam, as described in the present invention. According to a more particular embodiment, this additional step can be repeated several times, in particular one, two or three times.
Tel qu'utilisé ici, le terme "shampooing" comprend toute composition destinée à nettoyer les poils ou la peau de mammifères non humains et nécessite un rinçage à l'eau après application sur l’animal. Généralement, les shampooings possèdent certaines caractéristiques essentielles. Les shampooings utilisés dans la présente invention doivent être bien entendu des compositions bien tolérées destinées à une application topique chez le mammifère non humain. Un shampooing possède des propriétés mouillantes, moussantes et détergentes afin d’assurer un nettoyage satisfaisant du pelage ou de la peau. De manière générale, une composition de shampooing de l'invention contient des agents tensioactifs, de préférence au moins un agent tensioactif anionique, cationique, amphotère, ou non ionique polaire, ou encore un mélange de ceux-ci. As used herein, the term "shampoo" includes any composition intended to clean the hair or skin of non-human mammals and requires rinsing with water after application to the animal. Generally, shampoos have certain essential characteristics. The shampoos used in the present invention must of course be well tolerated compositions intended for topical application in non-human mammals. A shampoo has wetting, foaming and detergent properties to ensure satisfactory cleansing of the coat or skin. In general, a shampoo composition of the invention contains surfactants, preferably at least one anionic, cationic, amphoteric or polar nonionic surfactant, or else a mixture of these.
Parmi les tensioactifs anioniques, on peut citer en particulier : les alkylsulfates (tels que les laurylsulfates de magnésium ou de sodium), les alkyléthersulfates (tels que le lauryléthersulfate), les alkyl polyéthersulfates, les alkylsulfonates (les groupes alkyles ayant 8 à 18 atomes de carbone), savons d’acides gras, monosulfosuccinates d’alcools gras, produits de condensation d’acides gras avec l’acide iséthionique, produits de condensation d’acides gras avec la méthyltaurine, produits de condensation d’acides gras avec la sarcosine et produits de condensation d’acides gras avec un hydrolysat de protéines. Among the anionic surfactants, there may be mentioned in particular: alkylsulphates (such as magnesium or sodium laurylsulphates), alkylethersulphates (such as laurylethersulphate), alkyl polyethersulphates, alkylsulphonates (alkyl groups having 8 to 18 carbon atoms). carbon), fatty acid soaps, fatty alcohol monosulfosuccinates, condensation products of fatty acids with isethionic acid, condensation products of fatty acids with methyltaurine, condensation products of fatty acids with sarcosine and condensation products of fatty acids with a protein hydrolyzate.
Parmi les tensioactifs cationiques, on peut citer en particulier : les composés d'ammonium quaternaire à longue chaîne, les esters d'acides gras et d'amino-alcools et les polyétheramines. Among the cationic surfactants, there may be mentioned in particular: long-chain quaternary ammonium compounds, esters of fatty acids and of amino alcohols and polyetheramines.
Parmi les tensioactifs non ioniques polaires, on peut citer notamment : les esters de polyols et de sucres, les produits de condensation de l'oxyde d'éthylène avec les acides gras, avec les alcools gras, avec les alkylphénols à longue chaîne, avec les mercaptans à longue chaîne et avec les amides à longue chaîne, et les polyéthers d'alcools gras polyhydroxyliques. Among the polar nonionic surfactants, there may be mentioned in particular: esters of polyols and sugars, condensation products of ethylene oxide with acids fatty, with fatty alcohols, with long chain alkylphenols, with long chain mercaptans and with long chain amides, and polyethers of polyhydric fatty alcohols.
Parmi les tensioactifs amphotères, on peut citer en particulier : les dérivés d'aminoacides, tels que les dérivés d'asparagine, les produits de condensation de l'acide monochloroacétique avec des imidazolines et des alkylaminopropionates, plus spécifiquement des dérivés de la bétaïne ou de l'imidazoline. Among the amphoteric surfactants, there may be mentioned in particular: amino acid derivatives, such as asparagine derivatives, condensation products of monochloroacetic acid with imidazolines and alkylaminopropionates, more specifically derivatives of betaine or of imidazoline.
