EP3962502A4 - Method for the treatment of periodontal disease using characterized mesenchymal stem cell growth factors and exosomes - Google Patents

Method for the treatment of periodontal disease using characterized mesenchymal stem cell growth factors and exosomes Download PDF

Info

Publication number
EP3962502A4
EP3962502A4 EP20798340.4A EP20798340A EP3962502A4 EP 3962502 A4 EP3962502 A4 EP 3962502A4 EP 20798340 A EP20798340 A EP 20798340A EP 3962502 A4 EP3962502 A4 EP 3962502A4
Authority
EP
European Patent Office
Prior art keywords
exosomes
treatment
stem cell
cell growth
growth factors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP20798340.4A
Other languages
German (de)
French (fr)
Other versions
EP3962502A1 (en
Inventor
Kenneth Allen Pettine
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Direct Biologics LLC
Original Assignee
Direct Biologics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Direct Biologics LLC filed Critical Direct Biologics LLC
Publication of EP3962502A1 publication Critical patent/EP3962502A1/en
Publication of EP3962502A4 publication Critical patent/EP3962502A4/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP20798340.4A 2019-04-29 2020-04-29 Method for the treatment of periodontal disease using characterized mesenchymal stem cell growth factors and exosomes Pending EP3962502A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962839975P 2019-04-29 2019-04-29
PCT/US2020/030476 WO2020223349A1 (en) 2019-04-29 2020-04-29 Method for the treatment of periodontal disease using characterized mesenchymal stem cell growth factors and exosomes

Publications (2)

Publication Number Publication Date
EP3962502A1 EP3962502A1 (en) 2022-03-09
EP3962502A4 true EP3962502A4 (en) 2023-01-04

Family

ID=73028655

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20798340.4A Pending EP3962502A4 (en) 2019-04-29 2020-04-29 Method for the treatment of periodontal disease using characterized mesenchymal stem cell growth factors and exosomes

Country Status (9)

Country Link
US (1) US20220202871A1 (en)
EP (1) EP3962502A4 (en)
JP (1) JP2022530800A (en)
KR (1) KR20220002317A (en)
AU (1) AU2020264444A1 (en)
BR (1) BR112021021676A2 (en)
CA (1) CA3138177A1 (en)
IL (1) IL287649A (en)
WO (1) WO2020223349A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102523447B1 (en) * 2020-12-04 2023-04-20 브렉소젠 주식회사 Composition for preventing or treating periodontal disease comprising exosomes derived from induced pluripotent stem cells-derived mesenchymal stem cells
US11931458B2 (en) 2021-01-11 2024-03-19 Babak Ghalili Exosome systems, products and methods

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018131003A1 (en) * 2017-01-16 2018-07-19 Cells For Cells, S.A Composition comprising a substantially pure population of multipotent stromal cells encapsulated in platelet-poor plasma (ppp)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006036213A2 (en) * 2004-04-29 2006-04-06 Pediamed Pharmaceuticals, Inc. The use of gammaglobulin for the treatment of periodontal disease
ITRM20110403A1 (en) * 2011-07-28 2013-01-29 Ospedale Pediatrico Bambino Gesu MICROWELES ISOLATED BY MESENCHIMAL CELLS AS IMMUNOSOPPRESSORS.
PL3328397T3 (en) * 2015-07-31 2023-10-16 Exotropin, Llc Exosome compositions and methods for preparation and use thereof for regulating and conditioning skin and hair

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018131003A1 (en) * 2017-01-16 2018-07-19 Cells For Cells, S.A Composition comprising a substantially pure population of multipotent stromal cells encapsulated in platelet-poor plasma (ppp)

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEW JACOB REN JIE ET AL: "Mesenchymal stem cell exosomes enhance periodontal ligament cell functions and promote periodontal regeneration", ACTA BIOMATERIALIA, vol. 89, 13 March 2019 (2019-03-13), pages 252 - 264, XP085659610, ISSN: 1742-7061, DOI: 10.1016/J.ACTBIO.2019.03.021 *
See also references of WO2020223349A1 *
TALEGAONKAR SONIA S: "The Role of Human MSC Derived Exosomes in the Treatment of The Role of Human MSC Derived Exosomes in the Treatment of Periodontal Diseases", 7 October 2017 (2017-10-07), XP093002175, Retrieved from the Internet <URL:https://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=6042&context=etd> [retrieved on 20221125], DOI: 10.25772/M74Y-GD81 *

Also Published As

Publication number Publication date
KR20220002317A (en) 2022-01-06
US20220202871A1 (en) 2022-06-30
WO2020223349A1 (en) 2020-11-05
EP3962502A1 (en) 2022-03-09
CA3138177A1 (en) 2020-11-05
JP2022530800A (en) 2022-07-01
AU2020264444A1 (en) 2021-11-18
BR112021021676A2 (en) 2021-12-21
IL287649A (en) 2021-12-01

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Ipc: A61P 19/04 20060101ALI20221130BHEP

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