Classifications

• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
  • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
  • C11D3/16—Organic compounds
  • C11D3/20—Organic compounds containing oxygen
  • C11D3/2075—Carboxylic acids-salts thereof
  • C11D3/2086—Hydroxy carboxylic acids-salts thereof
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
  • C11D3/16—Organic compounds
  • C11D3/36—Organic compounds containing phosphorus
  • C11D3/361—Phosphonates, phosphinates or phosphonites
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
  • C11D3/39—Organic or inorganic per-compounds
  • C11D3/3942—Inorganic per-compounds
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
  • C11D3/39—Organic or inorganic per-compounds
  • C11D3/3947—Liquid compositions
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
  • C11D7/22—Organic compounds
  • C11D7/26—Organic compounds containing oxygen
  • C11D7/265—Carboxylic acids or salts thereof
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
  • C11D7/22—Organic compounds
  • C11D7/36—Organic compounds containing phosphorus

Definitions

• the present invention relates to the field of disinfection.
• it relates to a stable non-toxic and noncorrosive hydrogen peroxide-containing composition efficient for being used as disinfectant and cleaning composition. It also relates to processes for its preparation and a method for its use.
• Hydrogen peroxide solutions have been used for many years for a variety of purposes, including bleaching, disinfecting, and cleaning a variety of surfaces ranging from skin, hair, mucous membranes to contact lenses, instruments, household and industrial surfaces.
• hydrogen peroxide compositions are specially attractive because hydrogen peroxide displays broad spectrum antimicrobial activity and because it decomposes into innocuous products (i.e. water and oxygen). Broad spectrum antimicrobial activity is important in situations where harmful organisms are present, but their identity is not known. Furthermore, apart from the disinfectant activity of the hydrogen peroxide, it is also a reference product due to its versatile effect as cleaner which helps to remove limescale, calcium stains and yellow spots.
• hydrogen peroxide also involves some drawbacks.
• One of the most important problems of hydrogen peroxide compositions is the inherent instability of hydrogen peroxide solutions and the length of time required for hydrogen peroxide to disinfect a surface to which it had been applied.
• hydrogen peroxide solutions begin to decompose into oxygen gas and water within an extremely short time.
• Typical hydrogen peroxide solutions in use for the above mentioned purposes are in the range from about 0.5% to about 10% by weight of hydrogen peroxide in water.
• stabilizing agents are chelators or sequestering agents which are added to hydrogen peroxide solutions to combat decomposition due to the presence of trace impurities (mainly dissolved metals).
• hydrogen peroxide is a strong oxidizer and can be corrosive to the eyes, skin, and respiratory system, causing burns to the skin and tissue damage. In fact, they are associated with occupational safety. In lower concentrations as "household-grade" concentrations, hydrogen peroxide is generally considered safe to use, but should never be inhaled and/or ingested. In fact, even at low concentrations, the hydrogen peroxide should be handled and stored with care whether at home or in the workplace.
• hydrogen peroxide is highly corrosive having important material imcompatibility problems.
• hydrogen peroxide can damage both metallic surface such as tubes and metal instruments, and organic material surfaces such carbonate based surfaces (such as marble) which is neither desirable.
• the reduction of the undesirable corrosive effect of hydrogen peroxide solutions is achieved by lowering the amount of active ingredients or the increase of the pH values, compromising its disinfectant and/or cleaning activity.
• the cleaning activity is specially critical implying the removal of lime, calcium stains, yellow spots as well as the removal of soap (foam, scum and stains) and grease
• the addition of active ingredients having one or more of the above-mentioned activities is required.
• the introduction of more components, and particularly active ingredients can hinder the preparation of compositions since certain components can affect to the stability and/or the activity of other components of the composition.
• the inventors have provided a stable hydrogen peroxide composition having an efficient disinfectant activity and achieving a very thorough and at the same time broad cleaning effect.
• the inventors have found that the use of a low amount of hydrogen peroxide (from 0.5% to 4%) and lactic acid (from 0.25% to 0.8%) in combination with an amount of organic phosphonic acid from 0.1% to 0.5% allows providing a stable composition for being stored without decomposition of the hydrogen peroxide; and having at the same time the appropriate pH and concentration of active ingredients for providing an efficient dual disinfectant and cleaning effect. These effects are performed without causing corrosion and/or damage to the surface that have been treated. And, further, without causing inhalatory problems and skin damage to the person that is applying the composition on the surface that have been treated.
• the organic phosphonic acid is known to efficiently stabilize hydrogen peroxide.
• the organic phosphonic acid has a negative effect for the lactic acid present in the composition, greatly compromising its anti lime effect.
• the increase of the amount of the lactic acid in the presence of the organic phosphonic acid does not improve the anti lime effect of the composition but undesirably increase the incompatibility with the materials commonly use at both homeplace and workplace and instruments.
• the decrease in the amount of the lactic acid below the typically concentration used in this type of compositions until the claimed amount of lactic acid (from 0.25% to 0.8%) of the compositions of the present invention in combination with an amount of organic phophonic acid from 0.1% to 0.5% allows having an optimal stabilization of the hydrogen peroxide and the dual and broad disinfectant and cleaning effect without compromising the safety, toxicity and compatibility with the surfaces to treat.
• the composition of the present invention has a broad spectrum antimicrobial activity at short exposure time (about 5 min agaisnt bacterias and enveloped viruses).
• the composition has proved to be efficient against gram-positive and gram negative bacteria, fungi and enveloped virus without the need of rinsing the surface after application even at low amounts of hydroxy peroxide.
• due to its harmlessness it is also appropriate for the treatment of surfaces which are usually in contact with food.