Dans les compositions de shampooing, la concentration en tensioactifs est de préférence comprise entre 5 et 50 % en poids par rapport au poids total de la composition. Les shampooings selon l'invention peuvent également contenir d'autres ingrédients classiquement utilisés dans de telles compositions, tels que des agents augmentant la viscosité, en particulier des copolymères acrylate / méthacrylate, des huiles, des cires, des extraits végétaux, des émollients, des carbomères, des gommes, en particulier de la gomme de xanthane, les polyéthylèneglycols, les cyclométhicones, les conditionneurs, les conservateurs, tels que le para-hydroxybenzoate de méthyle ou le parahydroxybenzoate de propyle, les colorants, les parfums ou leurs mélanges. In the shampoo compositions, the concentration of surfactants is preferably between 5 and 50% by weight relative to the total weight of the composition. The shampoos according to the invention can also contain other ingredients conventionally used in such compositions, such as agents which increase the viscosity, in particular acrylate / methacrylate copolymers, oils, waxes, plant extracts, emollients, agents. carbomers, gums, in particular xanthan gum, polyethylene glycols, cyclomethicones, conditioners, preservatives, such as methyl para-hydroxybenzoate or propyl parahydroxybenzoate, dyes, perfumes or mixtures thereof.
Les mousses non rincées sont donc adaptées à une application non rincée, c'est-à-dire que les compositions ne sont pas éliminées par rinçage, et notamment par rinçage à l’eau, après leur application. Les mousses non rincées comprennent généralement une concentration en tensioactifs faible, généralement de 1 à 10%, et de préférence de 2 à 4%, en poids par rapport au poids total de la composition. Leave-in foams are therefore suitable for a leave-in application, ie the compositions are not removed by rinsing, and in particular by rinsing with water, after their application. Leave-in foams generally comprise a low concentration of surfactants, generally from 1 to 10%, and preferably from 2 to 4%, by weight relative to the total weight of the composition.
Les mousses non rincées utilisées dans la présente invention doivent bien entendu être des compositions bien tolérées destinées à une application topique chez le mammifère non humain. The leave-in foams used in the present invention should of course be well-tolerated compositions intended for topical application in the non-human mammal.
Les mousses non rincées utilisables dans la présente invention peuvent être de différents types. Il peut s’agir notamment : The leave-in foams that can be used in the present invention can be of different types. These may include:
- Des aérosols, dans lesquels la mousse est générée par un gaz propulseur, mousses dites aérosol ou spray, - Aerosols, in which the foam is generated by a propellant gas, so-called aerosol or spray foams,
- Des crèmes foisonnées, dans lesquelles des bulles d'air sont introduites dans le produit par l'intermédiaire d'un procédé de fabrication particulier, - Foamed creams, in which air bubbles are introduced into the product by means of a particular manufacturing process,
- Des formules moussantes peu riches en tensioactifs moussants mais conditionnées dans un emballage muni d'un système mécanique générateur de mousse (pompe avec grille de type pulvorex). - Foaming formulas not very rich in foaming surfactants but packaged in a packaging fitted with a mechanical foam generating system (pump with pulvorex type grid).
Les mousses non rincées sont de préférence des mousses dites aérosol ou spray. Tel qu'utilisé ici, les « mammifères non humains » ou « animaux » comprennent tous les mammifères à l'exception des êtres humains. De préférence, les mammifères non humains sont des animaux de compagnie, y compris, et sans limitation, des animaux domestiques tels que notamment des chiens, des chats, des lapins, des furets et des hamsters. Dans un mode de réalisation davantage préféré de l'invention, les mammifères non humains sont des chats et de préférence des chiens. The leave-in foams are preferably so-called aerosol or spray foams. As used herein, "non-human mammals" or "animals" include all mammals except humans. Preferably, non-human mammals are companion animals, including, without limitation, domestic animals such as especially dogs, cats, rabbits, ferrets and hamsters. In a more preferred embodiment of the invention, the non-human mammals are cats and preferably dogs.
