EP3970857B1 - Fluidic system comprising a fluidic component and an instrument adapted to the component - Google Patents

Fluidic system comprising a fluidic component and an instrument adapted to the component Download PDF

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Publication number
EP3970857B1
EP3970857B1 EP21195476.3A EP21195476A EP3970857B1 EP 3970857 B1 EP3970857 B1 EP 3970857B1 EP 21195476 A EP21195476 A EP 21195476A EP 3970857 B1 EP3970857 B1 EP 3970857B1
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EP
European Patent Office
Prior art keywords
fluidic
component
instrumented
aperture
strip
Prior art date
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Application number
EP21195476.3A
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German (de)
French (fr)
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EP3970857A1 (en
Inventor
Ayman CHMAYSSEM
Nicolas Verplanck
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Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Original Assignee
Commissariat a lEnergie Atomique CEA
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/126—Paper
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids

Definitions

  • the present invention relates to a fluidic system which comprises a fluidic component and an instrumented device adapted to said fluidic component to interact with the internal volume of the fluidic circuit.
  • Impedance sensors In the field of fluidic devices used in biological applications, it is sought to measure certain characteristics of a fluid present in the device. Impedance sensors, electrochemical sensors, thermal sensors, or sensors based on the principle of tomography are thus used.
  • These sensors or transducers can for example comprise two electrodes, which it is necessary to integrate into the fluidic component in order to perform the measurements.
  • this architecture requires the manufacture of dedicated components, which is not optimal in terms of cost and modularity. It is also possible to use devices external to the component, but these often do not have an architecture adapted to the fluidic component, making it impractical to take measurements.
  • the patent application US2020/216789A1 discloses a cell culture tray that includes multiple culture cavities, and a device that fits onto the tray to compartmentalize the cavities.
  • the object of the invention is to propose a fluidic system which comprises a fluidic component on which can be easily adapted an instrumented device capable of interacting with the internal volume of the component, this system being easy to manufacture, of moderate cost and easy to use.
  • each actuator or effector comprises at least one functional member selected from an electrode, a light-emitting diode, an optical sensor, an electrical resistor, a thermistor.
  • the functional member of the electrode type is produced in the form of a conductive ink.
  • the system comprises a separate electrical connection point and an electrical conductor, connecting said electrical connection point to each functional member of the actuator or of the effector.
  • each electrical conductor and each electrical connection point are made in the form of a conductive ink.
  • the instrumented device comprises at least one flexible, semi-rigid or articulated substrate of elongated shape, carrying said first element at a first end and said second element at a second end.
  • the first element and the second element are made of a conformable material, to adapt to the shape of the fluidic component at its two zones.
  • the deformable part is made in the form of at least one strip of material connecting the first element to the second element.
  • the substrate comprising the first element, the second element and the deformable part is produced in a single piece, in the form of a strip of flexible plastic material.
  • the band is made of a material chosen from PET, PEN, Kapton, silicone, polymer film, paper and fabric.
  • the substrate comprising the first element (10), the second element and the deformable part comprises two flexible/flexible, semi-rigid or articulated strips, joined together by a common part and forming two strands each carrying, respectively, at their free end, the first element and the second element.
  • each strip is made of a material chosen from PET, PEN, Kapton, silicone, polymer film, paper and fabric.
  • the fluidic component has the shape of a straight block and in that the first opening and the second opening open onto two opposite faces.
  • the invention relates to a fluidic system which comprises a fluidic component and an instrumented device 1 defined below.
  • the instrumented device 1 is intended to fit onto the fluidic component 4.
  • the fluidic component 4 comprises a substrate in which a fluidic circuit is made.
  • This fluidic circuit can be more or less complex.
  • the substrate of the fluidic component 4 can be in the form of a brick or a card, presenting at least two opposite faces, advantageously parallel to each other, called upper face 40 and lower face 41 and a wall said side 42 arranged between the two faces.
  • its base can be in the shape of a rectangle or a disk.
  • the substrate can of course have any other shape.
  • Its fluidic circuit may comprise a cavity 43, for example intended to be filled with a fluid 46.
  • the fluid may be a liquid, a gas or a gel or a mixture of several fluids.
  • Cavity 43 could also be placed under vacuum.
  • the cavity 43 can pass through and emerge via a first opening 430 on its lower face and via a second opening 431 on its upper face.
  • the fluidic circuit of component 4 may have two channels 44, 45 each opening, on the one hand, outside component 4 and on the other hand inside cavity 43, making it possible to inject a fluid into the cavity.
  • the two channels can for example lead to the upper face 40 of the component or to its side wall 42.
  • the instrumented device 1 advantageously comprises a flexible, semi-rigid or articulated substrate, having a thickness of a few ⁇ m.
  • the substrate can have a flat architecture with two opposite planar faces, called upper face and lower face, and is elongated along a longitudinal axis (X), so as to have two ends.
  • the substrate comprises at least one deformable intermediate part 12, formed by the use of a flexible or semi-rigid material or by an articulated assembly.
  • deformable it is meant that the substrate can present, at least at its intermediate part, characteristics mechanisms that allow it to deform sufficiently, for example to match the shape of a surface and to bend at least partially to fit on the fluidic component 4.
  • the substrate comprises, at a first end, a first element 10 and, at its second end, a second element 11.
  • the deformable intermediate part 12 connects its first element 10 to its second element 11 and extends, at rest, along its longitudinal axis (X).
  • the first element 10 and the second element 11 of the device can be in the form of a pellet.
  • the two elements 10, 11 can be of a conformable nature, allowing them to conform as well as possible to a surface, in particular the surface of the component on which they are intended to be affixed.
  • the deformable part 12 of the substrate can take the form of an intermediate junction strip connecting the two pads, and can thus form a conductive sheet.
  • the instrumented device 1 can be made from a single one-piece substrate. It can then comprise a single band or ribbon made of soft and flexible plastic material, semi-rigid or articulated, cut according to a profile adapted to form the first element, the second element and the deformable part joining the first element to the second element.
  • the cutting of the strip thus makes it possible to form two pellets and the deformable part 12.
  • This band can be made of transparent, partially transparent or opaque material.
  • the strip has two opposite main faces, called the upper face and the lower face.
  • the first element 10 and the second element 11 of said device can each be instrumented (references 20, 21).
  • the instrumentation 20, 21 of each element is advantageously made on a so-called functional face of the corresponding element of the device.
  • the instrumentation allows the device to interact with the internal volume of the fluidic circuit of the component.
  • the internal volume of the fluidic circuit can be filled with a fluid or placed under vacuum and the instrumented device is intended to perform a measurement of at least one parameter, to stimulate or react to the fluid placed in the fluidic circuit of the component, or to perform a measurement of at least one parameter, stimulate or react with respect to this volume put under vacuum.
  • the device can be adapted to measure parameters of the electrical type (impedance, capacitance, resistance), chemical, electrochemical, optical, thermal or other (in transmission or in reflection), to electrically stimulate or optically a fluid.
  • the electrical type impedance, capacitance, resistance
  • chemical, electrochemical, optical, thermal or other in transmission or in reflection
  • the instrumented device 1 can in fact comprise at least one actuator, at least one effector, or at least one actuator/effector pair arranged, as the case may be, in a single instrumented element or in both instrumented elements.
  • actuator is meant a device capable of performing an action on command and of generating a stimulation signal.
  • effector is meant a device capable of reacting to stimulation.
  • the actuator or the effector can thus comprise one or more functional members.
  • a functional member can be an electrode, for example used for an electrical measurement or a pH measurement, a light-emitting diode, a CMOS type optical sensor or equivalent, a thermistor, a resistor electric.
  • composition and architecture of each functional organ obviously depends on the function to be fulfilled.
  • the instrumented device can comprise at least two functional members.
  • an optical detector which may comprise a light-emitting diode and a CMOS sensor or equivalent, of a pH sensor which comprises a reference electrode and a measurement electrode, of an impedance sensor which comprises two electrodes.
  • the device may comprise a single functional member formed of a thermistor.
  • the device may comprise a single electrode.
  • the data collected by the instrumented device can be sent back to a measurement unit 8.
  • the figure 12 represents several embodiments of an instrumented element of the device 1.
  • the instrumented element comprises a single electrode in the form of a solid disc.
  • the instrumented element comprises a single ring-shaped electrode.
  • the instrumented element comprises several electrodes arranged in several concentric rings.
  • the instrumented element comprises several micro-electrodes organized in several rows and columns.
  • the instrumented element comprises a light source composed of at least one light-emitting diode.
  • the instrumented element comprises a CMOS type sensor.
  • each instrumented element can be partially transparent, non-transparent or totally transparent.