• the composition of the invention is useful as cleaning product because it is capable of removing lime, soap (foam, scum and stains) and grease from non-living surfaces, without damaging the treated surface thanks to the very low or nule reactivity towards materials, substrates and tissues. Therefore, the composition of the invention have a efficient cleaning activity of any surface regardless that a lime scale effect, a soap removal activity and/or a grease removal effect is needed. In fact, the composition of the invention includes the appropriate active cleaning ingredients and achieves a very thorough and broad cleaning effect without affecting the disinfectant activity nor the stability of the composition.
• the present application also includes a toxicity, irritability and corrosion test which shows that the composition of the invention can be considered non-toxic, non-irritant and safety for being use as disinfectant and cleaning of non-living surfaces even those which are formed or have metals or delicate organic materials.
• the use of the composition of the invention with a low amount of the active ingredients, particularly hydrogen peroxide results in an improved shelf life and ease packaging without involving any health and safety hazards.
• the first aspect of the invention relates to a composition
• a composition comprising:from 0.5% to 4% by weight of hydrogen peroxide; from 0.1% to 0.5% by weight of an organic phosphonic acid; from 0.25% to 0.8% by weight of lactic acid; and having a pH from 2 to 3.6.
• the second aspect of the invention relates to a process for the preparation of the composition of the first aspect of the invention.
• the third aspect of the invention relates to a use of the composition of the first aspect of the invention as disinfectant and cleaner.
• the fourth aspect of the invention relates to a method of disinfecting and cleaning a non-living surface comprising applying a composition as defined in the first aspect of the invention.
• any ranges given include both the lower and the upper endpoints of the range. Ranges and values given, such as temperatures, times, and the like, should be considered approximate, unless specifically stated.
• percentage (%) by weight refers to the percentage of each ingredient of the composition in relation to the total weight.
• the first aspect refers to a stable disinfectant and cleaning comprising from 0.5% to 4% by weight of hydrogen peroxide; from 0.1% to 0.5% by weight of an organic phosphonic acid, particularly 1-hydroxyethylidene-1,1-diphosphonic acid; from 0.25% to 0.8% by weight of lactic acid; and having a pH from 2 to 3.6.
• the composition comprises from 0.5% to 4% by weight of hydrogen peroxide. In an embodiment, the composition comprises from 1% to 3.5% by weight of hydrogen peroxide. In an embodiment, the composition comprises from 1% to 3% by weight of hydrogen peroxide. In an embodiment, the composition comprises from 1.5% to 3% by weight of hydrogen peroxide. In an embodiment, the composition comprises from 1.5% to 2.5% by weight of hydrogen peroxide. In an embodiment, the composition comprises about 1.5% by weight of hydrogen peroxide. In an embodiment, the composition comprises from 0.5% to lower than 2% by weight of hydrogen peroxide. In an embodiment, the composition comprises from 1% to lower than 2% by weight of hydrogen peroxide. In an embodiment, the composition comprises about 1.5% by weight of hydrogen peroxide.
• the composition comprises from equal to or higher than 2% to 4% by weight of hydrogen peroxide. In an embodiment, the composition comprises from equal to or higher than 2.5% to 3.5% by weight of hydrogen peroxide. In an embodiment, the composition comprises about 2.5% by weight of hydrogen peroxide.
• the compositions of the present invention are advantegeous because have a dual effect as disinfectant and cleaner (anti-lime and soap removal). Particularly, the compositions of the present invention have bactericidal, fungicidal and viricidal activity.
• the composition of the present invention comprises from 0.1% to 0.5% by weight of an organic phosphonic acid. In an embodiment, the composition comprises from 0.18% to 0.4% by weight of an organic phosphonic acid. In an embodiment, the composition comprises from 0.2% to 0.35% by weight of an organic phosphonic acid. In an embodiment, the composition comprises from 0.2% to 0.3% by weight of an organic phosphonic acid. In an embodiment, the composition comprises about 0.3% by weight of an organic phosphonic acid.
• organic phosphonic acid encompasses organic monophosphonic acids and organic biphosphonic acids.
• the composition is one wherein the organic phosphonic acid is selected from th group consisting of dimethylaminomethane diphosphonic acid, 1-amino-1-phenylmethane diphosphonic acid, amino tri-(methylene phosphonic acid) (ATMP),ethylene diamine tetra -(methylene phosphonic acid) (EDTMP), 2-hydroxyphosphonocarboxylic Acid (HPAA), 2-phosphonobutane -1,2,4-tricarboxylic acid (PBTCA), polyhydric alcohol phosphate ester (PAPE), bis-(hexamethylene triamine penta(methylene phosphonic acid)) (BHMTPMPA), aminoacetic acid-N-di-(methylene phosphonic acid), diethylenetriamine penta(methylene) phosphonic (DTMPA) acid and 1-hydroxyethane-1,1-diphosphonic acid.
• the organic phosphonic acid is selected from th group consisting of dimethylaminomethane diphosphonic acid, 1-amino-1-phen
• the composition is one wherein the organic phosphonic acid is 1-hydroxyethylidene-1,1-diphosphonic acid.
• the terms 1-hydroxyethylidene-1,1-diphosphonic acid and etidronic acid, and the abbreviature HEDP refers to the same compound which are commercially available with the name Dequest 2010 LC.
• the composition of the invention comprises from 0.25% to 0.8% by weight of lactic acid. In an embodiment, the composition comprises from 0.25% to 0.75% by weight of lactic acid. In an embodiment, the composition comprises from 0.3% to 0.75% by weight of lactic acid. In an embodiment, the composition comprises from 0.35% to 0.75% by weight of lactic acid. In an embodiment, the composition comprises from 0.35% to 0.5% by weight of lactic acid. In an embodiment, the composition comprises about 0.35% by weight of lactic acid.