Les compositions, shampooing et/ou compositions mousses non rincées, utilisées selon l’invention sont destinés à nettoyer ou laver la peau et/ou le pelage. Elles peuvent être utilisées pour maintenir la santé de la peau ou du pelage des animaux, notamment en maintenant l’équilibre cutané, en maintenant ou améliorant l’hydratation de la peau, en apaisant la peau, ou encore en réduisant ou apaisant les sensations de démangeaisons ou d’irritation. Ainsi, en particulier, le procédé de soin de la peau ou du pelage d’animaux selon l’invention est un procédé pour nettoyer ou laver la peau et/ou le pelage, pour maintenir la santé de la peau ou du pelage des animaux, pour maintenir l’équilibre cutané, pour maintenir ou améliorer l’hydratation de la peau, pour apaiser la peau, ou encore pour réduire ou apaiser les sensations de démangeaisons ou d’irritation. The compositions, shampoo and / or leave-in foam compositions used according to the invention are intended for cleaning or washing the skin and / or the coat. They can be used to maintain the health of the skin or coat of animals, in particular by maintaining the skin balance, by maintaining or improving the hydration of the skin, by soothing the skin, or by reducing or soothing the sensations of itching or irritation. Thus, in particular, the method for caring for the skin or coat of animals according to the invention is a method for cleaning or washing the skin and / or the coat, for maintaining the health of the skin or the coat of animals, to maintain the skin balance, to maintain or improve the hydration of the skin, to soothe the skin, or to reduce or soothe the sensations of itching or irritation.
Selon un mode préféré de la présente invention, les compositions, shampooing et/ou compositions mousses non rincées, utilisées selon l’invention comprennent en outre au moins un composé destiné à traiter ou soigner la peau ou le pelage des animaux. Il peut s’agir en particulier d’au moins un composé à propriétés hydratantes, restructurantes, un composé destiné à améliorer l’effet barrière de la peau ou restaurer son effet barrière, ou destiné à éliminer ou réduire les pellicules ou le sébum en excès, ou encore destiné à diminuer les démangeaisons ou aider à réduire les dermites des animaux, en particulier des animaux de compagnie. Les compositions, shampooing et/ou compositions mousses non rincées, utilisées selon l'invention peuvent comprendre, comme composés actifs, des antimicrobiens (composés limitant la prolifération des bactéries, levures ou champignons) ou des désinfectants, tels que la chlorhexidine. According to a preferred mode of the present invention, the compositions, shampoo and / or leave-in foam compositions used according to the invention further comprise at least one compound intended to treat or care for the skin or the coat of animals. It may in particular be at least one compound with moisturizing or restructuring properties, a compound intended to improve the barrier effect of the skin or restore its barrier effect, or intended to eliminate or reduce dandruff or excess sebum. , or even intended to reduce itching or help reduce dermatitis in animals, in particular pets. The leave-in compositions, shampoo and / or foam compositions used according to the invention can comprise, as active compounds, antimicrobials (compounds limiting the proliferation of bacteria, yeasts or fungi) or disinfectants, such as chlorhexidine.
Les composés destinés à traiter ou aider à soigner la peau ou le pelage des animaux peuvent être aussi par exemple des composés de type base sphingoïde ou encore des composés extraits de plantes. De manière particulière, les composés actifs présents dans les compositions du procédé selon l’invention, shampooing et compositions mousses non rincées, sont identiques ou différents, de préférence ils sont identiques. The compounds intended for treating or helping to care for the skin or the coat of animals can also be, for example, compounds of sphingoid base type or else compounds extracted from plants. In particular, the active compounds present in the compositions of the process according to the invention, shampoo and leave-in foam compositions, are identical or different, preferably they are identical.
Dans la composition de shampooing et/ou composition mousse non rincée de l'invention, la concentration en composé actif destiné à traiter ou aider à soigner la peau ou le pelage est de préférence comprise entre 0,001 et 30% en poids par rapport au poids total de la composition. Les concentrations plus préférées peuvent varier de 0,005 à 20% en poids %, 0,01 à 10% en poids %, 0,02-5% en poids % ou 0,05 à 3% en poids %. In the shampoo composition and / or leave-in foam composition of the invention, the concentration of active compound intended to treat or help care for the skin or the coat is preferably between 0.001 and 30% by weight relative to the total weight. of the composition. More preferred concentrations may vary from 0.005 to 20% by weight%, 0.01 to 10% by weight%, 0.02-5% by weight% or 0.05 to 3% by weight%.