  • the figures 2A and 2B represent a first alternative embodiment of the device 1, made from a single strip of material and of which the two elements are instrumented 20, 21.
  • the first instrumented element 21 thus comprises at least one first functional member and the second instrumented element 20 thus comprises at least one second functional member.
  • the first functional member and the second functional member can work together to measure a parameter (for example electrical measurement, pH measurement, optical detector).
  • a separate electrical conductor connects each functional component of each instrumented element to a separate electrical connection point.
  • the figures 4A and 4B represent a second alternative embodiment of the instrumented device, produced from a single strip of material and of which only one instrumented element 21.
  • the instrumented element 21 comprises at least one functional member connected by an electrical conductor 31 to an electrical connection point 30.
  • Each electrical conductor 31 which connects a distinct functional member of the first instrumented element 21 to a distinct electrical connection point 30 situated on the side of the first end of the instrumented device is integrated into the deformable intermediate part 12 of the device.
  • the functional members allowing the instrumentation of each element of the device 1 are for example arranged on the same face of the strip, for example its upper face thus forming a functional face 100 of the first element 10 and a functional face 110 of the second element 11.
  • Each electrical conductor 31, 33 may be in the form of a conductive track printed on one face of the strip of the measuring device, for example its upper face.
  • the instrumented device can be made of several elements assembled together. It can for example comprise two flexible, semi-rigid or articulated strips fixed to each other by one end only, a first strip carrying the first element at its free end and a second strip carrying the second element at its free end. .
  • the common fixing part of the two strips carries the electrical connection points.
  • each band used in the device can be made of a material chosen from among PET, PEN, Kapton, silicone, polymer film, paper and fabric.
  • Each strip used can have a thickness comprised between 70 and 400 ⁇ m, advantageously comprised between 100 and 300 ⁇ m.
  • the deformable part 12 of the instrumented device can also be in the form of a cord, connecting the two elements 10, 11 to one another, each element being for example in the form of a patch.
  • the functional members of the measuring electrode type and the electrical conductors can be made by any known solution, for example in the form of conductive inks deposited on their element and on the intermediate junction strip, by any known process, such as for example screen printing (for example with masking screen).
  • conductive inks deposited on their element and on the intermediate junction strip
  • screen printing for example with masking screen
  • electrolytic baths is another conceivable option for producing the electrodes.
  • each element can include a PCB-type support on which the electronic component is soldered.
  • the instrumented device may comprise fixing means, configured to fix its first element 10 and/or second element 11 to a surface.
  • These fastening means can be of the adhesive type, covering at least partially the functional face 100 of its first element 10 and/or the functional face 110 of its second element 11, respectively on the periphery of its instrumentation.
  • the material selected to manufacture each element can be conformable, their fixing makes it possible to best match the shape of the surface of the fluidic component 4 on which they are fixed. This is the case, for example, if the receiving surface of component 4 is curved, concave or convex.
  • the instrumented device may also comprise a third element 15 connected to the first element 10 via a second deformable part 62 extending in a direction perpendicular to the axis (X) when the device is at rest.
  • the second deformable part 62 is arranged to bend relative to the first element 10 along an axis parallel to its longitudinal axis (X).
  • the third element 15 can also be instrumented 61 on its functional face and comprise one or more conductive tracks dedicated to its functional organs.
  • this principle can be extended to other architectures, the device thus being able to comprise a greater number of branches, with different orientations.
  • the instrumented device 1 is fitted to the fluidic component 4 to form a first alternative embodiment of the system of the invention. It corresponds to the device described in connection with the figures 2A and 2B . Its two elements are instrumented. Its first element 10 is applied by its functional face 100 against the lower face 41 of the component 4, on the periphery of the first opening 430, to close this opening 430, advantageously in a sealed manner. Its instrumentation 20 is oriented towards the inside of the cavity of the component, for example to come into contact with the fluid 46 present in the cavity 43 if the functional member is an electrode.
  • Its second element 11 is applied by its functional face 110 against the upper face 40 of the component 4, on the periphery of the second opening 431, its instrumentation 21 being oriented towards the interior of the cavity 43, for example to come into contact with the fluid. present in the component cavity.
  • the instrumented device 1 is adapted to the fluidic component 4. It corresponds to the device described in connection with the figures 4A and 4B , to form a second variant of the system of the invention. Only one of its two elements 10, 11 has instrumentation.
  • first element 10 is applied by its functional face 100 against the lower face 41 of the component 4, on the periphery of the first opening 430, and comes to close said opening 430, advantageously in a sealed manner.
  • second element 11 is applied by its functional face 110 against the upper face 40 of the component 4, on the periphery of the second opening 431, its instrumentation 21 oriented towards the inside of the cavity 43.
  • the instrumentation of the device may or may not come into contact with the fluid 46 present in the cavity of the component.
  • the deformable part 12 of the device 1 then makes it possible to circumvent the component 4 at the level of its thickness to ensure the connection between the first element 10 and the second element 11.
  • the adhesive means of the instrumented device are configured to ensure the fixing of the first element 10 and of the second element 11 by adhesion of their functional face 100, 110 respectively against the lower face 41 and the upper face 40 of the component 4. This adhesion may be sufficient to seal the fluidic circuit at each opening, with respect to the outside.
  • the application of the second element 11, by its functional face 110, against the upper face 40 of the component 4 can indeed also make it possible to ensure the tightness of the fluidic circuit. at the level of the second opening 431.
  • the second element 11 can be placed inside the cavity 43 and be embedded therein.
  • the fluidic component 7 may comprise two superposed layers 70, 71, through which a through-cavity is formed.
  • the instrumented device thus presents the configuration of the figure 8 , allowing it to fit on this fluidic component 7.
  • the instrumented device comprises an extension 13 made in the extension of its second support 11, along the axis (X). This extension 13 is produced, in an identical manner, by cutting out the strip of the device.
  • a second deformable part 14 makes it possible to separate the extension from the second support 11.
  • the extension 13 can be integrated into the component and come to be inserted between its two layers 70, 71, to form a membrane separating the cavity into two spaces 72, 73 of the fluidic component 7.
  • the band of the instrumented device can be bent at its second deformable part 14 to apply the second support 11 against the upper face of the component 7 and bent at the first deformable part 12 to apply the first support 10 against the upper face. bottom of the component.
  • the strip of the measuring device thus follows a spiral profile.
  • the extension 13 can form a simple membrane between the two spaces. This membrane can be porous and/or filtering, thus allowing a fluid to pass partially or totally from one space to another.
  • the extension 13 can also carry an electrode 130 arranged on a single face or two electrodes 130, 131 on its two opposite faces, each oriented towards the inside, respectively of the lower space of the fluidic component 7 and of the space upper part of the fluidic component 7.
  • the instrumented device can be produced in the form of a single strip of flexible material, cut in a suitable manner.
  • the instrumented device 1' can be adapted to be positioned on a fluidic component 4' which comprises several juxtaposed cavities 43'. It carries several juxtaposed 10', 20' instrumented elements. Electrical conductors are arranged to connect each of its functional organs to a separate point of connection. A deformable part 12' of the device joins its first elements 10' to its second elements 11'. All the connection points can be brought together in connection means to which a layer of wires can be connected. In this configuration, the device can thus for example measure the parameters of fluids present in different juxtaposed cavities 43', of the same fluidic component 4' or of several adjacent fluidic components. Certain cavities 43' can be independent or interconnected by channels.
  • the figure 15 illustrates an example of manufacture of the instrumented device used in the invention.
  • the various functional organs of the instrumented elements, the conductors and the connection points are printed/deposited on a support, such as a transparent film 5, made of flexible material.
  • the pattern is duplicated several times on the film so as to produce several devices on the same support.
  • the film is cut (laser cut for example) to form the outer contour of each device 1, that is to say its two elements and its deformable part.
  • This manufacturing principle makes it possible in particular to automate manufacturing and to be able to easily manufacture several devices from the same film of flexible material.

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  • Analytical Chemistry (AREA)
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  • Hematology (AREA)
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Description

Domaine technique de l'inventionTechnical field of the invention

La présente invention se rapporte à un système fluidique qui comporte un composant fluidique et un dispositif instrumenté adapté sur ledit composant fluidique pour interagir avec le volume interne du circuit fluidique.The present invention relates to a fluidic system which comprises a fluidic component and an instrumented device adapted to said fluidic component to interact with the internal volume of the fluidic circuit.