• lactic acid is the International Non-proprietary Name of 2-hydroxypropionic acid having the CAS number 50-21-5. The structure of the lactic acid corresponds to the following formula:
• composition comprises:
• composition comprises:
• composition comprises:
• composition comprises:
• composition comprises:
• composition comprises:
• the composition of the invention further comprises one or more additives.
• the composition further comprises one or more additives selected from the group consisting of solvents, surfactants, builders, pH adjusting agent, pH buffering agents, thickening/viscosity modifying agent, perfumes or fragrances, preservatives; dyes and other colorants; UV absorbents or antioxidizing agents, fabric softening compositions; static control agents; optical opacifiers, and suds regulants.
• the composition of the invention comprises one or more solvents. In an embodiment, the composition of the invention comprises one or more miscible organic solvent. In an embodiment, the composition of the invention comprises one or more miscible organic solvent being water-miscible organic solvents. Examples of water-miscibles solvents includes alcohols, ethers, ketones, esters and a mixture thereof.
• the composition of the invention comprises one or more water-miscible organic solvents selected from the group consisting of (C 2 -C 6 ) alcohol, (C 1 -C 4 ) alkyl-CO-(C 1 -C 4 ) alkyl, (C 1 -C 4 ) alkyl-O-(C 1 -C 4 ) alkyl, (C 1 -C 4 ) alkyl-CO-O-(C 1 -C 4 ) alkyl and a mixture thereof.
• the amount of the solvents in the compositions of the present invention is from 2 to 7% by weight; particularly from 3 to 6% by weight.
• the composition of the invention comprises one or more (C 2 -C 6 )alcohols.
• alcohol refers to an "alkane” wherein at least one hydrogen atom is substituted by a hydroxyl group and which contains the number of carbon atoms specified in the description or claims.
• alkane refers to a saturated, branched or linear hydrocarbon which contains the number of carbon atoms specified in the description or claims. Examples include ethanol, n -propanol, iso-propanol, butanol, iso-butanol, and sec-butanol.
• the composition of the invention comprises one or more ethers as a solvents selected from the group consisting of (3-methoxy-3-methyl-1-butanol) (MMB), di(propylene glycol) n-butyl ether (commercially available with the name Dowanol Dpnb), di(propylene)glycol and a mixture thereof.
• MMB (3-methoxy-3-methyl-1-butanol)
• Dpnb di(propylene)glycol
• the composition comprises di (propylene glycol) n-butyl ether as solvent.
• the composition comprises di(propylene)glycol as solvent.
• the composition comprises a combination of one or more alcohols as defined above and one or more ethers as defined above.
• the composition comprises a mixture of ethanol and di (propylene glycol) n-butyl ether as solvents.
• composition of the invention comprises:
• composition of the invention comprises:
• composition of the invention comprises:
• composition of the invention comprises:
• composition of the invention comprises:
• composition of the invention comprises:
• composition of the invention comprises:
• composition of the invention comprises:
• composition of the invention comprises:
• composition of the invention comprises:
• composition of the invention comprises:
• composition of the invention comprises:
• composition i.e. hydrogen peroxide, organic phophoric acid and lactic acid
• pH value also applies to the above mentioned composition comprising one or more solvents.
• the composition of the invention further comprises one or more surfactants as additive.
• surfactant refers to a material which lowers the surface tension of a liquid and the interfacial tension between two liquids, allowing their easier spreading.
• Surfactants have a hydrophilic head that is attracted to water molecules and a hydrophobic tail that repels water and simultaneously attaches itself to oil and grease in dirt. These opposing forces loosen the dirt and suspend it in the water, having the ability to remove it from surfaces, when surfactants are dissolved in water.
• the amount of the surfactant in the composition of the present invention is from 0.1-6.5% by weigth of the composition.
• the amount of the surfactant in the composition of the present invention is from 0.5% to 5% by weight of the composition. In an embodiment, the amount of the surfactant in the composition of the present invention is from 1% to 4% by weight of the composition. In an embodiment, the amount of the surfactant in the composition of the present invention is from 1% to 3% by weight of the composition. In an embodiment, the amount of the surfactant in the composition of the present invention is from 1.5% to 2% by weight of the composition.
• the surfactant can be divided into three different groups: non-ionic, ionic (either anionic or cationic) or zwitterionic (or amphoteric wherein the head of the surfactant contains two oppositely charged groups) surfactants.
• the composition of the invention further comprises one or more amphoteric surfactant.
• amphoteric surfactant encompasses a surfactant that contains a head with two oppositely charged groups (e.g., positive and negative).
• amphoteric surfactants may be anionic (negatively charged), cationic (positively charged) or non-ionic (no charge) in solution, depending on the acidity or pH of the water.
• the composition further comprises one or more amphoteric surfactants selected from the group consisting of amine oxides and betaines.
• amine oxides appropriate for the present invention include, but without limited to, decyldimethyl-aminoxide, dodecyldimethylamine oxide, tridecyldimethylamine oxide, tetradecyldimethylamine oxide, pentadecyldimethylamine oxide, hexadecyldimethylamine oxide, heptadecyldimethylamine oxide, octadecyldimethylaine oxide, dodecyldipropylamine oxide, tetradecyldipropylamine oxide, hexadecyldipropylamine oxide, tetradecyldibutylamine oxide, octadecyldibutylamine oxide, bis(2-hydroxyethyl)dodecylamine oxide, bis(2-hydroxyethyl)-3-dodecoxy-I-hydroxypropylamine oxide, dimethyl-(2-hydroxydodecyl)
• betaines appropriate for the present invention include, but without limited to, amidobetaines, amidosulfobetaines, coco dimethyl carboxymethyl betaine, cocoamidopropyl betaine, cocobetaine, lauryl amidopropyl betaine, oleyl betaine, lauryl dimethyl carboxymethyl betaine, lauryl dimethyl alphacarboxyethyl betaine, cetyl dimethyl carboxymethyl betaine, lauryl bis-(2-hydroxyethyl)carboxymethyl betaine, stearyl bis-(2-hydroxypropyl)carboxymethyl betaine, oleyl dimethyl gamma-carboxypropyl betaine, lauryl bis-(2-hydroxypropyl)alpha-carboxyethyl betaine, coco dimethyl sulfopropyl betaine, stearyl dimethyl sulfopropyl betaine, lauryl dimethyl sulfoethyl betaine, or lauryl bis-(2-hydroxye
• the composition further comprises one or more amphoteric surfactants selected from the group consisting of amine oxides as defined above.