Des composés obtenus à partir d'une plante capable d'agir sur différents facteurs de la dermatite atopique animale sont particulièrement adaptés à aider à diminuer les démangeaisons des animaux. Il s’agit en particulier d’un composé obtenu à partir d 'Ophiopogon japonicus, tel que notamment décrit dans la demande de brevet WO2017121965. Ce composé est particulièrement adapté à une utilisation, en application topique sur la peau ou le pelage d’animaux, dans un traitement d’accompagnement de soin d’animaux atopiques. Il peut être utilisé sur les peaux atopiques en particulier pour aider à diminuer ou retarder le taux de rechute, diminuer le score de gravité de la dermatite atopique chez les animaux (score CADESI), réduire l'intensité et/ou la fréquence des démangeaisons ou de prurit, et plus généralement pour améliorer la qualité de vie de l'animal et/ou de son propriétaire. Compounds obtained from a plant capable of acting on various factors of animal atopic dermatitis are particularly suitable for helping to reduce itching in animals. It is in particular a compound obtained from Ophiopogon japonicus, as described in particular in patent application WO2017121965. This compound is particularly suitable for use, in topical application to the skin or coat of animals, in an accompanying treatment for the care of atopic animals. It can be used on atopic skin in particular to help decrease or delay the rate of relapse, decrease the severity score of atopic dermatitis in animals (CADESI score), reduce the intensity and / or frequency of itching or pruritus, and more generally to improve the quality of life of the animal and / or its owner.
Par « composé actif obtenu à partir d 'Ophiopogon japonicus » au sens de l'invention on entend toute molécule ou mélange de molécules obtenue(s) à partir d'Ophiopogon japonicus. Il peut s'agir de molécules natives de la plante ou de molécules obtenues par tout type de transformation des molécules natives de la plante, par exemple par hydrolyse. Le composé actif selon l'invention est préférentiellement un hydrolysat. By “active compound obtained from Ophiopogon japonicus” within the meaning of the invention is meant any molecule or mixture of molecules obtained from Ophiopogon japonicus. They may be molecules native to the plant or molecules obtained by any type of transformation of the native molecules of the plant, for example by hydrolysis. The active compound according to the invention is preferably a hydrolyzate.
Par « hydrolysat » on entend tout extrait issu d'Ophiopogon japonicus, obtenu avec un procédé comprenant au moins une étape d'hydrolyse enzymatique ou chimique d'Ophiopogon japonicus, préférentiellement au moins une étape d'hydrolyse enzymatique. Par « Ophiopogon japonicus » on entend tout ou partie de la plante. Il peut s'agir de la plante entière ou d'une partie de la plante. Préférentiellement, il s'agit de tubercules d'Ophiopogon japonicus. The term “hydrolyzate” means any extract derived from Ophiopogon japonicus, obtained with a process comprising at least one enzymatic or chemical hydrolysis step of Ophiopogon japonicus, preferably at least one enzymatic hydrolysis step. By “Ophiopogon japonicus” is meant all or part of the plant. It can be the whole plant or part of the plant. Preferably, they are tubers of Ophiopogon japonicus.
L'Ophiopogon japonicus est une espèce herbacée vivace, basse et foisonnante, à rhizome de la famille des Liliacées. Ophiopogon japonicus is a perennial, low and abundant herbaceous species with a rhizome of the Liliaceae family.
La base sphingoïde est de préférence choisie dans le groupe constitué de sphingosine, sphinganine et phytosphingosine. La phytosphingosine est plus particulièrement préférée. Des exemples appropriés de dérivés de bases sphingoïdes comprennent la N-lactyloyl- phytosphingosine, la N-salicyloyl-phytosphingosine ou la N-rétinoylphytosphingosine, c'est-à-dire des composés qui sont N-substitués. The sphingoid base is preferably selected from the group consisting of sphingosine, sphinganine and phytosphingosine. Phytosphingosine is more particularly preferred. Suitable examples of sphingoid base derivatives include N-lactyloyl-phytosphingosine, N-salicyloyl-phytosphingosine or N-retinoylphytosphingosine, i.e. compounds which are N-substituted.