Etat de la techniqueState of the art

Dans le domaine des dispositifs fluidiques employés dans des applications biologiques, on cherche à mesurer certaines caractéristiques d'un fluide présent dans le dispositif. On utilise ainsi des capteurs d'impédance, des capteurs électrochimiques, thermiques, ou basés sur le principe de la tomographie.In the field of fluidic devices used in biological applications, it is sought to measure certain characteristics of a fluid present in the device. Impedance sensors, electrochemical sensors, thermal sensors, or sensors based on the principle of tomography are thus used.

Ces capteurs ou transducteurs peuvent par exemple comporter deux électrodes, qu'il est nécessaire d'intégrer au composant fluidique pour effectuer les mesures.These sensors or transducers can for example comprise two electrodes, which it is necessary to integrate into the fluidic component in order to perform the measurements.

Il est connu d'intégrer les électrodes dans des couches du composant fluidique permettant ainsi de fonctionnaliser le composant.It is known to integrate the electrodes into layers of the fluidic component, thus making it possible to functionalize the component.

Cependant, cette architecture nécessite de fabriquer des composants dédiés, ce qui n'est pas optimal en termes de coût et de modularité. Il est également possible d'utiliser des dispositifs externes au composant mais ceux-ci ne disposent souvent pas d'une architecture adaptée au composant fluidique, rendant la prise de mesures peu pratique.However, this architecture requires the manufacture of dedicated components, which is not optimal in terms of cost and modularity. It is also possible to use devices external to the component, but these often do not have an architecture adapted to the fluidic component, making it impractical to take measurements.

La demande de brevet US2020/216789A1 décrit un plateau de culture de cellules qui comporte plusieurs cavités de culture, et un dispositif adaptable sur le plateau pour compartimenter les cavités.The patent application US2020/216789A1 discloses a cell culture tray that includes multiple culture cavities, and a device that fits onto the tray to compartmentalize the cavities.

Le but de l'invention est de proposer un système fluidique qui comporte un composant fluidique sur lequel peut être facilement adapté un dispositif instrumenté capable d'interagir avec le volume interne du composant, ce système étant facile à fabriquer, d'un coût modéré et d'usage aisé.The object of the invention is to propose a fluidic system which comprises a fluidic component on which can be easily adapted an instrumented device capable of interacting with the internal volume of the component, this system being easy to manufacture, of moderate cost and easy to use.

Exposé de l'inventionDisclosure of Invention

Ce but est atteint par un système fluidique comprenant un composant fluidique dans lequel est réalisé un circuit fluidique qui comporte au moins une première ouverture et une deuxième ouverture débouchant sur deux zones distinctes du composant, et un dispositif instrumenté adapté sur ledit composant fluidique, ledit dispositif instrumenté comportant :

  • Un premier élément fixé audit composant fluidique pour fermer ladite première ouverture et un deuxième élément fixé audit composant fluidique pour fermer ladite deuxième ouverture,
  • Une partie déformable reliant le premier élément au deuxième élément,
  • Le premier élément et/ou le deuxième élément étant instrumenté avec au moins un actionneur et/ou un effecteur agencé pour interagir avec un volume interne du circuit fluidique.
This object is achieved by a fluidic system comprising a fluidic component in which is produced a fluidic circuit which comprises at least a first opening and a second opening leading to two distinct zones of the component, and an instrumented device fitted to said fluidic component, said device instrumented comprising:
  • A first element fixed to said fluidic component to close said first opening and a second element fixed to said fluidic component to close said second opening,
  • A deformable part connecting the first element to the second element,
  • The first element and/or the second element being instrumented with at least one actuator and/or one effector arranged to interact with an internal volume of the fluidic circuit.

Selon une particularité, chaque actionneur ou effecteur comporte au moins un organe fonctionnel choisi parmi une électrode, une diode électroluminescente, un capteur optique, une résistance électrique, une thermistance.According to one feature, each actuator or effector comprises at least one functional member selected from an electrode, a light-emitting diode, an optical sensor, an electrical resistor, a thermistor.

Selon une autre particularité, l'organe fonctionnel de type électrode est réalisé sous la forme d'une encre conductrice.According to another feature, the functional member of the electrode type is produced in the form of a conductive ink.

Selon une autre particularité, le système comporte un point de connexion électrique et un conducteur électrique distincts, reliant ledit point de connexion électrique à chaque organe fonctionnel de l'actionneur ou de l'effecteur.According to another feature, the system comprises a separate electrical connection point and an electrical conductor, connecting said electrical connection point to each functional member of the actuator or of the effector.

Selon une autre particularité, chaque conducteur électrique et chaque point de connexion électrique sont réalisés sous la forme d'une encre conductrice.According to another feature, each electrical conductor and each electrical connection point are made in the form of a conductive ink.

Selon une réalisation particulière, le dispositif instrumenté comporte au moins un substrat souple, semi-rigide ou articulé de forme allongée, portant ledit premier élément à une première extrémité et ledit deuxième élément à une deuxième extrémité.According to a particular embodiment, the instrumented device comprises at least one flexible, semi-rigid or articulated substrate of elongated shape, carrying said first element at a first end and said second element at a second end.

Selon une particularité, le premier élément et le deuxième élément sont réalisés dans un matériau conformable, pour s'adapter à la forme du composant fluidique au niveau de ses deux zones.According to one feature, the first element and the second element are made of a conformable material, to adapt to the shape of the fluidic component at its two zones.

Selon une autre particularité, la partie déformable est réalisée sous la forme d'au moins une bande de matière reliant le premier élément au deuxième élément.According to another feature, the deformable part is made in the form of at least one strip of material connecting the first element to the second element.

Selon une réalisation particulière, le substrat comportant le premier élément, le deuxième élément et la partie déformable est réalisé en une seule pièce, sous la forme d'une bande de matière plastique souple.According to a particular embodiment, the substrate comprising the first element, the second element and the deformable part is produced in a single piece, in the form of a strip of flexible plastic material.

Selon une particularité, la bande est réalisée dans un matériau choisi parmi le PET, PEN, Kapton, silicone, film polymère, papier et tissu.According to one feature, the band is made of a material chosen from PET, PEN, Kapton, silicone, polymer film, paper and fabric.

Selon une autre réalisation particulière, le substrat comportant le premier élément (10), le deuxième élément et la partie déformable comporte deux bandes flexibles/souples, semi-rigides ou articulées, accolées entre elles par une partie commune et formant deux brins portant chacun, respectivement, à leur extrémité libre, le premier élément et le deuxième élément.According to another particular embodiment, the substrate comprising the first element (10), the second element and the deformable part comprises two flexible/flexible, semi-rigid or articulated strips, joined together by a common part and forming two strands each carrying, respectively, at their free end, the first element and the second element.

Selon une particularité, chaque bande est réalisée dans un matériau choisi parmi le PET, PEN, Kapton, silicone, film polymère, papier et tissu.According to one feature, each strip is made of a material chosen from PET, PEN, Kapton, silicone, polymer film, paper and fabric.

Selon une autre particularité, le composant fluidique présente une forme de pavé droit et en ce que la première ouverture et la deuxième ouverture débouchent sur deux faces opposées.According to another feature, the fluidic component has the shape of a straight block and in that the first opening and the second opening open onto two opposite faces.

Selon une réalisation particulière :

  • Le composant fluidique comporte deux couches superposées, une première couche et une deuxième couche, ledit circuit fluidique comportant une cavité traversante à travers les deux couches, qui communique d'une part avec la première ouverture et d'autre part avec la deuxième ouverture,
  • Le dispositif instrumenté comporte une extension reliée à son deuxième élément via une deuxième partie déformable, ladite extension étant agencée entre les deux couches du composant pour former une membrane séparant ladite cavité en deux espaces distincts.
According to a particular realization:
  • The fluidic component comprises two superposed layers, a first layer and a second layer, said fluidic circuit comprising a through-cavity through the two layers, which communicates on the one hand with the first opening and on the other hand with the second opening,
  • The instrumented device comprises an extension connected to its second element via a second deformable part, said extension being arranged between the two layers of the component to form a membrane separating said cavity into two separate spaces.