• the composition further comprises decyldimethyl-aminoxide.
• the decyldimethyl-aminoxide is commercially available by the name tegotens ® DO.
• the amount of amphoteric surfactants is from 0.1 to 2.5% by weight of the composition. In an embodiment, if present, the amount of amphoteric surfactants is from 0.2 to 1.5% by weight of the composition. In an embodiment, if present, the amount of amphoteric surfactants is from 0.3 to 1% by weight of the composition. In an embodiment, if present, the amount of amphoteric surfactants is from 0.4 to 1% by weight of the composition. In an embodiment, if present, the amount of amphoteric surfactants is from 0.4 to 0.6% by weight of the composition.
• the composition of the invention further comprises one or more non-ionic surfactant.
• non-ionic surfactants appropriate for the present invention include, but without limited to, ethoxylated and propoxylated alcohols, especially C 10-20 alcohols reacted with 2 to 100 moles of ethylene oxide and/or propylene oxide per mole of alcohol, especially ethoxylates of primary alcohols containing about 8 to 18 carbon atoms in a straight or branched chain configuration which have been reacted with about 5 to 30 moles of ethylene oxide, for example, the ethoxylates of decyl alcohol, cetyl alcohol, lauryl alcohol, or myristyl alcohol; ethoxylates of secondary aliphatic alcohols containing 8 to 18 carbon atoms in a straight or branched chain configuration with 5 to 30 moles of ethylene oxide; condensation of aliphatic alcohols containing about 8 to about 20 carbon atoms with ethylene oxide and propylene oxide; polyethylene glycol and polyethylene oxide;
• the composition of the invention further comprises one or more non-ionic surfactant as defined in the present invention.
• the composition of the invention further comprises a non-ionic surfactant selected from the group consisting of C8/C10 wheat bran glycoside, capryloyl/capryl methyl glucamide and a mixture thereof. If present, the amount of non-ionic surfactants in the composition of the present invention is from 0 % to 4% by weight. In an embodiment, the amount of non-ionic surfactants in the composition of the present invention is from 0.2% to 4% by weight. In an embodiment, the amount of non-ionic surfactants in the composition of the present invention is from 0.5 % to 2% by weight.
• the amount of non-ionic surfactants in the composition of the present invention is from 1 % to 2% by weight. In an embodiment, the amount of non-ionic surfactants in the composition of the present invention is from 1.2 % to 1.7% by weight. In an embodiment, the amount of non-ionic surfactants in the composition of the present invention is about 1.5% by weight.
• the composition of the invention further comprises a non-ionic surfactant being C8/C10 wheat bran glycoside in an amount from 0.2 to 4% by weight of the composition. In an embodiment, the composition of the invention further comprises a non-ionic surfactant being C8/C10 wheat bran glycoside in an amount from 0.5 to 2% by weight of the composition. In an embodiment, the composition of the invention further comprises a non-ionic surfactant being C8/C10 wheat bran glycoside in an amount from 0.8 to 1.5% by weight of the composition. In an embodiment, the composition of the invention further comprises a non-ionic surfactant being C8/C10 wheat bran glycoside in an amount about 1% by weight of the composition.
• the composition of the invention further comprises a non-ionic surfactant being, capryloyl/capryl methyl glucamide in an amount from 0.2 to 4 % by weight of the composition. In an embodiment, the composition of the invention further comprises a non-ionic surfactant being, capryloyl/capryl methyl glucamide in an amount from 0.3 to 2 % by weight of the composition. In an embodiment, the composition of the invention further comprises a non-ionic surfactant being, capryloyl/capryl methyl glucamide in an amount from 0.4 to 1.5 % by weight of the composition.
• the composition of the invention further comprises a non-ionic surfactant being, capryloyl/capryl methyl glucamide in an amount from 0.5 to 0.8 % by weight of the composition. In an embodiment, the composition of the invention further comprises a non-ionic surfactant being, capryloyl/capryl methyl glucamide in an amount fabout 0.5 % by weight of the composition.
• the composition of the invention further comprises one or more amphoteric surfactants and one or more non-ionic surfactant as defined in the present invention.
• the composition of the invention further comprises decyldimethyl-aminoxide (commercially available by the name tegotens ® DO) as amphoteric surfactant and a C8/C10 wheat bran glycoside, capryloyl/capryl methyl glucamide or a mixture thereof as non-ionic surfactants.
• composition of the invention comprises:
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• composition of the invention comprises:
• composition i.e. hydrogen peroxide, organic phophoric acid, lactic acid and solvents
• pH value also applies to the above mentioned composition comprising surfactants.
• the composition of the invention further comprises one or more builders.
• the builder is commonly used for stabilizing the composition.
• the term “builder” encompasses chelating agents (chelators), sequestering agents (sequestrants), detergent builders, water soluble salts thereof and a mixture thereof.
• water soluble builder salts encompasses inorganic alkaline builder salts which may be used alone or in admixture with other builders, but are not limited to, alkali metal or ammonia or substituted ammonium salts of carbonates, silicates, phosphates and polyphosphates, and borates.