D'autres exemples appropriés de dérivés de bases sphingoïdes comprennent les sels de bases sphingoïdes. L'anion du sel peut être dérivé de tout acide approprié, c'est-à- dire de ces acides, qui, après mélange avec la base sphingoïde dans un solide approprié, produisent un sel avec une solubilité dans l'eau améliorée. Les acides qui sont eux- mêmes efficaces lorsqu'ils sont appliqués sur le pelage ou la peau sont préférés. Les sels préférés de la base sphingoïde à utiliser dans la composition de la présente invention sont les sels pouvant être obtenus avec les acides qui, lors du mélange avec la base sphingoïde susmentionnée dans un solvant approprié, produisent un sel ayant une hydrosolubilité accrue par rapport à la solubilité dans l'eau de la base sphingoïde en tant que telle. Les sels de phytosphingosine sont préférés pour une meilleure solubilité et une meilleure biodisponibilité. Other suitable examples of sphingoid base derivatives include salts of sphingoid bases. The anion of the salt can be derived from any suitable acid, i.e., those acids which, when mixed with the sphingoid base in a suitable solid, produce a salt with improved water solubility. Acids which are themselves effective when applied to the coat or skin are preferred. Preferred salts of the sphingoid base for use in the composition of the present invention are the salts obtainable with acids which, when mixed with the above-mentioned sphingoid base in a suitable solvent, produce a salt having increased water solubility over the water solubility of the sphingoid base as such. Phytosphingosine salts are preferred for better solubility and better bioavailability.
Dans un mode de réalisation préféré, l'acide est un acide hydrophile capable de délivrer le sel de base sphingoïde à la phase aqueuse de la composition vétérinaire. Les acides hydrophiles appropriés comprennent l'acide a-hydroxy alcanoïque, un acide (hydroxy-3- alcanoïque, un acide a, p-dihydroxy alcanoïque, un acide alcanedioïque ou un acide minéral. Des exemples d'acides organiques hydrophiles préférés sont l'acide lactique, l'acide glycolique, l'acide malique, l'acide pyruvique, l'acide succinique, l'acide fumarique, l'acide ascorbique, l'acide gluconique et / ou l'acide pyroglutamique, des exemples d'acides minéraux préférés sont l'acide chlorhydrique, l'acide nitrique et / ou l'acide phosphorique. In a preferred embodiment, the acid is a hydrophilic acid capable of delivering the sphingoid base salt to the aqueous phase of the veterinary composition. Suitable hydrophilic acids include a-hydroxy alkanoic acid, an (hydroxy-3-alkanoic acid, an α, p-dihydroxy alkanoic acid, an alkanedioic acid or a mineral acid. Examples of preferred hydrophilic organic acids are. lactic acid, glycolic acid, malic acid, pyruvic acid, succinic acid, fumaric acid, ascorbic acid, gluconic acid and / or pyroglutamic acid, examples of acids preferred minerals are hydrochloric acid, nitric acid and / or phosphoric acid.
Dans un autre mode de réalisation préféré, l'acide est un acide organique lipophile pour permettre d'augmenter l'efficacité de l'acide lipophile et de la base sphingoïde dans le sel de base sphingoïde. In another preferred embodiment, the acid is a lipophilic organic acid to enable the effectiveness of the lipophilic acid and the sphingoid base in the sphingoid base salt to be increased.
Il va de soi que le procédé selon l’invention peut comprendre une ou plusieurs étapes supplémentaires à celles précédemment citées, par exemple des étapes antérieures ou ultérieures. Il peut être envisagé aussi une répétition des étapes successives du procédé selon l’invention. Ainsi, le protocole détaillé à la figure 1 (B) peut être répété autant de fois que nécessaire, sans nécessiter de période d’interruption si jugé opportun. It goes without saying that the method according to the invention may comprise one or more steps additional to those mentioned above, for example previous or subsequent steps. It is also possible to envisage repeating the successive steps of the process according to the invention. Thus, the protocol detailed in Figure 1 (B) can be repeated as many times as necessary, without requiring any downtime if deemed appropriate.
Un objet supplémentaire selon l’invention est un kit comprenant dans un ou plusieurs compartiment(s) au moins un shampooing à rincer et au moins une composition sous forme de mousse non rincée, et éventuellement une notice d’instructions détaillant le procédé d’utilisation desdits shampooing et composition, tel que défini dans la présente invention. La composition sous forme de mousse à rincer peut se présenter dans un seul compartiment ou dans plusieurs compartiments. Dans ce dernier cas, chaque compartiment comprend de préférence une composition sous forme de mousse non rincée correspondant à chacune des au moins quatre applications consécutives. Ainsi le kit présente au moins quatre compartiments comprenant chacun une composition sous forme de mousse non rincée et un autre compartiment comprenant le shampooing à rincer. An additional object according to the invention is a kit comprising in one or more compartment (s) at least one rinse-out shampoo and at least one composition in the form of a leave-in foam, and optionally an instruction manual detailing the method of use. of said shampoo and composition, as defined in the present invention. The composition in the form of a rinse-off foam can be presented in a single compartment or in several compartments. In the latter case, each compartment preferably comprises a composition in the form of a leave-in foam corresponding to each of the at least four consecutive applications. Thus the kit has at least four compartments each comprising a composition in the form of a leave-in foam and another compartment comprising the shampoo to be rinsed out.