Brève description des figuresBrief description of figures

D'autres caractéristiques et avantages vont apparaître dans la description détaillée qui suit faite en regard des dessins annexés dans lesquels :

  • La figure 1 représente un composant fluidique du système fluidique de l'invention ;
  • Les figures 2A et 2B représentent, respectivement en vue de dessus et en vue de perspective, une première variante de réalisation du dispositif instrumenté employé dans le système fluidique de l'invention ;
  • Les figures 3A et 3B représentent un premier mode de réalisation du système fluidique de l'invention, doté d'un dispositif instrumenté tel que représenté sur les figures 2A et 2B, adapté sur le composant fluidique de la figure 1 ;
  • Les figures 4A et 4B représentent, respectivement en vue de dessus et en vue de perspective, une deuxième variante de réalisation du dispositif instrumenté employé dans le système fluidique de l'invention ;
  • Les figures 5A et 5B représentent un deuxième mode de réalisation du système fluidique de l'invention, doté d'un dispositif instrumenté tel que représenté sur les figures 4A et 4B, adapté sur le composant fluidique de la figure 1 ;
  • La figure 6 montre une variante de réalisation du système fluidique de l'invention ;
  • La figure 7 représente une variante de réalisation d'un composant fluidique employé dans le système fluidique de l'invention ;
  • La figure 8 représente une autre variante de réalisation d'un dispositif instrumenté employé dans le système fluidique de l'invention ;
  • La figure 9 représente une autre variante de réalisation du système fluidique de l'invention, réalisée à partir du composant fluidique de la figure 7 et du dispositif instrumenté de la figure 8 ;
  • La figure 10 représente une variante de réalisation du système fluidique de la figure 9 ;
  • La figure 11 illustre une variante de réalisation du dispositif instrumenté employé dans le système fluidique de l'invention ;
  • La figure 12 représente plusieurs variantes de réalisation d'un élément instrumenté employé dans le dispositif instrumenté du système fluidique de l'invention ;
  • La figure 13 représente une variante de réalisation du dispositif instrumenté employé dans le système fluidique de l'invention ;
  • Les figures 14A et 14B représentent respectivement une variante de réalisation du composant fluidique du système fluidique de l'invention et une variante de réalisation du dispositif instrumenté employé pour s'adapter sur ce composant fluidique ;
  • La figure 15 illustre un principe de fabrication du dispositif instrumenté employé dans le système fluidique de l'invention ;
Other characteristics and advantages will appear in the detailed description which follows given with regard to the appended drawings in which:
  • The figure 1 represents a fluidic component of the fluidic system of the invention;
  • The figures 2A and 2B represent, respectively in top view and in perspective view, a first alternative embodiment of the instrumented device used in the fluidic system of the invention;
  • The figures 3A and 3B represent a first embodiment of the fluidic system of the invention, provided with an instrumented device as represented on the figures 2A and 2B , adapted to the fluidic component of the figure 1 ;
  • The figures 4A and 4B represent, respectively in top view and in perspective view, a second alternative embodiment of the instrumented device used in the fluidic system of the invention;
  • The figures 5A and 5B represent a second embodiment of the fluidic system of the invention, provided with an instrumented device as represented on the figures 4A and 4B , adapted to the fluidic component of the figure 1 ;
  • The figure 6 shows an alternative embodiment of the fluidic system of the invention;
  • The figure 7 represents an alternative embodiment of a fluidic component employed in the fluidic system of the invention;
  • The figure 8 represents another alternative embodiment of an instrumented device used in the fluidic system of the invention;
  • The figure 9 represents another alternative embodiment of the fluidic system of the invention, made from the fluidic component of the figure 7 and the instrumented device of the figure 8 ;
  • The figure 10 represents a variant embodiment of the fluidic system of the figure 9 ;
  • The figure 11 illustrates a variant embodiment of the instrumented device used in the fluidic system of the invention;
  • The figure 12 represents several alternative embodiments of an instrumented element used in the instrumented device of the fluidic system of the invention;
  • The figure 13 represents a variant embodiment of the instrumented device used in the fluidic system of the invention;
  • The figures 14A and 14B represent respectively an alternative embodiment of the fluidic component of the fluidic system of the invention and an alternative embodiment of the instrumented device used to fit on this fluidic component;
  • The figure 15 illustrates a manufacturing principle of the instrumented device used in the fluidic system of the invention;

Description détaillée d'au moins un mode de réalisationDetailed description of at least one embodiment

L'invention concerne un système fluidique qui comporte un composant fluidique et un dispositif instrumenté 1 défini ci-après.The invention relates to a fluidic system which comprises a fluidic component and an instrumented device 1 defined below.

Le dispositif instrumenté 1 est destiné à venir s'adapter sur le composant fluidique 4.The instrumented device 1 is intended to fit onto the fluidic component 4.

En référence à la figure 1, le composant fluidique 4 comporte un substrat dans lequel est réalisé un circuit fluidique. Ce circuit fluidique peut être plus ou moins complexe.With reference to the figure 1 , the fluidic component 4 comprises a substrate in which a fluidic circuit is made. This fluidic circuit can be more or less complex.

De manière non limitative, le substrat du composant fluidique 4 peut se présenter sous la forme d'une brique ou d'une carte, présentant au moins deux faces opposées, avantageusement parallèles entre elles, dites face supérieure 40 et face inférieure 41 et une paroi dite latérale 42 agencée entre les deux faces. De manière non limitative, sa base peut être en forme de rectangle ou de disque. Le substrat peut bien entendu présenter toute autre forme.In a non-limiting way, the substrate of the fluidic component 4 can be in the form of a brick or a card, presenting at least two opposite faces, advantageously parallel to each other, called upper face 40 and lower face 41 and a wall said side 42 arranged between the two faces. In a non-limiting way, its base can be in the shape of a rectangle or a disk. The substrate can of course have any other shape.

Son circuit fluidique peut comporter une cavité 43, par exemple destinée à être remplie d'un fluide 46. A titre d'exemple, le fluide peut être un liquide, un gaz ou un gel ou un mélange de plusieurs fluides. La cavité 43 pourrait être également placée sous vide.Its fluidic circuit may comprise a cavity 43, for example intended to be filled with a fluid 46. By way of example, the fluid may be a liquid, a gas or a gel or a mixture of several fluids. Cavity 43 could also be placed under vacuum.

La cavité 43 peut être traversante et déboucher par une première ouverture 430 sur sa face inférieure et par une deuxième ouverture 431 sur sa face supérieure.The cavity 43 can pass through and emerge via a first opening 430 on its lower face and via a second opening 431 on its upper face.

Le circuit fluidique du composant 4 peut présenter deux canaux 44, 45 débouchant chacun, d'une part, à l'extérieur du composant 4 et d'autre part à l'intérieur de la cavité 43, permettant d'injecter un fluide dans la cavité. De manière non limitative, les deux canaux peuvent par exemple déboucher sur la face supérieure 40 du composant ou sur sa paroi latérale 42.The fluidic circuit of component 4 may have two channels 44, 45 each opening, on the one hand, outside component 4 and on the other hand inside cavity 43, making it possible to inject a fluid into the cavity. In a non-limiting way, the two channels can for example lead to the upper face 40 of the component or to its side wall 42.

En référence aux figures 2A, 2B et 4A, 4B, le dispositif instrumenté 1 comporte avantageusement un substrat souple, semi-rigide ou articulé, ayant une épaisseur de quelques µm. Au repos, le substrat peut présenter une architecture plate à deux faces planes opposées, dites face supérieure et face inférieure, et est allongée suivant un axe longitudinal (X), de manière à présenter deux extrémités. Le substrat comporte au moins une partie intermédiaire déformable 12, formée par l'utilisation d'un matériau souple ou semi-rigide ou par un ensemble articulé. Par déformable, on entend que le substrat peut présenter, au moins au niveau de sa partie intermédiaire, des caractéristiques mécaniques qui lui permettent de se déformer suffisamment, par exemple pour épouser la forme d'une surface et pour se plier au moins partiellement pour venir s'adapter sur le composant fluidique 4.With reference to Figures 2A, 2B and 4A, 4B , the instrumented device 1 advantageously comprises a flexible, semi-rigid or articulated substrate, having a thickness of a few μm. At rest, the substrate can have a flat architecture with two opposite planar faces, called upper face and lower face, and is elongated along a longitudinal axis (X), so as to have two ends. The substrate comprises at least one deformable intermediate part 12, formed by the use of a flexible or semi-rigid material or by an articulated assembly. By deformable, it is meant that the substrate can present, at least at its intermediate part, characteristics mechanisms that allow it to deform sufficiently, for example to match the shape of a surface and to bend at least partially to fit on the fluidic component 4.

Le substrat comporte, à une première extrémité, un premier élément 10 et, à sa deuxième extrémité, un deuxième élément 11.The substrate comprises, at a first end, a first element 10 and, at its second end, a second element 11.