• Water soluble organic alkaline builders which are useful in the present invention include alkanolamines and cyclic amines.
• appropriate builders for the present invention include, but without limited to, phosphonic acids and phosphonates, phosphates, amino carboxylates and their derivatives including salts of hydroxy ethylenediaminetetraacetic acid (HEDTA), and diethylenetriaminepentaacetic acid, and glutamic acid, N,N-diacetic acid tetrasodium salt (commercially available as Dissolvine GL-47 ® ); pyrophosphates, polyphosphates, ethylenediamine and ethylenediamine derivatives, hydroxy acids, and mono-, di-, and tri-carboxylates and their corresponding acids, aluminosilicates, nitroloacetates and their derivatives, and mixtures thereof.
• organic chelating examples include polyanionic compositions such as polyacrylic acid compounds, N-hydroxyethylenediaminetriacetic acid (HEDTA), ethylenediaminetetraacetic acid (EDTA), nitrilotriaacetic acid (NTA), diethylenetriaminepentaacetic acid (DTPA), ethylenediaminetetraproprionic acid triethylenetetraaminehexaacetic acid (TTHA), and the respective alkali metal, ammonium and substituted ammonium salts thereof; amino phosphonates including ethylenediaminetetramethylene phosphonates, nitrilotrismethylene phosphonates, and diethylenetriamine-(pentamethylene phosphonate) for example.
• polyanionic compositions such as polyacrylic acid compounds, N-hydroxyethylenediaminetriacetic acid (HEDTA), ethylenediaminetetraacetic acid (EDTA), nitrilotriaacetic acid (NTA), diethylenetriaminepentaacetic acid (DTPA
• sequestrant agents include water soluble polycarboxylate polymers.
• Such homopolymeric and copolymeric chelating agents include polymeric compositions with pendant (-CO 2 H) carboxylic acid groups and include polyacrylic acid, polymethacrylic acid, polymaleic acid, acrylic acid-methacrylic acid copolymers, acrylic-maleic copolymers, hydrolyzed polyacrylamide, hydrolyzed methacrylamide, hydrolyzed acrylamide-methacrylamide copolymers, hydrolyzed polyacrylonitrile, hydrolyzed polymethacrylonitrile, hydrolyzed acrylonitrile methacrylonitrile copolymers, or mixtures thereof Water soluble salts or partial salts of these polymers or copolymers such as their respective alkali metal (for example, sodium or potassium) or ammonium salts may also be used.
• alkali metal for example, sodium or potassium
• ammonium salts may also be used.
• biodegradable aminocarboxylate or derivative thereof examples include Dissolvine GL-38 ® and Dissolvine GL-47 ® both available from Akzo; Trilon M ® available from BASF; Baypure CX100 ® available from Bayer; Versene EDG ® available from Dow; HIDS ® available from Nippon Shakubai; Octaquest E30 ® and Octaquest A65 ® both available from Finetex/Innospec Octel.
• the one or more builders are amino carboxylates and their derivatives as defined in the present invention.
• the composition further comprises one or more aminocarboxylate builders selected from the group consisting of methyl glycine N,N-diacetic acid trisodium salt (MGDA- commercially available as Dissolvine M-40 ® ) and glutamic acid, N,N-diacetic acid tetrasodium salt (commercially available as Dissolvine GL-38 ® ).
• the composition further comprises glutamic acid, N,N-diacetic acid tetrasodium salt (commercially available as Dissolvine GL-38 ® ) as builder. If present, the amount of builders in the composition of the present invention is from 0.04 to 1% by weight.
• the amount of aminocarboxylate builders, particularly N,N-diacetic acid tetrasodium salt (commercially available as Dissolvine GL-38 ® ), in the composition of the present invention is from 0.04 to 0.1% by weight.
• composition of the invention comprises:
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• composition of the invention comprises:
• composition of the invention comprises:
• composition i.e. hydrogen peroxide, organic phophoric acid, lactic acid, solvents, surfactants
• pH value also applies to the above mentioned composition comprising builders.
• composition of the present invention can also include other conventional additives, provided each ingredient is compatible with the other ingredients of the composition and the presence of the ingredient does not adversely affect the stability and the properties of the composition.
• Each additional ingredient may be used to modify the composition of the present invention in a conventional way and may be present in an effective amount, that is, in the amount required to achieve the desired disinfecatnt and cleaning effect without adversely affecting its stability, toxicity and material compatibility.
• Examples of conventional additives are selected from the group consisting of thickening/viscosity modifying agent, perfumes or fragrances, preservatives; dyes and other colorants; UV absorbents or antioxidizing agents, fabric softening compositions; static control agents; optical opacifiers, such as polystyrene particles; and suds regulants, such as dimethylpolysiloxane.
• the appropriate additional conventional additives as defined above and their amounts, can readily be determined by those skilled in the art according to the type of formulation being prepared.
• the composition of the present invention has a pH from 2 to 3.6.
• the composition has a pH from 2 to 3.5.
• the composition has a pH from 2.4 to 3.5.
• the composition has a pH from 2.4 to 3.2.
• the composition has a pH from 2.8 to 3.2.
• the pH is measured using the methods known in the state of the art. In the present invention, the pH is measured according to the CIPAC guideline MT75.3. This pH is the appropriate for having a stable, non-toxic and an efficient disinfectant and cleaning properties.
• the composition further comprises one or more pH adjusting agents.
• pH adjusting or “pH regulator” agent have the same meaning and are used interchangeable. They refer to acids or bases that can be used to adjust the pH of the finished composition to the desired level, without affecting the stability of the composition and its disinfectant and cleaning properties.