L'invention sera mieux comprise à l'aide des exemples qui suivent, lesquels se veulent illustratifs et non limitatifs. The invention will be better understood with the aid of the examples which follow, which are intended to be illustrative and not limiting.
Exemple 1 : Traitement de chiens selon la présente invention comparé à un protocole classique Example 1: Treatment of dogs according to the present invention compared to a conventional protocol
Le but de cette étude était d’évaluer l’efficacité d’une association de shampooing et de mousse comprenant de la phytosphingosine, de la gamme de produits (Douxo Calm®, vendus par la société Ceva Santé animale) pendant une crise de rechute de dermatite atopique chez des chiens. Afin de réaliser ces essais, pour chaque étude, 6 à 9 chiens, qui ont été préalablement diagnostiqués atopiques, recevant un traitement concomitant (oclacitinib ou ciclosporine) et présentant une rechute clinique de dermatite atopique, ont été traités pendant 3 semaines. The aim of this study was to evaluate the effectiveness of a combination of shampoo and foam comprising phytosphingosine, from the range of products (Douxo Calm®, sold by the company Ceva Santé Animale) during a relapse crisis of atopic dermatitis in dogs. In order to carry out these tests, for each study, 6 to 9 dogs, which were previously diagnosed atopic, receiving concomitant treatment (oclacitinib or ciclosporin) and presenting a clinical relapse of atopic dermatitis, were treated for 3 weeks.
Le traitement a consisté pour l’étude (A) (contrôle) en des applications d’un shampooing à J1 , J8 et J15, et en des applications deux fois par semaine d’une mousse non rincée entre les applications de shampooing J1 , J8 et J15 (Figure 1 (A). The treatment consisted for the study (A) (control) of applications of a shampoo on D1, D8 and D15, and twice weekly applications of a leave-in foam between the applications of shampoo D1, D8 and J15 (Figure 1 (A).
Pour l’étude (B) (selon l’invention), le traitement a consisté en une seule application de shampooing à J1 , suivie d’applications tous les deux-trois jours (48h-72h) d’une mousse pendant 21 jours. For study (B) (according to the invention), the treatment consisted of a single application of shampoo on D1, followed by applications every two to three days (48h-72h) of a mousse for 21 days.
Afin d’évaluer l’efficacité de ces études, les scores de gravité CADESI-04 (Vet Dermatol. 2014, Apr;25(2):77-85, e25. doi: 10.1 1 1 1/vde.12107. Epub 2014 Jan. 25) et les échelles analogues visuelles de prurit ont été analysés et enregistrés chaque semaine. Les valeurs obtenues à des temps donnés ont été comparés à la situation de départ à J0 (1 jour avant l’application du premier shampooing (J1 )). In order to assess the effectiveness of these studies, CADESI-04 severity scores (Vet Dermatol. 2014, Apr; 25 (2): 77-85, e25. Doi: 10.1 1 1 1 / vde.12107. Epub 2014 Jan. 25) and visual analogue pruritus scales were analyzed and recorded weekly. The values obtained at given times were compared to the starting situation on D0 (1 day before applying the first shampoo (D1)).
Après 21 jours de traitement, dans l’étude (A), 3/5 des chiens (60%) traités présentaient une diminution du score CADESI de 40% alors que 6/7 (85%) des chiens de l’étude (B) présentaient cette même diminution. After 21 days of treatment, in study (A), 3/5 of the dogs (60%) treated showed a decrease in CADESI score of 40% while 6/7 (85%) of the dogs in the study (B ) showed the same decrease.
