EP3950923A4 - Modèle et dispositif de vaisseau sanguin cérébral - Google Patents
Modèle et dispositif de vaisseau sanguin cérébral Download PDFInfo
- Publication number
- EP3950923A4 EP3950923A4 EP20779604.6A EP20779604A EP3950923A4 EP 3950923 A4 EP3950923 A4 EP 3950923A4 EP 20779604 A EP20779604 A EP 20779604A EP 3950923 A4 EP3950923 A4 EP 3950923A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- blood vessel
- brain blood
- vessel model
- brain
- model
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- G—PHYSICS
- G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
- G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
- G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
- G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
- G09B23/30—Anatomical models
- G09B23/306—Anatomical models comprising real biological tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/12—Well or multiwell plates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/14—Scaffolds; Matrices
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
-
- G—PHYSICS
- G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
- G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
- G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
- G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
- G09B23/30—Anatomical models
- G09B23/303—Anatomical models specially adapted to simulate circulation of bodily fluids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/08—Coculture with; Conditioned medium produced by cells of the nervous system
- C12N2502/086—Coculture with; Conditioned medium produced by cells of the nervous system glial cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/28—Vascular endothelial cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2513/00—3D culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/56—Fibrin; Thrombin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Sustainable Development (AREA)
- Medicinal Chemistry (AREA)
- Business, Economics & Management (AREA)
- Algebra (AREA)
- Computational Mathematics (AREA)
- Theoretical Computer Science (AREA)
- Mathematical Analysis (AREA)
- Mathematical Optimization (AREA)
- Mathematical Physics (AREA)
- Pure & Applied Mathematics (AREA)
- Medical Informatics (AREA)
- Educational Administration (AREA)
- Educational Technology (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Clinical Laboratory Science (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2019061326A JP7277874B2 (ja) | 2019-03-27 | 2019-03-27 | 脳血管モデル及びデバイス |
PCT/JP2020/013477 WO2020196678A1 (fr) | 2019-03-27 | 2020-03-25 | Modèle et dispositif de vaisseau sanguin cérébral |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3950923A1 EP3950923A1 (fr) | 2022-02-09 |
EP3950923A4 true EP3950923A4 (fr) | 2022-05-11 |
Family
ID=72611524
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP20779604.6A Pending EP3950923A4 (fr) | 2019-03-27 | 2020-03-25 | Modèle et dispositif de vaisseau sanguin cérébral |
Country Status (4)
Country | Link |
---|---|
US (1) | US20220130280A1 (fr) |
EP (1) | EP3950923A4 (fr) |
JP (1) | JP7277874B2 (fr) |
WO (1) | WO2020196678A1 (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020203579A1 (fr) * | 2019-04-01 | 2020-10-08 | 凸版印刷株式会社 | Construction de tissu tridimensionnelle et son procédé de production, et procédé de production de composition contenant des cellules |
EP4238985A4 (fr) * | 2020-10-29 | 2024-05-08 | Univ Osaka | Procédé de congélation d'une structure cellulaire |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017070224A1 (fr) * | 2015-10-19 | 2017-04-27 | EMULATE, Inc. | Modèle microfluidique de la barrière hémato-encéphalique |
US20170211029A1 (en) * | 2016-01-21 | 2017-07-27 | Hong-jun Lee | Neurovascular unit(nvu)-on-a-chip and method of fabricating the same |
WO2018143286A1 (fr) * | 2017-01-31 | 2018-08-09 | 凸版印刷株式会社 | Corps de tissu tridimensionnel, son procédé de production, et agent de formation pour corps de tissu tridimensionnel |
US20180298317A1 (en) * | 2015-04-24 | 2018-10-18 | President And Fellows Of Harvard College | Devices for simulating a function of a tissue and methods of use and manufacturing thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001238681A (ja) | 2000-03-03 | 2001-09-04 | Japan Science & Technology Corp | 共培養による血液脳関門再構築モデル |
US20190017999A1 (en) | 2015-09-04 | 2019-01-17 | Seoul National University R&DB Foudation | In vitro skin immune system simulation system |
-
2019
- 2019-03-27 JP JP2019061326A patent/JP7277874B2/ja active Active
-
2020
- 2020-03-25 EP EP20779604.6A patent/EP3950923A4/fr active Pending
- 2020-03-25 WO PCT/JP2020/013477 patent/WO2020196678A1/fr unknown
- 2020-03-25 US US17/441,602 patent/US20220130280A1/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20180298317A1 (en) * | 2015-04-24 | 2018-10-18 | President And Fellows Of Harvard College | Devices for simulating a function of a tissue and methods of use and manufacturing thereof |
WO2017070224A1 (fr) * | 2015-10-19 | 2017-04-27 | EMULATE, Inc. | Modèle microfluidique de la barrière hémato-encéphalique |
US20170211029A1 (en) * | 2016-01-21 | 2017-07-27 | Hong-jun Lee | Neurovascular unit(nvu)-on-a-chip and method of fabricating the same |
WO2018143286A1 (fr) * | 2017-01-31 | 2018-08-09 | 凸版印刷株式会社 | Corps de tissu tridimensionnel, son procédé de production, et agent de formation pour corps de tissu tridimensionnel |
Non-Patent Citations (1)
Title |
---|
See also references of WO2020196678A1 * |
Also Published As
Publication number | Publication date |
---|---|
EP3950923A1 (fr) | 2022-02-09 |
US20220130280A1 (en) | 2022-04-28 |
JP7277874B2 (ja) | 2023-05-19 |
JP2020156421A (ja) | 2020-10-01 |
WO2020196678A1 (fr) | 2020-10-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
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17P | Request for examination filed |
Effective date: 20211001 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 20220413 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12N 5/079 20100101ALI20220407BHEP Ipc: C12N 5/071 20100101ALI20220407BHEP Ipc: C12M 3/00 20060101AFI20220407BHEP |
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DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) |