EP3919058A4 - Use of composition containing cdk4/6 inhibitor in combination with anastrozole in preparation of medicament for treating tumor diseases - Google Patents

Use of composition containing cdk4/6 inhibitor in combination with anastrozole in preparation of medicament for treating tumor diseases Download PDF

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Publication number
EP3919058A4
EP3919058A4 EP20748834.7A EP20748834A EP3919058A4 EP 3919058 A4 EP3919058 A4 EP 3919058A4 EP 20748834 A EP20748834 A EP 20748834A EP 3919058 A4 EP3919058 A4 EP 3919058A4
Authority
EP
European Patent Office
Prior art keywords
anastrozole
medicament
inhibitor
preparation
combination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP20748834.7A
Other languages
German (de)
French (fr)
Other versions
EP3919058A1 (en
Inventor
Xiaoyu Zhu
Guorong Li
Jianjun ZOU
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Hengrui Medicine Co Ltd
Original Assignee
Jiangsu Hengrui Medicine Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co Ltd filed Critical Jiangsu Hengrui Medicine Co Ltd
Publication of EP3919058A1 publication Critical patent/EP3919058A1/en
Publication of EP3919058A4 publication Critical patent/EP3919058A4/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP20748834.7A 2019-01-30 2020-01-22 Use of composition containing cdk4/6 inhibitor in combination with anastrozole in preparation of medicament for treating tumor diseases Withdrawn EP3919058A4 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CN201910089738 2019-01-30
CN201910339438 2019-04-25
CN201910516489 2019-06-14
CN201910620303 2019-07-10
CN201910907616 2019-09-24
PCT/CN2020/073815 WO2020156446A1 (en) 2019-01-30 2020-01-22 Use of composition containing cdk4/6 inhibitor in combination with anastrozole in preparation of medicament for treating tumor diseases

Publications (2)

Publication Number Publication Date
EP3919058A1 EP3919058A1 (en) 2021-12-08
EP3919058A4 true EP3919058A4 (en) 2022-11-02

Family

ID=71840877

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20748834.7A Withdrawn EP3919058A4 (en) 2019-01-30 2020-01-22 Use of composition containing cdk4/6 inhibitor in combination with anastrozole in preparation of medicament for treating tumor diseases

Country Status (11)

Country Link
US (1) US20220125792A1 (en)
EP (1) EP3919058A4 (en)
JP (1) JP2022523088A (en)
KR (1) KR20210121188A (en)
CN (1) CN113395969A (en)
AU (1) AU2020214930A1 (en)
BR (1) BR112021014820A2 (en)
CA (1) CA3128072A1 (en)
MX (1) MX2021009188A (en)
TW (1) TW202042810A (en)
WO (1) WO2020156446A1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104470921B (en) 2013-05-17 2017-05-03 上海恒瑞医药有限公司 Thiophene miazines derivate, preparation method therefor, and medical application thereof
US10030018B2 (en) 2015-02-03 2018-07-24 Jiangsu Hengrui Medicine Co., Ltd. Hydroxyethyl sulfonate of cyclin-dependent protein kinase inhibitor, crystalline form thereof and preparation method therefor
CN107137408A (en) * 2016-03-01 2017-09-08 江苏恒瑞医药股份有限公司 A kind of CDK4/6 inhibitor combines the purposes in the medicine for preparing treatment breast cancer with arimedex
CN107137409A (en) * 2016-03-01 2017-09-08 江苏恒瑞医药股份有限公司 A kind of CDK4/6 inhibitor combines the purposes in the medicine for preparing treatment breast cancer with estrogen receptor antagon

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
LONG FEI ET AL: "Preclinical characterization of SHR6390, a novel CDK 4/6 inhibitor, in vitro and in human tumor xenograft models", CANCER SCIENCE, vol. 110, no. 4, 26 February 2019 (2019-02-26), JP, pages 1420 - 1430, XP055963838, ISSN: 1347-9032, Retrieved from the Internet <URL:https://onlinelibrary.wiley.com/doi/full-xml/10.1111/cas.13957> DOI: 10.1111/cas.13957 *
MA CYNTHIA X. ET AL: "NeoPalAna: Neoadjuvant Palbociclib, a Cyclin-Dependent Kinase 4/6 Inhibitor, and Anastrozole for Clinical Stage 2 or 3 Estrogen Receptor-Positive Breast Cancer", CLINICAL CANCER RESEARCH, vol. 23, no. 15, 1 August 2017 (2017-08-01), US, pages 4055 - 4065, XP055964721, ISSN: 1078-0432, Retrieved from the Internet <URL:https://aacrjournals.org/clincancerres/article-pdf/23/15/4055/2037430/4055.pdf> DOI: 10.1158/1078-0432.CCR-16-3206 *
MATTHEW P. GOETZ ET AL: "MONARCH 3: Abemaciclib As Initial Therapy for Advanced Breast Cancer", JOURNAL OF CLINICAL ONCOLOGY, vol. 35, no. 32, 10 November 2017 (2017-11-10), US, pages 3638 - 3646, XP055485774, ISSN: 0732-183X, DOI: 10.1200/JCO.2017.75.6155 *
RAMOS-ESQUIVEL ALLAN ET AL: "Cyclin-dependent kinase 4/6 inhibitors as first-line treatment for post-menopausal metastatic hormone receptor-positive breast cancer patients: a systematic review and meta-analysis of phase III randomized clinical trials", BREAST CANCER, JAPANESE BREAST CANCER SOCIETY, TOKYO, JP, vol. 25, no. 4, 22 February 2018 (2018-02-22), pages 479 - 488, XP036524211, ISSN: 1340-6868, [retrieved on 20180222], DOI: 10.1007/S12282-018-0848-6 *
See also references of WO2020156446A1 *

Also Published As

Publication number Publication date
WO2020156446A1 (en) 2020-08-06
EP3919058A1 (en) 2021-12-08
AU2020214930A1 (en) 2021-09-16
KR20210121188A (en) 2021-10-07
CN113395969A (en) 2021-09-14
TW202042810A (en) 2020-12-01
MX2021009188A (en) 2021-11-12
US20220125792A1 (en) 2022-04-28
CA3128072A1 (en) 2020-08-06
JP2022523088A (en) 2022-04-21
BR112021014820A2 (en) 2021-09-28

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