La partie intermédiaire déformable 12 relie son premier élément 10 à son deuxième élément 11 et s'étend, au repos, suivant son axe longitudinal (X).The deformable intermediate part 12 connects its first element 10 to its second element 11 and extends, at rest, along its longitudinal axis (X).

Cette partie 12 est avantageusement déformable en flexion, formant comme une charnière entre le premier élément 10 et le deuxième élément 11, autour d'un axe perpendiculaire à son axe longitudinal (X) et situé dans le plan de support. Elle peut également être déformable en torsion autour de son axe longitudinal (X). La déformation en flexion doit être suffisante pour permettre de ramener le deuxième élément au-dessus du premier élément. La déformation en torsion doit être au moins suffisante pour ajuster le positionnement du deuxième élément par rapport au premier élément. Sa déformabilité est avantageusement élastique, lui permettant de revenir dans son état de repos, en dehors de toute sollicitation mécanique.This part 12 is advantageously deformable in bending, forming like a hinge between the first element 10 and the second element 11, around an axis perpendicular to its longitudinal axis (X) and located in the support plane. It can also be deformable in torsion around its longitudinal axis (X). The bending deformation must be sufficient to allow the second element to be brought back above the first element. The torsional deformation must be at least sufficient to adjust the positioning of the second element relative to the first element. Its deformability is advantageously elastic, allowing it to return to its state of rest, apart from any mechanical stress.

Le premier élément 10 et le deuxième élément 11 du dispositif peuvent se présenter sous la forme d'une pastille.The first element 10 and the second element 11 of the device can be in the form of a pellet.

Les deux éléments 10, 11 peuvent être de nature conformable, leur permettant d'épouser au mieux une surface, notamment la surface du composant sur laquelle ils sont destinés à être apposés.The two elements 10, 11 can be of a conformable nature, allowing them to conform as well as possible to a surface, in particular the surface of the component on which they are intended to be affixed.

La partie déformable 12 du substrat peut se présenter sous la forme d'une bande intermédiaire de jonction reliant les deux pastilles, et peut ainsi former une nappe conductrice.The deformable part 12 of the substrate can take the form of an intermediate junction strip connecting the two pads, and can thus form a conductive sheet.

Le dispositif instrumenté 1 peut être réalisé à partir d'un seul substrat monobloc. Il peut alors comporter une unique bande ou ruban réalisé en matière plastique souple et flexible, semi-rigide ou articulé, découpé suivant un profil adapté pour former le premier élément, le deuxième élément et la partie déformable joignant le premier élément au deuxième élément.The instrumented device 1 can be made from a single one-piece substrate. It can then comprise a single band or ribbon made of soft and flexible plastic material, semi-rigid or articulated, cut according to a profile adapted to form the first element, the second element and the deformable part joining the first element to the second element.

Le découpage de la bande permet ainsi de former deux pastilles et la partie déformable 12.The cutting of the strip thus makes it possible to form two pellets and the deformable part 12.

Cette bande peut être réalisée en matériau transparent, partiellement transparent ou opaque.This band can be made of transparent, partially transparent or opaque material.

La bande comporte deux faces principales opposées, dites face supérieure et face inférieure.The strip has two opposite main faces, called the upper face and the lower face.

Le premier élément 10 et le deuxième élément 11 dudit dispositif peuvent être chacun instrumentés (références 20, 21). L'instrumentation 20, 21 de chaque élément est avantageusement réalisée sur une face, dite fonctionnelle de l'élément correspondant du dispositif. L'instrumentation permet au dispositif d'interagir avec le volume interne du circuit fluidique du composant. Le volume interne du circuit fluidique peut être rempli d'un fluide ou placé sous-vide et le dispositif instrumenté est destiné à effectuer une mesure d'au moins un paramètre, stimuler ou réagir au fluide placé dans le circuit fluidique du composant, ou effectuer une mesure d'au moins un paramètre, stimuler ou réagir par rapport à ce volume mis sous vide.The first element 10 and the second element 11 of said device can each be instrumented (references 20, 21). The instrumentation 20, 21 of each element is advantageously made on a so-called functional face of the corresponding element of the device. The instrumentation allows the device to interact with the internal volume of the fluidic circuit of the component. The internal volume of the fluidic circuit can be filled with a fluid or placed under vacuum and the instrumented device is intended to perform a measurement of at least one parameter, to stimulate or react to the fluid placed in the fluidic circuit of the component, or to perform a measurement of at least one parameter, stimulate or react with respect to this volume put under vacuum.

De manière non limitative, grâce à son instrumentation, le dispositif peut être adapté pour mesurer des paramètres de type électrique (impédance, capacité, résistance), chimique, électrochimique, optique, thermique ou autres (en transmission ou en réflexion), pour stimuler électriquement ou optiquement un fluide.In a non-limiting way, thanks to its instrumentation, the device can be adapted to measure parameters of the electrical type (impedance, capacitance, resistance), chemical, electrochemical, optical, thermal or other (in transmission or in reflection), to electrically stimulate or optically a fluid.

Pour cela, le dispositif instrumenté 1 peut en effet comporter au moins un actionneur, au moins un effecteur, ou au moins un couple actionneur/effecteur agencé, selon le cas, dans un seul élément instrumenté ou dans les deux éléments instrumentés.For this, the instrumented device 1 can in fact comprise at least one actuator, at least one effector, or at least one actuator/effector pair arranged, as the case may be, in a single instrumented element or in both instrumented elements.

Par actionneur, on entend un dispositif capable de réaliser une action sur commande et de générer un signal de stimulation.By actuator is meant a device capable of performing an action on command and of generating a stimulation signal.

Par effecteur, on entend un dispositif capable de réagir à une stimulation.By effector is meant a device capable of reacting to stimulation.

De manière non limitative, l'actionneur ou l'effecteur peut ainsi comporter un ou plusieurs organes fonctionnels.In a non-limiting way, the actuator or the effector can thus comprise one or more functional members.

De manière non limitative, à titre d'exemple, un organe fonctionnel peut être une électrode, par exemple employé pour une mesure électrique ou une mesure de pH, une diode électroluminescente, un capteur optique de type CMOS ou équivalent, une thermistance, une résistance électrique.In a non-limiting way, by way of example, a functional member can be an electrode, for example used for an electrical measurement or a pH measurement, a light-emitting diode, a CMOS type optical sensor or equivalent, a thermistor, a resistor electric.

La composition et l'architecture de chaque organe fonctionnel dépendent bien entendu de la fonction à remplir.The composition and architecture of each functional organ obviously depends on the function to be fulfilled.

A titre d'exemple, pour certaines fonctions de mesure, le dispositif instrumenté peut comporter au moins deux organes fonctionnels. C'est le cas d'un détecteur optique qui peut comporter une diode électroluminescente et un capteur CMOS ou équivalent, d'un capteur de pH qui comporte une électrode de référence et une électrode de mesure, d'un capteur d'impédance qui comporte deux électrodes. Pour un capteur de température, le dispositif peut comporter un seul organe fonctionnel formé d'une thermistance. Pour une stimulation électrique, le dispositif peut comporter une seule électrode.By way of example, for certain measurement functions, the instrumented device can comprise at least two functional members. This is the case of an optical detector which may comprise a light-emitting diode and a CMOS sensor or equivalent, of a pH sensor which comprises a reference electrode and a measurement electrode, of an impedance sensor which comprises two electrodes. For a sensor temperature, the device may comprise a single functional member formed of a thermistor. For electrical stimulation, the device may comprise a single electrode.

Les données récoltées par le dispositif instrumenté peuvent être renvoyées vers une unité de mesure 8.The data collected by the instrumented device can be sent back to a measurement unit 8.

La figure 12 représente plusieurs exemples de réalisation d'un élément instrumenté du dispositif 1.The figure 12 represents several embodiments of an instrumented element of the device 1.

Dans la réalisation V1, l'élément instrumenté comporte une seule électrode en forme de disque plein.In embodiment V1, the instrumented element comprises a single electrode in the form of a solid disc.

Dans la variante V2, l'élément instrumenté comporte une seule électrode en forme d'anneau.In variant V2, the instrumented element comprises a single ring-shaped electrode.

Dans la variante V3, l'élément instrumenté comporte plusieurs électrodes arrangées en plusieurs anneaux concentriques.In variant V3, the instrumented element comprises several electrodes arranged in several concentric rings.

Dans la variante V4, l'élément instrumenté comporte plusieurs micro-électrodes organisées en plusieurs lignes et colonnes.In variant V4, the instrumented element comprises several micro-electrodes organized in several rows and columns.

