EP3962651A4 - Dispositifs microfluidiques et leurs procédés de fabrication - Google Patents

Dispositifs microfluidiques et leurs procédés de fabrication Download PDF

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Publication number
EP3962651A4
EP3962651A4 EP20799361.9A EP20799361A EP3962651A4 EP 3962651 A4 EP3962651 A4 EP 3962651A4 EP 20799361 A EP20799361 A EP 20799361A EP 3962651 A4 EP3962651 A4 EP 3962651A4
Authority
EP
European Patent Office
Prior art keywords
making
methods
same
microfluidic devices
microfluidic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP20799361.9A
Other languages
German (de)
English (en)
Other versions
EP3962651A1 (fr
Inventor
Richard J. Paolini, Jr.
David ZHITOMIRSKY
Timothy J. O'malley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nuclera Ltd
Original Assignee
Nuclera Nucleics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nuclera Nucleics Ltd filed Critical Nuclera Nucleics Ltd
Publication of EP3962651A1 publication Critical patent/EP3962651A1/fr
Publication of EP3962651A4 publication Critical patent/EP3962651A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
    • F04B19/006—Micropumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B17/00—Pumps characterised by combination with, or adaptation to, specific driving engines or motors
    • F04B17/03—Pumps characterised by combination with, or adaptation to, specific driving engines or motors driven by electric motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/021—Adjust spacings in an array of wells, pipettes or holders, format transfer between arrays of different size or geometry
    • B01L2200/022—Variable spacings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0427—Electrowetting

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
EP20799361.9A 2019-04-30 2020-04-22 Dispositifs microfluidiques et leurs procédés de fabrication Withdrawn EP3962651A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962840443P 2019-04-30 2019-04-30
PCT/US2020/029276 WO2020223077A1 (fr) 2019-04-30 2020-04-22 Dispositifs microfluidiques et leurs procédés de fabrication

Publications (2)

Publication Number Publication Date
EP3962651A1 EP3962651A1 (fr) 2022-03-09
EP3962651A4 true EP3962651A4 (fr) 2022-11-23

Family

ID=73017701

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20799361.9A Withdrawn EP3962651A4 (fr) 2019-04-30 2020-04-22 Dispositifs microfluidiques et leurs procédés de fabrication

Country Status (4)

Country Link
US (1) US20200347840A1 (fr)
EP (1) EP3962651A4 (fr)
TW (1) TWI794603B (fr)
WO (1) WO2020223077A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3980184A4 (fr) * 2019-06-07 2023-06-14 Nuclera Nucleics Ltd Dispositifs microfluidiques contenant des échantillons de gouttelettes piégées de manière réversible et procédés
EP4061530A4 (fr) 2019-11-20 2023-12-27 Nuclera Nucleics Ltd Couches hydrophobes spatialement variables pour la microfluidique numérique
WO2021146573A1 (fr) 2020-01-17 2021-07-22 E Ink Corporation Couches diélectriques variables spatialement pour la microfluidique numérique
WO2021154627A1 (fr) 2020-01-27 2021-08-05 E Ink Corporation Procédé de dégazage de gouttelettes de liquide par électromouillage à des températures plus élevées
KR20220141862A (ko) 2020-02-18 2022-10-20 뉴클라 뉴클레익스 리미티드 전기습윤 장치 구동을 위한 적응형 게이트 구동
CN115135413A (zh) 2020-02-19 2022-09-30 核酸有限公司 用于EWoD阵列的高频AC驱动的锁存晶体管驱动
EP4142942A4 (fr) 2020-04-27 2024-05-22 Nuclera Ltd Plaque supérieure segmentée pour entraînement variable et protection courte destinée à la microfluidique numérique
CN114534805A (zh) * 2022-02-09 2022-05-27 上海天马微电子有限公司 微流控装置及其驱动方法、制作方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2040082A1 (fr) * 2006-07-10 2009-03-25 Hitachi High-Technologies Corporation Dispositif de transfert de liquide

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8187864B2 (en) * 2008-10-01 2012-05-29 The Governing Council Of The University Of Toronto Exchangeable sheets pre-loaded with reagent depots for digital microfluidics
US20140216559A1 (en) * 2013-02-07 2014-08-07 Advanced Liquid Logic, Inc. Droplet actuator with local variation in gap height to assist in droplet splitting and merging operations
AU2014258629B2 (en) * 2013-04-26 2016-09-29 Jx Nippon Oil & Energy Corporation Substrate having rugged structure obtained from hydrophobic sol/gel material
US20150377831A1 (en) * 2014-06-27 2015-12-31 The Governing Council Of The University Of Toronto Digital microfluidic devices and methods employing integrated nanostructured electrodeposited electrodes
US9623407B2 (en) * 2015-03-27 2017-04-18 International Business Machines Corporation Microfluidic device with longitudinal and transverse liquid barriers for transverse flow mixing
JP6891169B2 (ja) * 2015-10-27 2021-06-18 バークレー ライツ，インコーポレイテッド 共有結合した疎水性表面を有するマイクロ流体エレクトロウェッティングデバイス装置
CN109414663B (zh) * 2016-06-29 2022-05-17 数字生物系统公司 在数字微流体装置中创建高分辨率温度谱线
US10882042B2 (en) * 2017-10-18 2021-01-05 E Ink Corporation Digital microfluidic devices including dual substrates with thin-film transistors and capacitive sensing

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2040082A1 (fr) * 2006-07-10 2009-03-25 Hitachi High-Technologies Corporation Dispositif de transfert de liquide

Also Published As

Publication number Publication date
EP3962651A1 (fr) 2022-03-09
TWI794603B (zh) 2023-03-01
WO2020223077A1 (fr) 2020-11-05
US20200347840A1 (en) 2020-11-05
TW202103785A (zh) 2021-02-01

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