Ces études montrent également l’efficacité des shampooings et mousse Douxo Calm® utilisés dans les deux études, en parallèle d’un traitement à long terme immunomodulateur inchangé durant l’étude. Pour le deux groupes (A) et (B), les scores CADESI présentaient une diminution significative après 21 jours de traitement, avec une amélioration plus importante pour le groupe (B) que pour le groupe (A). These studies also show the effectiveness of Douxo Calm® shampoos and mousse. used in both studies, in parallel with long-term immunomodulatory treatment unchanged during the study. For the two groups (A) and (B), the CADESI scores showed a significant decrease after 21 days of treatment, with a greater improvement for the group (B) than for the group (A).
La Figure 2A présente les évolutions moyennes du score CADESI pour chacune des études (A) et (B). Dans les deux études, une diminution du score CADESI a été observée pendant le traitement (Figure 2A). Après 21 jours de traitement, le pourcentage moyen de diminution était proche du seuil prévu de -40% pour le groupe (A) et inférieur au seuil de -40% pour le groupe (B), ce qui signifie qu'en général après 21 jours de traitement, le CADESI est diminué en moyenne de moins de 40% (Figure 2B). Au jour 21 , les pourcentages moyens de variation CADESI sont de -39,8 ± 23,1 % pour le groupe (A) et de -75,6 ± 19,0% pour le groupe (B). Figure 2A shows the average changes in the CADESI score for each of the studies (A) and (B). In both studies, a decrease in the CADESI score was observed during treatment (Figure 2A). After 21 days of treatment, the mean percentage decrease was close to the expected threshold of -40% for group (A) and below the threshold of -40% for group (B), which means that in general after 21 days of treatment, CADESI is reduced on average by less than 40% (Figure 2B). On day 21, the mean percentages of CADESI change are -39.8 ± 23.1% for group (A) and -75.6 ± 19.0% for group (B).
Le critère principal était basé sur le pourcentage de diminution de CADESI entre J0 et J21 . Ainsi, un pourcentage obtenu plus élevé peut être utilisé comme critère principal distinguant les groupes testés. Différents pourcentages ont été testés (voir tableau 1 ). Le tableau 1 fournit des informations sur le nombre de chiens ayant atteint le pourcentage spécifique de diminution du CADESI. Le seuil de 50% correspond au niveau de différence observée entre les deux protocoles, en effet un seul chien a atteint ce seuil pour le groupe (A), alors que 6 sur 7 chiens l'ont atteint dans le groupe (B). The primary endpoint was based on the percentage decrease in CADESI between D0 and D21. Thus, a higher percentage obtained can be used as the main criterion distinguishing the groups tested. Different percentages were tested (see Table 1). Table 1 provides information on the number of dogs that achieved the specific percentage decrease in CADESI. The 50% threshold corresponds to the level of difference observed between the two protocols, in fact only one dog reached this threshold for group (A), while 6 out of 7 dogs reached it in group (B).
Tableau 1 Table 1
Pourcentages de chiens atteignant différents pourcentages de diminution du CADESI Percentages of Dogs Achieving Different Percentages of Decrease in CADESI

Claims

REVENDICATIONS
1 . Procédé de soin de la peau ou du pelage d’animaux, comprenant l’application sur la peau ou le pelage d’un shampooing à rincer, suivie d’au moins quatre applications consécutives sur la peau ou le pelage d’une composition sous forme de mousse non rincée. 1. A method of caring for the skin or coat of animals, comprising applying to the skin or the coat a rinse-out shampoo, followed by at least four consecutive applications to the skin or the coat of a composition in the form of non-rinsed foam.
2. Procédé selon la revendication 1 , caractérisé en ce que chaque application d’une composition sous forme de mousse non rincée est réalisée à au moins 24 heures, ou de préférence au moins 48 heures, d’intervalle de l’application précédente. 2. Method according to claim 1, characterized in that each application of a composition in the form of a leave-in foam is carried out at least 24 hours, or preferably at least 48 hours, apart from the previous application.
3. Procédé selon le revendication 1 ou 2, caractérisé en ce que chacune des applications de mousse consécutives et ultérieures à la première application du shampooing à rincer est réalisée entre 24 h et 72h, de préférence entre 48h et 72h, après l’application précédente. 3. Method according to claim 1 or 2, characterized in that each of the foam applications consecutive and subsequent to the first application of the rinse-out shampoo is carried out between 24 h and 72 h, preferably between 48 h and 72 h, after the previous application .