Dans la variante V5, l'élément instrumenté comporte une source lumineuse composée d'au moins une diode électroluminescente.In variant V5, the instrumented element comprises a light source composed of at least one light-emitting diode.

Dans la variante V6, l'élément instrumenté comporte un capteur de type CMOS.In variant V6, the instrumented element comprises a CMOS type sensor.

Selon leur architecture, chaque élément instrumenté peut être partiellement transparent, non-transparent ou totalement transparent.Depending on their architecture, each instrumented element can be partially transparent, non-transparent or totally transparent.

Les figures 2A et 2B représentent une première variante de réalisation du dispositif 1, réalisé à partir d'une seule bande de matière et dont les deux éléments sont instrumentés 20, 21.The figures 2A and 2B represent a first alternative embodiment of the device 1, made from a single strip of material and of which the two elements are instrumented 20, 21.

Le premier élément instrumenté 21 comporte ainsi au moins un premier organe fonctionnel et le deuxième élément instrumenté 20 comporte ainsi au moins un deuxième organe fonctionnel. De manière non limitative, le premier organe fonctionnel et le deuxième organe fonctionnel peuvent travailler ensemble à la mesure d'un paramètre (par exemple mesure électrique, mesure de pH, détecteur optique). Un conducteur électrique distinct relie chaque organe fonctionnel de chaque élément instrumenté à un point de connexion électrique distinct.The first instrumented element 21 thus comprises at least one first functional member and the second instrumented element 20 thus comprises at least one second functional member. In a non-limiting way, the first functional member and the second functional member can work together to measure a parameter (for example electrical measurement, pH measurement, optical detector). A separate electrical conductor connects each functional component of each instrumented element to a separate electrical connection point.

Les figures 4A et 4B représentent une deuxième variante de réalisation du dispositif instrumenté, réalisé à partir d'une seule bande de matière et dont un seul élément est instrumenté 21. L'élément instrumenté 21 comporte au moins un organe fonctionnel relié par un conducteur électrique 31 à un point de connexion électrique 30.The figures 4A and 4B represent a second alternative embodiment of the instrumented device, produced from a single strip of material and of which only one instrumented element 21. The instrumented element 21 comprises at least one functional member connected by an electrical conductor 31 to an electrical connection point 30.

Chaque conducteur électrique 31 qui relie un organe fonctionnel distinct du premier élément instrumenté 21 à un point de connexion électrique 30 distinct situé du côté de la première extrémité du dispositif instrumenté est intégré à la partie intermédiaire déformable 12 du dispositif.Each electrical conductor 31 which connects a distinct functional member of the first instrumented element 21 to a distinct electrical connection point 30 situated on the side of the first end of the instrumented device is integrated into the deformable intermediate part 12 of the device.

On aura ainsi autant de conducteurs électriques que d'organes fonctionnels présents dans le dispositif instrumenté.There will thus be as many electrical conductors as functional members present in the instrumented device.

Les organes fonctionnels permettant l'instrumentation de chaque élément du dispositif 1 sont par exemple agencés sur la même face de la bande, par exemple sa face supérieure formant ainsi une face fonctionnelle 100 du premier élément 10 et une face fonctionnelle 110 du deuxième élément 11.The functional members allowing the instrumentation of each element of the device 1 are for example arranged on the same face of the strip, for example its upper face thus forming a functional face 100 of the first element 10 and a functional face 110 of the second element 11.

Chaque conducteur électrique 31, 33 peut se présenter sous la forme d'une piste conductrice imprimée sur une face de la bande du dispositif de mesure, par exemple sa face supérieure.Each electrical conductor 31, 33 may be in the form of a conductive track printed on one face of the strip of the measuring device, for example its upper face.

Sur la figure 11, en variante de réalisation, le dispositif instrumenté peut être réalisé en plusieurs éléments assemblés entre eux. Il peut par exemple comporter deux bandes souples, semi-rigides ou articulées fixées l'une à l'autre par une extrémité uniquement, une première bande portant le premier élément à son extrémité libre et une deuxième bande portant le deuxième élément à son extrémité libre. La partie commune de fixation des deux bandes porte les points de connexion électrique.On the figure 11 , as an alternative embodiment, the instrumented device can be made of several elements assembled together. It can for example comprise two flexible, semi-rigid or articulated strips fixed to each other by one end only, a first strip carrying the first element at its free end and a second strip carrying the second element at its free end. . The common fixing part of the two strips carries the electrical connection points.

De manière non limitative, chaque bande employée dans le dispositif (une seule bande ou plusieurs selon la réalisation) peut être réalisée dans un matériau choisi parmi le PET, PEN, Kapton, silicone, film polymère, papier et tissu.In a non-limiting manner, each band used in the device (a single band or several depending on the embodiment) can be made of a material chosen from among PET, PEN, Kapton, silicone, polymer film, paper and fabric.

Chaque bande employée peut présenter une épaisseur comprise entre 70 et 400µm, avantageusement comprise entre 100 et 300µm.Each strip used can have a thickness comprised between 70 and 400 μm, advantageously comprised between 100 and 300 μm.

En variante de réalisation, la partie déformable 12 du dispositif instrumenté peut également se présenter sous la forme d'un cordon, reliant les deux éléments 10, 11 entre eux, chaque élément se présentant par exemple sous la forme d'une pastille.As a variant embodiment, the deformable part 12 of the instrumented device can also be in the form of a cord, connecting the two elements 10, 11 to one another, each element being for example in the form of a patch.

Les organes fonctionnels de type électrodes de mesure et les conducteurs électriques peuvent être réalisés par toute solution connue, par exemple sous la forme d'encres conductrices déposées sur leur élément et sur la bande intermédiaire de jonction, par tout process connu, tel que par exemple la sérigraphie (par exemple avec écran de masquage). Pour réaliser chaque électrode et les conducteurs électriques, des procédés de métallisation par évaporation, ou de pulvérisation peuvent également être envisagées. L'utilisation de bains électrolytiques est une autre option envisageable pour la réalisation des électrodes. Pour les organes fonctionnels de type électronique (diode, capteur CMOS,...), chaque élément peut comporter un support de type carte PCB sur lequel est soudé le composant électronique.The functional members of the measuring electrode type and the electrical conductors can be made by any known solution, for example in the form of conductive inks deposited on their element and on the intermediate junction strip, by any known process, such as for example screen printing (for example with masking screen). To produce each electrode and the electrical conductors, metallization processes by evaporation, or sputtering can also be envisaged. The use of electrolytic baths is another conceivable option for producing the electrodes. For the electronic-type functional components (diode, CMOS sensor, etc.), each element can include a PCB-type support on which the electronic component is soldered.

De manière non limitative, le dispositif instrumenté peut comporter des moyens de fixation, configurés pour fixer son premier élément 10 et/ou deuxième élément 11 sur une surface. Ces moyens de fixation peuvent être de type adhésif, recouvrant au moins partiellement la face fonctionnelle 100 de son premier élément 10 et/ou la face fonctionnelle 110 de son deuxième élément 11, en périphérie respectivement de son instrumentation. Le matériau retenu pour fabriquer chaque élément pouvant être conformable, leur fixation permet d'épouser au mieux la forme de la surface du composant fluidique 4 sur lequel ils sont fixés. C'est le cas, par exemple, si la surface de réception du composant 4 est bombée, concave ou convexe.In a non-limiting manner, the instrumented device may comprise fixing means, configured to fix its first element 10 and/or second element 11 to a surface. These fastening means can be of the adhesive type, covering at least partially the functional face 100 of its first element 10 and/or the functional face 110 of its second element 11, respectively on the periphery of its instrumentation. The material selected to manufacture each element can be conformable, their fixing makes it possible to best match the shape of the surface of the fluidic component 4 on which they are fixed. This is the case, for example, if the receiving surface of component 4 is curved, concave or convex.

Selon une variante de réalisation représentée sur la figure 13, le dispositif instrumenté peut également comporter un troisième élément 15 relié au premier élément 10 via une deuxième partie déformable 62 s'étendant suivant une direction perpendiculaire à l'axe (X) lorsque le dispositif est au repos. La deuxième partie déformable 62 est agencée pour fléchir par rapport au premier élément 10 suivant un axe parallèle à son axe longitudinal (X). Le troisième élément 15 peut également être instrumenté 61 sur sa face fonctionnelle et comporter une ou plusieurs pistes conductrices dédiées à ses organes fonctionnels. Bien entendu, on comprend que ce principe peut être étendu à d'autres architectures, le dispositif pouvant comporter ainsi un nombre de branches plus important, avec des orientations différentes.According to a variant embodiment shown in the figure 13 , the instrumented device may also comprise a third element 15 connected to the first element 10 via a second deformable part 62 extending in a direction perpendicular to the axis (X) when the device is at rest. The second deformable part 62 is arranged to bend relative to the first element 10 along an axis parallel to its longitudinal axis (X). The third element 15 can also be instrumented 61 on its functional face and comprise one or more conductive tracks dedicated to its functional organs. Of course, it is understood that this principle can be extended to other architectures, the device thus being able to comprise a greater number of branches, with different orientations.