• the acid(s) and/or base(s) may be added to the composition in any suitable form, such as anhydrous, hydrated, aqueous or salt.
• the pH adjusting agent is a base.
• the pH adjusting agent is an acid.
• appropriate acids include sulfur-containing acid, such as a sulfonic acid, sulfuric acid, an alkali metal bisulfate, phosphoric acid and nitric acid. If present, the amount of the pH adjusting agent in the composition of the present invention is such for having the appropriate pH value of the compositions of the present invention.
• the composition further comprises one or more pH buffering agents.
• pH buffering agent is an acid in a sufficient amonut that control the pH into the desired acidic pH range of the composition as defined above.
• the presence of one or more pH buffering agent allows minimizing the pH changes, particularly after dilution.
• appropriate pH buffering agent include weak inorganic acids of phosphoric acid, strong organic acids of sulfonic acids, weak organic acids of phosphoric acid, phosphonic acid, boronic acid and mono- or multi-carboxylic acid (such as acetic acid, citric acid). If present, the amount of the pH buffering agent in the composition of the present invention is from 0.25 to 0.50 % by weight.
• the composition of the first aspect of the invention may be packaged and used to treat a given surface in any suitable format known to one of ordinary skill in the art, such as liquid compositions, foam composition, gel composition or impregnated on solid surfaces (such as wipes).
• the composition of the invention is in liquid format.
• the liquid format is a water-based solution composition which can be in form of spray, aerosol, bottle, doypack and sachet.
• the liquid compositions of the present invention may be packaged in manually operated dispensing containers (such as a trigger or a pump dispenser). In such a dispenser, the liquid composition may be divided in fine liquid droplets resulting in a spray/aerosol that is directed onto the surface to be treated.
• the composition of the invention is in gel format.
• the composition when the composition is a gel, the composition further comprises one or more jellifying agents.
• jellifying agents and their amounts, can readily be determined by those skilled in the art according to the type of formulation being prepared. Examples of appropriate jellifying agents include, acrylates/palmeth-25 acrylate copolymer (POLYGEL W301), 2-propenoic acid, homopolymer (POLYGEL CA) and a mixture thereof.
• POLYGEL W301 acrylates/palmeth-25 acrylate copolymer
• POLYGEL CA 2-propenoic acid
• POLYGEL CA homopolymer
• the gel compositions of the present invention may be packaged in manually operated dispensing containers, bottle, doypack and sachet.
• the composition of the invention is in foam format.
• the composition further comprises one or more foaming agents.
• foaming agents and their amounts can readily be determined by those skilled in the art according to the type of formulation being prepared.
• appropriate foaming agents include any of the surfactants as defined above in the present invention.
• the foam compositions of the present invention may be packaged in manually operated dispensing containers.
• the composition of the invention is in wipes format such as disposable towels incorporated/impregnated/wetted with the composition of the first aspect of the invention.
• the second aspect of the invention relates to a process for the preparation of the composition of the first aspect of the invention.
• compositions of the present invention can be prepared according to methods well known in the state of the art according to the type of formulation being prepared.
• the process for the preparation of the composition of the first aspect of the invention comprises:
• the process for the preparation of the composition of the first aspect of the invention comprises:
• steps a), a'), b) and c) are performed under continuously stirring. In an embodiment, steps a), a') and b) are performed at room temperature.
• room temperature refers to a temperature of the environment, without heating or cooling, and it is generally from 20°C to 25°C.
• step a) is performed by simultaneoulsy addition of the organic phosphonic acid and the additives (if present).
• step b) comprises: firstly, adding the organic phosphonic acid; and secondly the simultaneulsly or sequentcially addition of the additives (if present). The addition of the additives can be performed in any order.
• step b) is performed by simultaneoulsy addition of the hydrogen peroxide and the lactic acid.
• step b) comprises: firstly, the addition of the hydrogen peroxide followed by the addition of the lactic acid.
• step a) comprises mixing from 80% to 100% of the total amount of water for providing the aqueous mixture containing the organic phosphonic acid of step a).
• composition of the first aspect of the invention comprises:
• steps c) and d) are performed under continuously stirring. In an embodiment, steps c) and d) are performed at room temperature.
• step c) is performed by simultaneoulsy addition of the organic phosphonic acid and the additives (if present).
• the addition of the additives can be performed in any order.
• the third aspect of the invention relates to the use of the composition of the first aspect of the invention as disinfectant and cleaner.
• the terms "disinfectant” and “disinfecting” have the same meaning and are used interchangeable. They refer to its ability of destroying, detering, rendering harmless and/or exerting a controlling effect on any harmful organism (including bacteria, fungi, spores, viruses, moulds and yeast), which exist on a non-living surface.
• a composition is considered effective as a disinfectant having bactericidal and fungicidal activity wherein the composition complies with the bactericide and fungicide activity of the UNE-EN13697:2015 regulation on surfaces, which includes between others, Pseudomona aeroginosa and Aspergillus brasiliensis as reference microorganisms.
• the composition of the present invention reduces at least in a number of 4 logaritmic units against Pseudomona aeroginosa and at least in a number of 3 logaritmic units against Aspergillus brasiliensis as it is shown in the experimental section.
• a composition is considered effective as a disinfectant having viricidal activity wherein the composition reduces at least in a number of 4 logaritmic units against rellevant virus such as Vacciniavirus and Coronavirus 229E as it is shown in the experimental section.
• composition of the invention includes the effective amount of each ingredient for performing its disinfecting action.
• composition of the present invention is also appropriate for being used as cleaner agent.
• cleaning agent or “cleaning composition” refers to a composition that when applied to non-living surfaces, effectively removes foreign matter located on the surface.
• cleaning encompasses composition capable of removing lime, soap (foam, scum and stains) and grease from non-living surfaces.