4. Procédé selon l’une des revendications précédentes, caractérisé en ce que le procédé comprend l’application d’un shampooing à rincer, suivie de 4, 5, 6, 7 ou 8 applications consécutives d’une composition sous forme de mousse non rincée. 4. Method according to one of the preceding claims, characterized in that the method comprises the application of a rinse-out shampoo, followed by 4, 5, 6, 7 or 8 consecutive applications of a composition in the form of non-foam. rinsed.
5. Procédé selon l'une quelconque des revendications 1 à 4, caractérisé en ce que le procédé comprend l’application d’un shampooing à rincer, suivie de 8 applications consécutives d’une composition sous forme de mousse non rincée. 5. Method according to any one of claims 1 to 4, characterized in that the method comprises the application of a rinse-out shampoo, followed by 8 consecutive applications of a composition in the form of a leave-in foam.
6. Procédé selon l'une quelconque des revendications 1 à 5, caractérisé en ce que le procédé comprend en outre, après lesdites au moins 4 applications consécutives de composition sous forme de mousse non rincée, au moins une étape consistant en une application d’un shampooing à rincer, ladite application de shampooing pouvant être suivie d’applications consécutives de composition sous forme de mousse non rincée, en particulier ladite application de shampooing pouvant être suivie d’au moins 4 applications consécutives de composition sous forme de mousse non rincée. 6. Method according to any one of claims 1 to 5, characterized in that the method further comprises, after said at least 4 consecutive applications of composition in the form of a leave-in foam, at least one step consisting of an application of a rinse-out shampoo, said application of shampoo possibly being followed by consecutive applications of composition in the form of a leave-in foam, in particular said application of shampoo being able to be followed by at least 4 consecutive applications of composition in the form of a leave-in foam.
7. Procédé selon l'une quelconque des revendications 1 à 6, caractérisé en ce que le shampooing et la composition sous forme de mousse non rincée sont des compositions comprenant au moins un composé destiné à traiter ou aider à soigner la peau ou le pelage des animaux, en particulier à diminuer les démangeaisons des animaux, et en particulier des animaux de compagnie. 7. Method according to any one of claims 1 to 6, characterized in that the shampoo and the composition in the form of a leave-in foam are compositions comprising at least one compound intended to treat or help to treat the condition. skin or coat of animals, in particular to reduce the itching of animals, and in particular of pets.
8. Procédé selon l’une quelconque des revendications précédentes, caractérisé en ce que le procédé est un procédé pour nettoyer ou laver la peau et/ou le pelage, pour maintenir la santé de la peau ou du pelage des animaux, pour maintenir l’équilibre cutané, pour maintenir ou améliorer l’hydratation de la peau, pour apaiser la peau, ou encore pour réduire ou apaiser les sensations de démangeaisons ou d’irritation. 8. A method according to any one of the preceding claims, characterized in that the method is a method for cleaning or washing the skin and / or the coat, for maintaining the health of the skin or the coat of animals, for maintaining the skin. skin balance, to maintain or improve the hydration of the skin, to soothe the skin, or to reduce or soothe itching or irritation sensations.
9. Kit, comprenant dans un ou plusieurs compartiment(s) au moins un shampooing à rincer et au moins une composition sous forme de mousse non rincée, et une notice d’instructions détaillant le procédé défini selon l’une des revendications précédentes. 9. Kit, comprising in one or more compartment (s) at least one rinse-out shampoo and at least one composition in the form of a leave-in foam, and an instruction leaflet detailing the process defined according to one of the preceding claims.
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FI128215B (en) * 2013-05-28 2019-12-31 Argenlab Global Ltd Low alcohol content disinfection foams
EP3285882A1 (en) * 2015-04-23 2018-02-28 The Procter and Gamble Company Method of achieving targeted delivery/application of hair
FR3046541B1 (en) 2016-01-12 2018-02-09 Societe Industrielle Limousine D'application Biologique ACTIVE PRINCIPLE OBTAINED FROM OPHIOPOGON JAPONICUS FOR THE TREATMENT OF ATOPIC DERMATITIS
US20190335878A1 (en) * 2016-11-14 2019-11-07 Covestro Deutschland Ag Foam of polyurethane for use in cosmetic applications
US20200390666A1 (en) * 2019-05-01 2020-12-17 Church & Dwight Co., Inc. Rinse-free shampoo composition

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CA3144540A1 (en) 2020-12-30
AU2020303297A1 (en) 2022-02-24

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