EP3975722A4 - Methods of otoprotection against platinum-based antineoplastic agents - Google Patents

Methods of otoprotection against platinum-based antineoplastic agents Download PDF

Info

Publication number
EP3975722A4
EP3975722A4 EP20815470.8A EP20815470A EP3975722A4 EP 3975722 A4 EP3975722 A4 EP 3975722A4 EP 20815470 A EP20815470 A EP 20815470A EP 3975722 A4 EP3975722 A4 EP 3975722A4
Authority
EP
European Patent Office
Prior art keywords
otoprotection
methods
antineoplastic agents
based antineoplastic
against platinum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP20815470.8A
Other languages
German (de)
French (fr)
Other versions
EP3975722A1 (en
Inventor
John Lee
John R. SOGLIA
Qi-Ying Hu
Fuxin Shi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Decibel Therapeutics Inc
Original Assignee
Decibel Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US16/427,567 external-priority patent/US10813947B1/en
Application filed by Decibel Therapeutics Inc filed Critical Decibel Therapeutics Inc
Publication of EP3975722A1 publication Critical patent/EP3975722A1/en
Publication of EP3975722A4 publication Critical patent/EP3975722A4/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
EP20815470.8A 2019-05-31 2020-05-29 Methods of otoprotection against platinum-based antineoplastic agents Pending EP3975722A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16/427,567 US10813947B1 (en) 2019-05-31 2019-05-31 Methods of otoprotection against platinum-based antineoplastic agents
US201962886865P 2019-08-14 2019-08-14
PCT/US2020/035271 WO2020243536A1 (en) 2019-05-31 2020-05-29 Methods of otoprotection against platinum-based antineoplastic agents

Publications (2)

Publication Number Publication Date
EP3975722A1 EP3975722A1 (en) 2022-04-06
EP3975722A4 true EP3975722A4 (en) 2023-02-08

Family

ID=73553934

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20815470.8A Pending EP3975722A4 (en) 2019-05-31 2020-05-29 Methods of otoprotection against platinum-based antineoplastic agents

Country Status (11)

Country Link
EP (1) EP3975722A4 (en)
JP (1) JP2022534617A (en)
KR (1) KR20220047217A (en)
CN (1) CN114302647A (en)
AU (1) AU2020284122A1 (en)
BR (1) BR112021023684A2 (en)
CA (1) CA3142153A1 (en)
IL (1) IL288532A (en)
MX (1) MX2021014447A (en)
SG (1) SG11202113053RA (en)
WO (1) WO2020243536A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190160094A1 (en) * 2017-11-29 2019-05-30 Edward A. Neuwelt Method for reducing ototoxicity in pediatric patients receiving platinum-based chemotherapy
WO2020256548A1 (en) * 2019-06-19 2020-12-24 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Sodium thiosulfate gel for preventing or reducing hearing loss

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0811175D0 (en) * 2008-06-18 2008-07-23 Prendergast Patrick T Anti-tumour compositions and methods
US8784870B2 (en) * 2008-07-21 2014-07-22 Otonomy, Inc. Controlled release compositions for modulating free-radical induced damage and methods of use thereof
AU2010270605B2 (en) * 2009-07-08 2014-07-31 Hope Medical Enterprises, Inc. Dba Hope Pharmaceuticals Sodium thiosulfate-containing pharmaceutical compositions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190160094A1 (en) * 2017-11-29 2019-05-30 Edward A. Neuwelt Method for reducing ototoxicity in pediatric patients receiving platinum-based chemotherapy
WO2020256548A1 (en) * 2019-06-19 2020-12-24 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Sodium thiosulfate gel for preventing or reducing hearing loss

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CECILIA ENGMÃ R BERGLIN ET AL: "Prevention of cisplatin-induced hearing loss by administration of a thiosulfate-containing gel to the middle ear in a guinea pig model", CANCER CHEMOTHERAPY AND PHARMACOLOGY, SPRINGER, BERLIN, DE, vol. 68, no. 6, 2 May 2011 (2011-05-02), pages 1547 - 1556, XP019980101, ISSN: 1432-0843, DOI: 10.1007/S00280-011-1656-2 *
DILLARD LAUREN K ET AL: "Global burden of ototoxic hearing loss associated with platinum-based cancer treatment: A systematic review and meta-analysis", CANCER EPIDEMIOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 79, 17 June 2022 (2022-06-17), XP087117343, ISSN: 1877-7821, [retrieved on 20220617], DOI: 10.1016/J.CANEP.2022.102203 *
See also references of WO2020243536A1 *

Also Published As

Publication number Publication date
IL288532A (en) 2022-01-01
MX2021014447A (en) 2022-02-11
JP2022534617A (en) 2022-08-02
EP3975722A1 (en) 2022-04-06
SG11202113053RA (en) 2021-12-30
CA3142153A1 (en) 2020-12-03
AU2020284122A1 (en) 2021-12-23
CN114302647A (en) 2022-04-08
KR20220047217A (en) 2022-04-15
WO2020243536A1 (en) 2020-12-03
BR112021023684A2 (en) 2022-04-12

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