• a composition is considered effective as cleaning agent wherein the laboratory results according to the IKW method (available in the website https://www.ikw.org/fileadmin/ikw/downloads/Haushaltswit/HP_EQ_AZR_2017_E.pdf on May 5th, 2020) show a low amount of traces (equal to or lower than 2.5) and a cleaning between 6-10 out of 10; and the removal of lime and soap residues is over 70% as it is shown in the experimental section.
• non-living surfaces encompasses hard-surfaces such as those typically found in hospital environments (e.g., operating theatres, surgical areas, recovery areas, moveable equipment such as gurneys, beds, and the like), medical laboratories, medical treatment environments, food services, food processing, and those found in residential and commercial spaces like kitchens, bathrooms, such as tiles, walls, floors, chrome, glass, smooth vinyl, any plastic, plasticized wood, table top, sinks, cooker tops, dishes, sanitary fittings such as sinks, showers, shower curtains, wash basins and toilets.
• non-living surfaces also include objects such as medical tools and food services equipment such as utensils.
• the method for disinfecting and cleaning of the present invention comprises contacting the surface with the composition for an exposure time from 1 min to 15 min, depending on the activity to reach.
• the compositions of the present invention are non-toxic non-irritant and allows having an efficient disinfectant activity and achieving a very thorough and at the same time broad cleaning effect with a short exposure time and without causing damage to the surface to be treated.
• compositions of the invention are 1.1. Compositions of the invention
• Tables 1 and 2 show the composition of the invention which have cleaning effect and effective disinfectant activity.
• Table 1 Ingredients function Ex.1 Ex.2 Ex.3 Ex.4 Hydrogen Peroxide Oxidant 1.5 1.5 1.5 1.5 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP).
• HEDP 1-hydroxyethylidene-1,1-diphosphonic acid
• the comparative compositions 1, 4, 5, 7 and 9 comprise an amount of lactic acid outside the claimed ranges (the amount of lactic acid in the Comp. Ex. 1 and 4 is higher than the claimed range, and in the Comp. Ex. 5, 7 and 9 is lower than the claimed range).
• comparative compositions 1 and 4 do not comprise an organic phosphonic acid; and the comparative composition 5 also has a pH value higher than the claimed range.
• comparative compositions Examples 6 and 8 do not contain lactic acid.
• the comparative compositions 2 and 3 contain formic acid instead of lactic acid.
• Table 3 Ingredients function Comp. Ex. 1 Comp. Ex.2 Comp. Ex.3 Comp.
• compositions of the invention and the comparative composition as defined above were prepared following the general process as defined below using the ingredients and the amounts specified in Tables 1, 2 and 3 respectively.
• the resultant compositions can be conditioned in small recipients of 100ml or in big reactors of 30 Tn.
• the fragrances can be added separately to the rest of additives (which are added in step a), Partiuclarly, the fragrances can be added to the resulting mixture obtained in step a) maintaining the stirring until an homogeneous solution was obtained (step a').
• the tested compositions were stored at 54°C ⁇ 2°C during 2 weeks period in its commercial packaging material (PE bottle). Only Example 5 was stored at 40°C during 12 weeks, which is an equivalent condition of stability.
• the determination of the hydrogen peroxide content from the tested compostions was performed according to CIPAC MT46.3 protocol. The % of degradation is calculated using the following equation: (%H 2 O 2 initial -%H 2 O 2 final)/%H 2 O 2 initial
• the percentage of hydrogen peroxide degraded after submitting the tested compositions under the stability test conditions show that the hydrogen peroxide is only stable in the composition of the invention, while the comparative compositions have a degradation degree of hydrogen peroxide equal to or higher than 9%.
• compositions of the present invention comprising the hydrogen peroxide, the organic phosphonic acid and the lactic acid in the claimed amounts meets the specifications stablish by the FAO/WHO to guarantee a toxicological safety and ensuring an appropriate disinfectant and cleaning effectivenes.
• the aim of the below-disclosed tests is the evaluation of the biocide activity of the compositions of the present invention in comparison with the comparative compositions falling outside the scope of the present invention.
• the bactericidal, fungicidal and/or viricidal activity were measured for the tested compositions (Examples 1, 2, 4, 5 and 7; and Comp. Ex. 6, 7 and 8).
• the procedure of the disinfectant test is based on the European Norms (Guidance on the Biocidal Product Regulation):
• the tested microorganisms, fungui and virus of study were: Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus hirae (EH), Escherichia coli, Candida albicans, Aspergillus brasiliensis (AB), H1N1 Virus, Human Coronavirus 229E and Vaccinia Virus.
• compositions of the present invention are biocide.
• the compositions of the invention show a triple bactericidal, fungicidal and viricidal activity even of comprising a low amount of hydrogen peroxide from 0.5 and 2% by weight (Ex. 1, 2, 4 and 5).
• the comparative compositions which does not contain lactic acid (Comp. Ex. 6 and 8) or contain it in a very low amount falling outside of the claimed range (Comp. Ex. 7 having a 0.09%) do not have an efficient disinfectant effect.
• the inefficient disinfectant effect is not enhanced even of increasing the amount of hydrogen peroxide until 2.5% by weight (Comp. Ex. 9).
• the aim of the below-disclosed tests is the qualitatively evaluation of the cleaning capacity of the compositions of the present invention in comparison with the comparative compositions falling outside of the scope of the present invention.
• the anti-lime and soap removal capability, the traces evaluation test and the degreasing effect are measured.
• the lime and soap removal effect of the compositions of the present invention was performed.
• the aim of this test is the qualitative and quantitative evaluation of the cleaning capacity of the above-mentioned tested compositions regarding the removal of lime and soap from surfaces.