Sur les figures 3A et 3B, le dispositif instrumenté 1 est adapté sur le composant fluidique 4 pour former une première variante de réalisation du système de l'invention. Il correspond au dispositif décrit en liaison avec les figures 2A et 2B. Ses deux éléments sont instrumentés. Son premier élément 10 est appliqué par sa face fonctionnelle 100 contre la face inférieure 41 du composant 4, en périphérie de la première ouverture 430, pour venir fermer cette ouverture 430, avantageusement de manière étanche. Son instrumentation 20 est orienté vers l'intérieur de la cavité du composant, par exemple pour venir en contact avec le fluide 46 présent dans la cavité 43 si l'organe fonctionnel est une électrode. Son deuxième élément11 est appliqué par sa face fonctionnelle 110 contre la face supérieure 40 du composant 4, en périphérie de la deuxième ouverture 431, son instrumentation 21 étant orienté vers l'intérieur de la cavité 43, par exemple pour venir en contact avec le fluide présent dans la cavité du composant.On the figures 3A and 3B , the instrumented device 1 is fitted to the fluidic component 4 to form a first alternative embodiment of the system of the invention. It corresponds to the device described in connection with the figures 2A and 2B . Its two elements are instrumented. Its first element 10 is applied by its functional face 100 against the lower face 41 of the component 4, on the periphery of the first opening 430, to close this opening 430, advantageously in a sealed manner. Its instrumentation 20 is oriented towards the inside of the cavity of the component, for example to come into contact with the fluid 46 present in the cavity 43 if the functional member is an electrode. Its second element 11 is applied by its functional face 110 against the upper face 40 of the component 4, on the periphery of the second opening 431, its instrumentation 21 being oriented towards the interior of the cavity 43, for example to come into contact with the fluid. present in the component cavity.

Sur les figures 5A et 5B, le dispositif instrumenté 1 est adapté sur le composant fluidique 4. Il correspond au dispositif décrit en liaison avec les figures 4A et 4B, pour former une deuxième variante du système de l'invention. Un seul de ses deux éléments 10, 11 est doté d'une instrumentation.On the figures 5A and 5B , the instrumented device 1 is adapted to the fluidic component 4. It corresponds to the device described in connection with the figures 4A and 4B , to form a second variant of the system of the invention. Only one of its two elements 10, 11 has instrumentation.

Son premier élément 10 est appliqué par sa face fonctionnelle 100 contre la face inférieure 41 du composant 4, en périphérie de la première ouverture 430, et vient fermer ladite ouverture 430, avantageusement de manière étanche. Son deuxième élément 11 est appliqué par sa face fonctionnelle 110 contre la face supérieure 40 du composant 4, en périphérie de la deuxième ouverture 431, son instrumentation 21 orienté vers l'intérieur de la cavité 43. Selon la fonction à remplir, l'instrumentation du dispositif peut venir en contact ou non avec le fluide 46 présent dans la cavité du composant.Its first element 10 is applied by its functional face 100 against the lower face 41 of the component 4, on the periphery of the first opening 430, and comes to close said opening 430, advantageously in a sealed manner. Its second element 11 is applied by its functional face 110 against the upper face 40 of the component 4, on the periphery of the second opening 431, its instrumentation 21 oriented towards the inside of the cavity 43. Depending on the function to be performed, the instrumentation of the device may or may not come into contact with the fluid 46 present in the cavity of the component.

Dans les deux configurations, la partie déformable 12 du dispositif 1 permet alors de contourner le composant 4 au niveau de son épaisseur pour assurer la liaison entre le premier élément 10 et le deuxième élément 11.In both configurations, the deformable part 12 of the device 1 then makes it possible to circumvent the component 4 at the level of its thickness to ensure the connection between the first element 10 and the second element 11.

Les moyens adhésifs du dispositif instrumenté sont configurés pour assurer la fixation du premier élément 10 et du deuxième élément 11 par adhésion de leur face fonctionnelle 100, 110 respectivement contre la face inférieure 41 et la face supérieure 40 du composant 4. Cette adhésion peut être suffisante pour assurer une étanchéité du circuit fluidique au niveau de chaque ouverture, par rapport à l'extérieur. Comme pour le premier élément 10 au niveau de la première ouverture 430, l'application du deuxième élément 11, par sa face fonctionnelle 110, contre la face supérieure 40 du composant 4 peut en effet également permettre d'assurer l'étanchéité du circuit fluidique au niveau de la deuxième ouverture 431.The adhesive means of the instrumented device are configured to ensure the fixing of the first element 10 and of the second element 11 by adhesion of their functional face 100, 110 respectively against the lower face 41 and the upper face 40 of the component 4. This adhesion may be sufficient to seal the fluidic circuit at each opening, with respect to the outside. As for the first element 10 at the level of the first opening 430, the application of the second element 11, by its functional face 110, against the upper face 40 of the component 4 can indeed also make it possible to ensure the tightness of the fluidic circuit. at the level of the second opening 431.

Selon un aspect particulier de l'invention, comme représenté sur la figure 6, le deuxième élément 11 peut être placé à l'intérieur de la cavité 43 et venir s'encastrer dans celle-ci.According to a particular aspect of the invention, as shown in the figure 6 , the second element 11 can be placed inside the cavity 43 and be embedded therein.

Dans une variante de réalisation représentée sur la figure 7, le composant fluidique 7 peut comporter deux couches 70, 71 superposées, à travers laquelle est formée une cavité traversante. Le dispositif instrumenté présente ainsi la configuration de la figure 8, lui permettant de s'adapter sur ce composant fluidique 7. Le dispositif instrumenté comporte une extension 13 réalisée dans le prolongement de son deuxième support 11, suivant l'axe (X). Cette extension 13 est réalisée, de manière identique, par découpe de la bande du dispositif. Une deuxième partie déformable 14 permet de séparer l'extension du deuxième support 11.In a variant embodiment shown in the figure 7 , the fluidic component 7 may comprise two superposed layers 70, 71, through which a through-cavity is formed. The instrumented device thus presents the configuration of the figure 8 , allowing it to fit on this fluidic component 7. The instrumented device comprises an extension 13 made in the extension of its second support 11, along the axis (X). This extension 13 is produced, in an identical manner, by cutting out the strip of the device. A second deformable part 14 makes it possible to separate the extension from the second support 11.

En référence à la figure 9, l'extension 13 peut être intégrée dans le composant et venir s'intercaler entre ses deux couches 70, 71, pour former une membrane séparant la cavité en deux espaces 72, 73 du composant fluidique 7.With reference to the figure 9 , the extension 13 can be integrated into the component and come to be inserted between its two layers 70, 71, to form a membrane separating the cavity into two spaces 72, 73 of the fluidic component 7.

La bande du dispositif instrumenté peut être pliée au niveau de sa deuxième partie déformable 14 pour venir appliquer le deuxième support 11 contre la face supérieure du composant 7 et pliée au niveau de la première partie déformable 12 pour venir appliquer le premier support 10 contre la face inférieure du composant. La bande du dispositif de mesure suit ainsi un profil en spirale.The band of the instrumented device can be bent at its second deformable part 14 to apply the second support 11 against the upper face of the component 7 and bent at the first deformable part 12 to apply the first support 10 against the upper face. bottom of the component. The strip of the measuring device thus follows a spiral profile.

Sur la figure 9, l'extension 13 peut former une simple membrane entre les deux espaces. Cette membrane pouvant être poreuse et/ou filtrante, permettant ainsi à un fluide de passer partiellement ou totalement d'un espace à l'autre. En variante de réalisation illustrée par la figure 10, l'extension 13 peut également porter une électrode 130 agencée sur une seule face ou deux électrodes 130, 131 sur ses deux faces opposées, orientées chacune vers l'intérieur, respectivement de l'espace inférieure du composant fluidique 7 et de l'espace supérieure du composant fluidique 7. Comme pour les réalisations précédentes, dans cette variante de réalisation, le dispositif instrumenté peut être réalisé sous la forme d'une unique bande de matière souple, découpée de manière adaptée.On the figure 9 , the extension 13 can form a simple membrane between the two spaces. This membrane can be porous and/or filtering, thus allowing a fluid to pass partially or totally from one space to another. In the alternative embodiment illustrated by the figure 10 , the extension 13 can also carry an electrode 130 arranged on a single face or two electrodes 130, 131 on its two opposite faces, each oriented towards the inside, respectively of the lower space of the fluidic component 7 and of the space upper part of the fluidic component 7. As for the previous embodiments, in this variant embodiment, the instrumented device can be produced in the form of a single strip of flexible material, cut in a suitable manner.

Selon une variante de réalisation illustrée par les figures 14A et 14B, le dispositif instrumenté 1' peut être adapté pour se positionner sur un composant 4' fluidique qui comporte plusieurs cavités 43' juxtaposées. Il porte plusieurs éléments 10', 20' instrumentés juxtaposées. Des conducteurs électriques sont agencés pour connecter chacun de ses organes fonctionnels à un point de connexion distinct. Une partie déformable 12' du dispositif joint ses premiers éléments 10' à ses deuxièmes éléments 11'. Tous les points de connexion peuvent être réunis dans des moyens de connexion sur lesquels peut venir se connecter une nappe de fils. Dans cette configuration, le dispositif peut ainsi par exemple mesurer des paramètres de fluides présents dans différentes cavités 43' juxtaposées, d'un même composant 4' fluidique ou de plusieurs composants fluidiques adjacents. Certaines cavités 43' peuvent être indépendantes ou reliées entre elles par des canaux.According to a variant embodiment illustrated by the figures 14A and 14B , the instrumented device 1' can be adapted to be positioned on a fluidic component 4' which comprises several juxtaposed cavities 43'. It carries several juxtaposed 10', 20' instrumented elements. Electrical conductors are arranged to connect each of its functional organs to a separate point of connection. A deformable part 12' of the device joins its first elements 10' to its second elements 11'. All the connection points can be brought together in connection means to which a layer of wires can be connected. In this configuration, the device can thus for example measure the parameters of fluids present in different juxtaposed cavities 43', of the same fluidic component 4' or of several adjacent fluidic components. Certain cavities 43' can be independent or interconnected by channels.

La figure 15 illustre un exemple de fabrication du dispositif instrumenté employé dans l'invention. Les différents organes fonctionnels des éléments instrumentés, les conducteurs et les points de connexion sont imprimés/déposés sur un support, tel qu'un film transparent 5, en matériau souple. Le motif est dupliqué plusieurs fois sur le film de manière à réaliser plusieurs dispositifs sur un même support. Puis le film est découpé (découpe laser par exemple) pour former le contour externe de chaque dispositif 1, c'est-à-dire ses deux éléments et sa partie déformable. Ce principe de fabrication permet notamment d'automatiser la fabrication et de pouvoir facilement fabriquer plusieurs dispositifs à partir d'un même film de matière souple.The figure 15 illustrates an example of manufacture of the instrumented device used in the invention. The various functional organs of the instrumented elements, the conductors and the connection points are printed/deposited on a support, such as a transparent film 5, made of flexible material. The pattern is duplicated several times on the film so as to produce several devices on the same support. Then the film is cut (laser cut for example) to form the outer contour of each device 1, that is to say its two elements and its deformable part. This manufacturing principle makes it possible in particular to automate manufacturing and to be able to easily manufacture several devices from the same film of flexible material.

L'invention présente ainsi de nombreux avantages, parmi lesquels :

  • Une facilité d'usage, permise notamment par une capacité d'adaptation à différentes formes de composants fluidiques ;
  • Une indépendance par rapport au composant fluidique, le dispositif instrumenté pouvant notamment être réutilisable ;
  • Une facilité de fabrication, à toutes les étapes (sérigraphie, découpe Laser,...) ;
  • Solution pouvant garantir une étanchéité au niveau du composant ;
  • Solution à bas coût de revient ;
The invention thus has many advantages, including:
  • Ease of use, made possible in particular by an ability to adapt to different forms of fluidic components;
  • Independence with respect to the fluidic component, the instrumented device being able in particular to be reusable;
  • Ease of manufacturing, at all stages (screen printing, laser cutting, etc.);
  • Solution that can guarantee sealing at the component level;
  • Low cost solution;

Claims (14)

  1. Fluidic system comprising a fluidic component (4, 7) in which is produced a fluidic circuit that comprises at least a first aperture and a second aperture opening onto two distinct regions of the component, and an instrumented device fitted on said fluidic component, characterized in that said instrumented device comprises:
    - first element (10) fastened to said fluidic component to close said first aperture and a second element (11) fastened to said fluidic component to close said second aperture,
    - deformable portion (12) joining the first element (10) to the second element (11), and in that
    - the first element and/or the second element is instrumented with at least one actuator and/or an effector arranged to interact with an internal volume of the fluidic circuit.
  2. System according to Claim 1, characterized in that each actuator or effector comprises at least one functional unit chosen from an electrode, a light-emitting diode, an optical sensor, an electrical resistor, a thermistor.
  3. System according to Claim 2, characterized in that the functional unit of electrode type is produced in the form of a conductive ink.
  4. System according to Claim 2 or 3, characterized in that it comprises an electrical connection point (30, 32) and an electrical conductor (31, 33) connecting said electrical connection point to each functional unit of the actuator or effector, said point and said conductor being distinct.
  5. System according to Claim 4, characterized in that each electrical conductor (31, 33) and each electrical connection point (30, 32) are produced in the form of a conductive ink.
  6. System according to one of Claims 1 to 5, characterized in that the instrumented device (1) comprises at least an elongate, supple, semi-rigid or articulated substrate bearing said first element at a first end and said second element at a second end.
  7. System according to Claim 6, characterized in that the first element and the second element are made of a conformable material, to fit to the shape of the fluidic component in its two regions.
  8. Fluidic system according to Claim 6 or 7, characterized in that the deformable portion (12) is produced in the form of at least one strip of material joining the first element to the second element.
  9. Fluidic system according to one of Claims 6 to 8, characterized in that the substrate comprising the first element (10), the second element (11) and the deformable portion (12) is produced in a single part, in the form of a strip of supple plastic material.
  10. System according to Claim 9, characterized in that the strip is made of a material chosen from PET, PEN, Kapton, silicone, polymer film, paper and a fabric.
  11. System according to Claim 6 or 7, characterized in that the substrate comprising the first element (10), the second element (11) and the deformable portion (12) comprises two flexible/supple, semi-rigid or articulated strips adhesively bonded to each other via a common portion and forming two strands each bearing, respectively, at their free end, the first element and the second element.
  12. System according to Claim 11, characterized in that each strip is made of a material chosen from PET, PEN, Kapton, silicone, polymer film, paper and a fabric.
  13. System according to one of Claims 1 to 12, characterized in that the fluidic component (4) has a right slab shape and in that the first aperture and the second aperture open onto two opposite faces.
  14. System according to Claim 13, characterized in that:
    - the fluidic component (4) comprises two superposed layers, a first layer (70) and a second layer (71), said fluidic circuit comprising a through-cavity that passes through the two layers, and that communicates on the one hand with the first aperture, and on the other hand with the second aperture,
    - the instrumented device comprises an extension (13) connected to its second element (11) via a second deformable portion (14), said extension being arranged between the two layers of the component (4) to form a membrane separating said cavity into two distinct spaces (72, 73).
EP21195476.3A 2020-09-21 2021-09-08 Fluidic system comprising a fluidic component and an instrument adapted to the component Active EP3970857B1 (en)

Applications Claiming Priority (1)

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FR2009539A FR3114253B1 (en) 2020-09-21 2020-09-21 Fluidic system comprising a fluidic component and an instrumented device fitted to said component

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EP3970857B1 true EP3970857B1 (en) 2022-11-09

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DE3843610A1 (en) * 1988-01-13 1989-07-27 Stephan Dr Diekmann DISCONNECTING OR REACTION PILLAR UNIT
JP6549355B2 (en) * 2014-06-16 2019-07-24 株式会社エンプラス Fluid handling device
IT201700075491A1 (en) * 2017-07-05 2019-01-05 Eltek Spa DEVICE FOR MULTI-COCKPIT CELL CULTURE PLATES, AND ITS EQUIPMENT

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US20220088597A1 (en) 2022-03-24
FR3114253B1 (en) 2022-08-26
FR3114253A1 (en) 2022-03-25

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