• the procedure is based in the contact for 5 min of the tested compositions with a surface impregnated with a mixture of lime and soap.
• the hard surface can be a metal or ceramic tile as these are the most representative surfaces in the domestic area. After 5 min of exposition, the surface must be treated with distilled water and the efficacy is evaluated.
• the capacity of removing the lime from the surface shows the efficacy of the composition on the surface using a visually scale rate.
• the scale rate was determined by the evaluation of the circle of the tile (which leaves the ring). The less lime it is leaved in the circle (circle more shiny), the better antime and soap cleaning efficacy is.
• the degree of lime and soap removal is expressed in percentage in relation to the initial amount. The higher the percentage, the better the lime scale and soap removal effect.
• the traces Test of the compositions of the present invention was performed.
• the aim of this test is the quantitative evaluation of the amount of visual residues that remains on the treated surface after the application of the tested compositions.
• the amount of visual residues on a surface is correlated with its brightness. The more the number of visual residues, the less brightness of the surface.
• the method used is the HP_EQ_AZR_2017_E protocol (IKW Recommendation for the Quality Assessment of the Product Performance of All-Purpose Cleaners 2014).
• the amount of traces on the surface are scored from 0 to 10, being 0 the no presence of traces (total elimination of visual residues) and 10 the nule elimination of visual residues.
• the score number the better the traces removal.
• the degreasing Evaluation Test of the compositions of the present invention (Ex. 2 and 4) was performed.
• the aim of this test is the quantitative evaluation of the amount of grease and particulate dirt that remains on the treated surface after the application of the tested compositions.
• the method used is the HP_EQ_AZR_2017_E protocol (IKW Recommendation for the Quality Assessment of the Product Performance of All-Purpose Cleaners 2014).
• the amount of grease on the surface are scored from 0 to 10, being 0 the nule elimination of grease and 10 the no presence of grease (total elimination of grease). Thus, the higher the score number, the better the grease removal.
• compositions of the present invention are capable of being used as cleaning compositions.
• they have a high efficiency for as anti-lime agent and also useful for the removal of soap removal in the commonly used surfaces at both homeplace and workplace, including delicate surfaces such as metal surfaces and organic based surfaces.
• the composition of the present invention are also effective as degreasing agent giving at the same time a brightness to the treated surface without damaging it.
• the aim of this test is the quantitatively evaluation of aggression of on a marble plate caused by the above-mentioned tested compositions.
• the procedure is based in the contact of marble block specimens with the tested composition for 5 min and after that time, the evaluation of the weight's loss of the CaCO 3 because of the effect of the composition was determinted.
• compositions of the present invention have not a high impact in the deposits of CaCO 3 even though with high concentrations of lactic acid. Furthermore, these results also show that the change of the lactic acid for another acid such as formic acid in the same amount (Comp. Ex. 2 and 3) do neither result in an enhancement of the aggression to the marble plates.
• compositions of the present invention (Ex. 2 and 5) were submitted to the material compatibility test based on the UNE-EN 13442 (Wood floors and interior and exterior wood wall coverings. Determination of resistance to chemical agents) changing the paper surface by a calcareum or metallic surface
• the aim of this test is the qualitatively evaluation of the damage caused by the application of the above-mentioned tested compositions over the above-mentioned hard surfaces.
• the objective is the determination of the resistance of the carcareoum or metallic element to a predetermined ratio of chemical agents to which it could be exposed during its service life.
• UNE-EN 13442 Method A paper impregnated with one of the above-mentioned tested composition was placed on the test surface and covered with a Petri dish to prevent evaporation. After a specified period of time, the paper is removed, the test surface is washed and dried, and visible changes are analyzed. These changes are evaluated against a numerical classification code.
• Results the damage caused by the tested compositions was evaluated by visual examination. A numerical value is associated to the tested area in comparison to the reference area, which has not been exposed to the tested compositions according to the following classification code: Code Visual evaluation Assesment 5 no visible changes 4 slight change in brightness or color, visible only when light is reflected from the tested surface or very close to the mark or the presence of some isolated marking on the filter paper barely visible Good or very good compatibility with the surface. The use of the composition on those surfaces is advisable. 3 moderate marking of filter paper visible under different angles Moderate compatibility with the surface. The use of the composition is advisable, but with some reservations, for example using it with high exposure times on the surface. 2 important mark of the filter paper, leaving the structure of the surface unchanged Poor compatibility with the surface.
• the structure of the surface is altered: the material being completely or partially removed from the surface, the filter paper adhering to the tested surface or other signs of attack such as corrosion, oxidation or cracking Very poor compatibility with the surface. It should be mentioned on the label that it is recommended not to use the composition on surfaces.
• composition of the present invention (Ex. 5) was submitted to the in-use test under dermatological control by the assestment of the cutaneous acceptability of the tested composition, applied under the normal conditions of use for 3 weeks.
• the aim of this test is the determination of the attack of the integrity of the skin by lesions in the epidermis and the appearance of an inflammatory reaction in the dermis, resulting in macroscopically visible phenomena, which manifests from a redness (erythema) to edema.
• the use test is performed under Dermatological control allowing the verification of the absence of discomfort reactions or cumulative irritation associated to the application of the tested composition for 3-4 weeks in normal conditions of use, under subjects who met specific inclusion criteria.

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• 2020
  • 2020-06-10 EP EP20382501.3A patent/EP3922706A1/fr not_active Withdrawn
• 2021
  • 2021-06-09 ES ES21730617T patent/ES2969795T3/es active Active
  • 2021-06-09 EP EP21730617.4A patent/EP4165158B1/fr active Active
  • 2021-06-09 WO PCT/EP2021/065377 patent/WO2021250049A1/fr unknown

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